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1 an the mitochondrial ribosome as the primary drug target.
2 ed in numerous cancers making it a potential drug target.
3 age response and is an attractive anticancer drug target.
4 other types of cancer, making it a promising drug target.
5 anism, and it is also of interest as a novel drug target.
6 isease, making it a promising cardiovascular drug target.
7 ision, and as such, it is a broad anticancer drug target.
8 n involved in hemozoin formation, as a novel drug target.
9 volution and favors LigA as an antibacterial drug target.
10 eases and led to identification of Ezh2 as a drug target.
11 ctor within the top GO term, and a potential drug target.
12 g factor PfCPSF3 as a promising antimalarial drug target.
13 can recognition is an important antifibrotic drug target.
14 of inhibitors of FadD32, a highly promising drug target.
15 al of this isozyme as a prognosis marker and drug target.
16 de a platform toward understanding TDP2 as a drug target.
17 has therefore attracted attention as a novel drug target.
18 nels as part of the disease process and as a drug target.
19 betes, and has received great attention as a drug target.
20 beta2)2 nAChR, is an important and promising drug target.
21 eage whose survival no longer depends on the drug target.
22 by offering a potential and species-specific drug target.
23 g efflux we suggest that CsrA is a potential drug target.
24 able therapeutic targeting of this potential drug target.
25 ent of p53 status underlining its value as a drug target.
26 irus, and hence it can serve as an important drug target.
27 onses and serves as an important category of drug targets.
28 siological processes, making GPCRs prominent drug targets.
29 anosomatid ribosome assembly offer potential drug targets.
30 um falciparum have long been investigated as drug targets.
31 ylation of CDK1 and are considered potential drug targets.
32 her enzymes previously viewed as intractable drug targets.
33 groups and lead to the identification of new drug targets.
34 on the identification and validation of the drug targets.
35 thylated genes and 49 genes as antipsychotic drug targets.
36 bout molecular pathophysiology and potential drug targets.
37 euroinflammation, rendering them interesting drug targets.
38 have engendered very high interest as future drug targets.
39 e historically the most successful family of drug targets.
40 of novel biomarkers, disease mechanisms, and drug targets.
41 s of senescent cells and developing specific drug targets.
42 -finding strategies or when prioritize among drug targets.
43 ological responses, therefore are attractive drug targets.
44 ual proteins but also for identifying useful drug targets.
45 ug-target interactions on both ARs and other drug targets.
46 ino acid biosynthetic pathways as future Mtb drug targets.
47 ortunities to discover new parasite-specific drug targets.
48 ifying cryptic sites could expand the set of drug targets.
49 ies potential anticryptococcal or antifungal drug targets.
50 dentifying novel disease genes and potential drug targets.
51 eptors and constitute about 50% of all known drug targets.
52 thogenesis and a test model system for novel drug targets.
53 SRSF proteins are known drug targets.
54 present one of the most important classes of drug targets.
55 chemotypes capable of modulating unexploited drug targets.
56 n and reveals novel potential protein kinase drug targets.
57 represents a useful strategy to uncover new drug targets.
58 ume and that these genes represent important drug targets.
59 chaperones might be potential candidates for drug targets.
60 pinning these diseases and suggest potential drug targets.
61 and represent one of the largest families of drug targets.
62 , from cancer-causing mutations to drugs and drug targets.
63 iological pathways and reveal possible novel drug targets.
64 our continuous search for novel antimalarial drug targets.
65 re of considerable interest as antibacterial drug targets.
66 identify disease genes, genetic modules and drug targets.
68 nd multiple mutant strains, (2) can identify drug targets, (3) detects not only essential genes, but
73 target electrostatics are validated against drug-target affinity data, yielding superior computation
74 phosphatase has been proposed as a potential drug target against Leishmania parasites that cause up t
75 n cysteine protease cathepsin B, a potential drug target and prognostic marker for tumor metastasis.
76 iomarkers are used as surrogate measures for drug targeting and approval and are generally based on p
77 a membrane-protein-supporting platform, or a drug targeting and delivery vehicle in general, is under
83 tin-like phospholipases are likely effective drug targets and progress in the tools available to the
86 face proteins, representing a major class of drug targets and thus playing an important role in nucle
88 nal information about the characteristics of drugs, targets and DTIs, such as chemical structure, gen
89 the N-terminal region of NHR trimer as a new drug target, and then we designed several short artifici
90 e recognized importance of these proteins as drug targets, and although the pharmaceutical industry h
91 volanesorsen, a second-generation antisense drug targeting apoC-III, were determined in 2 human inte
96 proposed method shows promising results for drug-target association prediction: 98.96% AUC ROC score
97 d in similarity-based methods for predicting drug-target associations based on the array of varying f
98 riant in TNFSF13B, encoding the cytokine and drug target B-cell activating factor (BAFF), was associa
103 received considerable attention as potential drug targets because of their ability to modulate Galpha
104 topoisomerases are attractive antibacterial drug targets because of their importance in bacterial gr
105 r cell mitochondria are promising anticancer drug targets because they control cell death and are str
108 biological predisposition and are potential drug targets) brought to the fore APOE and IL6 from amon
110 riptional regulators and have emerged as new drug targets, but their functional distinction has remai
111 are increasingly being explored as potential drug targets, but their potent and specific inhibitors a
113 ources including databases containing drugs, drug targets, chemical structures, protein-ligand struct
115 if slows the rate of formation for the final drug-target complex by up to 3 orders of magnitude.
