ライフサイエンスコーパス: dsRNA

1 dsRNA alone significantly increased the expression of mu

2 dsRNA elimination by RNase III treatment prior to DRIPc-

3 dsRNA is an important trigger of innate immune responses

4 dsRNA-2 and dsRNA-4 encode two CPs (P2 and P4, respectiv

5 dsRNA-mediated interruption of the GABA signaling and bl

6 ant strains were 23,493 bp in length, and 10 dsRNA segments ranged from 1192 bp (S4) to 3958 bp (L1),

7 trastructural observation of tsp-2 and tsp-3 dsRNA-treated flukes resulted in phenotypes with increas

8 In the nematode C. elegans, sid-1 encodes a dsRNA transporter that is highly conserved throughout an

9 or bulky secondary structures, indicating a dsRNA scanning mode of TRBP.

10 pe species of the family Quadriviridae, is a dsRNA fungal virus with a multipartite genome consisting

11 lyadenylic-polyuridylic acid (poly A:U) is a dsRNA mimetic explored empirically in cancer immunothera

12 wed an absence of sequences encoding R2D2, a dsRNA-binding protein that functions as a cofactor of Di

13 Here, we studied a dsRNA virus that infects the fungus Rosellinia necatrix,

14 and reproductive ability in A. suturalis, a dsRNA targeting the AsFAR gene (dsAsFAR) of A. suturalis

15 olecular mechanism by which infection with a dsRNA virus results in necroptosis.

16 enzyme Dicer forms a 1:1 association with a dsRNA-binding protein (dsRBP).

17 generation double-stranded ribonucleic acid (dsRNA) PIPs have been recently approved.

18 In addition, dsRNA is difficult to denature even at elevated temperat

19 lication equivalently and that no additional dsRNA pathway was crucial.

20 e many examples of inhibitors acting against dsRNA viruses more generally.

21 dsRNA-2 and dsRNA-4 encode two CPs (P2 and P4, respectively), which

22 ase when cells are exposed to both LL-37 and dsRNA, a condition that mimics normal wounding.

23 iated with the viral replication complex and dsRNA.

24 ne all of the elastic constants of dsDNA and dsRNA and provide an explanation for three striking diff

25 amics to simulate the structure of dsDNA and dsRNA subjected to stretching forces up to 20 pN.

26 eter and its different behavior in dsDNA and dsRNA traced down to changes in the sugar pucker angle o

27 through their non-canonical RNA editing and dsRNA binding-independent functions, albeit maybe less c

28 that lack any DNA of matching sequence, and dsRNA that reaches progeny can spread between cells to c

29 d activator of transcription 1 signaling and dsRNA viral sensors in macrophages.

30 l co-occurrence analyses of dsDNA, ssRNA and dsRNA viral markers of polyadenylation-selected RNA sequ

31 scriptional responses triggered by virus and dsRNA at three time-points post-infection.

32 lamp, motility phenotyping (Worminator), and dsRNA for RNAi for functional genomic studies that have

33 is known to be activated by interferons and dsRNAs, inhibits protein synthesis and induces apoptosis

34 nsects do not respond to exogenously applied dsRNAs, either degrading them or failing to import them

35 ation, whereas the viral E3 protein can bind dsRNA.

36 considered the only Dicer domains that bind dsRNA termini, unexpectedly, we found that the helicase

37 imetry experiments that dsRBD2 of TRBP binds dsRNA with a temperature-independent observed binding af

38 We further showed that blunt dsRNA is locally unwound and threaded through the helica

39 hila Dicer-2 alone and in complex with blunt dsRNA.

40 g of labeled dsRNA to siRNA showed that both dsRNA degradation and processing are variable among inse

41 ity of pTRS1 to antagonize PKR activation by dsRNA.

42 rter bearing the Nanos 3' UTR is enhanced by dsRNA-mediated Hrp38 knockdown as well as by mutating po

43 Whereas Dcr1 directly cleaves dsRNAs into 23-nucleotide siRNAs, RTL2 likely cleaves ds

44 to 23-nucleotide siRNAs, RTL2 likely cleaves dsRNAs into longer molecules, which are subsequently pro

45 d by a natively unstructured segment confers dsRNA binding activity.

