ライフサイエンスコーパス: dry eye

1 sociated keratoconjunctivitis sicca (KCS, or dry eye).

2 vators as a novel prosecretory treatment for dry eye.

3 t CFTR can correct the abnormal tear film in dry eye.

4 versing it when started after development of dry eye.

5 ress, suggesting protective effects of PS on dry eye.

6 cin deficiency observed in aqueous-deficient dry eye.

7 r SS in patients with clinically significant dry eye.

8 eyes, from patients with moderate to severe dry eye.

9 for translation to human clinical trials for dry eye.

10 ment of punctal plugs for moderate to severe dry eye.

11 MMPs in promoting galectin-3 degradation in dry eye.

12 proved contact lens comfort in patients with dry eye.

13 a lower threshold to test for SS in men with dry eye.

14 nd CCL-5), and MMP-3, that are stimulated by dry eye.

15 isease (MGD), as well as its relationship to dry eye.

16 ular surface impact, and the relationship to dry eye.

17 ployed as an objective clinical indicator of dry eye.

18 Tnf-alpha), all of which are up-regulated in dry eye.

19 aDry is sensitive and specific in diagnosing dry eye.

20 and tear volume, a phenotype consistent with dry eye.

21 ine in lacrimal cell function contributes to dry eye.

22 promising new approach for the management of dry eye.

23 y are important when evaluating and managing dry eye.

24 ed using the keywords inflammatory cycle and dry eye.

25 indicates increased epithelial thickness in dry eyes.

26 to be elevated in the tears of patients with dry eyes.

27 85 subjects, including both with healthy and dry eyes.

28 d PSP occur in some patients with idiopathic dry eyes.

29 gnificantly higher in tears of patients with dry eye (0.38 ng/mug total protein, range 0.04-1.36) com

30 nts within a session in the patients without dry eye (10.5 mOsm/L [95% CI, 9.0-12.4]) was significant

31 - 0.27), the ratio became slightly higher in dry eye (2.04 +/- 1.12 vs 1.99 +/- 1.21 in control) afte

32 y conjunctivitis (2.8%; 95% CI, 1.6-4.5) and dry eyes (2.0%; 95% CI, 1.1-3.7).

33 is were elevated IOP (75%), keratitis (59%), dry eyes (34%), posterior synechiae (34%), cataract (32%

34 In 19 of 47 patients confirmed with dry eye (40.4%) and in 3 of 54 controls (5.6%), the MMP-

35 ions of treatment were cataracts (12.1%) and dry eye (8.5%).

36 e (11 eyes), graft-vs-host disease (2 eyes), dry eye after keratomileusis in situ (2 eyes), and undif

37 gh standard procedures from 16 patients with dry eye and 11 age-matched healthy subjects.

38 Nineteen patients with dry eye and 20 asymptomatic controls were exposed to con

39 gery may aggravate the signs and symptoms of dry eye and affect dry eye test values in chronic dry ey

40 Adult patients with mild-to-moderate dry eye and asymptomatic subjects of similar ages can ex

41 okine expression in an experimental model of dry eye and bridge the gap between innate and adaptive i

42 Baseline scans of the dry eye and control groups did not show any statistical

43 epithelium of Sjogren syndrome patients with dry eye and decreased goblet cell mucin expression.

44 The prevalence of dry eye and its associated risk factors in the BOSS were

45 o evaluate how many patients with idiopathic dry eye and no evidence of systemic diseases from a dry

46 lity and quantity that can cause evaporative dry eye and ocular surface disruption, leading to dry ey

47 Associations between dry eye and risk factors were analyzed using logistic re

48 d sXBP1 expression was found in experimental dry eye and Sjogren syndrome models and was GC specific.

49 All subjects were required to fill in dry eye and smoking questionnaires, in addition to ocula

50 mmonly reported symptoms are blurred vision, dry eye and watering of the eye.

