ライフサイエンスコーパス: driver

1 lectrode is the same as that of the magnetic driver.

2 iciency of CRKL emerging as the main genetic driver.

3 s, with a community factor being the primary driver.

4 n a TH17 immune response with IL-23 as a key driver.

5 ent DNA adduct formation being a significant driver.

6 n edaphic conditions and other environmental drivers.

7 d efforts to link population dynamics to key drivers.

8 oans, connectivity effects, and hydrothermal drivers.

9 es in SCN physiology or provide SCN-specific drivers.

10 nt further investigation as potential cancer drivers.

11 patiotemporal dispersion is indicative of AF drivers.

12 mote resistance to and recovery from disease drivers.

13 apidly in response to numerous anthropogenic drivers.

14 temperature) and biotic (phytoplankton prey) drivers.

15 a widely recognized property of many cancer drivers.

16 nter the trend of decline and its associated drivers.

17 ing the likelihood that mutations are cancer drivers.

18 ome of their interactions with environmental drivers.

19 riability and that include the full range of drivers.

20 e under combined anthropogenic global change drivers.

21 mong organisms can result from purely biotic drivers.

22 Here, I first consider the constraints and drivers acting on influenza A virus reassortment, includ

23 g population responses to different climatic drivers along wide latitudinal and altitudinal gradients

24 The information on candidate cancer driver alterations available from public databases is of

25 This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reve

26 ociated with tumors bearing specific genetic driver alterations.

27 We propose that, in concert with other drivers, an overpressured sub-slab mantle supporting the

28 ting the cell-cycle-related kinase CDK7 as a driver and candidate therapeutic target in TNBC.

29 transgene expression; and we provide a basic driver and effector toolkit.

30 teracting with KCTD13, MVP, and MAPK3, major driver and modifiers of the proximal 16p11.2 600 kb BP4-

31 ulties for reliable distinction between true driver and passenger events.

32 The Notch1 gene is a major oncogenic driver and therapeutic target in T-cell acute lymphoblas

33 goes beyond the interactions between cancer drivers and can, for example, elucidate different mutage

34 mplicate distinct interactions between tumor drivers and mitochondria as critical modifiers of tumori

35 e results comprehensively define the genetic drivers and their functional roles in DLBCL to identify

36 However, the interrelation of SOC and these drivers and their potential connection networks are rare

37 enesis, to functionally assess NBL oncogenic drivers and to characterize NBL metastasis.

38 c shedding relative to more obvious epidemic drivers, and poor ability to differentiate between the e

39 ing are the result of multiple environmental drivers, and the effects of individual controls such as

40 cell type for which transgenic or viral Cre drivers are available.

41 ation and functional validation of oncogenic drivers are essential steps toward advancing cancer prec

42 mosquito vectors, but local epidemiological drivers are still poorly understood.

43 to assess the contributions of the different drivers at the global scale.

44 redict respiration rates using environmental drivers at the global scale.

45 tionary change have focused on anthropogenic drivers, but none of these studies has specifically exam

46 nother vehicle, and in street lighting-other drivers can better avoid hitting them, directly reducing

47 dentify both short- and long-term ecological drivers can have cascading impacts on understanding high

48 support for the hypothesis that many cancer drivers can substitute for each other in certain context

49 chanisms, including negative feedback to the drivers, can maintain resilience and promote resistance

50 copy-loss of wild-type SF3B1 as a novel, non-driver cancer gene dependency.

51 n of the immune response with or without the driver continues, a cascade of events can trigger immuno

52 ot been well quantified nor the key climatic drivers convincingly identified.

53 al fin trade is widely recognized as a major driver, demand for meat, liver oil, and gill plates also

54 e develop a statistically founded non-coding driver-detection method, ncdDetect, which includes sampl

55 In contrast to East Africa, environmental drivers did not trigger the epidemics: They only modulat

56 We rule out driver difference as an explanatory variable and empiric

57 ems-level analysis, mapping candidate cancer-driver DNA methylation (DNAm) alterations onto a human i

58 ch, a combination of EEG and NIRS, to detect driver drowsiness.

