ライフサイエンスコーパス: drawback

1 d removal of directing groups is a practical drawback.

2 death, but complications remain an important drawback.

3 , but acquired resistance remains a limiting drawback.

4 eir low luminescent efficiency is a critical drawback.

5 d analysis parameters, which remains a major drawback.

6 re with 6 indicating the seizure was a major drawback.

7 ularly for in cellulo applications) remain a drawback.

8 an directly isolate from these oils presents drawbacks.

9 and gives an insight to their advantages and drawbacks.

10 ion step of the conventional PCR are serious drawbacks.

11 heir advantages and overcoming most of their drawbacks.

12 ot suffer from some of their well-documented drawbacks.

13 ed methods; each associated with significant drawbacks.

14 t clears the major previously mentioned GNPS drawbacks.

15 e the capability of each technique and their drawbacks.

16 thods, each one with specific advantages and drawbacks.

17 en species richness and climate without such drawbacks.

18 (GC-MS); all have theoretical and practical drawbacks.

19 have been widely explored to overcome these drawbacks.

20 on a few well-known species, they also have drawbacks.

21 tlas-based approaches while minimizing their drawbacks.

22 are discussed for their relative merits and drawbacks.

23 ntial advantages as well as their respective drawbacks.

24 w approach that attempts to circumvent these drawbacks.

25 no exposure), which has potentially serious drawbacks.

26 materials, each with its own advantages and drawbacks.

27 ssment, on skin tests (STs), which both have drawbacks.

28 these activated aziridines have significant drawbacks.

29 and was therefore modified to overcome these drawbacks.

30 ule management, outlining their benefits and drawbacks.

31 ologous nerve graft (autograft), has several drawbacks.

32 refined cereals and limitation of their main drawbacks.

33 a step forward in this process but has some drawbacks.

34 uires fluorescent labeling which has several drawbacks.

35 d toxicological studies reveal no observable drawbacks.

36 propylbenzoates, largely overcomes the above drawbacks.

37 These approaches have two notable drawbacks.

38 ntional DMN fabrication methods have several drawbacks.

39 sting network alignment-free approaches have drawbacks: 1) They rely on naive measures of network top

40 f the donor cells, which has three principle drawbacks: (1) Stem-like cells retain the capacity to pr

41 To overcome these drawbacks, a chemoenzymatic method has been developed ut

42 tionships, and it is able to address all the drawbacks aforementioned.

43 -based approaches, each of which has its own drawbacks and advantages.

44 These schemes, however, have inherent drawbacks and are inadequate to capture complex organiza

45 oparticle-based PET imaging has its inherent drawbacks and can possibly lead to erroneous imaging res

46 omplex scenario and presenting the potential drawbacks and limitations in the techniques and methods

47 d for this purpose, many are associated with drawbacks and limitations that justify the development o

48 nefits and then highlighting the substantial drawbacks and potential unintended consequences of the m

49 benefit from the lessons learned from these drawbacks and the current developments in primate commun

50 uromodulin in urine has several preanalytic drawbacks, and sensitive assays for the detection of uro

51 zymes, aptamers, MIPs); their advantages and drawbacks are discussed in this review.

52 Major drawbacks are, however, an inherently low electrical con

53 Its main drawback as a probe is lack of UV detection and as a res

54 These current approaches have serious drawbacks as they are either computationally burdensome

55 inding partners, however, comes with certain drawbacks, as it relies on identifying binding events by

56 Biosensing methods overcome these drawbacks, as these are simple, fast, specific and highl

57 and biologic therapies, and may address many drawbacks associated with available treatments for cance

58 otential "green alternative" to overcome the drawbacks associated with conventional chemical methods.

59 le its current configuration carries several drawbacks associated with high-voltage electrical pulses

60 ethodologies and nanozymes to circumvent the drawbacks associated with natural enzymes.

