ライフサイエンスコーパス: drastically

1 consumption within nerve terminals increases drastically.

2 ver, the RRS features of fluorophores differ drastically.

3 myocardial infarction (STEMI) has decreased drastically.

4 erable efficiency and reduce production cost drastically.

5 d (BMDM) and peritoneal macrophages differed drastically.

6 hich the rhamnose-xylose ratio was increased drastically.

7 rful and simple-to-implement method that can drastically accelerate fully converged GW calculations f

8 inetic assays monitored by thioflavin-T show drastically accelerated aggregation leading to large fib

9 ticular, the VWD type 2A Gly1629Glu mutation drastically accelerates the proteolytic cleavage activit

10 n wave energy above which salt marsh erosion drastically accelerates.

11 at small chemical changes to the capsule can drastically affect its biological properties.

12 Degradation of the layer has been shown to drastically affect microvascular flow, permeability, and

13 The coordinated anions can drastically affect the reactivity of the complex and sho

14 tive structure and binding properties may be drastically affected by the elevated temperature.

15 Substitution of these two residues drastically affected DNA-binding affinity, resulting in

16 are reporting that MUC4 protein stability is drastically affected in PC, under hypoxic condition in a

17 cting its spatial distribution, HF diet also drastically affected microbiota composition with a profi

18 exon-skipping therapy was shown to decrease drastically after six months in treated muscles.

19 ggest that perturbations to salt marshes can drastically alter active microbial communities, however

20 tional cues, either alone or in concert, can drastically alter cell function.

21 Climate change may drastically alter patterns of species distributions and

22 as shown that mutations in conserved motif A drastically alter RdRP fidelity, which can be either inc

23 ave shown that promoter-specific effects can drastically alter synaptic function within a specific re

24 Finally, we show that rapid rebindings drastically alter the reaction's Michaelis-Menten rate e

25 These samarium vacancies drastically alter the resistance and plateauing magnitud

26 addition of each extra layer of graphene can drastically alter their electronic and structural proper

27 Loss of mitochondria resulted in drastically altered calcium signaling that could disrupt

28 oons display a time-activity balance that is drastically altered in comparison to individuals living

29 Humans have drastically altered the abundance of animals in marine e

30 single or combined SST/CORT KO-models is not drastically altered under normal conditions.

31 Reconfigurable devices, whose shape can be drastically altered, are central to expandable shelters,

32 former residues with nearby amino-acids are drastically altered, resulting in major changes of prote

33 ite and dynamic fluctuations of the PIs were drastically altered.

34 uctural dynamics at the trimer crown without drastically altering global Env trimer stability.

35 le calculations suggested the tensile strain drastically alters the band gap, and the vanishing gap o

36 a specific kinase inhibitor of BMP receptors drastically attenuated chondrogenesis in recombinant hum

37 Klf4 ablation drastically attenuates the formation of pancreatic intra

38 of the analytical instrumentation and would drastically benefit from improved sensitivity, reproduci

39 Here we extend such experimentation drastically, beyond dyads and beyond laboratory walls, t

40 h temperatures affected the stability of CTX drastically, but encapsulation in proniosomes retarded i

41 oncentration of Hg(2+) ions could be reduced drastically by 98% (from 200 to 4 ppb) in pure water.

42 mical properties of the radical were changed drastically by harnessing its binding energy to the meta

43 ork that the breakup limit can be overpassed drastically by using electric current to interfere.

44 rrigation of such varieties could be reduced drastically (ca. 80%) without affecting considerably the

45 in several steps, we find that the dynamics drastically change from backward to dominant forward sca

46 To divide, most animal cells drastically change shape and round up against extracellu

47 acancies on the C and Ni sites, but does not drastically change shape.

48 involving designed specific interactions can drastically change supramolecular morphology and even cr

49 a threefold increase in ice-free area could drastically change the availability and connectivity of

50 Here we show that HI drastically change the critical dimensions of water scar

51 ount during exposure experiments, since they drastically change the exposure conditions.

