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2 anism that takes advantage of the catalyst's dual ability to stabilize both negative and positive cha
5 binding to beta-catenin and Tcf-suggesting a dual action by beta-catenin as a signal and a feedforwar
6 ining extracytoplasmic domains requiring the dual action of the co-translational Sec and post-transla
8 rated by treatment with NitroSynapsin, a new dual-action compound related to the FDA-approved drug me
13 or bis(2-hydoxybenzylidene)acetone (HBB2), a dual activator of NRF2 and HSF1, protects against the de
14 Co-crystal structure analysis revealed a dual active site-directed and allosteric inhibition mode
15 estinal digestion of peptides improved their dual activity (10-14mumol Trolox eq./mumol peptide; IC50
16 receptor target to develop RNA aptamers with dual activity for effectively blocking both AMPA and kai
17 show that these minute changes separate the dual activity of BKM120 into discrete PI3K and tubulin i
18 Collectively, our findings suggest that the dual-activity inhibitor represents a highly promising le
19 is study applied a three-dimensional dynamic dual-agent hyperpolarized (13)C magnetic resonance spect
20 22-month-old C57BL/6J mice with the FXR-TGR5 dual agonist INT-767 induced caloric restriction-like ef
22 conscious mammals, breathing is subject to a dual and interdependent feedback regulation by chemorece
23 ct and peripheral tissue dynamics in single, dual and multiple unit microfluidic platforms (Solo-MFP,
24 ng in AT-IAP, a potent, orally bioavailable, dual antagonist of XIAP and cIAP1 and a structurally nov
28 commendation ("may be considered") to extend dual antiplatelet therapy after drug-eluting stent impla
32 , multicenter ADAPT-DES study (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents) were
33 -angiotensin system blockers, beta-blockers, dual antiplatelet therapy, and long-term cardiovascular
34 educed myocardial infarctions with prolonged dual antiplatelet therapy, findings that support the new
35 agulation (both NOACs and warfarin), but not dual antiplatelet therapy, was effective in prevention o
37 yonic antigen (CEA) and hemin, an all-in-one dual-aptasensor with 1,1'-oxalyldiimidazole (ODI) chemil
41 sis, and they identify TNFalpha and TGFbeta1 dual blockade as an antimetastatic strategy in solid tum
43 key roles in progression of renal fibrosis, dual blockade of TGF-beta1 and TNF-alpha is desired as i
44 transfer as the predominant pathway enabling dual C-Cl bond formation and contradict an alternative p
45 u generated amorphous carbon that serve as a dual carbon support and protectant system with which to
47 ddress this shortcoming a new, photoredox-Ni dual catalytic strategy for the cross-coupling of tertia
48 Scan database identified patients undergoing dual-chamber pacemaker implantation from 2008 to 2014.
50 this study we demonstrate the possibility of dual-channel operation of a microfluidic stripline NMR s
52 cribe an optimized protocol for simultaneous dual-channel two-photon fluorescence anisotropy microsco
54 thway (MSP) is a unique enzyme that exhibits dual chemistry determined solely by the identity of the
57 pproaches to establishing mechanisms for the dual chemistry, insights into the mechanism based on com
58 We discuss the potential relevance of this dual chemoreceptor feedback to cardiorespiratory abnorma
60 e introduce subunit-selective inhibitors and dual-color fluorescent activity-based probes for studyin
62 ation, two-photon imaging, optogenetics, and dual-color uncaging of glutamate and GABA, we demonstrat
64 lene oxide) than combustible cigarette-only, dual combustible cigarette-e-cigarette, or dual combusti
73 tice, and 77.2% of all participants believed dual degree MD/PhD students were superior to PhD student
76 e mechanistic analysis of PglC, a prototypic dual domain PGT from Campylobacter concisus Using a lumi
77 ide genomic insights into the divergence and dual domestication of these two important cultivated tet
79 single-dose O6-benzylguanine and carmustine, dual-dose O6-benzylguanine resulted in higher overall re
83 y due to Kv1.1 dysregulation that leads to a dual dysfunction consisting of enhanced neuronal excitab
84 ields to provide a topographical map of this dual dysregulation and explore potential cellular and ci
91 quantify the sensitivity and specificity of dual-energy computed tomographic (CT) virtual noncalcium
93 unknown significance sequentially underwent dual-energy CT and magnetic resonance (MR) imaging of th
94 ther single-phase contrast material-enhanced dual-energy material attenuation analysis improves the c