61 ar drugs, with a promise to mitigate several drawbacks associated with other degradable sustained del

62 ows a closer insight into the advantages and drawbacks associated with these tubulin-destabilizing ag

63 These safe and practical salts avoid many drawbacks associated with traditional HX sources includi

64 This is a drawback because an under-methylated position may be mis

65 and poor in vivo stability, with this latter drawback being most relevant to monophosphates than mono

66 one electron/Na) were identified as possible drawbacks, but strategies to address these issues were d

67 Next-generation sequencing overcomes this drawback by untargeted shotgun sequencing of whole metag

68 The graph-guided methods overcome this drawback by using the sample correlation to define the c

69 Many of these drawbacks can be minimized or eliminated by using protei

70 The impact of these drawbacks can be partly compensated by manual work that

71 This approach suffers from two key drawbacks: COF precipitates form concurrently and contam

72 hemical biosensors to overcome the enzymatic drawbacks, combining low cost scalable materials with su

73 ulted in the elimination of the most serious drawbacks concerning qtpy synthesis, consequently giving

74 We anticipated that these drawbacks could be overturned by judicious postsynthetic

75 Since most of these drawbacks could be solved during the past few years, we

76 er established MRI contrast agents, the main drawback deals with their low sensitivity.

77 hods are non-quantitative and have important drawbacks deriving from visually guided assessment of re

78 One of the drawbacks during second-generation biofuel production fr

79 cal routes to synthesize BT suffer from many drawbacks, e.g., harsh reaction conditions, multiple ste

80 he definition may vary among pathologists, a drawback especially in evaluation of biopsies for clinic

81 insolubility in water may constitute a major drawback, especially during the investigation of biochem

82 Drawbacks exist with the standard treatment (four-layer

83 to signal intensity, which is regarded as a drawback for metabolite discovery applications when samp

84 l liquid reagents, but this is a significant drawback for practical use.

85 attached, complex template is a substantial drawback for synthetic applications.

86 The drawback for these methods may include difficult control

87 from marine organisms often suffer from many drawbacks for cell biology applications, including poor

88 ts of the molecule, which presents potential drawbacks for characterizing individual paralogs of the

89 However, drawbacks for current chemotherapeutics lie in the fact

90 hasis on relative features, capabilities and drawbacks for different applications.

91 usions, but these therapies have significant drawbacks for patient safety and quality of life and do

92 n for replacing platinum--metals without any drawbacks for the reaction design.

93 in cannabis users that constitute important drawbacks for the use of cannabinoids as therapeutic age

94 ) and proteins/enzymes has both benefits and drawbacks: for example, it is put to good use in electro

95 To overcome these drawbacks, fusion of different invasive and noninvasive

96 potential for higher efficacy and may limit drawbacks generally arising from the use of a single-tar

97 The major drawback hampering siRNA therapies from being more widel

98 This drawback has limited previous experimental demonstration

99 een developed, they often have the following drawbacks: (i) lack of interpretability or interpreting

100 A drawback in all the in vitro studies was their failure t

101 terfering compounds in a sample form a major drawback in existing molecular sensor technologies, part

102 t deactivation by coke deposition is a major drawback in industrial processes.

103 le successful, the current techniques have a drawback in that they require fusion of a large degradat

104 A major drawback in the preparation of influenza vaccines is tha

105 ere, we present a method that overcomes both drawbacks in a very simple manner.

106 gn addresses concomitantly three fundamental drawbacks in EM lithotripters, namely, narrow focal widt

107 differentially private manner have had major drawbacks in terms of either accuracy or computational e

108 We discuss drawbacks in the techniques used to estimate coverage an

109 lthough, oxidation was found to be the major drawback, in general terms, high quality starter-free fr

110 Drawbacks include a more rigid regimen, a relative lack

111 used in optics and biological applications, drawbacks include low modulation speeds and diffraction-

112 quid amine absorption technology has several drawbacks including hazardous byproducts and a high-ener

113 ventional Caco-2 monolayer model has several drawbacks including labor-intensive culture process, unp

114 Currently available anticoagulants have some drawbacks including their non-specific actions.

115 ally approved thrombolytics have significant drawbacks, including bleeding complications.

116 on techniques used for LAMP and RT-LAMP have drawbacks, including poor discrimination capability, ina

117 y (GC-MS), and Nile red cell staining suffer drawbacks, including poor quantitation of neutral lipids

118 ophrenia (SZ) diagnosis, which overcomes the drawbacks inherent with the subjective diagnostic method

119 ments, technological issues, advantages, and drawbacks involved in natural gas storage in these two c

120 f a variety of diseases; however, their main drawback is a short half-life, which dictates multiple a

121 However, an important drawback is that standard meta-analyses can compare only

122 A drawback is that the large size of nanoparticles restric

123 Their prime drawback is that they detect sensitization which is only

124 Another drawback is that, because they perform just one statisti

125 spensable tool for laboratory science, but a drawback is the laborious sample processing required bef

126 A significant experimental drawback is the long time required to attain SE, which i

127 Amines react selectively with CO2, but a drawback is the unproductive weight of solvent or suppor

128 1/PD-L1 inhibitors that could overcome these drawbacks is slow because of the incomplete structural i

129 Therefore a possible solution to these drawbacks is to take advantage of the high tendency of s

130 epigenetics research, yet there are serious drawbacks: it is a relative measurement, which untethere

131 But the drawback lies in the fact that these methods require spe

132 tions in particular applications, some major drawbacks limit their use in whole-body PET/MR.

