ライフサイエンスコーパス: dream

1 ting cells, their repression is dependent on dREAM.

2 cleavage of HRK's transcriptional repressor DREAM.

3 ll as realization of our "one drug fits all" dream.

4 ed response compared to when they reported a dream.

5 ir release in the human body has long been a dream.

6 n and provide novel insights into memory and dreams.

7 nisms enabling higher-order consciousness in dreams.

8 e pronounced in lucid compared with nonlucid dreams.

9 ity and induces self-reflective awareness in dreams.

10 ippocampal associational function during REM dreams.

11 sufficient to account for the properties of dreams.

12 scle paralysis, and is associated with vivid dreams.

13 ol REM sleep, the brain state that underlies dreaming.

14 demonstrated by sleep states associated with dreaming.

15 hat are the properties of consciousness in a dream?

16 How does the brain control dreams?

17 ry (AAOM) principles explain the function of dreaming?

18 Our findings show that implantation of the DREAMS 2G device in de-novo coronary lesions is feasible

19 tion drug-eluting absorbable metal scaffold (DREAMS 2G) in patients with de-novo coronary artery lesi

20 (4 [10%] vs 2 [5%]), nightmares or abnormal dreams (4 [10%] vs none), upper respiratory tract infect

21 ) and dizziness (23/348 vs 86/352), abnormal dreams (53/348 vs 95/352), insomnia (30/348 vs 49/352),

22 In these studies, mepolizumab ( DREAM: 75 mg, 250 mg, or 750 mg intravenously; MENSA: 75

23 Reverse Engineering Assessments and Methods (DREAM 8) subchallenge: time course prediction in breast

24 ata and on synthetic tumors in the ICGC-TCGA DREAM 8.5 Somatic Mutation Calling Challenge primarily b

25 Reverse Engineering Assessments and Methods (DREAM) 8 Whole-Cell Parameter Estimation Challenge to de

26 ort the results and insights gained from the DREAM 9 Acute Myeloid Prediction Outcome Prediction Chal

27 eam regulatory element antagonist modulator (DREAM), a multifunctional Ca2+-binding protein, is reduc

28 eam regulatory element antagonist modulator (DREAM), a transcriptional repressor, is known to modulat

29 ts completed a questionnaire assessing lucid dreaming ability, and underwent structural and functiona

30 induced DREAM haplodeficiency or blockade of DREAM activity by chronic administration of the drug rep

31 To understand the genomic context in which dREAM acts we examined the distribution and localization

32 However, dreaming also occurs in non-REM (NREM) sleep, characteri

33 hod in recent crowdsourcing benchmark study, DREAM Alzheimer's Disease Big Data challenge to predict

34 The method was submitted to the DREAM Amyotrophic Lateral Sclerosis (ALS) Stratification

35 Analysis of mutant animals confirms that dREAM and CP190 are similarly required for transcription

36 tection was linked to an interaction between DREAM and the unfolded protein response (UPR) sensor act

37 es define the critical opposing functions of DREAM and USF1 in inhibiting and inducing A20 expression

38 se techniques shed light on the link between dreaming and emotional catharsis, post-traumatic stress

39 ion contributes to a fuller understanding of dreaming and memory.

40 s reveal shared neural systems between lucid dreaming and metacognitive function, in particular in th

41 an isomorphism between features of REM sleep dreaming and mnemonic principles.

42 imilar to those Llewellyn identifies in both dreaming and the ancient art of memory (AAOM).

43 ships between the neural correlates of lucid dreaming and thought monitoring.

44 However, the comparison between dreams and AAOM may be fruitful by suggesting new perspe

45 Although the analogy between dreams and ancient mnemotechniques is tempting because t

46 is protective role determines the content of dreams and any apparent relationship to the art of memor

47 icline-alone group experienced more abnormal dreams and headaches.

48 ating article about rapid eye movement (REM) dreams and how they promote the elaborative encoding of

49 characterised by complex motor enactment of dreams and is a potential prodromal marker of Parkinson'

50 hen awakened from sleep, we sometimes recall dreams and sometimes recall no experiences.