46 In contrast, dsRNA is not able to reduce its interstrand distance and

47 different folded structure than conventional dsRNA, the cytotoxicity of p-shRNA was either equal to o

48 The transcript abundance of Rs-cps dsRNA appeared to be diverse in the different transgenic

49 cotiana benthamiana plants expressing Rs-cps dsRNA were obtained and studied.

50 n of host inflammatory pathways by cytosolic dsRNA binding proteins.

51 virus (ERV) transcripts, increased cytosolic dsRNA, and activation of an IFN-inducing cellular respon

52 The mammalian system has developed dsRNA-dependent recognition receptors such as RLRs that

53 Larval injections of 125-500 ng of Diap1 dsRNA resulted in dose-dependent mortality which was sho

54 estica larvae injected with D. radicum Diap1 dsRNA, despite the absence of 21 bp identical sequence r

55 Insects injected with Diap1 dsRNA have approx. 1.5-2-fold higher levels of caspase a

56 For a range of different dsRNA, we have for the first time determined values of 4

57 fed and sequential feeding of two different dsRNAs increased mortality.

58 dsRNA), and Drosophila Dicer-2 distinguishes dsRNA substrates by their termini.

59 recognize microbial double-stranded (ds)DNA, dsRNA, and LPS to induce the expression of type I IFNs.

60 A-packaging motors, including those of dsDNA/dsRNA bacteriophages, adenoviruses, poxviruses, herpesvi

61 Crystal structures of dsRBD-dsRNA interactions suggest that the dsRNA helix must ben

62 e results suggest that this particular dsRBD-dsRNA interaction produces little to no change in the A-

63 olecular-dynamics simulations in which dsRBD-dsRNA interactions generate only modest bending of the R

64 g on transgenic maize roots expressing dvbol dsRNA also showed significant fecundity reduction.

65 beetles, as well as larvae to dvvgr or dvbol dsRNA in artificial diet, caused reduction of fecundity.

66 a specific, non-symmetric manner, with each dsRNA segment attached directly to a TEC.

67 The observation of many ADAR-edited dsRNAs in mammalian immune cells, a subset of which are

68 ctivation of PKR, by interaction with either dsRNA or PACT, another cellular DRBD-containing protein.

69 ses, arising from endogenous viral elements (dsRNA/LRV1), or exogenous coinfection with IFN-inducing

70 ately 3000 times higher than non-blunt ended dsRNAs commonly found in cellular RNAs.

71 a barrier to select against non-blunt ended dsRNAs.

72 is the primary sensor pathway for endogenous dsRNA that leads to cell death.

73 Here, we define the long, endogenous dsRNA repertoire in mammalian macrophages and monocytes

74 Expressing dsRNA in chloroplasts overcomes many of the difficulties

75 Nicotiana tabacum L. plants expressing dsRNA homologous to B. tabaci AChE and EcR were construc

76 Transgenic plants expressing dsRNA targeting dvssj1 show insecticidal activity and si

77 ired to transport internalized extracellular dsRNA from endocytic compartments into the cytoplasm for

78 Surprisingly, extracellular dsRNA can also reach progeny without entry into the cyto

79 idt2-deficient mice exposed to extracellular dsRNA, encephalomyocarditis virus (EMCV), and herpes sim

80 gainst non-specific RNA binding, facilitates dsRNA release, and prevents indiscriminate DNA aggregati

81 he majority of larvae injected with, or fed, dsRNA died during the final larval stage prior to pupati

82 Furthermore, while the first dsRNA-binding motif of Loqs-PD is dispensable for enhanc

83 For dsRNA, two pathways are proposed, either based on Dicer-

84 fold softer stretching constant obtained for dsRNA, the opposite twist-stretch coupling, and its nont

85 and follows the architectural principle for dsRNA viruses that a 120-subunit capsid is a conserved a

86 Surprisingly, analysis of the fat body from dsRNA-XDH1-injected mosquitoes fell into 2 groups: one g

87 ional kinase domain, as well as a functional dsRNA-binding domain.

