ライフサイエンスコーパス: drug action

1 AD may be an important aspect of antimitotic drug action.

2 l systems biology is empowering the study of drug action.

3 developed structural basis for understanding drug action.

4 or cells in select anatomical locations from drug action.

5 the Family B calcitonin receptor for agonist drug action.

6 ally providing a highly selective target for drug action.

7 drug and is independent of the mechanism of drug action.

8 itutions and the sponsor or the mechanism of drug action.

9 lar interface between gene transcription and drug action.

10 hologs, implying its intimate involvement in drug action.

11 l role for S-nitrosylation in antineoplastic drug action.

12 se to the drug or be potential biomarkers of drug action.

13 considered a required catalytic process for drug action.

14 l biosynthesis that accumulates as result of drug action.

15 ent models of neuropsychiatric conditions or drug action.

16 ptors (GPCRs) are the most common targets of drug action.

17 oltage-gated K(+) channels are refractory to drug action.

18 icacy as well as for real-time monitoring of drug action.

19 artly underlies the antianginal mechanism of drug action.

20 amics, which represent potential targets for drug action.

21 Clearance is the practical limit on drug action.

22 for channel gene expression in this delayed drug action.

23 information about the cellular physiology of drug action.

24 s an intracellular site for antiinflammatory drug action.

25 he introduction of an intracellular delay in drug action.

26 ontrol provides the safest means to regulate drug action.

27 lues, consistent with a bimodal mechanism of drug action.

28 on and thus a potential target for antiviral drug action.

29 new mechanism to account for this change in drug action.

30 aryl hydrocarbon receptor (AhR) may mediate drug action.

31 fore, this study characterized the basis for drug action.

32 dynamics and hence are promising targets for drug action.

33 hysiology of schizophrenia and antipsychotic drug action.

34 presents a novel mechanism of antiarrhythmic drug action.

35 neural mechanisms of atypical antipsychotic drug action.

36 y be an essential part of the antidepressant drug action.

37 activation gating and class I antiarrhythmic drug action.

38 binding sites are among the major targets of drug action.

39 utically desirable property of use-dependent drug action.

40 to doxorubicin, implicating these regions in drug action.

41 laque ACE probably is an important target of drug action.

42 rowth and is a potential site for anticancer drug action.

43 ical proteomics for discerning mechanisms of drug action.

44 bility and metabolic stability necessary for drug action.

45 ic physiological mechanisms of the treatment drug action.

46 unds, demonstrating that CA is the target of drug action.

47 nal classes and frequently occur at sites of drug action.

48 lopment but also to understand mechanisms of drug action.

49 ucidating genetic networks and mechanisms of drug action.

50 l drugs and propose respective mechanisms of drug action.

51 novel drug targets and deep understanding of drug action.

52 uptake and trafficking, and the mechanism of drug action.

53 simple inhibition and complex mechanisms of drug action.

54 molecule are among the most fundamental for drug action.

55 ells could provide a better understanding of drug action.

56 often provide an incomplete understanding of drug action.

57 enetic changes that may impact antipsychotic drug action.

58 idance conflict tests in terms of anxiolytic drug action.

59 an analytical model for the verification of drug action.

60 l interactions, barrier control function and drug action.

61 and lead to the understanding of disease and drug action.

62 deo-tracking analyses in zebrafish models of drug action.

63 toward novel signaling pathways involved in drug action.

64 urate models of the kinetics and dynamics of drug action.

65 intracellular digestive vacuole, the site of drug action.

66 or cells and to further define mechanisms of drug action.

67 that function to facilitate antitrypanosomal drug action.

68 ecular mechanisms enabling antihyperglycemic drug action.

69 nd links more than fifty additional genes to drug action.

70 ncer metabolism and its use in understanding drug actions.

71 t spatiotemporal Ca2+ patterns contribute to drug actions.

72 n nociception, analgesia, and antidepressant drug actions.

73 oside analogues for anticancer and antiviral drug actions.

74 drug(s), such as the molecular mechanisms of drug actions.

75 Owing to the complexity of drug actions, a broader genomics approach aims at findin

76 asy and less invasive application, sustained drug action, ability to tailor drug delivery, reduction

77 s, it is critical to understand the basis of drug action against M. tuberculosis gyrase and how mutat

78 (+)-channel blocking (class I antiarrhythmic drug) action, along with mathematical models of canine a

79 eceptor endocytosis in the biology of opiate drug action and addiction.

