ライフサイエンスコーパス: dsDNA

1 dsDNA library preparations, however, are insensitive to

2 lex with several nucleases, including the 5' dsDNA exonuclease EXO1.

3 e activity, but confers on hEXOG a strong 5'-dsDNA exonuclease activity that precisely excises a dinu

4 rovides new insight into SbcCD activity at a dsDNA end.

5 mined with the replication proteins bound, a dsDNA loop was frequently associated with the replicatio

6 rands: they make one of the two strands of a dsDNA accessible for hybridization to a probe, and they

7 the recombinase to selectively use abundant dsDNA substrate present during post-irradiation recovery

8 ts renaturation of the duplex nucleic acids (dsDNA/RNA).

9 However, BKV infection did not affect dsDNA-induced gene expression, indicating BKV did not mo

10 of the surveillance complex before and after dsDNA binding, or in complex with three virally encoded

11 ens secretion induced autoantibodies against dsDNA and heat shock protein 60 as well as antibody accu

12 nutes) measurement of autoantibodies against dsDNA.

13 agosomal membrane permeabilization, allowing dsDNA and IgG to leak into the cytosol and activate AIM2

14 ) experiments for mixed alkali chlorides and dsDNA.

15 references that differ for G4 disruption and dsDNA unwinding, most likely arising from differences in

16 IM2(PYD)) drives both filament formation and dsDNA binding.

17 us recombination between the host genome and dsDNA donor molecules, stimulated by the induction of ch

18 Here, we apply paired metaproteomics and dsDNA-targeted metagenomics to identify 1,875 virion-ass

19 ontaneously formed by mixing the protein and dsDNA building blocks.

20 eraction with lambdaexo as well as ssDNA and dsDNA recombination in vivo.

21 ferences enabled us to distinguish ssDNA and dsDNA without using a label or a tag.

22 us contacts can occur between long ssRNA and dsDNA in the absence of protein and that these contacts

23 ral infection as their ligands are ssRNA and dsDNA, respectively.

24 fect on systemic autoantibodies such as anti-dsDNA Abs or disease in other organs such as kidneys, lu

25 anti-dsDNA and glomerulonephritis, but anti-dsDNA titers were higher in the latter.

26 and NZM2328.DR3(+)AE(0) mice developed anti-dsDNA and glomerulonephritis, but anti-dsDNA titers were

27 s of these alloreactive cells developed anti-dsDNA autoantibodies starting at week 2 as expected, wit

28 In site-directed anti-dsDNA H chain transgenic mice, loss of VprBP function in

29 ristane-treated WT mice showed elevated anti-dsDNA, anti-snRNP, CXCL1, and MCP-1 levels compared to u

30 antigen-directed autoantibodies (e.g., anti-dsDNA).

31 lecule decoy antigens, which neutralize anti-dsDNA antibodies in vitro, in situ, and in vivo.

32 lls, leading to decreased production of anti-dsDNA Abs.

33 erent renal antigens, ii) the impact of anti-dsDNA antibodies targeting exposed chromatin in glomerul

34 to specifically inhibit the binding of anti-dsDNA antibodies to target antigens such as dsDNA and pe

35 ls had BLK genotype-dependent levels of anti-dsDNA IgG Abs as well as increased numbers of a B1-like

36 ils, monocytes, and ECs with aPL-IgG or anti-dsDNA-IgG antibodies deregulated microRNAs expression, a

37 ids with a preference of ssDNA approximately dsDNA > ssRNA, which is distinct from Rx1.

38 -dsDNA antibodies to target antigens such as dsDNA and pentapeptide DWEYS.

39 The nanobiosensors AuDE/SAM/rGO/Fe2Ni@Au/dsDNA were then subjected to the action of a model chemo

40 eosome is passively transferred to available dsDNA as predicted by a simple physical model of DNA loo

41 degrading activity, providing a link between dsDNA degradation and nucleic acid-mediated autoimmune d

42 nd IFN-gamma-inducible protein (IFI)16, bind dsDNA and form caspase-1-activating inflammasomes that a

43 ility to oligomerize is critical for binding dsDNA, and in turn permits the size of dsDNA to regulate

44 the HhH domain of ERCC1 preferentially binds dsDNA through the hairpin region.

