ライフサイエンスコーパス: dual-specificity phosphatase

1 entification and characterization of a novel dual specificity phosphatase.

2 PTEN) maps to chromosome 10q23 and encodes a dual specificity phosphatase.

3 e gene defective in ibr5 encodes an apparent dual-specificity phosphatase.

4 tions of protein tyrosine phosphatases and a dual-specificity phosphatase.

5 yrosine residues, indicating that P-TEN is a dual-specificity phosphatase.

6 P2 in combination with MSG5, which encodes a dual-specificity phosphatase.

7 f a subgroup of myristoylated VH1-like small dual specificity phosphatases.

8 nduced by T cell antigen receptor like other dual specificity phosphatases.

9 ymatic activity similar to that exhibited by dual specificity phosphatases.

10 ion of different MAP kinases by two distinct dual specificity phosphatases.

11 old selectivity across multiple tyrosine and dual specificity phosphatases.

12 phosphatases, Tyr-specific phosphatases, and dual-specificity phosphatases.

13 itical catalytic residues in Cdc25 and other dual-specificity phosphatases.

14 lls (VSMCs) indicate a role for induction of dual specificity phosphatase 1 (DUSP1) that decreases ER

15 cyclooxygenase 2 (COX-2; inflammation), and dual specificity phosphatase 1 (DUSP1), DUSP5, and DUSP1

16 Here, we report the first such gene, dual specificity phosphatase 1 (dusp1).

17 cts as a direct transcriptional regulator of dual specificity phosphatase 1 (DUSP1; CL100), a threoni

18 These candidate genes are dual specificity phosphatase 1 DUSP1), Kelch domain cont

19 les produced during the early phase, such as Dual Specificity Phosphatase 1, and a modest effect on I

20 op, in which PGE2 augments the expression of dual specificity phosphatase 1, impairs the activity of

21 eta1, proteoglycan 2, the RhoB oncogene, and dual specificity phosphatase 1.

22 Dual-specificity phosphatase 1 (DUSP-1) is a factor invo

23 activated protein kinase (MAPK) phosphatase, dual-specificity phosphatase 1 (DUSP1), in the dexametha

24 ative regulator of the hIL-10 feedback loop, dual-specificity phosphatase 1 (DUSP1), remained unchang

25 bit IFN-beta expression via the induction of dual-specificity phosphatase 1 (DUSP1), which dephosphor

26 terleukin-1beta (IL1B) induces expression of dual-specificity phosphatase 1 (DUSP1), ZFP36, and TNF.

27 sarcoma oncogene (c-FOS, encoded by Fos) and dual-specificity phosphatase 1 (DUSP1).

28 pression of mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1/DUSP1).

29 expression but had normal IL-10 production, dual-specificity phosphatase 1 expression, and MAPK phos

30 vity occurred primarily through induction of dual-specificity phosphatase 1 expression.

31 sphorylation of the negative IL-10 regulator dual-specificity phosphatase 1.

32 ive response by maintaining normal levels of dual-specificity phosphatases 1 and 5 in CD8(+) T cells.

33 ed 91 phosphatases (33 conventional PTPs, 31 dual specificity phosphatases, 1 Class III Cysteine-base

34 kinase phosphatase-1 (MKP-1), also known as dual specificity phosphatase-1 (DUSP-1), plays a crucial

35 mediated by protein phosphatase-1 (PP1) and dual specificity phosphatase-1 (DUSP1).

36 MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a

37 Dual specificity phosphatase 10 (DUSP10), also known as

38 sites indicated that B cell CLL/lymphoma 6, dual specificity phosphatase 10, and suppressor of cytok

39 ngly increased in ILT3Fc-induced Ts, such as dual specificity phosphatase 10, B cell CLL/lymphoma 6,

40 encing role for the mammalian PIR-1 homolog (dual specificity phosphatase 11 [DUSP11]) was unexpected

41 Human YVH1 (hYVH1), also known as dual specificity phosphatase 12 (DUSP12), is a poorly ch

42 Dual-specificity phosphatase 14 (DUSP14; also known as M

43 In addition, silencing of dual-specificity phosphatase 16 increased normoxic level

44 that hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for t

45 sphatase of activated cells 1; also known as dual specificity phosphatase 2, DUSP2) is a dual threoni