59 dies have shown how changes in environmental drivers, either alone or in pairs, affect the evolution

60 e change-driven trends in multiple ecosystem drivers emerge from the background of natural variabilit

61 utcome and to determine the clonal nature of driver events and evolutionary processes in early-stage

62 e RAC1 gene have recently been discovered as driver events in malignant melanoma.

63 Yet, which driver exerts the largest influence on ecosystem functio

64 Thus, selfish meiotic drivers exploit the asymmetry inherent in female meiosis

65 ntaged living with HIV-AIDS, and are a major driver for HIV-related deaths.

66 Specifically, mutated KRAS is a documented driver for malignant transformation, occurring early dur

67 one, extracellular Hsp90alpha as a potential driver for normal wound closure.

68 ese results suggest that there is a seasonal driver for PE, with effects that are not modified by par

69 A major driver for POC development is the ability to diagnose in

70 on emission tomography (PET) is an important driver for present day healthcare.

71 indicates that the ketoreductase is the key driver for selectivity, forming predominantly alpha-bran

72 gonal dipole-dipole interaction, as the main driver for this attraction.

73 Currently, the driver for this progression is not fully understood; in

74 sic mechanisms are thought to be the primary driver for this type of axon disintegration [8-10].

75 pies imposes complex light dynamics, but the drivers for photoacclimation in such fluctuating environ

76 to provide an exemplary system for exploring drivers for speciation, with a continuum of lineages coe

77 scuss the agonist requirements and molecular drivers for the dramatic morphological transformation pl

78 of single cells and their nuclei as critical drivers for the onset of cancer.

79 sually recognizable electric footprint of AF drivers, for the ablation of all forms of AF.

80 The association of one 3q driver gene FXR1 with distant metastasis in TNBC (P = 0.

81 that MAP3K13 (encoding LZK) is an amplified driver gene in HNSCC.

82 dition, Ep400 displayed characteristics of a driver gene in that it showed a mutually exclusive mutat

83 ancer patients, we attempted to identify the driver gene involved.

84 The driver gene mutation-associated methylation differences

85 The uniformity of known driver gene mutations among metastases in the same patie

86 We identified CSDE1 as a somatically mutated driver gene, complementing four known drivers (HRAS, RET

87 d in OGID and 260 somatically mutated cancer driver genes (p = 1.75 x 10(-14)).

88 es an increased power to detect known cancer driver genes and identifies new significantly mutated ge

89 identified associations between 737 mutated driver genes and site-specific methylation changes.

90 Increasing evidence shows that driver genes exhibit consistent aberration patterns acro

91 Many cancer driver genes have an intrinsic increase in carcinogen su

92 rations are hallmarks of CRC, and epigenetic driver genes have been identified that are thought to be

93 ultivariate statistical modeling to identify driver genes in an unsupervised fashion.

94 in each of the omics data to identify novel driver genes through an integrative framework.

95 and whole-exome sequencing, identifying new driver genes while also confirming the role of myeloid d

96 Bayesian network analysis revealed key driver genes within these modules.

97 aberrant expression patterns of some cancer driver genes, potentially due to aberrant hypomethylatio

98 Somatic mutations in the 3 driver genes, that is, JAK2, CALR, and MPL, represent ma

99 s were found to predict different subsets of driver genes, we propose a novel consensus-based approac

100 e deleterious by ALoFT are enriched in known driver genes.Variants causing loss of function (LoF) of

101 ary brain tumors by uncovering several novel driver genetic alterations.

102 These internal drivers hold a key to unlocking the potential of metamat

103 utated driver gene, complementing four known drivers (HRAS, RET, EPAS1, and NF1).

104 Traditionally, most algorithms for cancer-driver identification look for genes that have more muta

105 eliability, accuracy, and precision) are key drivers impeding the uptake of FDS by the majority of us

106 rs frequently in cancers and is an oncogenic driver in many solid tumors.

