ライフサイエンスコーパス: drug-induced

1 utropenia, which was initially thought to be drug induced.

2 All were drug-induced.

3 lly, TRF2-mediated p21 repression attenuated drug-induced activation of cellular DNA damage response

4 In drug-induced acute liver failure, plasma levels correlat

5 ial therapeutic target to reduce a subset of drug-induced adverse effects.

6 34 European adults with any non-chemotherapy drug-induced agranulocytosis (absolute neutrophil count

7 genetic variants associated with antithyroid drug-induced agranulocytosis in a white European populat

8 Drug-induced agranulocytosis is a potentially life-threa

9 taking clozapine, although the incidence of drug-induced agranulocytosis is lower than previously ex

10 Ps, the predicted probability of antithyroid drug-induced agranulocytosis was about 30% (OR 753, 95%

11 In white European people, antithyroid drug-induced agranulocytosis was associated with HLA-B*2

12 27:05 was 7.30 (3.81-13.96) when antithyroid drug-induced agranulocytosis was compared with populatio

13 Ps were strongly associated with antithyroid drug-induced agranulocytosis: rs652888 (OR 4.73, 95% CI

14 nal tubular cells and is a frequent cause of drug-induced AKI.

15 The primary outcome was drug-induced ALF (defined as coagulopathy and hepatic en

16 The incidence rates of any definite drug-induced ALF and acetaminophen-induced ALF were 1.61

17 d to determine the incidence and outcomes of drug-induced ALF in an integrated health care system tha

18 Drug-induced ALF is uncommon, but over-the-counter produ

19 We have hypothesized that drug-induced allergic hepatitis is as rare in animals as

20 nal approach for developing animal models of drug-induced allergic hepatitis mediated by the adaptive

21 c drug-protein adducts, also referred to as "drug-induced allergic hepatitis"; but detailed mechanist

22 gically different hind-limb tumor models and drug-induced alterations in an orthotopic breast tumor m

23 examine basal calcium levels and ligand- and drug-induced alterations in these levels in proximal tub

24 tors constitute a biological brake to opioid drug-induced analgesia.

25 e possible roles of MRGPRX2 on host defense, drug-induced anaphylactoid reactions, neurogenic inflamm

26 There was a significant increase in fatal drug-induced anaphylaxis over 12 years: from 0.27 (95% C

27 inuous shift from food- to insect venom- and drug-induced anaphylaxis up to age 10 years, and there w

28 lity of life and well-being in patients with drug-induced anaphylaxis.

29 of single-molecule photobleaching to resolve drug-induced and domain-dependent changes in the oligome

30 cause of DITP in most cases appears to be a drug-induced antibody that binds to a platelet membrane

31 as lower sensitivity to TRAIL or anticancer drug-induced apoptosis and greater clonogenicity.

32 nificant suppression of both spontaneous and drug-induced apoptosis in the tumor cells.

33 sensitized lung cancer cells to chemotherapy drug-induced apoptosis, miR-7 enhanced the drug resistan

34 s that shows intrinsic resistance to IR- and drug-induced apoptosis.

35 sitivity of human cancer cells to anticancer drug-induced apoptosis.

36 whereas YAP knockdown sensitizes CC cells to drug-induced apoptosis.

37 ally deficient in MDR1A against DNA-damaging drug-induced apoptosis.

38 ootprints at inferred initiation sites after drug-induced arrest of translation initiation, validatin

39 s a revolutionary tool to assess preclinical drug-induced arrhythmogenicity.

40 tylase HDAC5 has a dynamic relationship with drug-induced behavioral neuroadaptations.

41 nucleus accumbens (NAc) appear to drive this drug-induced behavioral plasticity.

42 odeling was shown to be critical for several drug-induced behaviors, but its role in acquisition and

43 e increased liver BA levels, and upon BA- or drug-induced biliary insults, these mice exhibit exacerb

44 y, and as congenital, disease-associated, or drug-induced blood disorders can cause significant morbi

45 ulnerability both to addictive behaviors and drug-induced brain damage.

46 nt, and long-term follow-up of children with drug-induced Brugada syndrome (BS).