51 of at least 32 weeks duration (NCT01000506 [DREAM] and NCT01691521 [MENSA]) done between 2009 and 20

52 neuropsychiatric events (including abnormal dreams, anxiety, dizziness, and somnolence) were signifi

53 y encoded material, rapid eye movement (REM) dreams are inherently difficult to remember, do not usua

54 both hematopoietic and nonhematopoietic cell DREAMs are required for platelet thrombus formation foll

55 ting new perspectives for the study of lucid dreaming as well an altered perspective on the efficacy

56 During dreaming, as well as during wakefulness, elaborative enc

57 on, we investigated the structural basis for DREAM assembly.

58 r, which is a parasomnia manifested by vivid dreams associated with dream enactment behaviour during

59 dREAM associates with thousands of sites in the fly geno

60 However, the link to lucid dreaming at the neural level has not yet been explored.

61 unoprecipitation studies for TP53, RB1, E2F, DREAM, B-MYB, FOXM1 and MuvB.

62 pecific thesis that rapid eye movement (REM) dreams, because of their similarities to mnemonic techni

63 dE2F2/dREAM binding sites are enriched at divergently transcri

64 m regulatory element antagonistic modulator (DREAM) binds to regulatory element sites called DRE in t

65 d in DREAM KO control mice, but not in WT or DREAM bone marrow chimeric mice.

66 re we found that the transcription repressor DREAM bound to the promoter of the gene encoding A20 to

67 lly viewed as a functionless by-product of a dreaming brain: the jerky limb movements called myocloni

68 ction case-studies, including the recent HPN-DREAM breast cancer challenge.

69 ords: "We will meet the future not merely by dreams but by concerned action and inextinguishable enth

70 hic (EEG) activity to conscious awareness in dreams, but a causal relationship has not yet been estab

71 modern notions like implicit memory subsume dreaming by definition.

72 egulation of these genes through the p53-p21-DREAM-CDE/CHR pathway appears to be a principal mechanis

73 are expected to be regulated by the p53-p21-DREAM-CDE/CHR pathway.

74 enes through the recently discovered p53-p21-DREAM-CDE/CHR pathway.

75 by extensive simulation studies based on the DREAM challenge benchmark data.

76 nducted three additional analyses beyond the DREAM challenge question to improve the clinical contrib

77 we report the results from a community-based DREAM challenge to predict toxicities of environmental c

78 t represented by the methods used in the HPN-DREAM challenge.

79 A patients was performed in the context of a DREAM Challenge.

80 rall survival and were evaluated through the DREAM challenge.

81 s, such as the ICGC Pilots, CPTAC, ICGC-TCGA DREAM Challenges, and the 1000 Genomes SV Project.

82 As in previous DREAM challenges, we found that aggregation of participa

83 histology demonstrate that in the absence of DREAM, chondrocytes fail to arrest proliferation.

84 Consistent with the idea that dREAM co-operates with insulator-binding proteins, genom

85 ailable at http://guanlab.ccmb.med.umich.edu/DREAM/code.html and as supplementary file online.

86 A long-term dream comes true: An acyclic, neutrally charged silanone

87 t expressing Lin37 proliferate normally, but DREAM completely loses its ability to repress genes in G

88 Mechanistically, this process involves the DREAM complex (DP, p130/RBL2, E2F4 and MuvB), a newly id

89 The Drosophila melanogaster Myb-MuvB/dREAM complex (MMB/dREAM) participates in both the activ

90 -mediated destruction thereby disrupting the DREAM complex and can prevent exit from the cell cycle i

91 the specificity for p107/p130 over Rb in the DREAM complex and how the complex is disrupted by viral

92 Targeting the DREAM complex and imatinib-induced quiescence could prov

93 d mouse model that is uniquely deficient for DREAM complex assembly.

94 oinformatic analysis is based on genome-wide DREAM complex binding data, p53-depedent mRNA expression

95 Our results indicate that the DREAM complex facilitates high gene body HTZ-1/H2A.Z, wh

96 ia of DNA Elements and ChIP-seq data for the DREAM complex finds that a set of core cell cycle genes

97 ture therapeutic interventions to target the DREAM complex for more efficient imatinib responses.