46 AK2 forms a complex with dual-specificity phosphatase 26 (DUSP26) phosphatase and

47 investigated the expression and function of dual-specificity phosphatase 26 (DUSP26), also known as

48 ich tags a gene with significant homology to Dual Specificity Phosphatase 3, maps within the CORD9 in

49 We identified dual-specificity phosphatase 3 (DUSP3) as a key KDM2A ta

50 This is the first report implicating the dual-specificity phosphatase 3 (DUSP3) in platelet signa

51 Dual-specificity phosphatase 3 (DUSP3) is a small phosph

52 enes whose expression changed significantly, dual specificity phosphatase 4 (DUSP4), encoding an anta

53 Here we uncover a pathogenic role of dual specificity phosphatase 4 (Dusp4), which is transcr

54 Dual specificity phosphatase-4 (DUSP4) is a negative reg

55 Dual specificity phosphatase 5 (dusp5), cadherin 5 (cdh5

56 some of the vital host genes such as DUSP5 (dual specificity phosphatase 5), ICAM-1 (intercellular a

57 ertrophy via inhibition of the gene encoding dual-specificity phosphatase 5 (DUSP5) DUSP5, a nuclear

58 ative feedback (by Egr1-driven expression of dual-specificity phosphatase 5 (DUSP5)) both reduced inf

59 Ectopic expression of dual-specificity phosphatase 5 (DUSP5), an inducible mit

60 eceptor (RDC1), cyclooxygenase-2 (COX-2) and dual-specificity phosphatase 5 (DUSP5).

61 ed by IL-2, IL-7, and IL-15 but not IL-4 was dual-specificity phosphatase 5 (DUSP5).

62 tory circuits: negative feedback mediated by dual-specificity phosphatase 5 and positive feedback by

63 Based on our previous work on dual specificity phosphatase-5 (DUSP5), and its role in

64 sequences identified contained exon 2 of the dual specificity phosphatase-5 gene (DUSP5).

65 nally regulates the ERK-specific phosphatase dual specificity phosphatase 6 (DUSP6) in a kinase depen

66 on of Ets-1, which inhibits its target gene, dual specificity phosphatase 6 (DUSP6), a negative regul

67 tion of NFkappaB and increased expression of dual specificity phosphatase 6 (DUSP6), indicating that

68 CCCTC-binding-factor-mediated expression of dual specificity phosphatase 6 (DUSP6), leading to react

69 enzyme NADPH oxidase 4 (NOX4), and increased dual specificity phosphatase 6 (DUSP6).

70 ugh targeted disruption of the gene encoding dual-specificity phosphatase 6 (Dusp6) in the mouse.

71 Binding studies revealed PR-B interacts with dual-specificity phosphatase 6 (DUSP6) via the CD domain

72 Although inducible expression of dual-specificity phosphatase 6 in the heart eliminated E

73 RK1/2-inactivating phosphatase in the heart, dual-specificity phosphatase 6.

74 ere downregulated, whereas the expression of dual-specificity phosphatase 8 (DUSP8) was upregulated.

75 lucidate the physiological role(s) of DUSP9 (dual-specificity phosphatase 9), also known as MKP-4 (mi

76 PTEN maps to 10q23 and encodes a dual specificity phosphatase, a substrate of which is ph

77 og of Tim50, recombinant TbTim50 possesses a dual specificity phosphatase activity with a greater aff

78 Among them CL-100, a dual-specificity phosphatase also known as MAP kinase ph

79 l cells, DOX also inhibits the expression of dual-specificity phosphatases (also referred to as MAPK

80 designing inhibitors specific for the Cdc25 dual-specificity phosphatase, an important anticancer ta

81 MKP3 is a dual specificity phosphatase and a specific antagonist o

82 The dual specificity phosphatase and oncogene Cdc25B has bee

83 t regulate transformation and members of the dual specificity phosphatase and Sprouty gene families,

84 The dual specificity phosphatases and the low molecular weig

85 PTEN/MMAC1/TEP1 codes for a dual-specificity phosphatase and is likely a tumor suppr

86 The dual-specificity phosphatase and tensin homolog deleted

87 y of enzymes are differentially regulated by dual-specificity phosphatases and also indicate that the

88 structurally equivalent counterparts in the dual-specificity phosphatases and the low molecular weig

89 The dual-specificity phosphatases and the protein tyrosine p

90 Although the dual-specificity phosphatases and the PTPases appear to

91 as new protein phosphatase candidates: five dual-specificity phosphatases and three PP2Cs.