47 Patients presenting with spontaneous or drug-induced Brugada type 1 electrocardiographic finding

48 Patients presenting with spontaneous or drug-induced Brugada type I ECG and in whom programmed e

49 Patients presenting with spontaneous or drug-induced Brugada type I ECG and no symptoms at our i

50 Data on drug-induced BS in patients <12 years of age are lacking

51 Understanding individual susceptibility to drug-induced cardiotoxicity is key to improving patient

52 R/Cas9-mediated pathway correction prevented drug-induced cardiotoxicity.

53 an MCC tumor growth through sensitization to drug-induced cell cytotoxicity.

54 shly isolated human-renal carcinoma cells to drug-induced cell death in xenograft models and ex vivo

55 ance, whereas its ectopic expression reduces drug-induced cell death.

56 the amperometric assay provided a measure of drug-induced cell death.

57 heir self-renewal potential and suggest that drug-induced cell differentiation may represent a promis

58 ' of the fluorescent proteins depends on the drug-induced cell surface changes, generating patterns t

59 genetic factors affecting susceptibility to drug-induced central nervous system (CNS) toxicities, an

60 n piriform cortex, and the magnitude of this drug-induced change predicted perceptual alterations in

61 CA in healthy older adults during vasoactive drug-induced changes in arterial pressure assessed at th

62 o understand molecular mechanisms underlying drug-induced changes in D2 autoreceptors.

63 n established fluorescence assay that senses drug-induced changes in lipid bilayer properties.

64 Drug-induced changes in metabolite levels in P. falcipar

65 Although widespread drug-induced changes in neuronal excitability have been

66 Furthermore, drug-induced changes in the amount of electronic charge

67 ic heterogeneity as well as the baseline and drug-induced changes in the metabolite-phosphoprotein co

68 at degradation of this function secondary to drug-induced changes is a critical and likely addressabl

69 differentiation, and may contribute to these drug-induced changes.

70 While drug-induced cholestasis due to the inhibition of the bi

71 ) exists and its role in the pathogenesis of drug-induced cholestasis is poorly understood.

72 ndividual differences in susceptibility to a drug-induced CNS toxicity.

73 and shell of NAc, BLA, and CeA, on cue- and drug-induced cocaine-seeking in the rat cocaine reinstat

74 ting revealed that garcinol had no effect on drug-induced cocaine-seeking, but was capable of blockin

75 to the NAc core and shell inhibited cue- and drug-induced cocaine-seeking, respectively.

76 Long QT syndrome (LQTS) is an inherited or drug induced condition associated with delayed repolariz

77 g speed in patients, which correlated with a drug-induced coupling increase of prefrontal cortex with

78 Platinum drug-induced cross-link repair requires the concerted ac

79 opathy, cystinosis, dihydroxyadeninuria, and drug-induced crystalline nephropathy (e.g., caused by in

80 ave roles in immune modulation and repair of drug-induced damage, and put forward the case for target

81 when cells are proficient in the removal of drug-induced damage.

82 ell line and clinical experiments that early drug-induced death signaling measured by Dynamic BH3 Pro

83 o 53%) by genotype-guided dosing (P < .001); drug-induced death was reduced from 10% to 0%.

84 Drug-induced decrease in IFP in human metastases has not

85 med 'challenge in the bath,' and showed that drug-induced decreases in synaptic strength occur rapidl

86 To better understand the drug-induced depotentiation, we replicated these in vivo

87 To our knowledge, drug-induced dermatomyositis from ipilimumab has not pre

88 al patterning, early cardiac development and drug-induced developmental toxicity.

89 the colon, which defines a novel paradigm of drug-induced diarrhea.

90 droplets (LD); however, mechanisms differ in drug induced (DIS) and/or non-alcoholic fatty liver dise

91 th mitochondrial uncouplers or dissipated by drug-induced disaggregation of the spheroids.

92 lated cardiac dysfunction is a mitochondrial drug-induced disease caused by focal direct myocyte inju

93 Drug-induced disinhibition of VTA DA neurons has been li

94 s a crucial role in repairing and recovering drug-induced DNA damage by recruiting Rad51 to damage si

95 DSBs and contributes to the mis-rejoining of drug-induced DSBs in BRCA1-deficient cells showing that

96 These unexplored drug-induced environmental changes enhancing the target

97 Drug-induced eosinophilia is common with parenteral anti

98 med regulatory regions identifies individual drug-induced epigenetic states involving large topologic

99 ed injury, known as an "adverse drug event." Drug-induced episodes were evaluated for medication erro

100 pair (MMR) is deleterious and, fueled by the drug-induced error-prone polymerase Pol IV, overwhelms c

101 finite or possible ALF, and 32 (51.6%) had a drug-induced etiology (27 definite, 5 possible).

