ライフサイエンスコーパス: drip

1 degradation of defective ribosomal products (DRiPs).

2 oteins, termed defective ribosomal products (DRiPs).

3 nct, multisubunit coactivator complex called DRIP.

4 cal to the nuclear hormone-receptor cofactor DRIP.

5 crobial biomass C with increasing summer fog drip.

6 y inhibit presentation of Shield-1-resistant DRiPs.

7 ation in normal tissue, and that the loss of DRIP-130 expression, as a result of the gross loss of hu

8 Our results thus suggest that DRIP-130 is a key regulator in KiSS-1 transactivation in

9 Co-expression of Sp1 and DRIP-130 not only rescues KiSS-1 expression, but also in

10 we show that loss of Sp1-coactivator protein DRIP-130, which is encoded by human chromosome 6q16.3-q2

11 gion spanning -93 to -58 interrupts Sp1- and DRIP-130-modulated transcriptional control of KiSS-1 exp

12 ve mainly from defective ribosomal products (DRiPs), a subset of nascent proteins that fail to achiev

13 Adjacent to the welt and at the top of the drip, a V-shaped cone of crust is being dragged down ten

14 )/vitamin D(3) receptor-interacting protein (DRIP)/activator-recruited cofactor (ARC) complex require

15 Additionally, presentation specifically from DRiP Ags was diminished by expression of a catalytically

16 ter from a piped irrigation system was found dripping along one well's outer casing, which was extens

17 To explore the relationship between DRIP and p160 coactivators, we examined the kinetics of

18 urified preparations were used as sources of DRIP and Pol II holoenzyme.

19 dmitted through the Saint-Antoine and Tenon (drip and ship) or the Fondation Rothschild (mothership)

20 avenous alteplase at the referring hospital (drip and ship) versus direct transfer (mothership).

21 eed to be transferred secondarily after IVT (drip and ship), which may have an effect on the neurolog

22 and symptomatic hemorrhagic transformation (drip and ship, 2 [2.0%]; mothership, 2 [3.4%]; P = .63).

23 come at 3 months was similar in both groups (drip and ship, 61 [61.0%]; mothership, 30 [50.8%]; P = .

24 bolysis in Cerebral Ischemia scores 2B to 3; drip and ship, 84 [84.0%]; mothership, 47 [79.7%]; P = .

25 can adopt a variety of structures, they can drip and spread, or withstand applied loads.

26 syringe irrigation delivered as a continuous drip and ultrasonic unit water spray minimized heat gene

27 f VDR coactivators, VDR-interacting protein (DRIP) and steroid receptor coactivator (SRC) at differen

28 arly represent defective ribosomal products (DRiPs) and a less rapidly degraded pool in which DRiPs m

29 recruitment of defective ribosomal products (DRiPs) and other short-lived proteins (SLiPs) into autop

30 of the multiprotein complexes such as TRAP, DRIP, and ARC that appear to play an important role in t

31 These studies have shown that VDR, DRIP, and SRC are all required for promotion of both ear

32 stricted to defective ribosomal products, or DRiPs, and total MHC class I levels remained unaltered.

33 eriod, 497 patients were hospitalized at the drip-and-ship and mothership hospitals for an AIS eligib

34 d were excluded, leaving 100 patients in the drip-and-ship group (mean age, 73 years; age range, 60-8

35 Patients had less severe conditions in the drip-and-ship group (median baseline National Institutes

36 Process times were longer in the drip-and-ship group (onset-to-needle time, 150 vs 135 mi

37 100 had been transferred after IVT from the drip-and-ship hospitals and 59 had received IVT on site.

38 study found that patients treated under the drip-and-ship paradigm also benefit from bridging therap

39 3 months between patients treated under the drip-and-ship paradigm and those treated on site (mother

40 lic (Sisyphus) processes in nature, such as "dripping ants" or drops from leaky faucets.

41 fering in others include the TRAP/SMCC, NAT, DRIP, ARC, and human Mediator complexes.

42 Several DRIP/ARC subunits are also components of other potential

43 ysically associates with the endogenous TRAP/DRIP/ARC/Mediator complex in a ligand-dependent manner.

44 oth Med220 and CDK8 (another subunit of TRAP/DRIP/ARC/Mediator) are recruited to the CYP1A1 enhancer

45 The DRIPs are almost indistinguishable from components of an

46 The DRIPs are distinct from known nuclear receptor coactivat

47 nated proteins; and last, that ubiquitinated DRiPs are formed from human immunodeficiency virus Gag p

48 te that for the constructs we have analyzed, DRiPs are not a more efficient source of class I peptide

49 DRiPs are polypeptides that never attain native structur

50 DRiPs are produced entropically, due to the inevitable i

51 Defective ribosomal products (DRiPs) are a subset of rapidly degraded polypeptides tha

52 uggesting that defective ribosomal products (DRiPs) are the major source of T cell epitopes.