107 3A and APOBEC3B have emerged as key mutation drivers in cancer.

108 Chromosome rearrangements are important drivers in genome and gene evolution, with implications

109 changes in virioplankton abundance and their drivers in this climatically sensitive region.

110 ytic ability, are often considered to be key drivers in this disease.

111 mechanisms that limit the effect of disease drivers include the complex set of metabolic and functio

112 gonia, the ranking of natural variability of drivers is as follows: precipitation>grazing>temperature

113 kaemia cells harboring a different oncogenic driver (K-562 cell line) did not result in selective gro

114 ly overlapping but different subsets of GAL4 driver lines of the Ir, Gr, and Ppk gene family.

115 Published approaches to decipher driver mechanisms do not explicitly model tissue-specifi

116 cancer type will deepen our understanding of driver mechanisms in cancer progression.

117 ges associated with aging, insights into the driver mechanisms of this fundamental biological process

118 Using a chemogenetic approach in three Cre-driver mouse lines, we found that selective activation o

119 ts, with 4.5% harboring presumptive leukemia driver mutations (CH-PD).

120 The acquisition of clonal hematopoiesis-driver mutations (CHDMs) occurs with normal aging and th

121 The numbers of tumor driver mutations are differentiated (p < 0.05) over the

122 important role in cancer development.Cancer driver mutations can occur within noncoding genomic sequ

123 distribution of sizes of subclones carrying driver mutations had a heavy right tail at the time of t

124 Efforts to identify driver mutations in cancer have largely focused on genes

125 pite the identification of several oncogenic driver mutations leading to constitutive JAK-STAT activa

126 Driver mutations were confidently assigned to most patie

127 ndings that defy the orthodoxy of oncogenic "driver mutations" are now accumulating: the ubiquitous p

128 ific genomic landscape, that is, type of MPN driver mutations, association with other mutations, and

129 Sample analyses were designed to detect driver mutations, chromosome copy number aberrations, an

130 The MPN-restricted driver mutations, including those in JAK2, calreticulin

131 nd spot sensilla are not labeled by any GAL4 driver, neurons of the pit, papilla, and knob type are l

132 ry, it is necessary to balance the number of driver nodes and control cost to achieve physical contro

133 We discuss CRTC deregulation as a new driver of aging that integrates the link between age and

134 A major driver of apical constriction and junctional disassembly

135 local immune response, and is also the main driver of autoimmune diseases.

136 e of the competitive network is an important driver of biodiversity and coexistence in natural commun

137 (iii) food consumption is the most important driver of biodiversity loss in most of the countries and

138 vide functional evidence that LOXL2 is a key driver of breast cancer metastasis in two conditional tr

139 By identifying Nck as an important driver of breast carcinoma progression and metastasis, t

140 TB domain-containing 7b (Zbtb7b) as a potent driver of brown fat development and thermogenesis and co

141 Cell-to-cell heterogeneity is a major driver of cancer evolution, progression, and emergence o

142 ith sFlt1 overproduction being a significant driver of clinical symptoms, placental Flt1 mRNA levels

143 or (BCR) pathway to trisomy 12, an important driver of CLL.

144 data establishes a PTRH2 mutation as a novel driver of congenital muscle degeneration and identifies

145 Beverage preferences are an important driver of consumption, and strong liking for beverages h

146 -dependent manner, but is unlikely a primary driver of disease progression of dysferlinopathy.

147 O2 on photosynthetic organisms will be a key driver of ecosystem change under ocean acidification.

148 esults indicate that water availability as a driver of ecosystem productivity in mesic temperate fore

149 We implicate the pioneer factor FOXA1 as a driver of enhancer activation in this system, a mechanis

150 LFP and that piriform cortex is an important driver of gamma-band oscillations in the vStr and associ

151 Intravitreal injections were the primary driver of growth.

152 Glucose is the primary driver of hypothalamic proopiomelanocortin (POMC) neuron

153 The identification of rs9828868 as a genetic driver of IFNgamma production in response to mycobacteri

154 ently demonstrated that ZEB2 is an oncogenic driver of immature T-cell acute lymphoblastic leukemia (

155 nthropogenic land use change is an important driver of impacts to biological communities and the ecos

156 e view that the globalization of food is the driver of increased intakes of UPFDs in low- to middle-i

157 ich, through its receptor C5aR1, is a potent driver of inflammation.