45 MTs labeled with 20-bp or 50-bp dsDNA molecules showed significantly different trajector

46 205 revealed that inflammasome activation by dsDNA, as well as ligands that engage the NLRP3 inflamma

47 Examination of immune responses induced by dsDNA and other microbial ligands in bone marrow-derived

48 ltiple single-stranded segments separated by dsDNA segments 500 to 1,000 nucleotides in length locate

49 rent affinity matches that for its canonical dsDNA ligand, suggesting a biological role for RNA bindi

50 hat were predicted to interact with the cGAS/dsDNA complex.

51 xture of two viruses with different circular dsDNA genomes.

52 and ISKpn21 Using the resistance of circular dsDNA molecules to exonuclease, internally calibrated wi

53 A substrates, we observed that SbcCD cleaved dsDNA using this activity when the substrate was 110 bp

54 l intermediate in the development of complex dsDNA viruses.

55 spontaneously occurred between the confined dsDNAs on the nanoparticles' surface in the second AND g

56 imited by the diffusion of the MB-conjugated dsDNA providing the robust "off-on" nanomolar DNA sensin

57 The TREX1 D18N dsDNA interactions coupled with catalytic deficiency exp

58 or promotes the enzyme's capacity to degrade dsDNA in conjunction with BLM or WRN and thus promote th

59 n the past decades, all involving denaturing dsDNA and hybridizing fluorescent nucleic acid probes.

60 nts had grade III-IV acute GVHD or developed dsDNA autoantibodies.

61 N-tier ring of the Mcm2-7 hexamer in the DH-dsDNA needs to tilt and shift laterally.

62 of the DNA frame, we created four different dsDNA substrates containing torsion-ally constrained or

63 We find that different dsDNA end structures have differential dependence on the

64 Double-strand DNA (dsDNA) can act as an effective template for the formatio

65 (ssDNA) with a homologous double-strand DNA (dsDNA) template.

66 pression protects against double-strand DNA (dsDNA)-damaging events, and show that this protective fu

67 ing double-stranded and single-stranded DNA (dsDNA and ssDNA) regions of varying lengths.

68 antibodies specific for double-stranded DNA (dsDNA) activated plasmacytoid dendritic cells (pDCs), a

69 uencing via ligation of double-stranded DNA (dsDNA) adapters.

70 : i) the impact of anti-double-stranded DNA (dsDNA) antibodies that cross-react with inherent renal a

71 event the generation of double-stranded DNA (dsDNA) breaks in cycling large pre-B cells.

72 Double-stranded DNA (dsDNA) can trigger the production of type I interferon (

73 Double-stranded DNA (dsDNA) cleavage by Cas9 is a hallmark of type II CRISPR-

74 cted repair (HDR) after double-stranded DNA (dsDNA) cleavage facilitates functional genomic research

75 emonstrate that, unlike double-stranded DNA (dsDNA) donors with central heterologies, ODNs generated

76 conformational state of double stranded DNA (dsDNA) following its interaction with unlabelled protein

77 een the release of host double-stranded DNA (dsDNA) following rhinovirus infection and the exacerbati

78 a 9.8- to 9.9-kb linear double-stranded DNA (dsDNA) genome with large inverted terminal repeats.

79 Translocation of viral double-stranded DNA (dsDNA) into the icosahedral prohead shell is catalyzed b

80 autoantibodies against double-stranded DNA (dsDNA) is used in the diagnosis of Systemic Lupus Erythe

81 tion to their canonical double-stranded DNA (dsDNA) ligand.

82 complex to bind to two double-stranded DNA (dsDNA) molecules.

83 So far, only double-stranded DNA (dsDNA) over 40 base pairs (bp) in length has been consid

84 n spCas9-sgRNA-mediated double-stranded DNA (dsDNA) recognition and cleavage, it is still unclear how

85 recognition of specific double-stranded DNA (dsDNA) regions has been a longstanding goal as evidenced

86 ions between homologous double-stranded DNA (dsDNA) segments.