133 ezing conditions and thus overcomes existing drawbacks limiting production of large gel-based devices

134 on and detection still has several technical drawbacks, mainly related with problems of sensitivity a

135 versatility, supervised machine learning has drawbacks, most notably its dependence on a priori knowl

136 clitaxel and docetaxel suffer from two major drawbacks, namely their very low aqueous solubility and

137 Its strengths and drawbacks, notably the associated effort, are discussed.

138 ndex to exploit rapid phase changes with the drawback of also modulating amplitude.

139 A drawback of analyzing population-based data is that it i

140 The unique gating mechanism overcomes the drawback of charge screening seen in traditional FET bas

141 A notable drawback of existing clustering methods is that they ign

142 the visible spectral region is a significant drawback of fullerenes.

143 The major drawback of HDACi is the broad inhibition of the plethor

144 previously required separate scans with the drawback of high intrasubject variability.

145 e contemporary algorithms either exhibit the drawback of inconsistency and poor reliability, or suffe

146 One major drawback of ion mobility spectrometry (IMS) is the depen

147 One practical drawback of many P-value-based meta-analysis methods, in

148 A major drawback of oral immunotherapy for food allergy is the p

149 The drawback of our method is that it has a complex algebrai

150 Our results thus show that the classical drawback of run-and-tumble navigation-wasteful runs in t

151 nsitivities for DA, but display the negative drawback of slow adsorption and electron transfer kineti

152 Major drawback of SPI systems has been their high burst releas

153 One drawback of such FRET-based GEZIs is their broad spectra

154 iting valve durability, remains an important drawback of surgical and transcatheter bioprostheses.

155 A serious drawback of the treatment is that a significant proporti

156 However, one drawback of these indicators is that they have optimal t

157 One drawback of these screens is the labor-intensive and som

158 However, the primary drawback of this approach is poor cell and in vivo oligo

159 A major drawback of this approach is that it cannot model the jo

160 A major drawback of this approach is that it cannot model the jo

161 The main drawback of this approach is the requirement of sharing

162 ments to test different scenarios is a major drawback of this approach.

163 A major drawback of this assay is that it relies on simply count

164 The major drawback of this drug is the high adverse events rate, b

165 However, the main drawback of this material is the low stability and high

166 ciated with transradial access is a possible drawback of this method.

167 One drawback of this purely statistical concentration rollba

168 The main drawback of this strategy is the time-consuming identifi

169 The main drawback of this traditional approach lies in the kineti

170 The drawback of this, however, was the tendency of particle

171 Delayed hematopoietic recovery is a major drawback of umbilical cord blood (UCB) transplantation.

172 The main drawback of using WFGD for mercury capture is the possib

173 A major drawback of zeolites is the mass transfer limitation due

174 We highlight the many drawbacks of a commitment to compositional representatio

175 dy of a nationwide WM-system, advantages and drawbacks of a mass balance approach are discussed.

176 The advantages and drawbacks of both strategies are discussed.

177 I discuss the advantages and drawbacks of cancer immunotherapy through personalized g

178 nojunction (s-BCN) overcomes a few intrinsic drawbacks of carbon nitride film (severe bulk charge rec

179 Our results also present the drawbacks of characterizing the data by a two-component

180 This helped to avoid the drawbacks of commonly used electrode immobilization meth

181 let activation and clogging, are significant drawbacks of conventional 'dead end' filtration.

182 sensors hold great potential to overcome the drawbacks of conventional analytical techniques.

183 on sludge removal, which is one of the major drawbacks of conventional Fenton processes.

184 stic profile, might overcome the therapeutic drawbacks of conventional mTOR inhibitors.