92 uppressor gene, PTEN/MMAC1, with homology to dual-specificity phosphatases and to the cytoskeletal pr

93 Cdc25A and Cdc25B dual-specificity phosphatases are key regulators of cell

94 ypertrophy and demonstrate the importance of dual-specificity phosphatases as counterbalancing regula

95 vestigate the cell division cycle 25 (Cdc25) dual-specificity phosphatases as potential upstream regu

96 These results propagate a role for dual specificity phosphatases at RNP particles and sugge

97 and can be inactivated by a unique family of dual specificity phosphatases, called MAP kinase phospha

98 one, these sites are dephosphorylated by the dual specificity phosphatase, Cdc25, leading to Cdc2-cyc

99 homologous in sequence or structure to other dual-specificity phosphatases, Cdc25 belongs to the clas

100 Like other dual-specificity phosphatases, Cdc25 contains an active

101 Like other dual-specificity phosphatases, Cdc25 exhibits a two-step

102 l-free conditions in vitro, particularly the dual specificity phosphatase Cdc25A.

103 The dual specificity phosphatases Cdc25a, Cdc25b and Cdc25c

104 types of human tumour cells overexpress the dual-specificity phosphatase Cdc25A.

105 The dual specificity phosphatase Cdc25B is capable of inhibi

106 ver two other PTP enzymes (LAR and SHP-2), a dual specificity phosphatase (cdc25b), and a serine/thre

107 ct high-throughput screens for inhibitors of dual-specificity phosphatases: CDC25B, mitogen-activated

108 Chk1 phosphorylates the dual specificity phosphatase cdc25C on Ser-216, and this

109 e G(2)-M transition differently by targeting dual-specificity phosphatase Cdc25C activity.

110 into mitosis depends upon activation of the dual-specificity phosphatase Cdc25C, which dephosphoryla

111 We show that the dual specificity phosphatases, Cdc25C and PP2Acalpha, wh

112 pro-influenza virus host gene identified was dual-specificity phosphatase cell division cycle 25 B (C

113 In addition, coexpression of a dual-specificity phosphatase, CL100/MKP-1, that is able

114 The Cdc25 dual specificity phosphatases coordinate cell cycle prog

115 Overexpression of the Cdc25A and Cdc25B dual-specificity phosphatases correlates with a wide var

116 95397 was more potent than any inhibitor of dual specificity phosphatases described previously and 1

117 CL100, a dual specificity phosphatase, displayed 10-25-fold highe

118 inding domain (CBD) at the N terminus or the dual specificity phosphatase domain (DSPD) at the C term

119 laforin carbohydrate-binding module and the dual specificity phosphatase domain generates an intimat

120 1) is an immediate-early gene comprised of a dual-specificity phosphatase domain and a noncatalytic N

121 re predicted to disrupt the protein tyrosine/dual-specificity phosphatase domain of this gene.

122 , encoding myotubularin-related protein-2, a dual specificity phosphatase (DSP).

123 virus gene H1, VH1, is the first identified dual specificity phosphatase (DSP).

124 ere, we identify two members of the atypical dual specificity phosphatases (DSP), DSP18 and DSP21, th

125 ns a carbohydrate binding module (CBM) and a dual-specificity phosphatase (DSP) domain.

126 he carbohydrate-binding module (CBM) and the dual-specificity phosphatase (DSP) domain.