52 ession of the bacterium that produces it and drastically change the metabolism and behaviour of the b

53 the experiments induce diversity, which may drastically change the outcome of biomarker detection al

54 tic Bax protein to OxPls-containing vesicles drastically changed the membranes' dynamic behavior, alm

55 ceptor T cells (CART) and blinatumomab, have drastically changed the outcome of patients with relapse

56 ss of the tryptophan side chain by mutation, drastically changes the coordinated motions and dynamica

57 rt here for the first time that black carbon drastically changes the development of bacterial biofilm

58 esistance, which, as we illustrate here, may drastically confound the evolutionary outcome.

59 Air-drying drastically converts the outer-sphere complexes to the i

60 was observed only for the G308E aberration, drastically damaging both the redox properties of AIF an

61 ils in the presence of local electric fields drastically decrease the overpotential of CO2 electrored

62 NA inhibition and lack of CLASPs resulted in drastically decreased GDMT nucleation, computational mod

63 ion of hTau at lysines 163, 280, 281 and 369 drastically decreased hTau phosphorylation and significa

64 genin at the protein, but not mRNA, level is drastically decreased in 4.1R knockdown myocytes.

65 Expression of sbnD-I is drastically decreased in an sbnI mutant, and the mutant

66 recipient cDCs after cardiac transplantation drastically decreased presentation of donor MHC molecule

67 of the replaced SNAP-23 residues to SNAP-25 drastically decreased the cleavability of SNAP-25.

68 e mass of (177)Lu-OPS201 from 10 to 200 pmol drastically decreased the effective dose from 0.0908 to

69 ermined in corridor and staircase tests, and drastically decreased tissue expression of anti-inflamma

70 hickness human skin, the delivery efficiency drastically decreased to a value of approximately 12%.

71 nscription level of Rs-cps in R. similis was drastically decreased.

72 nd the overall microbial community diversity drastically decreased.

73 c of DM1, DM2, and C9orf72-ALS/FTD cells was drastically decreased.

74 However, sporulation efficiency drastically decreases concomitant with an increase in th

75 We show that the presence of synergies drastically decreases the ability of the CNS to vary the

76 ults strongly suggest that inhibitor binding drastically decreases the cooperativity of unfolding by

77 tend to mate with more polyandrous females, drastically decreases the intensity of precopulatory sex

78 during embryonic and perinatal phases before drastically decreasing during adulthood.

79 powers and overall excitation times, thereby drastically decreasing photobleaching during repeated sc

80 selection for faster binders was achieved by drastically decreasing the library-ligand incubation tim

81 nesis, whereas K252a blocked that effect and drastically delayed and prevented the complete restorati

82 of matrix proteins in the mutant enamel was drastically delayed, which was coincided with the greatl

83 wetting properties of porous media can vary drastically depending on the type of media and pore flui

84 The degree of MDM drastically depends on cooling conditions.

85 l divergence from colinear regions, they are drastically depleted for meiotic recombination in hetero

86 of even single residues at the interface may drastically destabilize the SOD1 homodimer, with several

87 found in the crystal structure of Mo2B4 show drastically different activities for hydrogen evolution,

88 ntities, confirmed by engineering faces with drastically different appearance that elicited identical

89 Together, these findings show drastically different axonal targeting outcomes dependen

90 uring photochemical aging, thus exhibiting a drastically different behavior from that of beta-pinene

91 suggesting that these particles can display drastically different behavior than predicted by bulk pr

92 kappaB dimers that are responsible for these drastically different binding free energies.

93 nces in H-Ras(G12V) expression levels led to drastically different biological outputs, suggesting tha

94 ignored in treatments of IRSC and arrive at drastically different conclusions.

95 n leads to 15 representative structures with drastically different conformation of N-terminus, which

96 These strategies can result in drastically different consequences for leaf gas-exchange

97 ples covering a wide concentration range and drastically different d/l-cysteine ratios in simulated b

98 The drastically different effects of these mutants, interpre

99 lly modulated device can be designed to have drastically different emission and absorption properties

100 between otherwise equivalent drugs can drive drastically different evolutionary outcomes.

101 xity and motor indices in REM sleep suggests drastically different gating mechanisms across sleep sta

102 Last, our results suggest drastically different gating mechanisms in NREM and REM

103 similarity in the filter region, yet exhibit drastically different ion selectivity.