88 Analysis of bacterial, protozoal, and fungal dsRNA viruses has improved our understanding of their st

89 by growth inhibitors, in contrast to fungal dsRNA viruses.

90 which harbors six virus species, some having dsRNA and some positive-strand ssRNA genomes.

91 HCV dsRNA is the predominant form in the HCV-infected liver

92 HCV dsRNA was proportionally higher in patients with the unf

93 reatment increased rather than decreased HCV dsRNA.

94 treatment increased the total amount of HCV dsRNA through a process that required de novo viral RNA

95 Northern blotting established that HCV dsRNA contained genome-length minus strands.

96 HCV dsRNAs (Core, E1-P7, NS-3'NTR and NS5A) induced interfer

97 f HCV-infected hepatocytes with EGCG and HCV dsRNAs inhibited viral replication.

98 ven that EGCG has the ability to enhance HCV dsRNAs-induced intracellular antiviral innate immunity a

99 ng pathways, EGCG significantly enhanced HCV dsRNAs-induced the expression of IFN-lambda1, TLR3, RIG-

100 These HCV dsRNAs also induced the expression of Toll-like receptor

101 avirus nsp15 is critical for evasion of host dsRNA sensors in macrophages and reveal that modulating

102 h DNA strands and resembled RNA:RNA hybrids (dsRNAs), suggesting that dsRNAs form widely in fission y

103 IP contributes to stabilization of the RIG-I-dsRNA interaction.

104 (dsRBP) as well as for proteins involved in dsRNA transport and the systemic RNAi.

105 Here we show that identical 15 bp regions in dsRNA are sufficient to trigger non-target RNAi effects.

106 st that, like ADAR2, underlying sequences in dsRNA may influence how NF90 recognizes its target RNAs.

107 oduction of RNA interference (RNAi)-inducing dsRNA in host plants can trigger specific fungal gene si

108 s is attributable to degradation of ingested dsRNA by intra and extracellular RNAses.

109 itrus psyllid was very sensitive to ingested dsRNA, demonstrating a strong RNAi response.

110 contrast adults were insensitive to injected dsRNA.

111 have broad applicability for studying innate dsRNA pathways.

112 either or both protein kinase R and RNase L dsRNA effector pathways and/or the cellular 5' exonuclea

113 Fluorescently labeled dsRNA is imported from extracellular space into oocytes

114 dation by dsRNases and processing of labeled dsRNA to siRNA showed that both dsRNA degradation and pr

115 Large dsRNA molecules can cause potent cytotoxic and immunosti

116 provide evidence for the degradation of LDH, dsRNA uptake in plant cells and silencing of homologous

117 n a decapping enzyme mutant even though less dsRNA was made, leading to more profound effects on vira

118 ecognition of the 5'-monophosphate of a long dsRNA substrate by a phosphate-binding pocket in the Dic

119 propose that the 5'-monophosphate of a long dsRNA substrate is anchored by the phosphate-binding poc

120 e 21-nt pitch in the A-form duplex of a long dsRNA substrate, resulting in high-fidelity 21-nt siRNA

121 y recruiting an endonuclease to process long dsRNA into short dsRNA.

122 h type I IFN Notably, transfection with long dsRNA specifically vaccinates IFN-deficient cells agains

123 ific gene silencing can be triggered by long dsRNAs in differentiated mouse cells rendered deficient

124 The lower dsRNA stretching resistance is linked to its more open s

125 and signaling activity with 2'-O-methylated dsRNAs.

126 re tested and concentrations as low as 1 mug dsRNA/ mL diet led to significant mortality rates higher

127 However, the instability of naked dsRNA sprayed on plants has been a major challenge towar

128 eeding on N. tabacum plants, compared to non-dsRNA expressing plants, recorded at 24-hr intervals pos

129 ontribute, these results highlight noncoding dsRNA as an upstream coordinator of prostaglandin and Wn

130 that causes localized processing of nuclear dsRNA by p-Dicer to promote DNA repair.