127 ases) dephosphorylate phosphotyrosines while dual-specificity phosphatases (DSPases) dephosphorylate

128 Dual specificity phosphatases (DSPs) are members of the

129 The involvement of dual specificity phosphatases (DSPs) in the mitogen-acti

130 Dual-specificity phosphatases (DSPs) belong to the large

131 a H1 related phosphatase) is a member of the dual-specificity phosphatases (DSPs) that often act on b

132 on of SAPK results from dephosphorylation by dual-specificity phosphatases (DSPs), we studied regulat

133 fic protein tyrosine phosphatases (PTPs) and dual-specificity phosphatases (DSPs).

134 ive sequence similarity with myotubularin, a dual specificity phosphatase (dsPTPase) that is mutated

135 ily of proteins that display similarity with dual-specificity phosphatases (dsPTPases).

136 and show that despite belonging to the same dual specificity phosphatase (DUSP) family, its interact

137 ty is negatively regulated by members of the dual specificity phosphatase (Dusp) family, which differ

138 Dual-specificity phosphatase (DUSP) 1 dephosphorylates a

139 nscriptionally regulating two members of the dual-specificity phosphatase (DUSP) family.

140 biofilm formation A (TpbA) is a periplasmic dual-specificity phosphatase (DUSP) that controls biofil

141 otyrosyl (pY) library screening technique to dual-specificity phosphatase (DUSP) VH1 of vaccinia viru

142 P2Ac was sufficient to elevate levels of the dual specificity phosphatase DUSP1, reduce p38 MAPK acti

143 ly shown that a KIM-containing MAPK-specific dual specificity phosphatase DUSP10 uses a unique bindin

144 ike receptor agonists via suppression of the dual-specificity phosphatase, DUSP10/MKP5.

145 em-like cells and elevated expression of the dual specificity phosphatase DUSP4 by inhibiting NF-kapp

146 ind that a CpG island in the promoter of the dual-specificity phosphatase DUSP4 is aberrantly methyla

147 We report that a dual specificity phosphatase, Dusp4, is induced by AMPK

148 Ser/Thr and Tyr phosphatases and implicated dual specificity phosphatases (DUSPs) in the dephosphory

149 Dual specificity phosphatases (DUSPs) inactivate ERK 1/2

150 y members as well as MAPK pathway-regulating dual specificity phosphatases (DUSPs).

151 s), at least in part through upregulation of dual specificity phosphatases (DUSPs).

152 The dual-specificity phosphatases (DUSPs) are critical effec

153 A family of dual-specificity phosphatases (DUSPs) directly inactivat

154 X) is a catalytically inactive member of the dual-specificity phosphatases (DUSPs) family.

155 to Stx1 upregulate the expression of select dual-specificity phosphatases (DUSPs), enzymes that deph

156 tivation is counter-regulated by a family of dual-specificity phosphatases (DUSPs).

157 sphatase of the recently discovered atypical dual specificity phosphatase family as a physiological i

158 Cdc25C is a cell cycle protein of the dual specificity phosphatase family essential for activa

159 The Cdc25 dual specificity phosphatase family has a central role i

160 The CDC25 dual-specificity phosphatase family has been shown to pl

161 No genes other than members of the dual-specificity phosphatase family were induced in both

162 d phosphatase (VHR/DUSP3) is a member of the dual-specificity phosphatase family.

163 In mammalian cells the Cdc25 family of dual-specificity phosphatases has three distinct isoform

164 MKP-1, the founding member of this family of dual-specificity phosphatases, has been implicated in re

165 The Cdc25 dual specificity phosphatases have central roles in coor

166 Germline mutations in PTEN, which encode a dual-specificity phosphatase, have been implicated in at

167 We now show that the conserved dual-specificity phosphatase human cell-division cycle 1

168 n homologue deleted from chromosome 10) is a dual-specificity phosphatase implicated in embryonic dev

169 tein kinase phosphatase-1 (MKP-1), a nuclear dual-specificity phosphatase, in the transcriptional act

170 a first step in the development of selective dual-specificity phosphatase inhibitors, we have examine

171 rexpression of MAPK phosphatase-1 (MKP-1), a dual-specificity phosphatase, inhibits high NaCl-induced

172 Cdc25B is a dual specificity phosphatase involved in the control of

173 Human cdc25C is a dual-specificity phosphatase involved in the regulation

174 We have found that a dual-specificity phosphatase is essential for conveying

175 PTEN/MMAC1/TEP1, encoding a dual-specificity phosphatase, is a tumor suppressor gene

176 PRL-3, an oncogenic dual-specificity phosphatase, is overexpressed in 50% of

177 APKs are negatively regulated by a family of dual-specificity phosphatases known as the MAPK phosphat

178 essive mutations in either a gene encoding a dual-specificity phosphatase, known as laforin, or a rec

179 either the E3 ubiquitin ligase malin or the dual specificity phosphatase laforin.