104 tyrene is sensitive to CO concentration, and drastically different kinetic regimes are affected by mo

105 properties, AnsA and AnsB are shown to have drastically different local water environments surroundi

106 e reactions under CVD conditions that can be drastically diminished by the introduction of protective

107 Depletion of E-cadherin drastically diminished the cell-surface distribution of

108 tion, as mutating this residue to an alanine drastically diminishes the level of Ras1 phosphorylation

109 ation does not affect protein expression but drastically diminishes VRAC activity in T cells.

110 e mechanisms of transcription initiation are drastically dissimilar at these promoters.

111 suppressor activities in OSCC cells and was drastically downregulated in tumor tissues.

112 In yeast, dNTP pools expand drastically during DNA damage response.

113 alisation, but that PMA-induced PKC activity drastically dysregulates the localisation of ADAM17.

114 lopments in this field have the potential to drastically enhance our ability to assess and monitor el

115 A novel mechanism to drastically enhance the ECL is established by covalent a

116 This investigation shows drastically enhanced sensitivity and specificity of GNP

117 resistant to the respective miRNA exhibited drastically enhanced virulence in cotton plants.

118 ptical interface of a turbid medium, thereby drastically enhancing the coupling efficiency of light i

119 rinted interdigitated electrodes (IDEs) thus drastically enhancing the sensitivity of chemiresistive

120 which phylogenomic data can be generated has drastically escalated the computational burden for even

121 fication are lineage-specific and can differ drastically even among neighboring neuronal lineages.

122 limited advantages of nanoformulations were drastically exaggerated, and the assumptions used in nan

123 parallelized in a lossless manner, enabling drastically faster volumetric image acquisition rates fo

124 Measles incidence was reduced drastically following the introduction of attenuated vac

125 evices (</=0.1 cm(2) ), the PCEs deteriorate drastically for PSCs of larger areas because of the inco

126 oss of a 5 mum SWG waveguide bend is reduced drastically from 5.43 dB to 1.10 dB per 90 degrees bend

127 anchs, Pleurobranchaea californica, differed drastically from that of the nudibranchs.

128 r quantitative detection of biomarkers would drastically impact global health by enabling decentraliz

129 in the Gulf of Mexico have the potential to drastically impact marine systems.

130 rmation of multiple aberrant Atg8 puncta and drastically impaired autophagosome biogenesis, leading t

131 RMTg lesions drastically impaired the ability of foot shock to suppre

132 meloblasts, the cleavage of ameloblastin was drastically impaired.

133 Genetic inhibition or deletion of ACBD3 drastically impairs viral RNA replication and plaque for

134 ing interest: small changes in interest rate drastically improve returns over time.

135 Sharing rides could drastically improve the efficiency of car and taxi trans

136 ation of compounds that not only demonstrate drastically improved antiretroviral potency but also are

137 under the maximum electric field, leading to drastically improved recyclable energy densities.

138 ctively address this problem and resulted in drastically improved regioselectivities in this palladiu

139 ditional wing at the C5 position that led to drastically improved RNase H inhibition and significant

140 mbination anti-retroviral therapy (cART) has drastically improved the clinical outcome of HIV-1 infec

141 on microscopy (SRM) over the past decade has drastically improved the resolution of light microscopy

142 Short-term dietary restriction drastically improved the survival outcome of middle-aged

143 Their selective removal drastically improved their structural stability as demon

144 Here, we describe a method that drastically improves intracellular delivery of resonator

145 esent an optimized methodology that not only drastically improves the overall localization scores for

146 h facilitates the transport of O(2-) anions, drastically improves the reaction kinetics, and enables

147 We find that the functional selection step drastically improves the reproducibility and homogeneity

148 pes" or "community types", holds promise for drastically improving personalized medicine.

149 imination of IL-17 reduced sialadenitis more drastically in females than males.

150 since secondary OC4 and PC varies much less drastically in space or with local primary sources.

151 ge interaction is, surprisingly, observed to drastically increase compared to that of bulk, and to ex

152 Interaction between AtFTRc and MjTTL could drastically increase host reactive oxygen species-scaven

153 nsformed to the space of a target subject to drastically increase the number of angular samples to im

154 scales of millennia to just decades, and can drastically increase the rate of release of methane into

155 ry, that reducing the size of active NSs can drastically increase their oxidation resistance.