95 tic accuracy of attenuation measurements and dual-energy material densities was assessed and validate
96 centage change from baseline in areal BMD by dual-energy x-ray absorptiometry at the total hip throug
97 in Manitoba, Canada, referred for a baseline dual-energy x-ray absorptiometry scan from January 1, 19
102 of the biosynthesis of these molecules where dual enzymatic activities of the DSF synthase and the us
104 With enhanced concerns of terrorist attacks, dual exposure to radiation and thermal combined injury (
105 of the cell-of-origin (COO) classification, dual expression (DE) of MYC and BCL2 proteins, and MYC,
106 ed to identify prognostic subgroups, whereas dual expression of MYC and BCL2 was predictive of poor s
108 scription in living Drosophila embryos using dual-fluorescence detection of nascent transcripts conta
110 describe a generalizable platform to create dual-FP biosensors with large dynamic ranges by employin
111 approach, we demonstrate that E2D holds the dual function of affecting both approach and avoidance b
112 Salmonella invasion protein A (SipA) is a dual-function effector protein that plays roles in both
113 e, PCM2713, and thus should be regarded as a dual-function macromolecule that exhibits both structura
114 sis and anion-binding catalysis sites of the dual-function rotaxane catalyst can be sequentially conc
116 n antagonizing beta-catenin is caused by its dual functionality as a cell adhesion molecule and a sig
117 th-based metal-organic framework (MOF), with dual functionality for moisture control within the recom
126 laments, SH3-containing class I myosins, the dual-GEF Trio, and other adaptors and signaling molecule
127 h films of the oxidized starches, single and dual, had increased stiffness, providing a higher tensil
129 gions either from the FRP system or from the dual infection culture, and very few from the HIV epidem
133 TNBC phenotypic screen and possess a unique dual inhibition profile targeting TTK (mitotic exit) and
135 is to determine the efficacy of a PI3K/mTOR dual inhibitor, LY3023414, on established EAC in an in v
136 ew thiourea quinazoline derivatives that are dual inhibitors of both EGFR kinase and the NF-kappaB ac
137 entified a set of compounds with the desired dual inhibitory activity and enhanced antiproliferative
138 udy is to test the feasibility of applying a dual-input two-compartment liver perfusion model to pati
139 s, this study illustrates the potential of a dual isotope analysis to differentiate between aerobic a
140 oncentrations (8 ngm(-3) to 302 ngm(-3)) and dual-isotope-constrained sources (19 to 73% contribution
142 strategy to generate high-complexity pooled dual-knockout libraries to identify synthetic lethal and
145 This study demonstrated that PSMA-11-derived dual-labeled dye conjugates are feasible for providing P
146 This multiplex real-time PCR, based on the dual-labeled probe strategy, guarantees target detection
147 of methods for generating either individual dual-labeled protein samples at high throughputs or prot
149 e (percentage injected dose per gram) of the dual-labeled tracer in tumors was 17.2 +/- 5.4 and 16.5
159 hat ApoE binding to ApoE receptors activates dual leucine-zipper kinase (DLK), a MAP-kinase kinase ki
160 an AT2R-selective ligand and to an AT1R/AT2R dual ligand, capturing the receptor in an active-like co
166 isease-associated microglia are removed by a dual mechanism of cell egress and apoptosis to re-establ
168 e in BR signaling by inhibiting BIN2 through dual mechanisms of blocking substrate access and promoti
169 endothelial cells (CEnCs) propagated using a dual media approach refined towards regulatory complianc
170 statins with high adherence, and those with dual Medicare/Medicaid coverage and more cardiologist vi
178 ble to discriminate between cell subsets and dual-modality may therefore be used a means for validati
180 ction for the potential use of such emerging dual mode nanorod bundles as photon sources for next gen
182 ation was performed based on single-particle dual-mode total internal reflection scattering (SD-TIRS)
186 flammatory disorders; however, its role as a dual modulator of CD4(+) T cell function and metabolism
188 ed in combination with trastuzumab, AZD2014 (dual mTORC1/2i), AZD5363 (AKTi) and selumetinib (AZD6244
191 reformation results in self-recovery of the dual network structure as well as its mechanical propert
193 tant implications for the recently developed dual Ni/photoredox catalytic systems proposed to involve
194 llection, Microcystis populations were under dual nitrogen (N) and phosphorus (P) stress, as genes in