51 ded lower eyelid ectropion (6 malignancies), dry eye and/or exposure symptoms (8 malignancies), unila

52 the sera of well-characterized patients with dry eyes and dry mouth and lip biopsies from the Sjogren

53 In patients with dry eyes and dry mouth but F = 0, increased expression o

54 and symptoms of dysfunctional tear syndrome (dry eyes) and 63 healthy individuals serving as controls

55 luding modification of technique, to prevent dry eye, and postoperative dry eye prevention and manage

56 nt of ADD placement, diagnosis of uveitis or dry eye, and prior conjunctival surgery were not correla

57 is associated with epithelial dysfunction in dry eye, and that galectin-3 proteolytic cleavage may co

58 nderstanding the mechanisms of postoperative dry eye as well as patient risk factors for dry eye, pat

59 stemic disease with a known association with dry eye, as a way of validating our approach.

60 umbers, were made when patients had not only dry eye but also dry mouth.

61 nthal rhytids has been reported to result in dry eye, but its effect on tear film stability and tear

62 ial therapeutic indications in constipation, dry eye, cholestatic liver diseases, and inflammatory lu

63 Patients from a dry eye clinic and normal controls were assessed by Schi

64 Ongitudinal Sicca StudY (GLOSSY), a tertiary dry eye clinic patient cohort from the Netherlands.

65 A dry eye condition was documented by the Schirmer's I tes

66 s were those who showed 3 of the following 4 dry eye criteria: ocular surface disease index (OSDI) sc

67 risk factors that have been associated with dry eye cross-sectionally, such as psychiatric comorbidi

68 : Somatosensory dysfunction likely underlies dry eye (DE) symptoms in many individuals yet remains an

69 er of nociceptor sensitization, to facets of dry eye (DE), including symptoms and signs.

70 However, in long-term, signs and symptoms of dry eye decrease and dry eye test values return to preop

71 ition, and meniscus height and their role in dry eye diagnosis and therapeutic efficacy grading is as

72 with disease for less than 2 years and mild dry eyes did not express anti-Ro or anti-La, while 25% e

73 ng those most often cited as differing in AD dry eye, differed significantly between non-AD and AD gr

74 Dry eye disease (DED) affects millions of people worldwi

75 ent estimates of the prevalence of diagnosed dry eye disease (DED) and associated demographics among

76 the severity of ocular pain in patients with dry eye disease (DED) and evaluate factors associated wi

77 driving visual performance in patients with dry eye disease (DED) and to determine clinical predicto

78 was to compare patient-reported symptoms of dry eye disease (DED) as assessed by the Ocular Surface

79 A majority of experimental data on dry eye disease (DED) immunopathogenesis have been deriv

80 Dry eye disease (DED) is a common ocular disorder affect

81 Dry eye disease (DED) is a highly prevalent, ocular diso

82 Dry eye disease (DED) is multifactorial, affecting 5-34

83 Dry eye disease (DED) represents a heterogeneous group o

84 he association between serum metabolites and dry eye disease (DED) using a hypothesis-free metabolomi

85 o initiate a 5-year natural history study of dry eye disease (DED) using objectively assessed and pat

86 act, glaucoma, diabetic retinopathy (DR) and dry eye disease (DED) was assessed.

87 Diagnostic tests for dry eye disease (DED), including ocular surface disease

88 The immunopathogenic mechanisms of dry eye disease (DED), one of the most common ophthalmic

89 of discordance between symptoms and signs in dry eye disease (DED).

90 T-cell-mediated inflammation associated with dry eye disease (DED).

91 rimary effector cells in the pathogenesis of dry eye disease (DED).

92 mediating the ocular surface autoimmunity in dry eye disease (DED).

93 nd triacylglyceride (fish oil), for treating dry eye disease (DED).

94 tagonist developed to reduce inflammation in dry eye disease (DED).

95 tion (MGD) is the major cause of evaporative dry eye disease (EDED) and dysfunction is widely thought

96 The adjusted odds ratio for dry eye disease and anxiety was 2.8 (95% confidence inte

97 junctival epitheliopathies that may occur in dry eye disease and contact lens wear.

98 the human ocular surface in mild to moderate dry eye disease and controls.

99 For dry eye disease and depression, the odds ratio was 2.9 (

100 Separate odds ratios were calculated for dry eye disease and each of anxiety and depression.

101 tatistically significant association between dry eye disease and each of depression and anxiety.