158 y, these findings establish SMARCE1 as a key driver of invasive progression in early-stage tumors.

159 ncreased mitochondrial fusion is not a major driver of longevity, but rather is essential to allow th

160 bolically active carnivores has been a major driver of metazoan evolution.

161 In this dataset, individuality was a major driver of microbiota composition (P = 0.002) and was mor

162 gulators are thought to constitute the major driver of morphological evolution.

163 The Akt/mTOR pathway is a key driver of murine CD4(+) T cell differentiation, and indu

164 alpha-Synuclein (aSyn) is the main driver of neurodegenerative diseases known as "synuclein

165 genes, Kctd13 has been implicated as a major driver of neurodevelopmental phenotypes.

166 rn Atlantic overturning circulation, a major driver of Northern Hemisphere climate, is uncertain.

167 Here, we show that SP1 is the major driver of PKCbetaII expression in CLL cells where enhanc

168 viously identified renal miR-182 as the main driver of post-transplantation AKI.

169 Herein, it is demonstrated that miR-194 is a driver of prostate cancer metastasis.

170 ns used in predicting Rs and is the dominant driver of Rs in global models; however, within certain b

171 eal electrostatic interactions as the common driver of selectivity.

172 ctories of the neural population are the key driver of sequential categorical decisions.

173 innesota, which is considered to be the main driver of serotype IV GBS expansion in North America.

174 redator, the dingo (Canis dingo), could be a driver of shrub encroachment in the Strzelecki Desert, A

175 abnormal carotid body (CB) activity may be a driver of sleep apnea.

176 ependent neuromodulators and acts as a major driver of sleep homeostasis.

177 ied thaw history was reported to be the main driver of soil and plant differences across a gradient o

178 hysical template heterogeneity as a dominant driver of spatial patterns.

179 reported that plasmodial DNA is the primary driver of systemic inflammation in malaria, both within

180 ression of the transcription factor T-bet, a driver of Th1 differentiation and cytotoxic effector cel

181 iploids, which has been shown to be a potent driver of the strata and reduced recombination that char

182 hesized that chronic inflammation is a major driver of the transformation of genetically defective li

183 her demonstrate that Gag-Pro is not the main driver of this association, suggesting that additional p

184 gly, less intense selection is the strongest driver of this Red King effect, whereas relative mutatio

185 lution in lymphoid and myeloid leukemia as a driver of tumor initiation, disease progression and rela

186 Here we explored the climatic and geological drivers of a particularly striking Neotropical-Oriental

187 ler, more bioactive components are important drivers of Abeta toxicity.

188 nclude that conflict might be one among many drivers of adjustments in executive control and that the

189 global spatial and temporal variation in the drivers of alien introduction and species richness remai

190 d it is likely that recurrence of the T-cell drivers of allergic immunity abrogated the potential for

191 orally analyze biochemical and biomechanical drivers of angiogenesis in murine corneal neovessels.

192 that sulfate-reducing bacteria (SRB) are key drivers of arsenic methylation in metabolically versatil

193 lar (RV) morphology has been associated with drivers of atrial fibrillation (AF) risk, including left

194 disparity, using it to investigate potential drivers of biodiversity.

195 lobal and regional scales suggest consistent drivers of biotic interaction strength, a finding that n

196 Despite its prevalence, the drivers of caching behaviour, and its impacts on individ

197 egrated approaches that incorporate multiple drivers of change and account for multiple sources of un

198 By disentangling the drivers of change on the exotic wild boar population's n

199 ied in Afrotropical forests and the regional drivers of deadwood stocks are unknown.