80 This results in prolonged drug action and allows for reduction of drug doses requi

81 mathematical models to study the kinetics of drug action and decay within vertebrate hosts has a long

82 n healthy human hematopoiesis, against which drug action and disease can be compared for mechanistic

83 l in understanding the relationships between drug action and disease susceptibility genes.

84 biased agonism as a significant mechanism of drug action and do so in CNS-derived neurons expressing

85 to encode rich information on mechanisms of drug action and drug resistance.

86 rich, detailed information on mechanisms of drug action and drug resistance.

87 s for new drugs, determining the duration of drug action and examining potential drug interactions.

88 ul for understanding molecular mechanisms of drug action and for identifying protein targets that may

89 nd enhance the utility of yeast for studying drug action and for mechanism-based drug discovery.

90 tissues to provide mechanistic insights into drug action and for the purpose of identifying candidate

91 a reveal a novel mechanism of antiarrhythmic drug action and highlight the possibility for new agents

92 Despite its importance for drug action and in revealing potential sites of topoisom

93 However, the mechanism of drug action and its effect on FtsZ in other bacterial sp

94 linkage between a loss of fitness caused by drug action and Mtb's sensitivity to host-derived stress

95 ramework for understanding the mechanisms of drug action and parasite resistance.

96 l facilitate understanding the mechanisms of drug action and possible side effects.

97 ein-drug interactions illuminate the mode of drug action and provide a framework for rational design

98 h on dopamine as a mediator of antipsychotic drug action and putative roles for this transmitter in t

99 a better understanding of the mechanisms of drug action and resistance are essential for fulfilling

100 nogalactan, but the molecular mechanisms for drug action and resistance are unknown.

101 standing the mechanisms underlying selective drug action and resistance for the development of improv

102 rium cells has implications in understanding drug action and resistance mechanisms.

103 Knowledge of the mechanisms of drug action and resistance was stressed to be essential

104 To better assess drug action and resistance, we sequenced the genomes of

105 be necessary to understand the mechanisms of drug action and resistance.

106 ata; (c) providing insights on mechanisms of drug action and resistance; and (d) generating leads for

107 rovide useful fingerprints for mechanisms of drug action and response.

108 vant, drug-resistant mutants must both evade drug action and retain pathogenicity.

109 um glucose for galactose sensitized cells to drug action and revealed novel response parameters.

110 roaches, we identify SOD as a target of this drug action and show that chemical modifications at the

111 ns remain as to the exact mechanisms of both drug action and side-effect profile, nevertheless it is

112 atment likely reflect the different modes of drug action and sites of infection for these two helmint

113 om getting to its protein target, that mimic drug action and thereby partially alleviate drug craving

114 Antiarrhythmic drug actions and electrophysiological characteristics of

115 By considering drug actions and side effects in the context of the regu

116 -signaling pathways to understand unintended drug actions and to facilitate drug discovery and screen

117 between mechanistic and operational modes of drug action, and allows operational parameters to be giv

118 g from the inhibition of a protein through a drug action, and demonstrate how this approach can be us

119 ach to the development of models of disease, drug action, and drug toxicity.

120 aging of cell migration, signaling pathways, drug action, and interacting protein partners in vivo al

121 tions for parasite development, antimalarial drug action, and mechanisms of drug resistance.

122 o bridge specific biomarkers to mechanism of drug action, and specific clinical outcomes.

123 iality, discover leads for gene function and drug action, and understand higher-order organization of

124 tive-state tissue signaling biology, complex drug actions, and dysfunctional signaling in diseased ce

125 mic medications with germline sensitivity to drug actions, and might identify ALL patients at highest

126 oviding a profile in which changes caused by drug action are directly observed.

127 ential reactivation rates and differences in drug action are not known.

128 tient-to-patient variability and independent drug action are sufficient to explain the superiority of

129 ons, although proper frameworks to represent drug actions are still lacking.

130 rmacology which utilizes network analysis of drug action as one of its approaches.

131 nia (SCZ) both as a target for antipsychotic drug action as well as a SCZ-associated risk gene.