102 lar odds ratios were also calculated between dry eye disease and rheumatoid arthritis, a systemic dis

103 ith LASIK, further reducing the incidence of dry eye disease and subsequent degradation in quality of

104 n proteins represent a potential therapy for dry eye disease and the strategy of ELP-mediated phase s

105 hich can be further developed as a model for dry eye disease and therapeutic evaluation.

106 Cataract, glaucoma, diabetic retinopathy and dry eye disease are common with high prevalence in Jorda

107 of HC-HA/PTX3 is a novel approach to prevent dry eye disease caused by cGVHD and allow us to test its

108 free on the ocular surface of patients with dry eye disease during 60 days of intervention.

109 o examine whether HC-HA/PTX3 could attenuate dry eye disease elicited by cGVHD.

110 dvances in understanding the pathogenesis of dry eye disease has revealed that inflammation is a core

111 Inflammation was induced to mimic dry eye disease in the coculture model system.

112 Dry eye disease is a major public health problem that af

113 A phase 1 study has reported that dry eye disease is the most common adverse effect of hum

114 Dry eye disease is the prominent ocular sequel of cGVHD

115 Ophthalmic care for dry eye disease may be needed when patients with cancer

116 oliferation and germinal center formation in dry eye disease mice, suggesting that a stable Ag-depend

117 Immune-driven dry eye disease primarily affects women; the cause for t

118 However, the role of PMNs in dry eye disease remains unexplored.

119 ectors and, in turn, preventing key signs of dry eye disease such as aqueous tear secretion, conjunct

120 Dry eye disease was defined from the validated Short Que

121 High incidence of mild to moderate dry eye disease was observed in both groups 1 month post

122 Complete evaluation of dry eye disease was performed at 1 and 6 months postoper

123 diseases like corneal transplant rejection, dry eye disease, and allergy.

124 Millions of Americans suffer from dry eye disease, and there are few effective therapies c

125 fined according to ICD-9 diagnosis codes for dry eye disease, anxiety, and depression.

126 on mechanisms of refractive surgery induced dry eye disease, surgical options, including modificatio

127 Using a preclinical model of IL-17-mediated dry eye disease, we demonstrate that upon encountering b

128 ease tear secretion and prevent experimental dry eye disease.

129 l activation and initiation of immune-driven dry eye disease.

130 -specifically regulated during immune-driven dry eye disease.

131 mologists in the management and treatment of dry eye disease.

132 XA4 formation that remained depressed during dry eye disease.

133 iagnose, classify, and grade the severity of dry eye disease.

134 sis, classification, and severity grading of dry eye disease.

135 symptoms or corneal fluorescein staining in dry eye disease.

136 ith figitumumab, the IGF-1 inhibitor, causes dry eye disease.

137 cacy in treating ocular inflammation such as dry eye disease.

138 e and summarizes the role of inflammation in dry eye disease.

139 glycol/propylene glycol in the treatment of dry eye disease.

140 es for ocular infections, wound healing, and dry-eye disease that affect the vision of millions world

141 immune mediator in many diseases, including dry-eye disease, and its inhibition is clinically effica

142 tic approach for allergic conjunctivitis and dry eye diseases.

143 lly delivered 12 may be efficacious in human dry eye diseases.

144 Dry eye disorders are a significant health problem for w

145 Dry eye disorders, including Sjogren's syndrome, constit

146 Experimental dry eye (EDE) was induced in C57BL/6 mice and TLR mRNA a

147 bles the sudden worsening that patients with dry eye experience daily.

148 mune-regulatory role for PMN-derived LXA4 in dry eye, females were treated with LXA4.

149 Almost all patients (98%) had a history of dry eye for an average of 10.4 years (median, 7.9 years)

150 A total of 648 patients with dry eye from the Groningen LOngitudinal Sicca StudY (GLO

151 ar asymmetry (hypoglobus, enophthalmos), and dry eyes from lagophthalmos could all indicate the diagn

152 The pathogenic mechanisms of the 2 forms of dry eye give an account for the different MMP9 and TG2 e

153 t baseline (0.75 +/- 0.52) compared with the dry eye group (0.41 +/- 0.27), the ratio became slightly

154 trol (unoperated, no ocular pathology) and a dry eye group (clinically confirmed dry eye, unoperated

155 um thickness metrics between the control and dry eye group show statistically significant difference

156 For the dry eye group, central epithelial thickness was 59.5 +/-

157 replicate major NS tear differences between dry eye groups.