131 a model virus in the presence or absence of dsRNA, a virus associated molecular pattern.

132 the ongoing environmental fate assessment of dsRNA PIPs.

133 Both an increase in the concentration of dsRNA fed and sequential feeding of two different dsRNAs

134 We speculate that similar control of dsRNA movement could modulate tissue-specific silencing

135 Oral delivery of dsRNA caused dose-dependant mortalities of between 19 an

136 The current study evaluates the delivery of dsRNA targeted to the sodium ion channel paralytic A (Tc

137 we developed a bioassay for oral delivery of dsRNA to an invasive forest and urban tree pest, the eme

138 and effective bioassay for oral delivery of dsRNA to screen additional genes.

139 acrophages revealed significant dispersal of dsRNA early during infection, whereas in WT virus-infect

140 A small dose of dsRNA administered through a citrus flush was enough to

141 Adenosine-to-inosine (A-to-I) editing of dsRNA by ADAR proteins is a pervasive epitranscriptome f

142 endoribonuclease, is required for evasion of dsRNA sensors.

143 d the ratio of viral dsRNA/ssRNA in favor of dsRNA.

144 ittle to no change in the A-form geometry of dsRNA in solution.

145 -specific recognition in the minor groove of dsRNA are conserved between NF90 and ADAR2.

146 rval mortalities up to 73% post injection of dsRNA.

147 studies and provide much of our knowledge of dsRNA viruses.

148 -47.29 mug/mL/A260 for the quantification of dsRNA using UV spectrophotometry.

149 phila In vitro, Loqs-PD enhances the rate of dsRNA cleavage by Dicer-2 and also enables processing of

150 e pairing but is required for the release of dsRNA.

151 anes to help facilitate the sequestration of dsRNA from host defenses and concentrate replication fac

152 Significantly, a single spray of dsRNA loaded on LDH (BioClay) afforded virus protection

153 as RLRs that recognize the long stretches of dsRNA as PAMPs to activate interferon-mediated antiviral

154 f similar invaginations for the synthesis of dsRNA precursors of highly abundant viral and host siRNA

155 bditis elegans Intergenerational transfer of dsRNA occurs even in animals that lack any DNA of matchi

156 al expression in response to co-treatment of dsRNA and virus.

157 Different concentrations of dsRNAs mixed with artificial diet were tested and concen

158 hy to analyze the location of Cy3 and Cy5 on dsRNA, using complexes of an RNA stem-loop bound to L5 p

159 ation response RNA binding protein (TRBP) on dsRNA, yet the mechanistic details remain elusive.

160 either double-stranded RNA (dsRNA)-ALAT1 or dsRNA ALAT2 significantly decreased mRNA and protein lev

161 pesticides, the use of either Cry protein or dsRNA PIPs results in their release to receiving environ

162 Applying sRNAs or dsRNAs that target Botrytis DCL1 and DCL2 genes on the s

163 o that of homodimers of reoviruses and other dsRNA mycoviruses.

164 The three best performing dsRNAs, targeting prosalpha2, rps13 and the homolog of D

165 t RIG-I's selectivity for blunt-ended 5'-ppp dsRNAs is approximately 3000 times higher than non-blunt

166 rted as well as other sites that limit 5'ppp-dsRNA sensing and virtually abrogate RIG-I activation.

167 ted molecular patterns (LPS, MDP, and 5'-ppp-dsRNA), and profile the transcriptomes at three time poi

168 ed in vitro that S9.6 can immuno-precipitate dsRNAs and provide evidence that dsRNAs can interfere wi

169 nexpected finding suggests that HCV produces dsRNA in response to IFN, potentially to antagonize anti

170 In the prototypic dsRNA bacteriophage phi6, the assembly reaction is promo

171 s OAS gene expression, as well as to provide dsRNA to activate OAS.

172 m-dependent siRNAs, through the nuclear RdDM dsRNA synthesis pathway.