102 remic syndrome, have been reported to have a drug-induced etiology, and many different drugs have bee

103 sitive reinforcement, subjectively linked to drug-induced euphoria, and negative reinforcement, subje

104 Drug-induced exon skipping preferentially affects shorte

105 g Renshaw cells did not impact any aspect of drug-induced fictive locomotion in the neonatal mouse or

106 Congenital and acquired (drug-induced) forms of the human long-QT syndrome are as

107 Using the large collection of drug-induced gene expression data from Connectivity Map,

108 g transcriptomes imputed from GWAS data with drug-induced gene expression profiles from the Connectiv

109 Net amalgamates the prior drug knowledge and drug-induced gene expression via random walk algorithms.

110 Drug-induced gingival overgrowth is a tissue-specific co

111 Drug-induced gingival overgrowth is caused by the antise

112 Characteristics of these drug-induced gingival overgrowth lesions differ.

113 are based on estimation of the magnitude of drug-induced growth rate inhibition (GR) using endpoint

114 We determined that abrogation of drug-induced H3K27 hypermethylation is associated with c

115 Cs and presumably higher predictive power of drug induced haemolytic risk.

116 Drug-induced hepatocellular injury is identified interna

117 ments for which can induce anti-tuberculosis drug-induced hepatotoxicity (ATDH) and SCZ-like disorder

118 resence of biothiols, for early detection of drug-induced hepatotoxicity in living mice.

119 ugation, drug-mediated CYP450 induction, and drug-induced hepatotoxicity.

120 sors are specific and sensitive to image the drug-induced histone methylation changes in living anima

121 Our data point to an idiopathic, genetic, or drug-induced hyperglutamatergic state within the NAC as

122 -induced diabetes is the most common form of drug-induced hyperglycemia.

123 Cell adhesion counteracted anticancer drug-induced hypermethylation of H3K27 via inactivating

124 Importance: Drug-induced hypersensitivity syndrome (DIHS), also know

125 The maximum drug-induced IFN-activation state was similar for all th

126 However, the impact of drug-induced immune activation and cereblon/ikaros in an

127 Drug-induced immune thrombocytopenia (DITP) is caused by

128 n antibody and suggest that, in this type of drug-induced immunologic injury, the primary reaction in

129 Drug-induced immunosuppression is a risk factor for nonm

130 Drug-induced impairments are long lasting; thus, interve

131 nts and the slope of an individual subject's drug-induced increase in heart rate-corrected QT (QTc) v

132 ize intracellularly, we showed that a modest drug-induced increase in the fraction/stability of the E

133 their anti-inflammatory action, paradoxical drug-induced inflammatory events have been occasionally

134 lated livers were unable to fully respond to drug-induced injury or clear bacteria for at least 1 mon

135 se drug reaction and the subsequent onset of drug-induced injury, known as an "adverse drug event." D

136 These neurons undergo robust drug-induced intrinsic and extrinsic synaptic mechanisms

137 ute liver injury and potential biomarkers of drug-induced kidney injury.

138 reported APAP toxicity - being unaffected by drug-induced kidney injury.

139 proteins drastically reduced spontaneous and drug-induced latency reversal by suppressing HIV-1 trans

140 d 2012 in a prospective registry by the U.S. Drug Induced Liver Injury Network, 22 were attributed to

141 s to identify microRNA (miRNA) biomarkers of drug-induced liver and kidney injury by profiling the ci

142 Liver biology and function, drug-induced liver injury (DILI) and liver diseases are

143 The association of drug-induced liver injury (DILI) and Stevens-Johnson syn

144 We investigated the role of JNK in drug-induced liver injury (DILI) in liver tissue from pa

145 Drug-induced liver injury (DILI) is a major public healt

146 Drug-induced liver injury (DILI) is an important cause o

147 Drug-induced liver injury (DILI) is an important cause o

148 Drug-induced liver injury (DILI) presents a significant

149 Drug-induced liver injury (DILI) remains a leading cause

150 Toxic liver diseases are mainly caused by drug-induced liver injury (DILI).

151 e associated with positive rechallenge after drug-induced liver injury (DILI): antimicrobials; and ce