117 a clear example in which the lifetime of the drug-target complex is controlled by interactions in the
119 st class of both human membrane proteins and drug targets-depends critically on their ability to chan
120 e accelerated the identification of putative drug targets derived from the nematode nervous system.
122 pe effects for the reaction catalyzed by the drug target dihydrofolate reductase and established that
124 nal nanomaterials and the design of anti-HIV drugs targeting (dis)assembly and biocompatible nanocoat
126 The ability to directly image and quantify drug-target engagement and drug distribution with subcel
127 clinical response was associated with taxane drug-target engagement, evidenced by decreased percent a
128 r antibody imaging can potentially elucidate drug target expression, tracer uptake in the tumor, tumo
129 nase DDR1 (discoidin domain receptor 1) is a drug target for a wide range of human diseases, but the
132 mine synthesis capacity as a potential novel drug target for bipolar disorder and schizophrenia.
135 n Protein Tyrosine Phosphatase 1B (PTP1B), a drug target for diabetes and cancer that catalyzes the d
136 h the GLP-1 receptor (GLP-1R) is a validated drug target for diabetes, the importance of the GIP rece
138 kinase as an oncogenic driver and candidate drug target for FL-HCC, and establishes a practical mode
146 pro-tumorigenic role makes Cdk5 a promising drug target for the development of new cancer therapies.
147 rs, suggesting that TAAR1 may be a promising drug target for the treatment of cocaine addiction.
151 This study establishes the PLKs as potential drug targets for influenza and contributes to a more det
152 Because Hsp70s are emerging as potential drug targets for many diseases, fully mapping an alloste
154 nits KChIP1, KChIP2, and DPP10 are potential drug targets for neuropathic pain because they form a ch
156 these modulatory subunits could be potential drug targets for neuropathic pain.SIGNIFICANCE STATEMENT
159 ng-term goal is to establish some of them as drug targets for the development of the next generation
161 ic gelsolin signaling pathway, providing new drug targets for the treatment of demyelination diseases
169 entification), a network analysis method for drug target identification in haploinsufficiency profili
177 indings highlight the relevance of MLL2 as a drug target in MLL-rearranged leukemia and suggest its b
178 in-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart d
179 peptide 1 (GLP-1) make it a potent candidate drug target in the treatment of type 2 diabetes mellitus
181 engineering of ligands, enabling studies of drug targeting in animal species and subsequent use in h
182 uble-sgRNAs directed against 21,321 pairs of drug targets in K562 leukemia cells and identified synth
185 hy, and predict further efficacious pairs of drug targets in the network through a network-wide combi
196 ly, we outline a novel approach for relating drug-target interactions and potency to discrete motivat
197 ing heterogeneous information to predict new drug-target interactions and repurpose existing drugs.Ne
198 nt and membrane effects, we demonstrate that drug-target interactions are strengthened by pronounced
199 al pipeline, called DTINet, to predict novel drug-target interactions from a constructed heterogeneou
200 computational methods for predictioning new drug-target interactions have gained a tremendous intere
201 Here, we identify a novel mechanism by which drug-target interactions in resistant bacteria can be en
204 awareness to consider the kinetic aspects of drug-target interactions on both ARs and other drug targ
205 st, a prediction model for identification of drug-target interactions using evolutionary and structur
206 At the molecular level, DrugCentral bridges drug-target interactions with pharmacological action and
207 n of both the thermodynamics and kinetics of drug-target interactions, it follows that the structures
208 functional families can be used to identify drug-target interactions, opening a new research directi
209 Drug resistance mechanisms include altered drug-target interactions, reduced cellular drug concentr
213 Evaluation of the BRPF family as a potential drug target is at an early stage although there is an em
217 izophrenic patients suggests that additional drug targets may be effective in improving aspects of th
219 rs influencing mortality; with this in mind, drug-targeting mechanisms involved in liver injury shoul
221 disease aetiology and identifying potential drug targets, microbial GWAS are likely to further advan
222 We anticipate that rational development of drugs targeting molecular chaperones might help in futur
223 ted database of paediatric biological tumour drug targets; molecular profiling of all paediatric tumo
224 resents the potential to deliver more potent drugs targeted more specifically to the site(s) of disea
227 e lipid lysophosphatidic acid (LPA) and is a drug target of considerable interest for numerous pathol
228 e essential core of the glideosome, enabling drug targeting of both of its core components to inhibit