87 was dependent upon the double-stranded DNA (dsDNA) sensor cyclic GMP-AMP synthase (cGAS), the innate

88 ssociation of Cas9 from double-stranded DNA (dsDNA) substrates is slow (lifetime approximately 6 h) b

89 otein filament (NPF) on double-stranded DNA (dsDNA) that is capable of unwrapping the nucleosomal DNA

90 t the binding of target double-stranded DNA (dsDNA) to a type I-F CRISPR system yersinia (Csy) survei

91 proteins together with double-stranded DNA (dsDNA) to form extracellular fibers known as NETs.

92 or proteins that unwind double-stranded DNA (dsDNA) to reveal single-stranded DNA (ssDNA) needed for

93 mplete 70.8-kb circular double-stranded DNA (dsDNA) viral genome content, and identification of its c

94 capsids that encase the double-stranded DNA (dsDNA) viral genome.

95 re, we use quantitative double-stranded DNA (dsDNA) viral-fraction metagenomes (viromes) and whole vi

96 Bacteriophage P22, a double-stranded DNA (dsDNA) virus, has a nonconserved 124-amino-acid accessor

97 infection with certain double-stranded DNA (dsDNA) viruses after allogeneic hematopoietic cell trans

98 n adenoviruses (Ad) are double-stranded DNA (dsDNA) viruses associated with infectious diseases, but

99 Ascoviruses are double-stranded DNA (dsDNA) viruses that attack caterpillars and differ from

100 tranded DNA (ssDNA) and double-stranded DNA (dsDNA) with acetone, ethanol, H2S and HCl.

101 lity to directly detect double-stranded DNA (dsDNA) without sequence-preference continues to be a maj

102 les functionalized with double-stranded DNA (dsDNA), a sequence of the breast cancer gene BRCA1.

103 cytosolic detection of double-stranded DNA (dsDNA), but how dsDNA is detected is controversial.

104 velop autoantibodies to double-stranded DNA (dsDNA), but the source of DNA antigen is unknown.

105 on between the rates of double-stranded DNA (dsDNA), single-stranded RNA (ssRNA), and ssDNA/reverse-t

106 e ssDNA with homologous double-stranded DNA (dsDNA), which serves as the template to guide DSB repair

107 mechanism of the viral double-stranded DNA (dsDNA)-packaging motor with sequential one-way revolving

108 noparticles (AuNPs) and double-stranded DNA (dsDNA).

109 ical samples comprising double-stranded DNA (dsDNA).

110 randed DNA (ssDNA) than double-stranded DNA (dsDNA).

111 formed, it interrogates double-stranded DNA (dsDNA).

112 that detect cytoplasmic double-stranded DNA (dsDNA).

113 ase of the AuNPs-S2 from double-stranded DNA(dsDNA) and the recovery of the ECL signal of QDs (second

114 d DNA-ssDNA) and hybrid (double stranded DNA-dsDNA) both via 3-NT reduction and guanine oxidation sig

115 ional activities and variability of dominant dsDNA viruses in the open ocean's euphotic zone over dai

116 or the specific recognition of target dsDNA (dsDNA-T), which in turn leads to the formation of a high

117 the TREX1 D18N enzyme exhibits dysfunctional dsDNA-degrading activity, providing a link between dsDNA

118 Thus, dysfunctional dsDNA degradation by TREX1 D18N induces disease in mice

119 us, NETosis and its associated extracellular dsDNA contribute to the pathogenesis and may represent p

120 ways, including increasing its affinity for dsDNA and its preference for dATP over ATP.

121 the impact of relative antibody avidity for dsDNA, chromatin fragments, or cross-reacting antigens.

122 fects of ssRNA on force extension curves for dsDNA.

123 ignificantly different from that deduced for dsDNA using NMR.

124 nt (T1024G/T1086G) relative to normal B-form dsDNA substrates.