152 The mechanism of idiosyncratic drug-induced liver injury (IDILI) remains poorly underst

153 ug-related serious adverse events (potential drug-induced liver injury and depression or lipodystroph

154 ophen (APAP) overdose is a frequent cause of drug-induced liver injury and the most frequent cause of

155 sts that many cases of serious idiosyncratic drug-induced liver injury are mediated by the adaptive i

156 The biosensor is able to detect a drug-induced liver injury by monitoring the oxidative st

157 29%), indeterminate ALF (23%), idiosyncratic drug-induced liver injury DILI (22%), acute hepatitis B

158 In a high HIV burden area, drug-induced liver injury due to antiretroviral therapy

159 Among 1,188 cases of drug-induced liver injury enrolled between 2004 and 2012

160 All cases of drug-induced liver injury enrolled into a prospective da

161 -induced liver injury in mice is a model for drug-induced liver injury in humans.

162 Drug-induced liver injury is an important clinical entit

163 Drug rechallenge following drug-induced liver injury is associated with up to 13% m

164 Bile duct loss during the course of drug-induced liver injury is uncommon, but can be an ind

165 important element in assessing causality in drug-induced liver injury is whether the implicated agen

166 However, the complexity of idiosyncratic drug-induced liver injury means that no current single-c

167 The Drug-Induced Liver Injury Network is conducting a prospe

168 We analyzed patients in the US Drug-Induced Liver Injury Network prospective study havi

169 Drug-induced liver injury was the predominant finding (4

170 clinical features, and outcomes of cases of drug-induced liver injury with histologically proven bil

171 engineering because of the high frequency of drug-induced liver injury.

172 based instruments for assessing causality in drug-induced liver injury.

173 amic behaviour in the biological response to drug-induced liver injury.

174 ies have evaluated the incidence of ALF from drug-induced liver injury.

175 y revealed signs of immune-mediated toxic or drug-induced liver injury.

176 lates what is believed to occur during human drug-induced liver injury.

177 the frequency and decreased the amplitude of drug-induced locomotor bursting, effects that were depen

178 o the central pattern generator (CPG) during drug-induced locomotor-like activity.

179 Drug-induced long QT syndrome (diLQTS) and congenital LQ

180 elatively well-developed case of acquired or drug-induced long QT syndrome as an exemplar case.

181 This syndrome of drug-induced long QT syndrome has moved from an interest

182 the PI3K signaling pathway as the cause of a drug-induced long-QT syndrome in which alterations in se

183 In a drug-induced LQT3 model, acute interstitial edema exacer

184 events, except for one death possibly due to drug-induced lung injury.

185 There are few reports of drug-induced lupus caused by minocycline in Japan.

186 n of minocycline, she was considered to have drug-induced lupus.

187 e, we investigated the impact of genetic and drug-induced lysosomal cholesterol (LC) accumulation in

188 computational models to provide insight into drug-induced maladaptive decision making that may ultima

189 g addiction and abundant research describing drug-induced maladaptive synaptic plasticity, there are

190 However, the mechanisms underlying these drug-induced metabolic perturbations remain poorly under

191 ity of a protein, influences both native and drug-induced metabolic states.

192 ransporter itself and may explain aspects of drug-induced metabolic syndrome.

193 of hepatocyte VEGF markedly ablates the 'off-drug'-induced metastasis.

194 Drug-induced MICA and PVR gene expression are transcript

195 dependent kinase 1 (CDK1) during antimitotic drug-induced mitotic arrest and also in normal mitosis.

196 hat cell-type variation in susceptibility to drug-induced mitotic death arises primarily from differe

197 istant to streptozotocin-induced diabetes, a drug-induced model of autoimmune diabetes.

198 s of addiction demonstrate that a variety of drug-induced molecular adaptations responsible for relap

199 e, we also demonstrated that dose-dependent, drug-induced morphological change from different experim

200 the mesolimbic reward system and can reduce drug-induced motor behaviors, craving and dependence.