158 ed lesion size without causing leukocytosis, dry eye, hair loss, or a reduced life span.

159 plugs improve symptoms of moderate to severe dry eye; however, retention rates differ significantly.

160 ictors is helpful in assessing patients with dry eye in clinical practice.

161 The prevalence of dry eye in the BOSS was 14.5%: 17.9% of women and 10.5%

162 ts showed superficial punctate keratitis and dry eye in the NK eye and a healthy contralateral eye.

163 The dry eye in this patient appears to be due to tear aqueou

164 original data on plugs for the treatment of dry eyes in at least 25 patients.

165 er the past few decades have discovered that dry eye is a chronic inflammatory disease that can be in

166 Dry eye is a common problem in Ophthalmology and may occ

167 Dry eye is a complicated ocular surface disease whose ex

168 Aqueous tear-deficient dry eye is a multifactorial chronic disorder in which th

169 MGD pathophysiology and its relationship to dry eye is important in order to optimize diagnosis and

170 XCL10, and CXCL11 expression in experimental dry eye is T cell-independent, requiring IFN-gamma-produ

171 undesirable phenotypes, including hair loss, dry eye, leukocytosis, xanthomatosis, and a reduced life

172 s having an increased risk for postoperative dry eye may benefit from surgical techniques such as sma

173 rative management of inflammation related to dry eyes may reduce dry eyes that develop after laser in

174 blepharitis were taking systemic or topical dry eye medications at the time of enrollment.

175 The second costliest category, dry eye medications, was attributable mostly to a single

176 applied Dex eye drops in experimental mouse dry eye model, and these results provide a strong ration

177 NW was evaluated using an experimental mouse dry eye model.

178 mice and showed efficacy in an experimental dry eye model.

179 unctival GC loss occurs in both experimental dry eye models and patients with keratoconjunctivitis si

180 zed among age, sex, aqueous tear deficiency, dry eye, ocular demodicosis, follow-up period, surgical

181 A majority of men reported dry eye on presentation (92%), albeit less chronic compa

182 When the same analysis was repeated in the dry eye or control groups, the ratio was significantly h

183 However, blurred vision (p = 0.003) and dry eye (p = 0.004) are higher among the REG than the NC

184 None of the subjective dry eye parameters demonstrated statistically significan

185 in regulatory T cells (Treg), and increased dry eye pathogenesis.

186 Treg in draining lymph nodes, while reducing dry eye pathogenesis.

187 that trigger the initial immune response in dry eye pathology.

188 dry eye as well as patient risk factors for dry eye, patient satisfaction and surgical outcomes can

189 Twenty dry eye patients and 20 age- and sex-matched control sub

190 analyzed by sampling tears from control and dry eye patients at various times.

191 In this study 60% of the dry eye patients expressed one of these autoantibodies.

192 ye and affect dry eye test values in chronic dry eye patients in short-term.

193 Fourteen female SS dry eye patients were exposed for 2 hours to a controlle

194 Dry eye patients who have had established signs or sympt

195 n of the lacrimal function unit in female SS dry eye patients.

196 linically significant inflammation in 40% of dry eye patients.

197 lar surface inflammation in 40% of confirmed dry eye patients.

198 ABX + DS mice had a significantly worse dry eye phenotype compared to controls, a decrease in Cl

199 and no evidence of systemic diseases from a dry eye practice have these autoantibodies.

200 Dry eye precedes these findings on average by 1 decade.

201 nique, to prevent dry eye, and postoperative dry eye prevention and management by way of both establi

202 e cases all had BCVA of 20/20 and mild or no dry eye problems.

203 d abandoned contact lenses because of latent dry eye problems.

204 In a mouse model of aqueous-deficient dry eye produced by lacrimal ablation, topical administr

205 Patients filled out the Dry Eye Questionnaire 5 (DEQ5) and underwent measurement

206 compared dry eye symptoms (determined by the Dry Eye Questionnaire 5 [DEQ5] score) to tear film indic

207 io [OR], 3.80; 95% CI, 1.00-14.49; P = .05), Dry Eye Questionnaire 5 score (OR, 1.15; 95% CI, 1.02-1.