125 dividual, torsionally constrained, nick-free dsDNA molecules, we measured the contour lengths and mol

126 in vivo is to unwind the excised 13-mer from dsDNA and that mutation of uvrD results in remarkable pr

127 also promotes the dissociation of RAD51 from dsDNA and not ssDNA.

128 The FtsK dsDNA translocase functions in bacterial chromosome unli

129 Furthermore, dsDNA-loaded Mcm2-7 harboring the DDK phosphomimetic Mcm

130 ch forms both parallel and antiparallel GQs, dsDNA displays only parallel folding.

131 hydrolysis is present, flanking heterologous dsDNA regions increase the reversibility of sequence mat

132 , inverse strand exchange between homologous dsDNA and RNA is a distinctive activity of Rad52; neithe

133 w propose that, in somatic cells, homologous dsDNA-dsDNA interactions between a small number of repea

134 RNA and ssDNA viruses recombining with host dsDNA genomes and, more surprisingly, RNA virus genes re

135 tion of double-stranded DNA (dsDNA), but how dsDNA is detected is controversial.

136 ces were required to convert hypermethylated dsDNA into an extended S-form configuration.

137 insic stiffness decreased in hypermethylated dsDNA, pointing at structural compaction which may facil

138 pair parameter and its different behavior in dsDNA and dsRNA traced down to changes in the sugar puck

139 Thus, mice deficient in dsDNA-sensing pathway, but not Toll like receptor (TLR)

140 GQ formation is substantially diminished in dsDNA, likely due to the competition from the Watson-Cri

141 tered lesions have only been investigated in dsDNA models.

142 y, is strikingly similar to that observed in dsDNA viruses of the PRD1-adenovirus lineage, characteri

143 ion of this distance leads to overwinding in dsDNA.

144 A spike in dsDNA production around day +14 during engraftment was a

145 Increased dsDNA levels at days +30, +60, and +100 were also associ

146 e programmed with a guide RNA, do not induce dsDNA breaks, and mediate the direct conversion of cytid

147 encoded anti-CRISPR suppressors that inhibit dsDNA binding, reveals mechanistic details underlying ta

148 ction and that they functioned by inhibiting dsDNA stimulation of cGAS.

149 d normal cells in response to cell-intrinsic dsDNA sensing dependent upon cGAS-STING.IMPORTANCE By an

150 terodimer binds sequence-specifically to its dsDNA-binding site within the P-element TIRs.

151 DEP sorting of 1.0, 10.2, 19.5, and 48.5 kbp dsDNA analytes, including both plasmid and genomic DNA.

152 Bacteriophages and large dsDNA viruses encode sophisticated machinery to transloc

153 the genome, an unusual occurrence for large dsDNA viruses.IMPORTANCE Unlike all other DNA viruses, a

154 Phycodnaviruses are algae-infecting large dsDNA viruses that are widely distributed in aquatic env

155 lga Emiliania huxleyi and its specific large dsDNA virus (EhV) is a major factor determining the fate

156 smaller type II-C Cas9 proteins have limited dsDNA binding and unwinding activity and promiscuous gui

157 Linear dsDNA replicons with hairpin ends are found in the three

158 gest that SbcCD processes hairpin and linear dsDNA ends with this novel DNA end-dependent binary endo

159 in general and more specifically for linear dsDNA; equations are derived linking the measured acoust

160 ng electron microscopy revealed long, linear dsDNAs, and in 87%, one end, presumably the end with the

161 de multiple parallel collisions between long dsDNA molecules, and find that those additional interact

162 long ssRNA interacts paranemically with long dsDNA via periodic short homologous interactions, e.g. m

163 Many dsDNA bacterial viruses (bacteriophages/phages) have lon

164 Many dsDNA viruses encode DNA-packaging terminases, each cont

165 Many dsDNA viruses have morphogenic pathways utilizing an int

166 opose a distinctive model wherein RecQ melts dsDNA internally to initiate unwinding and subsequently

167 B lymphocyte development to prevent mistimed dsDNA breaks and their deleterious consequences.

168 In particular, we first model dsDNA molecules as short rigid rods containing periodica

169 efficient and specific recognition of model dsDNA targets in buffers of high ionic strength.