173 The Ptgs2 inhibitor celecoxib reduces dsRNA-induced WIHN and Wnt7b, and exogenous prostaglandi

174 restricted expression of an inverted-repeat dsRNA specifically in the Arabidopsis (Arabidopsis thali

175 modulation of Dicer-2 cleavage also requires dsRNA binding by Loqs-PD.

176 ll lines using the HzAPN1 double strand RNA (dsRNA).

177 degradation and prevent double-stranded RNA (dsRNA) accumulation, whereas the viral E3 protein can bi

178 he effects of injecting double-stranded RNA (dsRNA) against XDH1, XDH2, or both.

179 ate the strands of long double-stranded RNA (dsRNA) and allow the released RNAs to be quantified in r

180 atalyze the cleavage of double-stranded RNA (dsRNA) and have diverse functions in RNA maturation.

181 etection of cytoplasmic double-stranded RNA (dsRNA) and promotion of host antiviral responses.

182 upon exposure to viral double-stranded RNA (dsRNA) before the induction of interferon and prior to t

183 d their RNA editing and double-stranded RNA (dsRNA) binding functions.

184 de siRNAs produced from double-stranded RNA (dsRNA) by DCL4 and DCL2, respectively.

185 Long double-stranded RNA (dsRNA) can silence genes of matching sequence upon inges

186 Studies on double-stranded RNA (dsRNA) degradation by dsRNases and processing of labeled

187 Viruses that generate double-stranded RNA (dsRNA) during replication must overcome host defense sys

188 on of pathogen-specific double-stranded RNA (dsRNA) for virus resistance in plants represents an attr

189 Total RNA and double-stranded RNA (dsRNA) from mycelia and RNA from samples enriched for vi

190 transient expression of double stranded RNA (dsRNA) homologous to the acetylcholinesterase (AChE) and

191 Viruses induce double-stranded RNA (dsRNA) in the host cells.

192 ediated in part through double-stranded RNA (dsRNA) induction.

193 A viruses that generate double-stranded RNA (dsRNA) intermediates during replication, yet evade detec

194 ) proteins that process double-stranded RNA (dsRNA) into small-interfering RNAs (siRNAs).

195 Double-stranded RNA (dsRNA) is a common by-product of viral infections and ac

196 port of this idea, when double-stranded RNA (dsRNA) is introduced into some animals, the dsRNA can si

197 Endogenous double-stranded RNA (dsRNA) must be intricately regulated in mammals to preve

198 nthetic analog of viral double-stranded RNA (dsRNA) polyinosinic-polycytidylic acid, and type-II inte

199 f viral siRNAs from IAV double-stranded RNA (dsRNA) precursors in infected cells is mediated by wild-

200 as shown that noncoding double-stranded RNA (dsRNA) released during wounding is both necessary and su

201 as a model to study the double-stranded RNA (dsRNA) Reoviridae family, the members of which infect an

202 ch functions to degrade double-stranded RNA (dsRNA) replication intermediates.

203 re transfected with the double-stranded RNA (dsRNA) targeting an individual ESCRT-I or ESCRT-III gene

204 ct feeding assays using double-stranded RNA (dsRNA) targeting dvssj1 and dvssj2 demonstrate targeted

205 Injection of double-stranded RNA (dsRNA) targeting gene coding for inhibitor of apoptosis

206 RIG-I detects double-stranded RNA (dsRNA) to trigger antiviral cytokine production.

207 ntiviral responses that double-stranded RNA (dsRNA) triggers in host cells.

208 enveloped, nonsegmented double-stranded RNA (dsRNA) virus infecting Giardia lamblia, the most common

209 The endogenous double-stranded RNA (dsRNA) virus Leishmaniavirus (LRV1) has been implicated

210 Most double-stranded RNA (dsRNA) viruses are transcribed and replicated in a speci

211 efficient synthesis of double-stranded RNA (dsRNA) within infected cells is required for necroptosis

212 n Dicer to cleave viral double-stranded RNA (dsRNA), and Drosophila Dicer-2 distinguishes dsRNA subst

213 hutdown mediated by the double-stranded RNA (dsRNA)-activated kinase PKR and thereby allowed virus-in

214 NP associates with the double-stranded RNA (dsRNA)-activated protein kinase (PKR), a well-characteri

215 mosquitoes with either double-stranded RNA (dsRNA)-ALAT1 or dsRNA ALAT2 significantly decreased mRNA

216 ntified mutation in the double-stranded RNA (dsRNA)-binding domain (I64T) decreased NS1-mediated gene

217 -like receptors (RLRs), double-stranded RNA (dsRNA)-dependent protein kinase receptor (PKR), or TIR d

218 eplication intermediate double-stranded RNA (dsRNA).