180 novel tumor suppressor gene PTEN, encoding a dual specificity phosphatase, located at 10q23.3.

181 inhibited the cytokine-induced expression of dual specificity phosphatases, MAP kinase phosphatase-L,

182 nic mice overexpressing the p38-inactivating dual specificity phosphatase MAPK phosphatase-1 (MKP-1)

183 MAPK activity and enhances expression of the dual specificity phosphatase MAPK phosphatase-1 (MKP-1).

184 se (TMDP) and a novel DSP, muscle-restricted dual specificity phosphatase (MDSP).

185 TPase1 (SHP-1), SHP-2, and PTP1B but not the dual-specificity phosphatase mitogen-activated protein k

186 s study, we have also identified the nuclear dual-specificity phosphatase mitogen-activated protein k

187 In contrast to M3/6, the dual specificity phosphatase MKP-3 is selective for inac

188 resolubilization, was found with a distinct dual-specificity phosphatase MKP-1 but not with MKP-2.

189 lasses of PTPs, the receptor PTP LAR and the dual-specificity phosphatase MKP1.

190 Dual-specificity phosphatase MKP3 down-regulates mitogen

191 -tyrosine phosphatases, Ptp2 and Ptp3, and a dual specificity phosphatase, Msg5.

192 Conversely, cells lacking the dual-specificity phosphatase (msg5Delta) or that are def

193 The PTEN gene encodes a dual-specificity phosphatase mutated in a variety of hum

194 RNAi of the dual-specificity phosphatase, Myotubularin, or the relat

195 Here we describe two new dual specificity phosphatases of the CL100/MKP-1 family

196 Cdk)-associated protein phosphatase KAP is a dual-specificity phosphatase of which the only known fun

197 Germline mutations in PTEN, encoding a dual-specificity phosphatase on 10q23.3, cause Cowden sy

198 ze to a P-loop active site characteristic of dual specificity phosphatases or to a non-catalytic site

199 d more selective for Cdc25A than VH1-related dual-specificity phosphatase or protein tyrosine phospha

200 The dual-specificity phosphatase, PAC1, which does not inhib

201 mine the roles played by PI-3 kinase and the dual-specificity phosphatase, phosphatase and tensin hom

202 The Cdc14 dual-specificity phosphatase plays a key role in the mit

203 maps to 10q23.3 and encodes a 403 amino acid dual specificity phosphatase (protein tyrosine phosphata

204 Here, we show that the dual specificity phosphatase PTEN, a gene almost univers

205 regulation of MAPK may occur via a family of dual specificity phosphatases referred to as mitogen-act

206 The Cdc14 dual-specificity phosphatases regulate key events in the

207 For example, Cdc25 dual-specificity phosphatases regulate mammalian cell cy

208 lity to induce the expression of tyrosine or dual specificity phosphatase(s).

209 ochemical evidence that the stress-inducible dual specificity phosphatase, Sdp1, negatively regulates

210 Selective ablation by dual-specificity phosphatases should be a general method

211 racterization of PIR1, a novel member in the dual-specificity phosphatase subfamily of the protein ty

212 ine phosphatase domain fold, resembling many dual-specificity phosphatases such as phosphatase and te

213 Previous studies showed that PTEN, a dual specificity phosphatase that antagonizes phosphatid

214 Vaccinia VH1-related (VHR) is a dual specificity phosphatase that consists of only a sin

215 he Vaccinia virus H1 gene product, VH1, is a dual specificity phosphatase that down-regulates the cel

216 ly regulated phosphatase (ERP or MKP-1) is a dual specificity phosphatase that has been implicated in