53 rface onto which an artificial saliva medium drips at a rate comparable to human salivary flow.

54 These findings place DRiPs at the center of the MHC class I antigen processin

55 may participate in the degradation of EBNA1 DRiPs before they are further processed by proteasomes.

56 d asymmetric flow into a mantle downwelling (drip) beneath the adjacent Great Valley.

57 DRIPs bind to several nuclear receptors and mediate liga

58 Here, recent progress in understanding DRiP biogenesis is reviewed.

59 production of defective ribosomal products (DRiPs) by binding to nascent protein to prevent prematur

60 ow show that alternative reading frame (ARF) DRiPs can also induce robust CD8(+) T cell responses.

61 ns of kilometres into the core of the mantle drip, causing the disappearance of the Moho in the seism

62 ydrostatic height between the transducer and drip chamber accounted for 90% of the variance in P(DC),

63 enters and was related to deltaH between the drip chamber and the armrest of the dialysis chair.

64 an external transducer as PT) and the venous drip chamber pressure, PDC; at zero flow, the difference

65 ylogenetic group has been referred to as the DRIP clade (an acronym of the original members: Dermocys

66 l group of fish parasites referred to as the DRIP clade (Dermocystidium, rossete agent, Ichthyophonus

67 hese observations suggest a key role for the DRIP coactivator complex in estrogen-ER signaling.

68 d to the ligand-dependent recruitment of the DRIP coactivator complex to VDR and to the ability of th

69 : RXR, GRIP-1, and DRIP205, a subunit of the DRIP coactivator complex.

70 rmone-bound receptor requires binding to the DRIP coactivator, and this induced ternary complex can t

71 the vitamin D receptor interacting protein (DRIP) coactivator complex shares components with the RNA

72 ays in the presence of overexpressed p160 or DRIP coactivators.

73 teraction between the DRIP205 subunit of the DRIP complex and the estrogen receptor (ER) AF2 domain.

74 In addition, the DRIP complex contains histone acetyltransferase activity

75 On initial purification steps, the DRIP complex copurified with the Pol II holoenzyme.

76 The DRIP complex is a 15-subunit complex required for nuclea

77 rast to the p160 family of coactivators, the DRIP complex is devoid of any histone acetyltransferase

78 oprecipitation experiments revealed that the DRIP complex was not pre-associated with the Pol II holo

79 addition, we show that another member of the DRIP complex, DRIP205, interacts with the GR ligand bind

80 ng features of DRIP205, a key subunit of the DRIP complex, that interacts directly with VDR and thyro

81 imiting factors, including components of the DRIP complex.

82 e that both endogenous p160 coactivators and DRIP complexes bind to the VDR LBD from nuclear extracts

83 Here we show, first, that DRiPs constitute upwards of 30% of newly synthesized pro

84 , and only in certain of the holoenzyme- and DRIP-containing fractions did Pol II bind to the ligande

85 I peptides were observed to be derived from DRiPs, defined here as HLA peptides that shift from thei

86 es direct Ag presentation, preferentially of DRiP-derived peptides, suggesting that the processing of

87 Thus, the most likely sources of DRiPs-derived HLA peptides are full-sized, misassembled,

88 ge fraction of defective ribosomal products (DRiPs) due to frequent initiation on downstream Met resi

89 main parts: a temperature control, a co-flow dripping element and a congealing element.

90 DRiPs enable the immune system to rapidly detect alterat

91 by ionic gelation (IG) using two techniques: dripping-extrusion and atomization, both by means of a d

92 Both the dripping-extrusion and the atomization have shown to be

93 'Drip feeding' information created moments for reflection

94 close to the air-liquid interface using the drip flow reactor (DFR).

95 gated using Microtiter Well Plates (MWP) and Drip Flow Reactors (DFR), two models characterized by th

96 stricted to the defective ribosomal product (DRiP) form of the protein.

97 ing intracellular parasites such as viruses, DRiP formation may be enhanced by changes in the cellula

98 on of truncated polypeptides and thereby the DRiP fraction of inserted gene products, which can poten

99 Propofol emulsions (3.5 mL) were dripped from spiked 50-mL vials at each hour for 12 hrs.

100 econtaminant, sufficiently viscous to resist dripping from the contaminated surface, is necessary.

101 he air or may be washed off by precipitation dripping from the plants to the soil.

102 e and oxytocin, administered through a micro-drip gravity infusion set.