219 the A-form geometry of double-stranded RNA (dsRNA).

220 Double-stranded-RNA (dsRNA)-activated protein kinase R (PKR) is another host

221 analyzed how non-coding double-stranded RNA (dsRNAs) act as a DAMP in the skin and how the human cath

222 ine DeAminases acting on double-stranded RNA(dsRNA) (ADAR), occurs predominantly in the 3' untranslat

223 The ingestion of double-strand RNAs (dsRNA) targeting essential genes in an insect could caus

224 Double-stranded RNAs (dsRNA) produced during human cytomegalovirus (HCMV) infe

225 red for p38 binding to double-stranded RNAs (dsRNAs) and interaction with RNA-induced silencing compl

226 onstrate that spraying double-stranded RNAs (dsRNAs) and small RNAs (sRNAs) that target essential pat

227 d by the production of double-stranded RNAs (dsRNAs) by RNA-DEPENDENT RNA POLYMERASEs (RDRs) and proc

228 Feeding with SmedOB1 double-stranded RNAs (dsRNAs) led to homeostasis abnormalities in the head and

229 ants stably expressing double-stranded RNAs (dsRNAs) that target essential genes in pest insects.

230 ne, three fragments of double-stranded RNAs (dsRNAs) were designed to target different regions of the

231 21-nt siRNAs from long double-stranded RNAs (dsRNAs).

232 up external sRNAs and double-stranded RNAs (dsRNAs).

233 s to the production of double-stranded RNAs (dsRNAs).

234 We show that the ten segmented dsRNAs in CPV are organized with ten TECs in a specific,

235 for virion infectivity in many multi-shelled dsRNA viruses.

236 ndonuclease to process long dsRNA into short dsRNA.

237 gest that silencing by the movement of short dsRNA between cells is not an obligatory feature of feed

238 These short dsRNAs are thought to move between cells because muscle-

239 icularly the role of a non-sequence specific dsRNA-mediated antiviral pathway.

240 Dicer-mediated processing of virus-specific dsRNA into short interfering RNAs (siRNAs) in plants and

241 rst screening via injection of gene-specific dsRNAs showed that the dsRNAs were highly toxic for C. b

242 Regardless of sequence specificity, dsRNA reduced virus abundance.

243 cause producing sufficient amounts of stable dsRNA in plants has proven to be difficult to achieve wi

244 ions (EERs), indicative of highly structured dsRNA.

245 ptosis) or COP (COPI coatomer, beta subunit) dsRNA silenced their target genes and caused mortality.

246 capsid is a conserved assembly that supports dsRNA replication and organization.

247 m dsRBDs of NF90 in complex with a synthetic dsRNA.

248 ha, even following exposure to the synthetic dsRNA poly(I.C), a potent PKR agonist.

249 Delivery of TcNav dsRNA caused severe developmental arrest with larval mor

250 We found that TcSOD2 dsRNA treatment in larvae resulted in increased expressi

251 Two N-terminal dsRNA Binding Domains (DRBD) are required for activation

252 osely with Wnt7b production in vivo and that dsRNA potently induces Wnt7b in a manner that requires P

253 We demonstrate that dsRNA can be loaded on designer, non-toxic, degradable,

254 The system was used to demonstrate that dsRNA is protected from nuclease digestion by virus-indu

255 We found that dsRNA is transported and processed to siRNAs by EAB larv

256 Here, we hypothesized that dsRNA similarly induces the beta-catenin pathway through

257 These methods revealed that dsRNA, a pathogen-associated molecular pattern (PAMP), c

258 Here, we show that dsRNA can be directly transferred between generations in

259 We showed that dsRNA and E3 colocalized within cytoplasmic viral factor

260 These data suggest that dsRNA digestion by dsRNases and its processing to siRNAs

261 precipitate dsRNAs and provide evidence that dsRNAs can interfere with its binding to R-loops.