98 Importantly, inhibition of DREAM complex formation by depletion of the DREAM regula

99 Interfering with DREAM complex formation either by siRNA-mediated knockdo

100 ors are regulated epigenetically and the MMB/dREAM complex plays a critical role in specifying, maint

101 The DREAM complex represses cell cycle genes during quiescen

102 DKN1A) and the recruitment of the repressive DREAM complex to the A3B gene promoter, such that loss o

103 vivo and that this process also involves the DREAM complex, a multisubunit complex that has recently

104 s p107 and p130, which are components of the DREAM complex, had been suggested to be responsible for

105 er 600 gene products that are targets of the DREAM complex, which is a transcription factor complex t

106 histone in transcriptional repression by the dREAM complex.

107 readout of transcriptional repression by the dREAM complex.

108 of cells undergoes quiescence involving the DREAM complex.

109 ere also identified as CC genes bound by the DREAM complex.

110 DREAM complexes have been identified in worm, fly, and m

111 the possibility of the existence of multiple DREAM complexes in plants.

112 dREAM complexes represent the predominant form of E2F/RB

113 r-blocking activity that depends on multiple dREAM components.

114 The DREAM consortium launched an open challenge to foster th

115 DREAM contains an E2F, a retinoblastoma (RB)-family prot

116 rtical motor generators, possibly related to dream content in REM sleep.

117 ty in these regions correlated with specific dream contents.

118 -relieving effects, even Morpheus the god of dreams could not have dreamt that his opium tincture wou

119 The protein DREAM decreases development of L-DOPA-induced dyskinesia

120 DREAM-deficient mice displayed persistent and unchecked

121 DREAM-deficient mice show defects in endochondral bone f

122 We found that DREAM deletion does not alter the ultrastructural featur

123 ow that p130 and p107 are not sufficient for DREAM-dependent repression.

124 ers, we designed an open-data, crowdsourced, DREAM (Dialogue for Reverse Engineering Assessments and

125 re we report an alternative approach, deemed DREAMing (Discrimination of Rare EpiAlleles by Melt), wh

126 DREAM downregulation was observed early after birth and

127 llular proliferation by interacting with the DREAM (DP, RB-like, E2F and MuvB) complex at two distinc

128 The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) comp

129 ents of the multiprotein complexes, known as DREAM/dREAM in human and flies.

130 narily conserved multiprotein complex termed dREAM/DREAM/LINC.

131 rmance of random forest based methods in NCI-DREAM drug sensitivity prediction challenge.

132 In this manuscript we consider the NCI-DREAM Drug Synergy Prediction Challenge dataset to ident

133 When dreaming during rapid eye movement (REM) sleep, we can p

134 a manifested by vivid dreams associated with dream enactment behaviour during REM sleep.

135 The dream enactment of rapid eye movement sleep behavior dis

136 ye movement sleep motor activity, leading to dream enactment.

137 In both NREM and REM sleep, reports of dream experience were associated with local decreases in

138 dividual reported dreaming or the absence of dream experiences during NREM sleep, suggesting that it

139 ons in vivo, enabling previously impossible 'dream experiments'.

140 ive and fluid cognitive processes during REM dreaming facilitate consolidation.

141 een memories during rapid eye movement [REM] dreams followed by indexation and network junction insta

142 site-specific DNA mutation is the long-term dream for cotton breeding scientists.

143 What, then, is consciousness in a dream for?

144 mine from early junior high school, where my dreams for adventure were shaped by Arthur Conan Doyle's

145 their total structures have long been major dreams for nanochemists.

146 Other analogs of dreams, for example, jokes, do not invoke function but d

147 leep that may be consistent with its role in dream formation and memory consolidation.

148 tand the biochemical mechanisms underpinning DREAM function and regulation, we investigated the struc

149 udy MuvB have generated limited insight into DREAM function.

150 uvB protein Lin37 as an essential factor for DREAM function.

151 DREAM functioned by transcriptionally repressing A20 thr

152 tegrity at these gene pairs and suggest that dREAM functions in concert with CP190 to establish bound

153 These findings suggest that dREAM functions in the organization of transcriptional d

154 ve encoding" during rapid eye movement (REM) dreams, generating novel associations between recent and

155 ogram called Building Recovery of Individual Dreams & Goals through Education & Support.