185 peroxymonosulfate (PMS) activation to avoid drawbacks of conventional transition metal-containing ca

186 e remains a significant challenge due to the drawbacks of current adsorbents such as low uptake capac

187 Despite the drawbacks of current approaches, the advances in neurobi

188 Drawbacks of current carbon dioxide capture methods incl

189 sed vaccine with D antigenicity, without the drawbacks of current vaccines, will be a major step towa

190 The drawbacks of currently applied treatment include high sy

191 Second, the label-free sensing avoids drawbacks of currently used radiolabel-immunoassays for

192 are measureable through the skin, obviating drawbacks of dual sugar absorption tests.

193 on of natural gas including the benefits and drawbacks of each of the processes.

194 mns) was performed, being the advantages and drawbacks of each one presented.

195 tical and empirical techniques without major drawbacks of either.

196 olecules into bio-MOF-1, can circumvent some drawbacks of existing approaches for encapsulating guest

197 anic bridging ligands, and can overcome many drawbacks of existing drug delivery systems by virtue of

198 scular disease rate coupled with significant drawbacks of existing therapies emphasise the necessity

199 to more accurately evaluate the benefits and drawbacks of femtosecond laser cataract surgery.

200 work, we show that ASM eliminates the major drawbacks of FSM including complex elution solvent profi

201 The drawbacks of global stochastic optimization methods are:

202 The 1990s saw what had been major drawbacks of haploidentical transplantation, ie, very st

203 Given the drawbacks of implementing multivariate analysis for mapp

204 e lifetime-based measurement circumvents the drawbacks of intensity-based measurements and enables th

205 Finally, we consider the opportunities and drawbacks of intensively interrogating antibodies isolat

206 need for retreatment are the most important drawbacks of intracranial aneurysm embolization.

207 ever enters the MS, TIPS addresses two major drawbacks of IPC for ESI-MS: it avoids both ion suppress

208 es of the wealth of nations, the benefits or drawbacks of markets and international trade, the effect

209 Avoiding the drawbacks of most conventional BAM instruments, this con

210 Apart from drawbacks of MR-based PET attenuation correction in osse

211 eview covers the principles, advantages, and drawbacks of passive and active targeting based on vario

212 However, the inherent drawbacks of plasmonic mode limited on UV-green waveleng

213 cting human biosignals, but have significant drawbacks of power consumption issues that limit sustain

214 ls is a promising approach to overcoming the drawbacks of protein delivery of growth factors.

215 acy issues with the potential advantages and drawbacks of sharing genetic data with patients and thei

216 ages of different components to overcome the drawbacks of single component photocatalysts.

217 sed on such prior knowledge, we overcome the drawbacks of snap-shot data by considering the possible

218 Drawbacks of some of these materials may include high co

219 We discuss the advantages and drawbacks of targeted parathyroidectomy and the performa

220 commercially established technology, several drawbacks of the current process provide an essential im

221 Moreover, the advantages and drawbacks of the different types of transducers are disc

222 microRNAs (miRNAs) in serum can overcome the drawbacks of the existing diagnostic methods.

223 A detailed comparison of the merits and drawbacks of the experimental and computational techniqu

224 The advantages and drawbacks of the methodology adopted are discussed.

225 ualization method addresses some of the main drawbacks of the original methodology and might bring th

226 the diagnostic performance, advantages, and drawbacks of the technique, and its potential roles in c

227 ploits the advantages and eliminates several drawbacks of the traditional approaches (i.e., large sam

228 One of the main drawbacks of the use of e-PTFE covered stent-graft is hi

229 We also discuss the advantages and drawbacks of these methods and highlight the application

230 idate drivers; we discuss the advantages and drawbacks of these methods as well as their latest refin

231 Here we address the benefits and drawbacks of these systems, as well as their most recent

232 been performed, it evidencing advantages and drawbacks of these.

233 Noting some drawbacks of this approach, we introduce a new 'logistic

234 an judgment, and we discuss the benefits and drawbacks of this approach.

235 Understanding the current drawbacks of this model is essential for the correct dat

236 zation across the whole brain, they overcome drawbacks of traditional univariate approaches.

237 This study thus highlighted the merits and drawbacks of transcription regulation by each system.

238 SSM circumvents the drawbacks of transposon-mediated transgenesis, where ran

239 fibrillate ventricular arrhythmias, avoiding drawbacks of transvenous leads.