170 erm persistence (>1 y) was the rule for most dsDNA viruses observed, suggesting that both core viral

171 In conclusion, detection of multiple dsDNA viruses was frequent after allogeneic HCT and had

172 pseudorabies virus (PRV), are neuroinvasive dsDNA viruses that establish life-long latency in periph

173 ptic filaments interacting with the observed dsDNA molecules.

174 hese investigations establish a global ocean dsDNA viromic data set with analyses supporting the seed

175 endogenous DNA could explain the absence of dsDNA-reactive autoantibodies in DKO mice, we used a nov

176 Statistical co-occurrence analyses of dsDNA, ssRNA and dsRNA viral markers of polyadenylation-

177 sca type I-E Cascade: (1) unwinding 11 bp of dsDNA at the seed-sequence region to scout for sequence

178 case surface, showing that at least 10 bp of dsDNA enter the E1 helicase via a side tunnel.

179 g with 18 ligands of various combinations of dsDNA and ssDNA regions, which mimicked different DELSMs

180 The concentration of dsDNA-specific IgE found in patient serum correlated wit

181 s constraints, we derive 14 conformations of dsDNA by molecular dynamics simulations.

182 We determine all of the elastic constants of dsDNA and dsRNA and provide an explanation for three str

183 In addition, intracellular delivery of dsDNA or stimulation with IFN did elicit a rapid and pro

184 or the direct, highly sensitive detection of dsDNA based on the strand replacement of dsDNA by peptid

185 ficient solution for the direct detection of dsDNA.

186 on exploring the abundance and diversity of dsDNA viruses.

187 e presence of ssRNA impedes the extension of dsDNA, specifically at low forces, dependent on homology

188 ng the evolutionary trajectory of a group of dsDNA bacteriophages known as the phiKMVviruses.

189 e helicase capable of unwinding kilobases of dsDNA in length.

190 e much longer than the persistence length of dsDNA, so we extended the model to include multiple para

191 We measured levels of dsDNA, as a surrogate for NETs in 103 consecutive pediat

192 electrochemical signal and the logarithm of dsDNA-T concentration over the range from 1.0 fM to 1.0n

193 simulations spanning several microseconds of dsDNA packing inside nanometer-sized viral capsids.

194 the measured acoustic ratio to the number of dsDNA base pairs for two acoustic sensors, the QCM and L

195 g activity that is coupled to the opening of dsDNA.

196 bsequently HRCA process, producing plenty of dsDNA.

197 n be assessed in humans by quantification of dsDNA in serum.

198 g strategy for mixed-sequence recognition of dsDNA targets for applications in molecular biology and

199 NHEJ proteins in the mechanism of repair of dsDNA breaks, but interpretations can be confounded by o

200 of dsDNA based on the strand replacement of dsDNA by peptide nucleic acid (PNA) and the in situ grow

201 Due to the strand replacement of dsDNA by PNA, dsDNA can be directly detected without seq

202 nding dsDNA, and in turn permits the size of dsDNA to regulate the assembly of the AIM2 polymers.

203 ecular dynamics to simulate the structure of dsDNA and dsRNA subjected to stretching forces up to 20

204 l dsDNA-packaging motors, including those of dsDNA/dsRNA bacteriophages, adenoviruses, poxviruses, he

205 rt the cryo-EM structure of the Mcm2-7 DH on dsDNA and show that the DNA is zigzagged inside the cent

206 located in the NTD impairs HR stimulation on dsDNA/ssDNA junction containing substrates.

207 Studies on dsDNA bacteriophages have revealed that a DNA packaging

208 estimulation of primary TEC with IFNalpha or dsDNA did not hamper replication of BKV, whereas influen

209 (LT) hexameric helicase bound to its origin dsDNA.

210 The origin dsDNA inside the narrower AAA+ domain channel shows part

211 xameric helicases interact with their origin dsDNA remains unknown.