217 ed protein kinase phosphatase-1 (MKP-1) is a dual specificity phosphatase that is overexpressed in ma

218 otein (MAP) kinase phosphatase-3 (MKP3) is a dual specificity phosphatase that specifically inactivat

219 Cdc25B and Cdc25C are closely related dual specificity phosphatases that activate cyclin-depen

220 Cdc25 phosphatases are dual specificity phosphatases that dephosphorylate and a

221 cle 25 (Cdc25) proteins are highly conserved dual specificity phosphatases that regulate cyclin-depen

222 Cdc25 is a dual-specificity phosphatase that catalyzes the activati

223 Cdc25 is a dual-specificity phosphatase that catalyzes the activati

224 Cdc25 is a dual-specificity phosphatase that catalyzes the activati

225 CDC14 is an essential dual-specificity phosphatase that counteracts CDK1 activ

226 Cdc25, the dual-specificity phosphatase that dephosphorylates the C

227 ologue deleted on chromosome ten (PTEN) is a dual-specificity phosphatase that has activity toward bo

228 PTEN on 10q23.3 encodes a dual-specificity phosphatase that negatively regulates t

229 ur suppressor gene PTEN/MMAC1/TEP1 encodes a dual-specificity phosphatase that recognizes phosphatidy

230 The tumour suppressor gene PTEN encodes a dual-specificity phosphatase that recognizes protein and

231 The tumour suppressor gene PTEN encodes a dual-specificity phosphatase that recognizes protein sub

232 DUSP1 is a dual-specificity phosphatase that regulates mitogen-acti

233 Human CDC14A is a dual-specificity phosphatase that shares sequence simila

234 Msg5p is a dual-specificity phosphatase that was previously demonst

235 Myotubularins are a family of dual-specificity phosphatases that act to modify phospho

236 ymes that include both tyrosine specific and dual-specificity phosphatases that hydrolyze pSer/Thr in

237 hosphatases (MKPs) constitute a family of 11 dual-specificity phosphatases that inactivate the MAPKs

238 tenuated at several levels, and one class of dual-specificity phosphatases, the MAPK phosphatases (MK

239 escribed testis and skeletal muscle-specific dual specificity phosphatase (TMDP) and a novel DSP, mus

240 he identification of authentic substrates of dual-specificity phosphatases utilizing affinity absorbe

241 e, topologically similar to the prototypical dual specificity phosphatase VH1.

242 codes two protein kinases (B1 and F10) and a dual-specificity phosphatase (VH1), suggesting that phos

243 he low microM range, whereas the Kis for the dual specificity phosphatase VHR is at least 10-fold hig

244 In this article we show that the small dual-specificity phosphatase VHR selectively dephosphory

245 f modest potency against PTP1B, SHP-1, and a dual-specificity phosphatase, VHR.

246 tive site substrate specificity of the human dual-specificity phosphatase, VHR.

247 PTEN is a tumour suppressor and dual-specificity phosphatase which affects apoptosis via

248 Cdc25 A and B are dual-specificity phosphatases which have been implicated

249 sidues of the TXY motif independently and by dual specificity phosphatases, which dephosphroylate bot

250 suppressed ERK activation by both protecting dual-specificity phosphatases, which was dependent on th

251 Therefore, we assayed levels of MKP-2, a dual specificity phosphatase whose substrates include ER

252 MAP kinase phosphatase (MKP) is a family of dual-specificity phosphatases whose function is evolutio

253 (DUSP12), is a poorly characterized atypical dual specificity phosphatase widely conserved throughout

254 ene at 10q 23.3, designated PTEN, encoding a dual specificity phosphatase with lipid and protein phos

255 The gene that encodes laforin, a dual-specificity phosphatase with a carbohydrate-binding

256 novel tumour suppressor gene that encodes a dual-specificity phosphatase with homology to adhesion m

257 jor new tumor suppressor gene that encodes a dual-specificity phosphatase with sequence similarity to

258 t of other protein tyrosine phosphatases and dual specificity phosphatases, with the exception of the

259 In this study, we show that the dual-specificity phosphatase Yvh1 is required for the re