132 ly useful to cast light on the mechanisms of drug action as well as to monitor the treatment of depre

133 y information on the structural dynamics and drug action at metabotropic glutamate receptors and vali

134 rived modelling improve our understanding of drug action at single-cell resolution in vivo.

135 sights into the molecular level mechanism of drug action at the membrane site, we have carried out ex

136 eptor antagonist, SCH 23390, consistent with drug actions at D1 receptors.

137 ere is considerable evidence to suggest that drug actions at the kappa-opioid receptor (KOR) may repr

138 ential mechanisms of use- or state-dependent drug action based on activation gating, or slower pore-b

139 may have implications for the selectivity of drug actions based on the subcellular distribution of th

140 also suggests that this unique mechanism of drug action can be further exploited to develop strategi

141 This drug action can be observed with native cells, such as H

142 Understanding the molecular basis of drug action can facilitate development of more potent an

143 Control experiments indicated that these drug actions could be attributed to local and not system

144 ling pathways to facilitate understanding of drug action, disease pathogenesis, and identification of

145 signaling, metabolic and regulatory pathway, drug action, disease susceptibility, and organ specifici

146 dria or liposomes, indicating a mechanism of drug action downstream from this event.

147 In a combination exhibiting independent drug action, each patient benefits solely from the drug

148 ations in interpretation of the mechanism of drug actions, especially when the drugs are given togeth

149 The dominant paradigm in understanding drug action focuses on the intended therapeutic effects

150 s, and suggest possible molecular markers of drug action for use in hypothesis testing clinical trial

151 tiple occasions, and a proposed mechanism of drug action had previously been assigned to each agent.

152 ponicum The reason for this species-specific drug action has remained a mystery for decades.

153 anisms governing neurotransmitter uptake and drug action have moved into high gear with the publicati

154 suggest a novel mechanism of antidepressant drug action having a delayed onset.

155 Our single-cell analysis of drug action illustrates the strength of quantitative app

156 an impact on our understanding of antibiotic drug action in bacteria.

157 A break implies that there are two sites for drug action in every enzyme-DNA cleavage complex.

158 a systematic understanding of small-molecule drug action in genetically distinct individuals.

159 s important determinants of polyamine analog drug action in melanoma cells.

160 or calcineurin B in virulence and antifungal drug action in the human fungal pathogen C. neoformans.

161 u receptor agonists to reduce hallucinogenic drug action in this region is believed to be directly re

162 se accessibility to amino acids critical for drug action in TM1, TM2, and TM3, which may provide a me

163 ew questions about the fundamental nature of drug actions in vivo.

164 del for isolating SERT/5-HT contributions of drug actions in vivo.

165 pproaches to understanding of antidepressant drug action include a focus on early changes in emotiona

166 mechanisms to account for the slow onset of drug action, including drug accumulation and structural

167 e data elucidate a novel basis for antitumor drug action: induction in sensitive cells of a metaboliz

168 Bu-induced reactivation of HSV-1 is twofold: drug action involving significant moderation of specific

169 The mechanism of drug action is a combination of remodeling of the gliobl

170 smitter-based explanation for antidepressant drug action is challenged by the delayed clinical onset

171 Currently, drug action is determined with a fluorimetric/colorimetr

172 An early event in drug action is the direct targeting of mitochondria by r

173 , the role of HERG inactivation in class III drug action is uncertain: pore mutations that remove ina

174 skin rash may be a pharmacodynamic marker of drug action, its potential as a surrogate marker of clin

175 were subsequently evaluated to elucidate the drug action mechanism in vivo.

176 This finding unveils a novel drug-action mechanism where the binding of INHs to Hec1

177 cortex are secondary to this primary site of drug action, mediated through classically described stri

178 rrent pulses to determine the time course of drug action (n=85 cells) and with prototypical taste sti

179 behaving animals and link them to anxiolytic drug action, novelty, and the metric for self-motion.

180 Additionally, the specificity of the drug action on A20 was confirmed using cell lines with t

181 ry cells and can report pharmacodynamics for drug action on an intended target, this methodology coul

182 urons for studying the mechanisms of triptan drug action on CGRP synthesis.

183 e the assessment of dose- and time-dependent drug action on gametocyte maturation and transmission.