212 ot of a hexameric helicase binding to origin dsDNA, and suggests a possible mechanism of origin melti

213 eins that closely interact with the packaged dsDNA genome.

214 ith the corresponding aptamer of the partial dsDNA probes and liberates single stranded initiation se

215 Peak dsDNA production around day +14 was associated with inte

216 ethod performed on routinely prepped plasmid dsDNA.

217 e to the strand replacement of dsDNA by PNA, dsDNA can be directly detected without sequence-preferen

218 cy explain how this mutant nuclease prevents dsDNA degradation.

219 egrates with BLM or WRN helicases to promote dsDNA degradation by forming a heterodimeric molecular m

220 2 modulates telomere structures by promoting dsDNA compaction and T-loop formation.

221 s is consistent with the previously proposed dsDNA genome-capsid coassembly for adenoviruses, which r

222 om the well-established mechanism of pumping dsDNA into a preformed protein capsid exemplified by tai

223 Remarkably, dsDNA triggered ISG15 accumulation even in uninfected ce

224 EJ) pathway is a key mechanism for repairing dsDNA breaks that occur often in eukaryotic cells.

225 in a programmable manner, without requiring dsDNA backbone cleavage or a donor template.

226 here multiple filaments interact on the same dsDNA simultaneously.

227 ated that cGAS and Ifi204 cooperate to sense dsDNA and activate the STING-dependent type I IFN pathwa

228 robes that recognize specific mixed-sequence dsDNA regions under physiological conditions.

229 obes, which are activated for mixed-sequence dsDNA-recognition through the introduction of pseudocomp

230 Type I CRISPR systems feature a sequential dsDNA target searching and degradation process, by crRNA

231 lar dynamics simulations of the spCas9-sgRNA-dsDNA system with and without Mg(2+) bound.

232 ng the construction of hybrid conjugates, sh-dsDNA-MBD1-AuNPs (named DMAs).

233 onjugate between short double-strand DNA (sh-dsDNA) and human methyl binding domain protein 1 (MBD1).

234 By varying the length of sh-dsDNA backbone and the spacer between two adjacent mCGs,

235 nucleotides (mCGs) within the sequence of sh-dsDNA.

236 a gateway over FEN1's active site and shift dsDNA for catalysis.

237 Significantly, dsDNA itself was sufficient to induce cGAS-, STING-, and

238 ajor bacterial nucleoid protein, from single dsDNA binding sites.

239 mulation, a fused pol Sdbh with non-specific dsDNA binding protein Sso7d in the N-terminus was design

240 ection probe containing three scCro-specific dsDNA binding sites, we demonstrate an improvement by ov

241 We show that CST binds preferentially to ss-dsDNA junctions, an activity that can explain the increm

242 t the binding to single-stranded DNA (ssDNA)/dsDNA junctions is dependent on joint binding to the DNA

243 ing protein tag conjugate and a hybrid ssDNA-dsDNA detection probe.

244 NA overhang, where it localized to the ssDNA-dsDNA junction and efficiently blocked resection by Exo1

245 CC1-XPF heterodimer jointly bind to an ssDNA/dsDNA substrate and, thereby, at least partially dictate

246 e retaining information provided by standard dsDNA library preparation methods.

247 in, aptamer/FAM-labeled complementary strand dsDNA is stable, resulting in the aggregation of AuNPs b

248 ng a DNA replication fork with streptavidin (dsDNA end) and Fab (5' ssDNA) we located the positions o

249 rface for the specific recognition of target dsDNA (dsDNA-T), which in turn leads to the formation of

250 y necessary in the pathway leading to target dsDNA degradation by a trans-acting helicase-nuclease.

251 leads to gradual shortening of the telomeric dsDNA, similar to that observed in cells lacking telomer

252 T first aids in duplication of the telomeric dsDNA.

253 olecular tension on E-cadherin is lower than dsDNA unzipping force (nominal value: 12 pN) during init

254 iated by RNA/DNA triplex-formation, and that dsDNA extension is impeded by formation of RNA secondary

255 We find that dsDNA react differently than ssDNA to the targeted molec

256 In addition, we show that dsDNA from F. novicida is an important type I IFN stimul

257 between the nucleoprotein filaments and the dsDNA can be achieved.