208 ere dry eye symptoms at 1 year, defined as a Dry Eye Questionnaire 5 score of 12 or more.

209 ere dry eye symptoms at 1 year, defined as a Dry Eye Questionnaire 5 score of 12 or more.

210 tionnaires regarding ocular symptoms (5-Item Dry Eye Questionnaire [DEQ5], Ocular Surface Disease Ind

211 The patients completed the Single-Item Score Dry Eye Questionnaire and the following diagnostic tests

212 l sensitivity was negatively correlated with dry eye-related corneal damage (R(2) = 0.48, P < 0.01),

213 ing (CFS), complete bilateral CFS clearance, dry eye-related symptoms as measured by the Ocular Surfa

214 An international survey was distributed to dry eye researchers and expert practitioners via an inte

215 es from healthy subjects, whereas 50% of the dry eye samples were characterized by the additional pre

216 ar osmolarity, and the Symptom Assessment in Dry Eye (SANDE) questionnaire scores were determined at

217 sease Index (OSDI) and Symptom Assessment in Dry Eye (SANDE) questionnaires.

218 questionnaire, and the Symptom Assessment iN Dry Eye (SANDE), a 2-item frequency- and severity-based

219 Dry eye scores were lower in the TA group at month 1 (P=

220 Normal subjects with no symptoms of dry eyes served as controls.

221 ificant correlations between corneal ECD and dry eye severity parameters including the OSDI score (rs

222 Visual acuity, dry eye severity, and scarring of the ocular surface and

223 onal studies have evaluated risk factors for dry eye severity, but few have assessed risk factors or

224 sfunction, all in both eyes, and a composite dry eye signs severity score was calculated from these 6

225 score of the OSDI and the rank score of the dry eye signs severity score.

226 Dry eye signs were assessed by tear osmolarity, Schirmer

227 experiments, elevated expression of MMP9 in dry eye subjects correlated with the ability of active M

228 Participants also completed serial dry eye surveys using the same subscales (frequency, sev

229 y during 1 year, as assessed by responses to dry eye symptom questionnaires administered at the initi

230 y during 1 year, as assessed by responses to dry eye symptom questionnaires administered at the initi

231 Change in dry eye symptom severity during 1 year, as assessed by r

232 Main Outcomes and Measures: Change in dry eye symptom severity during 1 year, as assessed by r

233 We compared dry eye symptoms (determined by the Dry Eye Questionnair

234 Dry eye symptoms (Ocular Surface Disease Index [OSDI]),

235 clusions and Relevance: Patients with severe dry eye symptoms and ocular pain at baseline were more l

236 Patients with severe dry eye symptoms and ocular pain at baseline were more l

237 There were also significant improvements in dry eye symptoms and quality of life as assessed by the

238 Seven of 10 had only mild or no dry eye symptoms and scarring sequelae.

239 rans Affairs Hospital with a wide variety of dry eye symptoms and signs (ranging from none to severe)

240 rans Affairs Hospital with a wide variety of dry eye symptoms and signs (ranging from none to severe)

241 Baseline ocular risk factors for severe dry eye symptoms at 1 year included more severe dry eye

242 as baseline risk factor analysis for severe dry eye symptoms at 1 year, defined as a Dry Eye Questio

243 as baseline risk factor analysis for severe dry eye symptoms at 1 year, defined as a Dry Eye Questio

244 cular pain, were also associated with severe dry eye symptoms at 1 year.

245 The proportion with dry eye symptoms at 1, 2, or 3 years after LASIK was not

246 % CI, 19%-37%) had mild, moderate, or severe dry eye symptoms at 3 months.

247 Sixty-four patients with dry eye symptoms between the ages of 45 and 90 years wer

248 erall, the prevalence of visual symptoms and dry eye symptoms decreased, although a substantial perce

249 ye and ocular surface disruption, leading to dry eye symptoms in some individuals.

250 associations between the NEI-VFQ-25 and the dry eye symptoms measured by the OSDI and SANDE question

251 e were more likely to have persistent severe dry eye symptoms on 1-year follow-up.

252 e were more likely to have persistent severe dry eye symptoms on 1-year follow-up.