103 n of heparin (200 U/kg bolus, 70 U. kg-1.h-1 drip), human plasminogen (50 mg/kg), and tPA at 20 (n=10

104 Here, we critically examine the DRiP hypothesis and discuss recent studies indicating th

105 ese observations extend the relevance of the DRiP hypothesis to viral proteins generated in their nat

106 Here, we consider findings that address the DRiP hypothesis, and extend the hypothesis by proposing

107 there is broad experimental support for the DRiP hypothesis, careful kinetic analysis of the generat

108 The DRiPs hypothesis proposes that epitopes derive from Defe

109 The defective ribosomal product (DRiP) hypothesis of endogenous Ag processing posits that

110 bial metabolism was highly responsive to fog drip, illustrated by an observed ~3-fold increase in mic

111 th fast transient and one with slow constant dripping, in a temperate semi-arid location (Wellington,

112 Sensations of nasal pain, blockage, and drip increased with concentration and were significantly

113 her than that reported for hand-injection or drip-infusion techniques, but there is no correlation be

114 ture content, and received more frequent fog drip inputs than the site with less cloud cover.

115 double shells are developed through a single dripping instability in a microfluidic flow-focusing dev

116 iency of the 20-epi analogue in inducing VDR/DRIP interactions, transactivation in vitro, and its enh

117 hand, scenarios of increased application of drip irrigation and of mandarin area expansion would lea

118 This paper analyzes solar-powered drip irrigation as a strategy for enhancing food securit

119 n those villages, we find that solar-powered drip irrigation significantly augments both household in

120 Thus, ARC/DRIP is a large composite co-activator that belongs to a

121 ion of R. seeberi to this clade, the acronym DRIP is no longer appropriate.

122 sing, suggesting that a minute population of DRiPs is a highly efficient source of antigenic peptides

123 peptides, suggesting that the processing of DRiPs is in some ways different from other forms of Ag.

124 One potential source of DRiPs is premature translation termination.

125 The placement of the neutron drip line for the heavier elements is based on theoretic

126 t, the present work shows that nuclei at the drip line gain stability from an unpaired proton, which

127 an experimental indication that the neutron drip line may be located further towards heavier isotope

128 This limit, known as the neutron drip line, provides a benchmark for models of the atomic

129 pes--40Mg and 42Al--that are predicted to be drip-line nuclei.

130 We find that extrapolations for drip-line positions and selected nuclear properties, inc

131 the chart of nuclides, which is bounded by 'drip lines' indicating the values of neutron and proton

132 bution (via furrow, watering can, sprinkler, drip lines, etc.), and use all occur at or near the same

133 e increased blood lactate, rigor index (Ir), drip loss (DL), content of astaxanthin and intensity of

134 rs by cross-validation (RMSECV) of 0.067 for drip loss and a rCV of 0.877 with RMSECV of 0.046 for pH

135 Drip loss and pH are important indices in quality assess

136 r rapid and non-destructive determination of drip loss and pH distribution in salmon fillets using ne

137 for determining the spatial distribution of drip loss and pH in salmon fillets.

138 used to correlate the spectra with reference drip loss and pH values.

139 Distribution maps of drip loss and pH were generated based on the new PLSR mo

140 , pH, total volatile basic nitrogen (TVB-N), drip loss, ATP-related compounds and K(1)-value and micr

141 The physico-chemical [pH, drip loss, moisture content, total volatile basic nitrog

142 Drip loss, water-holding capacity (WHC) and muscle pH du

143 s) and a less rapidly degraded pool in which DRiPs may also predominate.

144 indicating that at least one or more of the DRIPs may function at the level of nucleosomal modificat

145 the vitamin D receptor interacting protein (DRIP)/mediator complex was purified from primary keratin

146 recruited by liganded estrogen receptor, the DRIP/Mediator complex and p160 proteins, although the re

147 overage can be obtained from the antisolvent dripping method.

148 cous forces is found to be negligible in the dripping mode since the capillary number is small.

149 In the dripping mode, the normalized dropsize decreases linearl

150 the promoter, with recruitment of p160s and DRIPs occurring in opposite phases, suggesting an exchan

151 d breakup of liquid filaments are central to dripping of leaky faucets, inkjet drop formation, and ra

152 -methylphenol-hydrochloride] (20 mug/mL) was dripped onto the gingiva between the mandibular incisors

153 biofilm experiences a low shear as the media drips onto a surface set at a 10 degrees angle.

154 Pain, endotracheal intubation, vasoactive drips, or pharmacologic paralysis did not affect accurac

155 igate the contentions that Jackson Pollock's drip paintings are fractals produced by the artist's Lev

156 nd, as we show here, compartmentalization of DRiP peptide generation to prevent competition from abun

157 sistent with its generation from a cytosolic DRiP pool.