156 In the R6/2 mouse HD model, induced DREAM haplodeficiency or blockade of DREAM activity by c

157 Mostly on these grounds, lucid dreaming has been associated with metacognition.

158 Traditionally, dreaming has been identified with rapid eye-movement (RE

159 In a dream, how do contents get into the conscious field?

160 s, such as system justification and American Dream ideology, in engendering Americans' relative insen

161 ntly ordered locations--should appear during dreaming if the latter is, in fact, elaborative memory e

162 wellyn's claim that rapid eye movement (REM) dream imagery may be related to the processes involved i

163 ere is a lack of intentionality in producing dream images.

164 -/-)) were used to define the involvement of DREAM in dyskinesias.

165 further indicated the importance of platelet DREAM in thrombogenesis.

166 y, we contrasted the presence and absence of dreaming in NREM and REM sleep.

167 lationships between memory, imagination, and dreams in accordance with current state-of-the-art princ

168 this commentary emphasizes that the role of dreams in emotional integration and adaptation contribut

169 CANT1, and of the regulation of its gene by DREAM, in the control of protein synthesis and degradati

170 acterize the role of the Drosophila complex, dREAM, in the regulation of differentiation-specific E2F

171 events than did the nicotine patch for vivid dreams, insomnia, nausea, constipation, sleepiness, and

172 ding, Sue Llewellyn has provided a method of dream interpretation that takes into account both modern

173 ange of novel functionalities and to convert dreams into reality.

174 Mammalian DREAM is a conserved protein complex that functions in c

175 nsights from the structure, we addressed how DREAM is disassembled upon cell cycle entry.

176 However, it is unknown whether DREAM is expressed in anucleate platelets and plays a ro

177 an megakaryoblastic MEG-01 cells showed that DREAM is important for A23187-induced Ca(2+) mobilizatio

178 ecific inhibitors, we observed that platelet DREAM is important for alpha-granule secretion, Ca(2+) m

179 This reveals that assembly of mammalian DREAM is required to induce cell cycle exit in chondrocy

180 A lasting dream is to elucidate the side-chain-dependent driving f

181 Lucid dreaming is a state of awareness that one is dreaming, w

182 ditions have linked dreams to memory (e.g., "dreaming is another kind of remembering") and modern not

183 article argues that rapid eye movement (REM) dreaming is elaborative encoding for episodic memories.

184 The hypothesis that dreaming is involved in off-line memory processing is di

185 ess and dreaming support the hypothesis that dreaming is part of a larger process of cognitive explor

186 hen more detailed analysis of NREM sleep and dreams is absolutely necessary.

187 The memory for dreams is also fragile, and dependent on encoding once a

188 If this hypothesis is correct, the stuff of dreams is the stuff of memory.

189 that is premised on rapid eye movement (REM)/dream isomorphism is unsupportable on empirical grounds.

190 capture of neuronal proteins by immobilized DREAM/KChIP3 in the presence and absence of calcium (Ca(

191 The addition of Ca(2+)-bound DREAM/KChIP3 increases the activation of calcineurin (CN

192 demonstrate that in the presence of Ca(2+), DREAM/KChIP3 interacts with the EF-hand protein, calmodu

193 The amino-terminal portion of DREAM/KChIP3 is required for its binding to CaM because

194 or its binding to CaM because a construct of DREAM/KChIP3 lacking the first 94 amino-terminal residue

195 broadening upon the addition of CaM to (15)N DREAM/KChIP3.

196 wild-type (WT) control and nonhematopoietic DREAM knockout (KO) mice, DREAM KO control and hematopoi

197 t-active DREAM transgenic mice (daDREAM) and DREAM knockout mice (DREAM(-/-)) were used to define the

198 d nonhematopoietic DREAM knockout (KO) mice, DREAM KO control and hematopoietic DREAM KO mice showed

199 Tail bleeding time was prolonged in DREAM KO control mice, but not in WT or DREAM bone marro

200 KO) mice, DREAM KO control and hematopoietic DREAM KO mice showed a significant delay in time to occl

201 t the lack of rapid eye movement (REM)-sleep dreaming leading to loss of personal identity and defici

202 A review of the literature suggests that dreamed locations are neither familiar nor coherently or

203 e split participants based on their reported dream lucidity.

204 An alternative to both of these dream machines, grounded in the distribution of choliner

205 a possible example of a broader approach to dream material.