200 g from environmental variability, were clear drivers of differences in biogeochemical cycling and res

201 ons are increasingly recognized as important drivers of disease dynamics.

202 aled transcriptomic changes in potential key drivers of drug resistance, such as KLF4.

203 hese threats will likely depend on how other drivers of ecological change and interactions among spec

204 Many known drivers of EID emergence also converge in LMICs.

205 dwelling microbes are rarely investigated as drivers of evolutionary change in plants.

206 A review of the drivers of extinction risk revealed that the heaviest ve

207 ontradictory nature of published results for drivers of FCL.

208 ay key roles in ecosystem processes, but the drivers of fine-root trait diversity remain poorly under

209 s approach allows BA to be linked to the key drivers of fire in the region.

210 been studied independently and the taxonomic drivers of functional imbalances have not been systemati

211 e properties of current drainages can act as drivers of genetic structure and demographic processes i

212 ource of DNA double-strand breaks, potential drivers of genome structure evolution.

213 o increase ecosystem sensitivity to multiple drivers of global environmental change.

214 nent of global change, and understanding the drivers of global invasion patterns will aid in assessin

215 However, intracellular drivers of global reprogramming of the inflammatory gene

216 ting there are genetic as well as ecological drivers of horizontal gene transfer rates.

217 Marine viruses are key drivers of host diversity, population dynamics and bioge

218 s CCR8(+) regulatory T cells (Treg cells) as drivers of immunosuppression.

219 red to confirm these results and examine the drivers of increased ED costs.

220 ta and human mobility proxies to explore the drivers of influenza spread in the US during 2002-2010.

221 cal analogs to better understand demographic drivers of invasions.

222 tic ductal adenocarcinoma (PDAC) and the key drivers of its initiation and progression.

223 Social interactions are often powerful drivers of learning.

224 address the question of how rapidly multiple drivers of marine ecosystem change develop in the future

225 owth arrest-specific 6 (GAS6), are important drivers of metastasis and therapeutic resistance in huma

226 ogical programs currently proposed to be key drivers of metastasis.

227 the long-term trend, regional variation and drivers of methane (CH4 ) emission remain unclear.

228 its inflammation, but the dominant molecular drivers of MI-associated inflammation remain unclear.

229 l winter resource availability are important drivers of migratory movements, with birds from larger c

230 Given the importance of STEM careers as drivers of modern economies, this deficiency in preparat

231 or progress has been made in identifying the drivers of oestrogen-receptor-positive breast cancer and

232 ent in about 30% of human cancers, are major drivers of oncogenesis and render tumors unresponsive to

233 a systems-wide approach are illuminating the drivers of phenotypic diversity.

234 f climate shifts, the location and timing of drivers of physiological stress, and the extent of novel

235 nsification can contribute to mitigating the drivers of pollinator decline.

236 We discuss in detail drivers of poor care in each domain.

237 In turn, by gaining better insight into the drivers of population cycles, we can begin to understand

238 For many threatened species the rate and drivers of population decline are difficult to assess ac

239 a different ecological understanding of the drivers of population declines, and fundamentally differ

240 ultievent models, (ii) determine demographic drivers of population growth using matrix models, and (i

241 tronger than the effects of other well-known drivers of productivity, including climate and nutrient

242 ive of oil palm and other major monocrops as drivers of prosperity and development.

243 ity were the predominant and most consistent drivers of seedling survival, with the majority of speci

244 However, landscape-scale patterns and drivers of shrub expansion remain poorly understood, inh

245 transitivity interacts with more traditional drivers of species coexistence such as niche partitionin

246 Land-use change is one of the primary drivers of species loss, yet little is known about its e

247 of ecosystem services, and understanding the drivers of stability across spatial scales is important

248 To characterize drivers of state-level heterogeneity in TB epidemiology

249 We used three steps to deeply understand the drivers of such dramatic changes: (i) describe fundament

250 ogical processes including identification of drivers of synchrony, a long-standing challenge.