156 es of pEAbeta (3-42) possibly underlying its drastically increased aggregation propensity compared to

157 exposure, the sensitivity of the hepatocytes drastically increased and toxicity of a set of hepatotox

158 yed an abnormal microtubule structure with a drastically increased fragmentation within bone marrow a

159 r deleting two E protein genes in the thymus drastically increased ILC2 counts in the thymus and othe

160 the cellular filamentous actin (F-actin) is drastically increased in Rictor KO B cells after BCR sti

161 2(+) stem cells and clonogenic potential are drastically increased in the mutant pituitaries.

162 obtained with a batch setup, while providing drastically increased material throughput of valuable al

163 tment, although antimicrobial resistance has drastically increased over the years.

164 is second site of PA biosynthesis results in drastically increased PA levels within the inflorescence

165 (NSCs) in the postnatal dentate gyrus (DG), drastically increased perinatal apoptosis, altered DG ce

166 operty of TiO2 photoelectrodes, leading to a drastically increased photocurrent density ( Jph ).

167 osome profiling shows that eliminating HPFSa drastically increased ribosome occupancy at the 5' end o

168 Furthermore, neuraminidase 3 deficiency drastically increased storage of GM2 in the brain tissue

169 This drastically increased the complete silylation of the pyr

170 IL-21 drastically increased the number of IL-10(+) Bregs withi

171 cacy of cervical cancer cell elimination was drastically increased when circular polarization of inci

172 ults, and the distribution coefficients (KD) drastically increased with the GQS fraction that was ele

173 ng of the role of secondary metabolites have drastically increased.

174 Yet, daily poultry meat consumption drastically increases during Lunar New Year festival thr

175 Capsule shedding drastically increases invasion of epithelial cells and i

176 We report that higher proton availability drastically increases the acetate production rate, with

177 the non-conserved h1 of TCTP by that of Bax drastically increases the affinity of this hybrid for Bc

178 ocytosis, whereas the overexpression of VNUT drastically increases the quantal size of exocytotic eve

179 Physical inactivity, which drastically increases with advancing age, is associated

180 KEY POINTS: Physical inactivity, which drastically increases with advancing age, is associated

181 ng new electrode materials for LIBs has been drastically increasing due to the surging demands for cl

182 increase the quality of predictions without drastically increasing reconstruction time, thus making

183 oustic beam generated by a transducer array, drastically increasing the information channels and capa

184 Context can drastically influence responses to environmental stimuli

185 These properties can drastically influence the economy; thus, it has been of

186 nditions, where linear electron transfer was drastically inhibited due to impaired photosystem I acti

187 TZD drastically inhibited in vitro HIV-1 replication (>87%).

188 Interestingly, MYST3 depletion drastically inhibited proliferation in MYST3-high, ER+ b

189 n, which carries an AMPK-agonistic activity, drastically inhibited the expression of viral lytic gene

190 rge Lebanese family with high consanguinity, drastically inhibited this interaction by 90%.

191 Accordingly, C/EBPalpha knockdown drastically inhibits osteoclastogenesis and markedly abr

192 equired harsh reaction conditions, which has drastically limited their use as tools for the synthesis

193 nd of antibiotic resistance in Acinetobacter drastically limits the range of therapeutic agents requi

194 TR in tumor-infiltrating Tregs despite being drastically lower in other human TILs and in many human

195 ium salts leads to narrower band gaps and to drastically lower LUMO energies.

196 energy barrier for magnetization reversal is drastically lowered.

197 nd in other cyanobacteria, concomitantly and drastically lowering photosynthetic pigments and endurin

198 This drastically mitigates the Me(+) migration artifact, comm

199 4,5,9,10-tetraazaphenanthrene ligand, which drastically modifies the electronic structure and tunes

200 nds may degrade individually in vivo and can drastically modify the life cycle and biodistribution of

201 hysical details and topology of the junction drastically modify the properties of the supercurrent an

202 assical alkyne complexes of Pt(II) and their drastically more reactive Au(III) congeners.