201 nderstanding of the underlying mechanisms of drug-induced muscle toxicity will promote enhanced aware

202 mutagenesis by demonstrating that all three drugs induced mutations and led to an increase in the ge

203 s of the nucleus accumbens in the control of drug-induced negative affect, a hallmark of continued dr

204 plays differential roles in the emergence of drug-induced negative affect.

205 model previously shown to be a predictor of drug-induced nephrotoxicity and compared its response to

206 into an OOC enabled dual-mode monitoring of drug-induced nephrotoxicity in situ.

207 It is now critical to view drug-induced neuroadaptations from a circuit-level persp

208 These results, along with evidence for drug-induced neuroadaptations in glutamatergic neurons a

209 ve splicing, suggesting a novel function for drug-induced neuroepigenetic remodeling.

210 methodology can detect the known effects of drug-induced neuronal inactivity and can be used to inve

211 to explain this paradox, we found that both drugs induced NMDA receptor-containing, AMPA receptor-si

212 ntaneous reports to the National Registry of Drug-Induced Ocular Side Effects and case reports in the

213 were collected from the National Registry of Drug-Induced Ocular Side Effects.

214 (CHQ) is considered as potential trigger of drug-induced or drug-aggravated psoriasis, in which Th17

215 There were no cases of incident drug-induced osteonecrosis and only 1 case of femoral sh

216 osome associated with hypersusceptibility to drug-induced ototoxicity.

217 PFC is necessary for extinction, but whether drug-induced overexpression of bFGF in this region affec

218 formed a reach-to-grasp task in either acute drug-induced parkinsonian akinesia (0.03-0.07 mg/kg halo

219 lated dynamically during behavior and during drug-induced pathological states.

220 Although drug-induced peripheral eosinophilia complicates antimic

221 eutic strategy to protect against anticancer drug-induced peripheral neurotoxicity.

222 ized MRI as a sensitive technique to monitor drug-induced perturbation of the PI3K/mTOR pathway in sa

223 Moreover, drug-induced perturbations of cholesterol homeostasis ca

224 Therefore, assays that can measure drug-induced perturbations of defined functional tumor p

225 With the drug-induced phenotypic fitness defect of the deletion o

226 oven effective in drug discovery to evaluate drug-induced phenotypic variations.

227 is predicted to underlie the development of drug-induced phospholipidosis, somatic mutations in LCAT

228 ifferent fluorescent proteins that can sense drug-induced physicochemical changes on cell surfaces.

229 -expressing neurons, indicating differential drug-induced plasticity between the variants.

230 is study assessed the calcium-dependence and drug-induced plasticity of D2S and D2L receptor-dependen

231 subpopulations, and consolidate findings of drug-induced plasticity of VTA DA neurons and highlight

232 We report three cases of drug-induced pneumonia caused by mesalazine.

233 ient's cough or fever for early detection of drug-induced pneumonia.

234 Mouse livers from drug-induced porphyria phenocopied the in vitro findings

235 tion were associated with decreased platinum drug-induced proliferating cell nuclear antigen (PCNA) a

236 We propose the drug-induced proliferation (DIP) rate, the slope of the

237 al anesthetics (LA) is largely determined by drug-induced prolongation of the time course of reprimin

238 rogenic protein sensor is reported to detect drug-induced proteome stress prior to cell death.

239 Drug-induced proteome stress that involves protein aggre

240 s new VNTR AKT1 variant in schizophrenia and drug-induced psychoses.

241 Drug-induced QT interval prolongation, a risk factor for

242 usly associated with baseline QT interval to drug-induced QT prolongation and arrhythmias is not know

243 significant proportion of the variability in drug-induced QT prolongation and is a significant predic

244 The genetic QT score was correlated with drug-induced QTc prolongation.

245 ic symptoms (DRESS) is a rare severe adverse drug-induced reaction with multiorgan involvement.

246 hly sensitive assay allows discrimination of drug-induced reactivation of productive HIV based on pro

247 Drug-induced readthrough over premature stop codons (PTC

248 We also revealed a previously unseen drug-induced rearrangement of nucleotides U2506 and U258

249 to alter EpoR upregulation, indicating that drug-induced receptor modulation is independent of cereb

250 cellular RNF41 is a critical determinant of drug-induced receptor modulation.