258 alone and also of the Mcm2-7 complex and the dsDNA-loaded Mcm2-7 complex.

259 s on both strands and continues cleaving the dsDNA stem at approximately 10-bp intervals.

260 By fixing the dsDNA at the connectors of the DNA frame, we created fou

261 post-synaptic joint, or dissociate from the dsDNA.

262 During the interrogation, bases in the dsDNA attempt to form Watson-Crick bonds with the corres

263 an engineered interstrand cross-link in the dsDNA that prevented unwinding.

264 dye SYBR Green I (SG) was inserted into the dsDNA, generating enhanced fluorescence signals.

265 tion was used to hydrolyze the 3'-end of the dsDNA after the recognition of target AFB1, which caused

266 ts decreases rapidly after saturation of the dsDNA population, suggesting a reduction in interaction

267 reactive species within the vicinity of the dsDNA, is likely to play an important role in ensuring t

268 NA and is abolished by overstretching of the dsDNA.

269 mics were modulated by the GC-content of the dsDNA.

270 tacts alter the mechanical properties of the dsDNA.

271 arrangement of protein-binding sites on the dsDNA, an irregular bulk nanoparticle or a nanowire with

272 dicates that vSAGs likely best represent the dsDNA viral populations dominating the oceans.

273 duced, back-and-forth motion relative to the dsDNA that opens and closes the duplex.

274 ase activity as it remains hybridized to the dsDNA.

275 tous contamination, similar in appearance to dsDNA, in eluates from the Zymo, Qiagen, and ChargeSwitc

276 activation, production of autoantibodies to dsDNA, and deposition of immune complexes in the kidney.

277 ropose that the HhH domain of ERCC1 binds to dsDNA upstream of the damage, and XPF binds to the non-d

278 Positively charged MB binds to dsDNA via electrostatic and intercalative/groove binding

279 or-ligated oligonucleotides are converted to dsDNA with an appropriate translesion DNA synthesis (TLS

280 to lupus in humans, and these data point to dsDNA as a key substrate for TREX1 and a major antigen s

281 iated adjuvanicity was ascribed primarily to dsDNA and other "danger" signals released from laser-dam

282 lizing effects of direct binding of RAD51 to dsDNA in human tumor cells.

283 genes, and their Abs were highly reactive to dsDNA.

284 ocus resulting from the cellular response to dsDNA breaks.

285 ufficient to blunt ISGylation in response to dsDNA sensing in uninfected cells.

286 the uninfected cell proteome in response to dsDNA, potentially impacting responses to DNA vaccines,

287 FRET, we show that AID binds to transcribed dsDNA and translocates unidirectionally in concert with

288 , we show that rhinovirus infection triggers dsDNA release associated with the formation of neutrophi

289 emical and genetic analyses to show that two dsDNA binding sites set the 5'polarity and to reveal une

290 ing, we sandwiched one G-quadruplex with two dsDNA handles while leaving the other unit free.

291 of Saccharomyces cerevisiae Pif1 can unwind dsDNA (double-stranded DNA).

292 DHX36 unwound dsDNA poorly compared with G4s of comparable intrinsic l

293 All viral dsDNA-packaging motors, including those of dsDNA/dsRNA b

294 Herein, we review the structures of viral dsDNA-packaging motors, the stoichiometries of motor com

295 evaded precise description, since the viral dsDNA molecule condensed by proteins (core) lacks icosah

296 While dsDNA viruses exhibited some fluctuation in abundance in

297 xchange, in which Rad52 forms a complex with dsDNA and promotes strand exchange with homologous ssRNA

298 harged surface of MT minus ends labeled with dsDNA via a streptavidin-biotin interaction.

299 ptococcus species correlated positively with dsDNA.

300 ed proteins in uninfected cells treated with dsDNA was prevented by expressing the HCMV multifunction