184 th anti-depressant, antipsychotic and opioid drug action on primary human neurons in vitro.

185 In order to achieve selectivity in drug action on the CXCR4/CXCL12 pair, in particular in t

186 ill slopes, suggesting that the isoboles for drug actions on ion channel function are not linear.

187 red together for a complete understanding of drug actions on ligand-gated ion channels.

188 It was of interest to determine drug actions on these receptors, and we investigated the

189 However, drug actions on these systems are not necessarily the sa

190 e antitumor response was triggered by direct drug actions on tumor cells, relied on innate immune sen

191 ication period is divided into pre- and post-drug action parts, allowing for the introduction of an i

192 tanding how specific genetic variants modify drug action pathways may provide informative blueprints

193 interactions may unravel previously unknown drug action patterns, leading to the development of new

194 creens link ubiquinone availability to nitro-drug action, plasma membrane P-type H(+)-ATPases to pent

195 This mechanism of drug action potently removes SAP from human amyloid depo

196 An understanding of the molecular basis of drug action provides opportunities for refinement of dru

197 However, the mechanism of the drug action remain a conjecture.

198 The target tissues of drug actions remain unclear.

199 act of this environment on antimycobacterial drug action remains incomplete.

200 l peptidyltransferase as the primary site of drug action, some biochemical studies conducted in vitro

201 into the spatial and temporal specificity of drug action that can be provided by allosteric modulatio

202 nd could provide an alternative mechanism of drug action that can explain its clinical activity.

203 ysosome as a potential new site of CGP-48664 drug action that could be involved in antitumor activity

204 noclustering, revealing a novel mechanism of drug action that has important consequences for cell sig

205 provide novel insight into the mechanism of drug action that influence treatment outcome: drug sensi

206 anism of pol II transcription inhibition and drug action that is dramatically different from transcri

207 quires an integrative modeling framework for drug action that leverages advances in data-driven stati

208 In contrast to the traditional mechanism of drug action that relies on the reversible, noncovalent i

209 activity measured directly in the target of drug action, the leukemic cell.

210 d in livestock, the possible mechanism(s) of drug action, the proposed mechanisms and genetic basis o

211 nformation available regarding mechanisms of drug action, the relative significance of downstream eve

212 pharmacokinetic/pharmacodynamic analyses of drug action; the two approaches gave consistent results.

213 ng of the mechanisms of complex diseases and drug actions through network analysis, novel drug method

214 typic response to the molecular mechanism of drug action, thus offering a unique pathway-centric stra

215 ling in a manner relevant to psychostimulant drug actions, thus inviting evaluation of psychostimulan

216 h used in systems pharmacology can allow for drug action to be considered in the context of the whole

217 gments are central to processes ranging from drug action to selective catalysis.

218 To understand drug action today, we characterize the targets through w

219 that a detailed mechanistic understanding of drug action, together with careful selection of disease

220 Assays of drug action typically evaluate biochemical activity.

221 However, mechanisms of drug action underlying side effect pathogenesis remain l

222 Compartment-specific drug action was indeed observed.

223 The next step for polymeric drug action was inhibition of tumor angiogenesis by spec

224 insight into the potential mechanisms of ART drug action, we developed a suite of ART activity-based

225 mine whether RhoB-GG has a necessary role in drug action, we examined the FTI response of murine fibr

226 his knowledge and the rapid reversibility of drug action, we examined the restoration of rod shape in

227 ns among diseases, genetic perturbation, and drug action, we have created the first installment of a

228 ic, epigenetic, and environmental factors on drug action, we must study the structural energetics and

229 PITX2-dependent mechanisms of antiarrhythmic drug action were studied in human embryonic kidney (HEK)

230 icacy, two of the most important features of drug action, which represent the latest chapter in the s

231 tabolic response to molecular expression and drug action, which would greatly accelerate drug develop

232 may limit opportunities to grasp unintended drug actions, which can open up channels to repurpose ex

233 standing the molecular mechanisms underlying drug action while addressing some very practical questio

234 Testing these potential mechanisms of drug action will facilitate rational improvement of anti

235 ramework for understanding gene function and drug action within the context of energy metabolism.

236 that a detailed molecular analysis of opiate drug actions would someday lead to better treatments for