158 an glucose 3 months pre-LT, need for insulin drip post-LT, mean total glucose during the post-LT hosp

159 ein synthesis (defective ribosomal products, DRiPs) preferentially contribute to the class I-presente

160 ting enzymes as playing an important role in DRiP presentation.

161 es derive from defective ribosomal products (DRiPs), presumed to be polypeptides arising from in-fram

162 lex of at least 10 VDR interacting proteins (DRIPs) ranging from 65 to 250 kD that associate with the

163 of concurrent high-precision temperature and drip rate monitoring to explore what controls the temper

164 The amount of cooling is dependent on the drip rate, relative humidity and ventilation.

165 by a transcript depends on its abundance and DRiP rate, which is regulated to a large extent by miRNA

166 ntion profiles such as vasoactive medication drip rates and ventilator settings, nursing progress not

167 ounger plates favoured episodic lithospheric drips rather than self-sustained subduction and global p

168 es derive from Defective Ribosomal Products (DRiPs), rather than degradation of mature protein produc

169 ically detect a MG132-dependent cohort of NA DRiPs relevant for Ag processing, suggesting that a minu

170 ature of these defective ribosomal products (DRiPs) remains largely undefined.

171 ty of cell types; second, that at least some DRiPs represent ubiquitinated proteins; and last, that u

172 monstrate that defective ribosomal products (DRiPs) represent a major and highly efficient source of

173 However, we show that the DRIPs selectively enhance the transcriptional activity o

174 We report a novel whole-genome method, S1-DRIP-seq (S1 nuclease DNA:RNA immunoprecipitation with d

175 Thus, the hybrid map generated by S1-DRIP-seq led to the identification of the first global g

176 ersus off hours, 41% (24 minutes) shorter in drip-ship patients versus mothership, and 43% (22 minute

177 In contrast, DRIP silencing had no apparent effect on these processes

178 Lipase entrapment was carried out by dripping sodium alginate (Na-Alg)-chitosan (Chi)-lipase

179 iated with rhinorrhea, congestion, postnasal drip, sputum, and cough; HCoV infection was not associat

180 A single DRIP subunit, DRIP205 (TRAP220, PBP), binds directly to

181 the in vivo recruitment of other endogenous DRIP subunits to ER in response to estradiol treatment i

182 in response to ligand and anchors the other DRIP subunits to the nuclear receptor LBD.

183 gastro-oesophageal reflux disease, postnasal drip syndrome or rhinosinusitis, chronic obstructive pul

184 Here we report the identities of thirteen DRIPs that constitute this complex, and show that the co

185 peptides from defective ribosomal products (DRiPs) that are encoded by standard open reading frames

186 controls the expression of the water channel Drip, the chloride conductance channel CLC-a and the Leu

187 f downstream initiation is a major source of DRiPs, there should be positional bias towards the C-ter

188 If this is a major source of DRiPs, this should be reflected in positional bias towar

189 We measured variation in two traits, leaf drip tips and leaf water repellency, in a series of nine

190 Our findings suggest that drip tips and repellency may not solely reflect the nega

191 we found that the proportion of species with drip tips did not increase with increasing precipitation

192 Instead, drip tips increased with increasing temperature.

193 he droplet frequency increases steadily from dripping to microdripping mode, but stays roughly consta

194 ributed a disproportionately large number of DRiPs to the HLA peptidomes.

195 ominant use of defective ribosomal products (DRiPs) to generate peptides from nascent proteins and, a

196 n enhanced ability to bind components of the DRIP/TRAP complex, coactivators required for fat differe

197 to CBP/p300 and DRIP130, a component of the DRIP/TRAP/ARC complex, which suggests that TRBP may acti

198 DR binds to two major coactivator complexes, DRIP (VDR-interacting protein) and SRC (steroid receptor

199 ed a novel multisubunit coactivator complex, DRIP (VDR-interacting proteins), required for transcript

200 nct biochemical pathways for presentation of DRiPs versus retirees and implicate polyubiquitin chain

201 With continuing flow into the mantle drip, viscous drag at the base of the remaining approxim

202 nced solutions in use today.The intravenous "drip" was introduced by Rudolph Matas in 1924.

203 l causing significant disequilibrium between drip water and host rock/air temperatures.

204 cation (Wellington, NSW, Australia), exhibit drip water temperatures which deviate significantly from

205 ntrols the temperature of speleothem forming drip water.

206 g the temperature of speleothem-forming cave drip waters is vital for assessing the reliability of su

207 l peptides are defective ribosomal products (DRiPs), which consist of prematurely terminated polypept

208 proteins can be defective ribosome products (DRiPs), which include polypeptides produced as part of t

209 inct set of ligand-dependent proteins called DRIPs, which interact with the vitamin D receptor (VDR);