206 st that therapeutic approaches that activate DREAM may be useful to alleviate L-DOPA-induced dyskines

207 d by Christopher Morrison suggests that this dream may become a reality; however, a complete understa

208 eriodic occurrence of REM sleep episodes and dreaming may be regarded as a recurrent adaptive interfe

209 Freud's theory requires a new way of seeking dream meaning.

210 Under normal conditions, vivid dream mentation combined with skeletal muscle paralysis

211 potentiated the intensity of dyskinesia, and DREAM(-/-) mice exhibited an increase in expression of m

212 olocalizes with core members of the Myb-MuvB/DREAM (MMB/DREAM) transcriptional regulatory complex gen

213 been shown that such genes are controlled by DREAM, MMB and FOXM1-MuvB and that these protein complex

214 t a general mechanism: sequential binding of DREAM, MMB and FOXM1-MuvB complexes to late cell cycle g

215 ional regulation of late cell cycle genes by DREAM, MMB and FOXM1-MuvB.

216 ements in most late cell cycle genes binding DREAM, MMB, or FOXM1-MuvB.

217 confidence ranked target gene maps for TP53, DREAM, MMB-FOXM1 and RB-E2F and enables prediction and d

218 d a previously undiscovered function for the dREAM/MMB complex in regulating programmed cell death (P

219 b protein), has been shown to be part of the dREAM/MMB complex, a large multi-subunit complex, which

220 The DREAM modifications did not affect the kinetic profile o

221 transgenic mice expressing a dominant active DREAM mutant (daDREAM) showed a drastic reduction of the

222 ly repressive Drosophila RBF, E2F2, and Myb (dREAM)/Myb-MuvB complex.

223 Here we describe the HPN-DREAM network inference challenge, which focused on lear

224 All dreamed new prospects require the use of suitable substr

225 n, 12% [245 of 2006 participants]), abnormal dreams (nicotine patch, 12% [251 of 2022 participants]),

226 By using intravital microscopy with DREAM-null mice and their bone marrow chimeras, we demon

227 Using DREAM-null platelets and PI3K isoform-specific inhibitor

228 It has long been the dream of biologists to map gene expression at the single

229 His dream of finding a virus as the likely cause of the myst

230 other techniques are helping us realize the dream of seeing--in atomic detail--how different parts o

231 er these approaches will help us realize the dream of understanding the biological "glue" that sustai

232 nd molecular characterizations that were not dreamed of a decade ago.

233 are reaching resolutions that could only be dreamed of just a couple of years ago.

234 For decades, scientists have dreamed of preventing vision loss or of restoring the vi

235 Rhizobium-legume symbioses, researchers have dreamed of transferring this capability into nonlegume c

236 of memory (AAOM) in a scanner--to study the dreams of persons who use AAOM regularly.

237 se results imply that reviving the "American dream" of high rates of absolute mobility would require

238 We therefore organized the crowd-sourced DREAM Olfaction Prediction Challenge.

239 The impact of DREAM on L-DOPA efficacy was evaluated using the rotarod

240 as dream recall and the effect of remembered dreams on memory.

241 ime predicted whether an individual reported dreaming or the absence of dream experiences during NREM

242 and asking them if they had been conscious (dreaming) or not.

243 ila melanogaster Myb-MuvB/dREAM complex (MMB/dREAM) participates in both the activation and repressio

244 The DREAM-Phil Bowen ALS Prediction Prize4Life challenge als

245 Here, we report results from the DREAM-Phil Bowen ALS Prediction Prize4Life challenge.

246 Biochemical studies revealed that platelet DREAM positively regulates phosphoinositide 3-kinase (PI

247 r-binding proteins, genomic regions bound by dREAM possess enhancer-blocking activity that depends on

248 Conversely, genetic inactivation of DREAM potentiated the intensity of dyskinesia, and DREAM

249 The dream presented in the target article is used, within th

250 e Enhancement Against AIDS and Malnutrition (DREAM) Program was used to generate a realistic model fo

251 Reverse Engineering Assessment and Methods (DREAM) project, we analyzed a total of 44 drug sensitivi

252 ution and localization of Drosophila E2F and dREAM proteins.