240 To overcome the drawbacks of unrefined magnetite we used an electrochemi

241 Major drawbacks of using such functions are the size dependenc

242 r remediation (SEAR), which may overcome the drawbacks of using surfactants at hyper-CMC concentratio

243 of fluorescent labels, however with a strong drawback: polarized fluorescence imaging is indeed spati

244 In order to overcome some of the drawbacks presented by these approaches, we developed a

245 However, in order to improve some drawbacks previous identified, the product was submitted

246 All these approaches have some drawbacks ranging from instability of hairpin constructs

247 t and comparison of large data sets, several drawbacks related to the MS-Cluster tool routinely used

248 stinal tract has been faced with a number of drawbacks related to their prolonged use.

249 However, their main drawback relies on the poor reliability derived from the

250 Its main drawback remains the long time required for reconstructi

251 Despite these drawbacks, scientific societies and colleges are intense

252 To address this drawback, single-molecule methods offer a way to access

253 These membranes, however, cause many drawbacks such as a high pumping cost and a need for per

254 In addition, traditional animal models have drawbacks such as high-cost, long periods and physiologi

255 de side reactions/corrosions, but introduces drawbacks such as intergranular cracking.

256 This technique has some fundamental drawbacks such as low sample throughput and a lack of di

257 Potentiometric probes suffer from many drawbacks such as potential drift and lack of selectivit

258 However, these vaccines present many drawbacks such as slow development, high price, and batc

259 tifungal activity, could be helpful to solve drawbacks such as solubility and stability.

260 ested scientific and industrial communities, drawbacks such as the poor availability of precursors, l

261 Ga-labeled imaging agents possessing certain drawbacks, such as longer synthesis time because of a re

262 non-volatile memory market currently, it has drawbacks, such as low operation speed, and limited cycl

263 compartments and organelles but avoid their drawbacks, such as membrane instability and limited cont

264 wever, liposomes still present some unsolved drawbacks, such as poor colloidal stability, short shelf

265 for large-scale genomic data due to several drawbacks, such as the high computation complexity O(|V|

266 this study design is associated with several drawbacks, such as the high variability of allergen expo

267 These therapies have, however, drawbacks, such as, the reduction in quality of life and

268 ntibodies can be associated with significant drawbacks that are often overlooked including lot-to-lot

269 OV platform that lacks several of the major drawbacks that have limited the clinical potential of th

270 he need for sample dilution are still common drawbacks that hinder their use in routine diagnosis.

271 er to offer a clear view of the benefits and drawbacks that HPSDS can provide over what we could cons

272 in self-assembly has several well-recognized drawbacks that limit performance in certain technical ar

273 However, there still exist several drawbacks that single-pixel architectures must address,

274 ed with a clinically relevant and increasing drawback, the development of infections due to multidrug

275 To overcome this drawback, the use of cytokine-based sustained therapy mi

276 mal models of S. aureus SSTI suffer from two drawbacks: these models are a better representation of h

277 parental haplotype construction is a primary drawback to noninvasive prenatal diagnosis (NIPD) of mon

278 Since a common drawback to ontology enrichment analyses is its verbosit

279 One drawback to previous studies has been the inability to c

280 A major drawback to the extension of NaOH-free olive debittering

281 A drawback to this approach is that substitution at more t

282 However, there are some potential drawbacks to PEG that are driving the development of alt

283 le each model system has unique benefits and drawbacks, ultimately, organoids hold special promise fo

284 que approach to overcome TRAIL-based therapy drawbacks using sequential administration of a tumor-hom

285 A main drawback was insufficient quality of the byproducts from

286 To overcome such drawback we here introduce an alternative and more flexi

287 To eliminate these drawbacks, we develop a novel magnetic soft capsule devi

288 To overcome these drawbacks, we investigate the feasibility of receptor-me

289 To overcome these drawbacks, we proposed to filter decay curves instead of

290 In order to overcome these drawbacks, we rearranged the genome of an avian H9N2 inf

291 inine quantification suffer from significant drawbacks when aiming to combine accuracy, simplicity, a

292 of the most mature nanocrystals is a serious drawback which may ultimately preclude their use in cons

293 ope for patients, they are not without their drawbacks, which include adverse side-effects, drug resi

294 It overcomes previous drawbacks, which were mainly due to the necessity of rel

295 Each regimen has drawbacks with regard to maternal or fetal risk.

296 All approaches have significant drawbacks with respect to stability and efficacy, but th

297 Potential drawbacks with such peptides include poor pharmacodynami

298 This drawback would be overcome if cellular ablation could be

299 A possible solution to this drawback would be to radically decrease detection thresh

300 Even its major drawback--zero bandgap--has resulted in something positi