251 Drug-induced reduction of oxidative stress prevented dis

252 score of at least "possible" was considered drug induced, referred to as a "drug-related hazardous c

253 ence, but this phenomenon is not observed in drug-induced reinstatement models.

254 ic system distinctly contributes to cue- and drug-induced reinstatement of cocaine-seeking behavior.

255 ic system distinctly contributes to cue- and drug-induced reinstatement of cocaine-seeking behavior.

256 ach brain region immediately before cue- and drug-induced reinstatement of cocaine-seeking.

257 Therapy with all four drugs induced remission in 83% of new-onset mice and, re

258 oncogene, loss of tumour suppressor gene and drug-induced replication stress with APOBEC3B activity,

259 a and UV, thus promoting hypersensitivity to drug-induced replication stress.

260 m decreases in blood oxygen levels caused by drug-induced respiratory depression.

261 Drug-induced retained introns are typically shorter, dis

262 cularly in the forebrain, and sensitivity to drug-induced seizures.

263 Taken together, these findings suggest that drug-induced selective apoptosis of Mtb-infected macroph

264 our findings reveal a new mechanism by which drug-induced senescence is epigenetically regulated by m

265 unction, but the epigenetic basis underlying drug-induced senescence remains unclear.

266 ulation at the tumor region (inefficacy) and drug-induced severe side effects (toxicity).

267 ue of "readthrough therapy" while mitigating drug-induced side effects.

268 In p53-wildtype cells, both drugs induced significant G2 cell cycle arrest and apopt

269 ng dynamic changes in the upper airway using drug-induced sleep computed tomography (DI-SCT) in patie

270 gs during in-lab full-night polysomnography, drug-induced sleep endoscopy (DISE), and relocation phar

271 General anesthesia (GA) is a reversible drug-induced state of altered arousal required for more

272 vel target gene of PXR and may contribute to drug-induced steatosis and metabolic disorders in humans

273 ion, in line with our previous findings that drug-induced stimulation of autophagy has anti-prion eff

274 mechanistic relevance of Nrf2 as a marker of drug-induced stress it is important to know if this adap

275 Both drugs induced substantial changes in the oxidative PTPM

276 ing electrode to measure the release rate of drug-induced superoxides from C2C12 cells through a poro

277 c, or anaphylactoid, reactions; we show that drug-induced symptoms of anaphylactoid responses are sig

278 To prevail over this obstacle of drug-induced systemic toxicity, a novel approach termed

279 isplayed discrete expression profiles during drug-induced T cell activation, and expression of each r

280 osis include thyroiditis, iodine-induced and drug-induced thyroid dysfunction, and factitious ingesti

281 Efforts at improving predictability of drug-induced tissue injury in humans include using stem

282 An increased awareness of drug-induced TMA is also essential because the key to th

283 TMA presentations in the critically ill, drug-induced TMA, cancer-associated TMA, and hematopoiet

284 rmly consistent with a direct dose-dependent drug-induced TMA.

285 ically searched for all published reports of drug-induced TMA.

286 etic QT score was a significant predictor of drug-induced torsade de pointes in an independent sample

287 olongation and is a significant predictor of drug-induced torsade de pointes.

288 ssfully used to build a predictive model for drug-induced torsadogenic and non-torsadogenic drugs bas

289 rapeutic effects toward the tumor but severe drug-induced toxic side effects.

290 l lines, pinpointing a possible link between drug-induced toxicity and Golgi morphology alterations.

291 Its activation can be a critical factor in drug-induced toxicity and the development of diseases, i

292 Drug-induced toxicity is a significant problem in clinic

293 ent in vitro systems that can better predict drug-induced toxicity.

294 ion about the genetic factors affecting this drug-induced toxicity.

295 ducible resistance that relies on programmed drug-induced translation arrest.

296 Interestingly, the drug-induced upregulation of a disintegrin and metallopr

297 eous disease, nonsteroidal anti-inflammatory drug-induced urticaria/angioedema (NIUA), and single NSA

298 Nonsteroidal anti-inflammatory drugs-induced urticaria/angioedema does not seem to prec

299 pattern of adverse events, the mechanisms of drug-induced vasculopathy are not well understood.

300 of the Kv11.1 channel efficiently suppresses drug-induced ventricular arrhythmias in vitro by prevent