253 r TBUT (P < 0.001), 26% and 4% (P=0.004) for dry eye symptoms, and 22.3% and 5.1% for Schirmer's scor

254 -corrected visual acuity (BCVA) of 20/20, no dry eye symptoms, and no scarring sequelae.

255 ell as an improvement in the patients' BCVA, dry eye symptoms, and quality of life.

256 ight driving, did not significantly increase dry eye symptoms, and resulted in higher levels of satis

257 , and outcomes with regard to visual acuity, dry eye symptoms, and scarring sequelae at least 3 month

258 in the PTSD and depression groups had severe dry eye symptoms, defined as a DEQ5 score >/= 12 (77% an

259 eye symptoms at 1 year included more severe dry eye symptoms, ocular pain, and neuropathic pain-like

260 n studies reported metrics of improvement in dry eye symptoms, ocular-surface status, artificial tear

261 le images, glare, halos, and/or starbursts), dry eye symptoms, participant satisfaction (with vision

262 ouble images, glare, halos, and starbursts), dry eye symptoms, satisfaction with vision, and satisfac

263 equency of patient-reported visual symptoms, dry eye symptoms, satisfaction with vision, and satisfac

264 Dry eye symptoms, tear break up time (TBUT) and corneal

265 te to significant improvements in subjective dry eye symptoms.

266 s due to persistent ocular pain secondary to dry eye symptoms.

267 d from the validated Short Questionnaire for Dry Eye Syndrome (SQDES) as a previous diagnosis of DED

268 spective study was to evaluate the course of dry eye syndrome after phacoemulsification surgery.

269 patients (30 males, 66 females) with chronic dry eye syndrome and cataract, who had undergone phacoem

270 To assess symptom progression in dry eye syndrome and determine risk factors associated w

271 Objectives: To assess symptom progression in dry eye syndrome and determine risk factors associated w

272 ating room predisposes surgical residents to dry eye syndrome because of environmental conditions.

273 to determine the prevalence and severity of dry eye syndrome in a group of Mexican residents of diff

274 Importance: Dry eye syndrome is a common condition that affects mill

275 Dry eye syndrome is a common condition that affects mill

276 Median time to the development of dry eye syndrome was 5 months after HSCT, whereas all ot

277 A higher number of residents with dry eye syndrome was found in the cardiothoracic surgery

278 t of ocular diseases affecting the anterior (dry eye syndrome) and posterior (age-related macular deg

279 on can result in tear film disorders such as dry eye syndrome, a widely encountered and debilitating

280 se Index, together with diagnostic tests for dry eye syndrome, such as tear breakup time, Oxford Sche

281 rrhagic complications, optic disc edema, and dry eye syndrome.

282 erstand the mechanisms behind ocular pain in dry eye syndrome.

283 the signs and symptoms of dry eye and affect dry eye test values in chronic dry eye patients in short

284 , signs and symptoms of dry eye decrease and dry eye test values return to preoperative values.

285 It correlated well with other dry eye tests and identified the presence of ocular surf

286 The following dry eye tests were performed before and after the exposu

287 s improve the signs and symptoms of moderate dry eye that are not improved with topical lubrication,

288 inflammation related to dry eyes may reduce dry eyes that develop after laser in situ keratomileusis

289 these therapies represent a major advance in dry eye therapy, they are not effective in improving dis

290 y) and a dry eye group (clinically confirmed dry eye, unoperated and no other ocular pathology).

291 lthy controls or for a clinical diagnosis of dry eye using the Ocular Surface Disease Index, Schirmer

292 Dry eye was also associated with lower scores on the Med

293 In this study, dry eye was associated with lower quality of life on a h

294 Dry eye was determined by self-report of frequency of sy

295 apeutic evaluation and pathogenesis study of dry eye, we established an in vitro three-dimensional (3

296 f their diagnosis relative to that of SS and dry eye were assessed.

297 Twenty subjects with aqueous deficient dry eye were enrolled.

298 1 patients were screened; 7207 patients with dry eye were included, while 20 004 patients with anxiet

299 A total of 15 subjects (5 normal and 10 dry eye) were enrolled in a 3-visit study consisting of

300 onjunctiva and lid margins and also moderate dry eyes with severe photophobia.