230 mals so may be exploited as an antimicrobial drug target or used as a substitute for dysfunctional re
233 door to the rapid development of additional drugs targeting other disease-associated genes in the sa
234 ion, might be used in combination with other drugs targeting other mechanisms of disease, although ad
235 f cysteine proteases are highly sought-after drug targets owing to their essential roles in apoptosis
236 ukemia cells and identified synthetic lethal drug target pairs for which corresponding drugs exhibit
237 domly select negative samples from unlabeled drug-target pairs, which introduces a lot of false-posit
238 apable of providing a promising solution for drug-target prediction based on topological similarity w
239 ing drugs.Network-based data integration for drug-target prediction is a promising avenue for drug re
243 re consists of four steps: (1) inferring new drug/target profiles and constructing profile kernel mat
245 f diseases, protein-protein interactions, or drug target relations, and demonstrate performance that
246 d improved utility for predicting both known drug-target relationships and overall drug sensitivity a
247 logical roles of AMPK and its potential as a drug target remain incompletely understood, largely beca
248 izable for improvements in cellular potency, drug target residence time, and pharmacokinetic paramete
253 ite interactions, identification of putative drug targets, screening of potential interventions, and
254 ggable CATH functional families, enriched in drug targets, show that relatives exhibit highly conserv
255 hy pathogenesis and as potential therapeutic drug targets.SIGNIFICANCE STATEMENT Neurodegenerative di
257 y demonstrates glycation constitutes a novel drug target that can be explored in synucleinopathies as
258 strategy and identify Bdf1 as an antifungal drug target that can be selectively inhibited without an
261 chemokine receptor 3 (CXCR3) is a potential drug target that mediates signaling involved in cancer m
262 ion might aid in the identification of novel drug targets that can promote larger hippocampal volumes
263 ponse of MCTS following UNC1999 treatment, a drug targeting the enzymes that catalyze H3K27me3, namel
264 tive treatment with etanercept, a biological drug targeting the TNF pathway and suppressing inflammat
265 the way for the development of new selective drugs targeting the amyloidogenic proteins implicated in
266 be considered in the clinical development of drugs targeting the cytochrome bc1 :aa3 , as well as for
267 of vaccine strategies and the development of drugs targeting the early stages of Hepatitis C virus (H
270 malian cell DNA replication, indicating that drugs targeting the terminase complex could be safe and
271 aripiprazole, and risperidone, and of kinase drugs targeting the VEGF receptor, demonstrates how unde
273 ist includes a number of known and potential drug targets, the identification of NTP binding can dire
275 ht reveal the pharmacodynamic (PD) effect of drugs targeting this cancer-specific metabolic pathway.
276 e responsible for parasite transmission, and drugs targeting this stage are needed to support malaria
277 nd thus the potential efficacy of envisioned drugs targeting this tissue to treat metabolic disease.
280 p41 NHR trimer has been known as the classic drug target to develop fusion inhibitors derived from th
281 highlighted the great potential of TCTP as a drug target to enhance conventional chemotherapy for can
282 making serine 14 phosphorylation a potential drug target to interfere with TRPC6 channel activity.
283 ying new disease markers and potential novel drug targets to better define and combat obesity and rel
285 eported data and will help to identify novel drug targets to combat HIV-1 infection.IMPORTANCE HIV-1
286 ay offer a therapeutically relevant panel of drug targets to correct basic defects in F508del-CFTR pr
287 etylcholine receptors (nAChRs) are promising drug targets to manage several neurological disorders an
288 ens are a powerful way to identify candidate drug targets to specifically kill tumor cells, but this
289 nteracting molecules that could serve as new drug targets to treat APOL1-associated renal diseases.
291 lications in identifying protein regions for drug targets, understanding the biological underpinnings
293 nterfering with IL-31, a currently evaluated drug target, we will have to consider that low doses of
294 s the MEP pathway's potential as a selective drug target, which is absent in humans but essential to
295 The diverse nAChRs represent distinguishable drug targets with different functions: Knockdown of unc-
297 evidence that 5-HT2C receptors are suitable drug targets with fewer side effects, greater therapeuti
298 nhibition of HMG-CoA reductase (the intended drug target) with the same lipids and metabolites for 27
299 onsensus that GR deserves a second life as a drug target, with either refined classic GCs or a novel
300 toyltransferase (NMT) represents a promising drug target within the parasitic protozoa Trypanosoma br
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