251 roups and overlook key social and contextual drivers of temporal decision making.

252 ent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are required for the initi

253 we propose mouse DUX and human DUX4 as major drivers of the cleavage or 2C state.

254 e feasibility and relevance of understanding drivers of the differences.

255 ion-free and overall survival and may act as drivers of the disease.

256 and accumulated water deficit were the main drivers of the distribution of tree cover and vegetation

257 ese insights expand our understanding of the drivers of the evolution of divergent substrate specific

258 trics are therefore needed to understand the drivers of the lytic-lysogenic decision in viral communi

259 CC3 fusion proteins, which were validated as drivers of the resistant phenotype by several approaches

260 ) and farming practices (FARM) were the main drivers of the spatial variability in cropland soil P co

261 Independent drivers of these aberrant developmental trajectories of

262 on loss and apical constriction are the main drivers of this process.

263 However, the drivers of this tolerogenic program are incompletely def

264 event apoptosis, both of which are important drivers of tumorigenesis.

265 The role of abiotic drivers on the tempo of phenotypic evolution has been te

266 ls for revisiting the prevailing single-gene driver-oncogene view and links clinical outcomes to co-o

267 Driver oncogenes were amplified most commonly in ecDNA,

268 ma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated wi

269 a create a potential opportunity to identify driver patterns in ovarian cancer, which will acquire so

270 hese findings assess state-of-the-art cancer driver prediction methods and develop a new and improved

271 The performance of driver prediction methods varied considerably, with conc

272 romise to harness the strengths of different driver prediction paradigms.Significance: These findings

273 arable in size to effects of other important drivers related to climate, topography, and land cover.

274 report the generation of a new Gal4- and Cre-driver resource for zebrafish neurobiology.

275 d using an epicardium-specific inducible Cre driver revealed unique roles for epicardium-derived Shha

276 nd the general population (n = 16,340) using driver's license files.

277 tation actionability and identify potential "drivers," so that the treating physician can prioritize

278 eneity and resulted in parallel evolution of driver somatic copy-number alterations, including amplif

279 teristics and influencing factors, including drivers, strategy, timeline, costs, and limitations.

280 Half of driver substitutions occur in yet-to-be-discovered cance

281 arily driven by other important biodiversity drivers such as climate, soil spatial heterogeneity, soi

282 ogens were climate sensitive; 82% to primary drivers such as rainfall and temperature.

283 uncovered mutated LCP1 and WNK1 as novel CLL drivers, supported by functional evidence demonstrating

284 ease in harmful nanoparticles by a third, as drivers switched from ethanol to cheaper gasoline, showi

285 that Rheb-Y35N is a dominantly active tumor driver that activates both mTORC1 and MAPK to promote tu

286 his genomic variability, but the fundamental drivers that shape bacterial and archaeal genomic proper

287 will also facilitate the discovery of novel drivers, the study of tumor evolution, and the identific

288 ase has revealed that inflammation is a core driver: the so-called "vicious circle" of inflammation.

289 used German monitoring data to quantify the drivers thereof and to assess current risks in small str

290 We crossed these drivers to conditional DREADD mouse lines to further cha

291 ent mature RPE cell-specific Cre recombinase drivers to inactivate either Dicer1 or DiGeorge syndrome

292 ulting harms necessitate an investigation of drivers to inform potential solutions.

293 he use of ATS and the perceived barriers and drivers to their adoption by toxicologists and by others

294 eing assessed, and the extent to which other drivers, uncertainties, and decision making are incorpor

295 This review discusses the financial drivers upon which health care organizations base invest

296 ii) identify environmental and anthropogenic drivers using ANOVAs.

297 Alfven waves associated with high frequency drivers which contain a huge amount of energy ( 10(5) W

298 This suggests multiple evolutionary drivers: while the shrinking likely facilitates survival

299 agricultural development, humans emerge as a driver with dominant global C cycle impacts only in the

300 ed several global data sets describing these drivers with a soil P dynamics model to simulate the dis