262 es higher than 50%.These results proved that dsRNAs targeting essential genes show great potential to

263 ed RNA:RNA hybrids (dsRNAs), suggesting that dsRNAs form widely in fission yeast.

264 ut not the OW arenavirus LASV, activated the dsRNA-dependent PKR, another host non-self RNA sensor, d

265 (dsRNA) is introduced into some animals, the dsRNA can silence genes of matching sequence and the sil

266 A previously unidentified mutation in the dsRNA-binding domain decreased NS1-mediated general inhi

267 e of 21 bp identical sequence regions in the dsRNA.

268 Once loaded on LDH, the dsRNA does not wash off, shows sustained release and can

269 NF90 is a member of the dsRNA binding domain (dsRBD) family of proteins.

270 nsistent with Dicer-mediated cleavage of the dsRNA genome.

271 of both Cy3 and Cy5 with the terminus of the dsRNA is significantly different from that deduced for d

272 endogenous RNA to prevent activation of the dsRNA sensor MDA5 (Ifih1).

273 WT virus-infected cells, the majority of the dsRNA was associated with replication complexes.

274 Depending on the dsRNA considered, RTL2-mediated maturation either improv

275 Thus, SIDT2 has retained the dsRNA transport activity of its C. elegans ortholog, and

276 of dsRBD-dsRNA interactions suggest that the dsRNA helix must bend in such a way that its major groov

277 We showed that the dsRNA produced in excess in cells infected with a vaccin

278 nterferon response and apoptosis through the dsRNA-sensing pathway.

279 The behavioral and physical response to the dsRNA mimetic poly I:C is dependent on signaling via MyD

280 n the worm Caenorhabditis elegans, where the dsRNA-binding protein RDE-4 initiates silencing by recru

281 tion of gene-specific dsRNAs showed that the dsRNAs were highly toxic for C. brunneus.

282 efficient antiviral immune response through dsRNA-dependent RLR receptor-mediated necroptosis agains

283 First, binding to dsRNA triggers PKR homodimerizaton.

284 e quantum yield (<PhiF > = 0.24) compared to dsRNA, with a broader distribution (PhiF = 0.17-0.34) an

285 Mortality of adult whiteflies exposed to dsRNA by feeding on N. tabacum plants, compared to non-d

286 lar pathway defining the central response to dsRNA is distinct from that found in the periphery.

287 ocytes exaggerates inflammatory signaling to dsRNA or endotoxin and results in over production of typ

288 nt amplification of secondary and transitive dsRNA and siRNAs.

289 2 (RTL2), which carries one RNaseIII and two dsRNA binding (DRB) domains, is a unique Arabidopsis RNa

290 Haemocytes take up dsRNA from infected cells and, through endogenous transp

291 hereby inhibiting activation of PKR by viral dsRNA.

292 on can be blocked by the expression of viral dsRNA-binding proteins.

293 RNA synthesis and shifted the ratio of viral dsRNA/ssRNA in favor of dsRNA.

294 idation rendered RIG-I unable to sense viral dsRNA, thus blocking its ability to trigger antiviral im

295 ng BtPGRP with artificial media amended with dsRNA led to reduced expression of a gene encoding an an

296 thorax, and Malpighian tubules compared with dsRNA firefly luciferase-injected control mosquitoes.

297 lity of both larvae and adults injected with dsRNA targeting gene coding for green fluorescence prote

298 exist: canonical Type A dsRBDs interact with dsRNA, while non-canonical Type B dsRBDs lack RNA-bindin

299 Injection of 3(rd) nymphs with dsRNA fragments successfully knocked down the target gen

300 e crystal structures of RIG-I complexes with dsRNAs bearing 5'OH, 5'ppp, and Cap-0 show that RIG-I ca