203 ustrate that the number of safe wells may be drastically overestimated in some regions when Mn contam

204 Patterns of cannabis use are changing drastically owing to legalization, the availability of s

205 lly when the sulfonamide NH is deprotonated, drastically raises the activation barrier for the nucleo

206 is the principal discriminating feature: it drastically rearranges a network of proximal hydrogen bo

207 Here we show that great hammerhead sharks drastically reconfigure the function of these structures

208 ic level, it is necessary in a first step to drastically reduce complexity and then systematically in

209 ogical levels of extracellular Ca(2+), which drastically reduce hemichannel activity.

210 tative Concentration Pathways (RCPs), we can drastically reduce more than 50% of the DeltaTs uncertai

211 the LGS1 (LOW GERMINATION STIMULANT 1) locus drastically reduce Striga germination stimulant activity

212 The substitutions also drastically reduce the affinity of DnaC for ATP as measu

213 ly recommended 12 weeks to 3 weeks, we could drastically reduce the cost of therapy and the rate of a

214 monstrate that single-residue disruption can drastically reduce the effects of cross-seeding, a findi

215 modalities help overcome this challenge and drastically reduce the synthetic cost and complexity.

216 zing the data, (iii) the computing effort is drastically reduced (with a gain in computation efficien

217 highly modified parasitic invertebrates, is drastically reduced and compact, yet it shows the bilate

218 Maternal food restriction drastically reduced apelinemia in both mothers and growt

219 -hexen-1-ol, and (Z)-3-hexenyl acetate] were drastically reduced by blanching and suppressed by boili

220 ound GRP75, a key MAM tethering protein, was drastically reduced by long-term diabetes.

221 nimized the use of treatment antibiotics and drastically reduced C. difficile infection.

222 d in these mice grew robustly, but exhibited drastically reduced cytokine expression and leukocyte in

223 The mutant virus exhibited drastically reduced expression of miR-H2 but showed wild

224 chromosome and one segment of D. mauritiana drastically reduced fertility in the presence of Ysim, w

225 f key Ca(2+) modelling protein densities, is drastically reduced following the aortic banding procedu

226 Symbiont elimination results in a drastically reduced host survivorship and a diminished c

227 e interstitium, whereas neutrophil depletion drastically reduced IC formation and ameliorated vascula

228 This injury was drastically reduced in C3-deficient mice, suggesting C3

229 LHCII phosphorylation was drastically reduced in ch1-2, and the inactivation of ST

230 dels, we demonstrate that melanoma growth is drastically reduced in mice lacking c-Rel, but not p65,

231 induced oxidative damage and cell death were drastically reduced in the OXI1 null mutant (oxi1) and i

232 Expression of NLRC3 is drastically reduced in the tumour tissue of patients wit

233 protein complexes involved in autophagy was drastically reduced in these transgenic roots.

234 (beyond 700 nm) is highly advantageous with drastically reduced interference signals over visible on

235 e growth temperature from 30 to 37 degrees C drastically reduced its biotinylation level.

236 ly impacted not only larval traits, but also drastically reduced lifetime mating success of adult fem

237 ses were protected from mortality and showed drastically reduced lung viral titers.

238 GluA1 deletion drastically reduced palatability (as measured by the mea

239 Interestingly, overexpression of PDLP5 drastically reduced PD permeability, yet also impaired S

240 nts in which TF is not palmitoylated display drastically reduced plasma membrane localization, which

241 ongenital brain malformation, explaining its drastically reduced potency.

242 We observe drastically reduced rates of weak-to-strong substitution

243 tants with impaired CXCL12 affinity required drastically reduced receptor expression levels, suggesti

244 velets with Hidden Markov Models, we achieve drastically reduced running times for Bayesian inference

245 nt negative effect on collagen biosynthesis; drastically reduced secretion of collagen and induced hy

246 imitation in warmer waters; poor oxygenation drastically reduced site occupancy, and reductions were

247 Depletion of these proteins drastically reduced spontaneous and drug-induced latency

248 n 2 and 5 months post-status epilepticus and drastically reduced the frequency of spontaneous seizure

249 with the F1534C mutation, the V410L mutation drastically reduced the sensitivity of mosquito sodium c

250 Continuous feeding on leaves of RNAi lines drastically reduced the target gene transcripts and cons

251 ng highly efficient isolation of aptamers in drastically reduced times and with minimized consumption

252 In this study FeRh films with drastically reduced transition temperatures and a large

253 tems to climate change-induced stress can be drastically reduced via climate mitigation measures; wit

254 in infected primary CD4+ T-cell cultures and drastically reduced viral load in ex vivo culture of CD4

255 re fluctuations in the culture medium can be drastically reduced, while maintaining a high level of i

256 , and secreted peptidases and effectors were drastically reduced.