199 ity on adult human OPCs, leads us to propose dual PDE7-GSK3 inhibition, and specifically VP3.15, as a
200 raphene oxide (GO) nanosheets functionalized dual-peak long period grating (dLPG) based biosensor for
201 tents and discuss promising research avenues.Dual Perspectives Companion Paper: Should a Few Null Fin
209 tumor-bearing Kit(V558Delta/+) mice with the dual PI3K/mTOR inhibitor voxtalisib, the pan-PI3K inhibi
210 These results suggest that TGR-1202 is a dual PI3Kdelta/CK1epsilon inhibitor, which may in part e
213 The Tyr-Au NPs were successfully used as a dual probe for colorimetric and fluorescence turn-on ass
214 with emotional memories as estimated using a dual process signal detection analysis of confidence jud
216 laser ignited mixtures and shows that a new dual-pulse scheme can be used to control the kernel form
217 work, we investigate the capabilities of the dual-pulse to control the plasma-driven fluid dynamics b
218 activation could increase the feasibility of dual RAF/MEK inhibition to overcome sorafenib treatment
219 tors) bound at a single DNA site to act as a dual regulator of cmr transcription and an activator of
225 e lysine-specific demethylase KDM3A played a dual role in breast cancer cell invasion and apoptosis b
234 s instance, localized Fgf signaling performs dual roles, as it regulates Six3(+) rostral polarization
239 during evolution N-glycosylation triggered a dual selection pressure on secretory pathway proteins: w
241 gous 4-kb deletion/20-bp insertion in DSTYK (dual serine-threonine and tyrosine protein kinase) in al
244 Of 701 accessory genes identified among dual-serotype IPD isolates, four were common between iso
246 yos via zygotic co-delivery of Cas9 mRNA and dual sgRNAs targeting the PDX1 gene, which when combined
247 n-water emulsions, from which yolk-shell and dual-shell hollow SiNPs@C composites are produced via po
248 The Li-ion anodes composed of 46 wt % of dual-shell SiNPs@C, 46 wt % of graphite, 5 wt % of acety
250 Co-administration of TGF-beta shRNA and HBV dual-shRNA decreased HBV DNA, HBV RNA, HBsAg, HBeAg, and
256 of action of bimagrumab (BYM338), as a human dual-specific anti-ActRIIA/ActRIIB antibody, at the mole
258 op, in which PGE2 augments the expression of dual specificity phosphatase 1, impairs the activity of
259 that hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for t
263 Here we report that the inducible nuclear dual-specificity MAP kinase phosphatase (MKP) DUSP2, a k
266 sion (<2 years) had either low levels of the dual-stained cells or high levels of single-stained cell
269 in, people from Africa had a higher risk for dual-strain infection (risk ratio [RR] = 9.20, 95% CI =
270 ng that microbial communities subject to the dual stresses of low nutrient availability and reduced a
271 weighting was used to estimate the effect of dual-system versus VA-only prescribing on 4 indicators o
272 G, 3xHA, 3xStrep-tag II, 18xHis, 13xMyc, and dual tags, all of which were driven from a strong consti
274 e biomarker for this treatment.Significance: Dual targeting of MYC-regulated homologous recombination
275 mor suppression function of p53 in cancer by dual targeting of the negative regulators HDM2 and HDMX.
276 n standing postural sway-particularly during dual task conditions- appears to be a better predictor o
279 as the percentage change between single- and dual-task gait velocities: ([single-task gait velocity -
280 it velocities: ([single-task gait velocity - dual-task gait velocity]/ single-task gait velocity) x 1
281 y non-allergic controls (n = 42) performed a dual-task paradigm and a verbal learning and memory test
282 ere are any areas additionally activated for dual-task performance, and compared the neural activity
283 ese data support a novel hypothesis by which dual TCR expression can promote autoimmunity by limiting
287 to assess the therapeutic noninferiority of dual therapy with darunavir/ritonavir and lamivudine com
289 ity derived from various texture features on dual time FDG PET/CT images (DTPI) can differentiate bet
290 tral assumption is that food intake serves a dual to gather information about the external food level
291 behavior was designed and validated using a dual-transducer system operating at the clinically relev
294 ed the minimally effective HCV treatment for dual, triple, or all-oral therapy had a 30% decreased ri
295 r, our results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting b
299 k (annular shaped) energy deposition through dual-wavelength synthesis of the fundamental frequency (
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