253 rect catalytic methane functionalization, a "dream reaction", is typically characterized by relativel

254 logical issues have to be addressed, such as dream recall and the effect of remembered dreams on memo

255 lyn's proposal that rapid eye movement (REM) dreaming reflects elaborative encoding mediated by the h

256 These results suggest that platelet DREAM regulates PI3K-Ibeta activity and plays an importa

257 DREAM complex formation by depletion of the DREAM regulatory kinase DYRK1A or its target LIN52 was f

258 DREAM-related neuroprotection was linked to an interacti

259 ounter-evidence in respect of its claim that dreaming relies upon hippocampal functions.

260 inversely correlated with the length of the dream report (i.e., total word count).

261 Dream reports show that self-reflection and volitional c

262 Since DREAM requires DYRK1A (dual-specificity tyrosine phospho

263 Rapid eye movement (REM) dreaming results in "emotionally intelligent encoding,"

264 A dream scene may be instantiated as omnidirectional neoco

265 el, this composite image is experienced as a dream scene.

266 do not invoke function but do contribute to dream science.

267 ggests that the answer is no: The phenomenal dream self lacks certain dimensions that are crucial for

268 eneration of vivid perceptual scenery during dreaming.SIGNIFICANCE STATEMENT Fifty years ago, Michel

269 Together, our results identify a role for DREAM silencing in the activation of ATF6 signaling, whi

270 triking and unexpected overlap between dE2F2/dREAM sites and binding sites for the insulator-binding

271 olve these issues, we launched the ICGC-TCGA DREAM Somatic Mutation Calling Challenge, a crowdsourced

272 Absence of the dREAM subunit Mip130 or E2F2 suppressed the Myb-null cyt

273 p107 complexes, which also contain E2F/DPs, DREAM subunits, and/or cyclin/CDK complexes.

274 The analysis of self-experience in dreams suggests that the answer is no: The phenomenal dr

275 Links between Openness and dreaming support the hypothesis that dreaming is part of

276 actors RB, E2F1 and E2F7 bind to a subset of DREAM target genes that function in G1/S of the CC while

277 The dream target of artificial photosynthesis is the realiza

278 a repressive role for gene body H2A.Z, many DREAM targets are up-regulated in htz-1/H2A.Z mutants.

279 Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body

280 5, the sole p130/Rb-like gene in C. elegans, DREAM targets have reduced gene body HTZ-1/H2A.Z and inc

281 , MYC, MYBL2 (B-Myb) and FOXM1 are among the DREAM targets that are diminished by SmgGDS depletion.

282 d Alliance-National Ovarian Cancer Coalition Dream Team Translational Research Grant, and V Foundatio

283 Thus, Lin37 is an essential component of DREAM that cooperates with Rb to induce quiescence.

284 Any hypothesis regarding the function of dreams that is premised on rapid eye movement (REM)/drea

285 en Morpheus the god of dreams could not have dreamt that his opium tincture would be both a gift and

286 t is suggested that neither "high" nor "low" dream theory is sufficient to account for the properties

287 rd illuminating the structure of Llewellyn's dream theory, I compare it in formal terms to Freud's dr

288 ory, I compare it in formal terms to Freud's dream theory.

289 stresses the neurobiology and psychology of dreams, this commentary emphasizes that the role of drea

290 Targeting of DREAM to induce USF1-mediated A20 expression is therefor

291 Classic traditions have linked dreams to memory (e.g., "dreaming is another kind of rem

292 with core members of the Myb-MuvB/DREAM (MMB/DREAM) transcriptional regulatory complex genome-wide, a

293 Dominant-active DREAM transgenic mice (daDREAM) and DREAM knockout mice

294 eas after ketamine they reported long, vivid dreams unrelated to the external environment.

295 iveness, but subjects often report "ketamine dreams" upon emergence from anesthesia.

296 enic mice (daDREAM) and DREAM knockout mice (DREAM(-/-)) were used to define the involvement of DREAM

297 to see the fulfillment of their visions and dreams, which was commemorated at the joint session of t

298 dreaming is a state of awareness that one is dreaming, without leaving the sleep state.

299 f the sometimes indiscernibility of wake and dream worlds are considered.

300 al data via the Bayesian optimization method DREAM(ZS).