257 pensity to learn from successful individuals drastically reduces cultural diversity within fully conn

258 that combined deletion of the AR and C-tail drastically reduces DNA replication, by 85%, and that fu

259 on of the endothelial glycocalyx layer (EGL) drastically reduces EC production of NO in response to f

260 76 of the influenza A virus M2 protein that drastically reduces infectious virus production and fila

261 osphatase 2A (PP2A) inhibition or knock-down drastically reduces NLRP3 activation, showing that PP2A

262 hei-infected mice, oral administration of 1o drastically reduces parasitaemia and cures the animals.

263 sing its incorporation into transcripts, and drastically reduces SMOC2 gene expression in brachycepha

264 rmation of the reacting NH3 with the solvent drastically reduces the barrier of NH3 addition.

265 hat therapeutic inhibition of RANK signaling drastically reduces the cancer stem cell pool, decreases

266 A method is described that drastically reduces the effective thickness of ZIF-8 mem

267 This chemical modification drastically reduces the enzymatic degradation in serum,

268 regulation of ODZ1 by small interfering RNAs drastically reduces the invasive capacity of GBM cells.

269 t tools for fast epistasis detection, LinDen drastically reduces the number of tests performed while

270 Water drastically reduces the strength of olivine and this eff

271 Depletion of SCMsmall ef, Cyrillic also drastically reduces the Th1 but not the TFH response.

272 tions, such as customs inspections, since it drastically reduces time and costs of analysis.

273 centrations ( approximately 300-400 pmol/L), drastically reducing glucose in Gipr null and Lepr(db/db

274 The SMART approach, while drastically reducing system complexity, allows for a str

275 L28A mutation severely destabilized the NTD, drastically reducing TDP-43's in vitro splicing activity

276 controllable shape morphing potential, while drastically reducing the required fabrication times for

277 tain hematopoietic stem cells (HSCs) and are drastically remodeled in leukemia to support pathologica

278 ses of episodic silicic volcanism would have drastically remodelled landscapes and ecosystems occupie

279 This DNA-binding probe exhibits a drastically short lifetime in solution, leading to a hig

280 Mechanical wounding of freshly-pruned canes drastically shortens the time required to reach maximal

281 orm of atrial fibrillation, S140G and V141M, drastically slow IKs deactivation.

282 The drastically slowed sampling of potentially folding-compe

283 g(2+) cation to N7 of G33 makes the ribozyme drastically slower.

284 that increasing force from 0.5 to 10 pN can drastically speed up the actin polymerization rate.

285 changes the enzymatic activity of KLK2 in a drastically substrate-dependent manner.

286 , using these approximate protocols, one can drastically suppress heating and increase fidelity of qu

287 tabolism, did not affect muscle wasting, but drastically suppressed markers of hepatic amino acid cat

288 tion of a predicted central alpha-helix most drastically suppressed the inhibitory activity of RD3 an

289 tivity in the vicinity of the metallic layer drastically suppresses the localized mode along with the

290 Both heat treatments did not affect drastically the anthocyanins content and their percentag

291 an algorithm on a global basis could reduce drastically the rate of vision loss attributed to DR.

292 he US diet, the food environment has changed drastically to an obesogenic one with increased portion

293 ulture, however, GABA sensitivity diminished drastically to less than 10%, while that of glutamate an

294 These findings suggest we may be drastically underestimating the biochemical capabilities

295 ble to compete with the reaction centers and drastically undermine light-harvesting efficiency.

296 TSG-6 expression is drastically up-regulated after injury, and the TSG-6 pro

297 Young adult mutant soleus was drastically wasted, with highly atrophied type 1 fibers,

298 hanical properties have been shown to change drastically when abnormalities develop in arterial tissu

299 eins, such as Phe-Gly repeat domains, alters drastically when they are confined in, and tethered to,

300 and re-duced the cleavage efficiency of Cas9 drastically, whereas torsional constraints on the target