ライフサイエンスコーパス: ductular

1 urotransmitters, isolated HPCs, and immature ductular 603B cells were initially used to investigate S

2 norCDCA occurred, consistent with efficient ductular absorption (calculated to be 94%) and cholehepa

3 ular regeneration accompanied by marked bile ductular and septal duct hyperplasia.

4 rsity: focal hepatocytic differentiation and ductular areas (mixed-ICCs).

5 Cyclic AMP-induced ductular bicarbonate secretion depends on an autocrine s

6 lated bile ducts from these animals, whereas ductular bicarbonate secretion was examined in isolated

7 epithelial cells, which in turn may regulate ductular bile formation through the opening of Cl- chann

8 l cells (BECs) provide the driving force for ductular bile formation.

9 trosamine (DEN) hepatocarcinogenesis; 2) the ductular "bipolar" progenitor cell, which responds to ce

10 ntial target for the treatment of pancreatic ductular cancer that at present remains largely unrespon

11 rially located PDC-E2 and subsequent biliary ductular cell damage.

12 In AH patients, ductular cell expansion correlated with portal hypertens

13 LPS-TLR4 pathway role in ductular cell expansion was assessed in human and mouse

14 It is unknown whether LPS mediates ductular cell expansion.

15 s and identified keratin 23 (KRT23) as a new ductular cell marker.

16 xocrine degeneration, atrophy, inflammation, ductular cell proliferation, and/or observations in larg

17 There was no ductular cell replication in the fetal livers.

18 y hepatocyte, hepatocyte-like cell, atypical ductular cell, neocholangiole, etc., are used to describ

19 that Hh signaling promotes EMT in adult bile ductular cells (cholangiocytes).

20 essential for the hepatic differentiation of ductular cells after liver damage.

21 cyte proliferation, expansion of inefficient ductular cells and high lipopolysaccharide (LPS) levels.

22 nhances the viability and growth of residual ductular cells and promotes accumulation of inflammatory

23 ining for TARC was present on lacrimal gland ductular cells but not on the infiltrating lymphocytes,

24 Hh-mediated EMT in ductular cells contributes to the pathogenesis of cirrho

25 ildren with BA, both intra- and extrahepatic ductular cells demonstrated striking up-regulation of Hh

26 rgo a phenotypic switch (metaplasia) to form ductular cells during fetal development.

27 Ductular cells isolated from adult rats with and without

28 capacity to differentiate into OV-6 positive ductular cells or lobular hepatocytes.

29 otypic switch to ductules and replication of ductular cells play a role in the increase in the ductul

30 In other selective cholangiopathies, ductular cells positive for HAI-1 or HAI-2 also increase

31 Studies are revealing that ductular cells produce and respond to hedgehog (Hh) liga

32 iptional mechanisms modulate Hh signaling in ductular cells remains unclear.

33 Functional studies in ductular cells showed that KRT23 regulates collagen expr

34 During NASH, ductular cells strongly expressed OPN.

35 ers of Shh-producing cells and Hh-responsive ductular cells that expressed EMT markers increased in p

36 In contrast, when the isolated bile ductular cells were cultured for 7 to 16 days in the pre

37 Immature ductular cells were exposed to Sonic hedgehog (Shh) in t

38 of the BA samples demonstrated that immature ductular cells with a mesenchymal phenotype were Hh-resp

39 enesis by promoting accumulation of immature ductular cells with a mesenchymal phenotype.

40 Treating immature ductular cells with Hh ligand-enriched medium induced me

41 and Hh-responsive MF progeny (i.e., HSCs and ductular cells).

42 remodeling, proliferation of hepatocytes and ductular cells, and restoration of liver mass.

43 xpanding ducts likely further converted into ductular cells, the incidence was rare.

44 ong Ihh expression was detected in most bile ductular cells.

45 cies that evolve from secretin receptor-rich ductular cells.

46 K1), in dysplastic and neoplastic pancreatic ductular cells.

47 le to differentiate into hepatocytes or bile ductular cells.

48 restricted to scarce expression in the bile ductular cells.

49 ling and blocked accumulation of both MF and ductular cells.

50 sly develop portal inflammation with biliary ductular damage and colitis with features similar to hum

51 pha(-/-) CD4(-/-) mice had increased biliary ductular damage but reduced inflammation in the colon.

52 and 2-AAF/PHx) as affected by previous bile ductular damage caused by 4,4'-methylene dianiline (4,4'

53 is an aromatic diamine, known to cause bile ductular damage in both humans and animals.

54 ols, develop portal inflammation and biliary ductular damage similar to human patients with PBC.

55 unction in mice, CD8 T cells mediate biliary ductular damage whereas CD4 T cells mediate induction of

56 inflammation but markedly attenuated biliary ductular damage.

57 f the MMTV promoter in transgenic mice, both ductular development in virgin mice and alveolar develop

58 n and AE1, indicative of both hepatocyte and ductular differentiation.

59 etaRII mice) develop an inflammatory biliary ductular disease that strongly resembles human primary b

60 nTGFbetaRII) develop an inflammatory biliary ductular disease with elevated serum levels of interleuk

61 iferation, only occasional and small foci of ductular dysplasia, and none of 16 rats developed CCAs.

62 racteristic changes in the morphology of the ductular epithelia including a loss of secondary membran

63 y cyst formation in kidney tubules and other ductular epithelia.

64 In addition, bile ductular epithelial (BDE) cells both in the AAF/PH model

65 at this gene is expressed in both acinar and ductular epithelial cell populations from the exocrine p

66 procedure to obtain and culture viable bile ductular epithelial cells in high numbers and with a hig

67 likely contributed by NAT1 expressed in the ductular epithelial cells of the mammary gland.

68 e readily established when the isolated bile ductular epithelial cells were cultured in plastic tissu

69 ne-arginine protein kinase 1 (SRPK1), to the ductular epithelial cells within human pancreas and have

70 smaller oval cell areas, fewer proliferating ductular epithelial cells, and lower cholestasis serum m

71 or vessels and inflammatory, fibrogenic, and ductular epithelial cells, collectively referred to as t

72 otypic features typical of hyperplastic bile ductular epithelium but did not show evidence of ductal

73 zation of CBP, SRC-1, and TTF-1 increased in ductular epithelium in association with type II cell dif

74 These results suggest that the bile ductular epithelium in the young rats responds to bile s

75 a that include beta cells proliferating from ductular epithelium, and by a six-fold increase in the n

76 tocytes and to the luminal side of the renal ductular epithelium.

77 tocytic (expressing AFP and albumin) or bile ductular (expressing only CK-19), had proliferated.

78 mature hepatocytes (HEPs), and 3) CK19+/AE1+ ductular hepatocyte (DH) cells lying at the interface be

79 A newly described lesion, isolated ductular hyperplasia (IDH) was found in patients with pr

80 normal, the liver still exhibits biliary and ductular hyperplasia along with varying degrees of hepat

81 d bile ductules formed in rat models of bile ductular hyperplasia and the cell types of normal adult

82 sociated with the SARS coronavirus, Isolated Ductular Hyperplasia in patients with liver function tes

83 ran is a unique animal model of massive bile ductular hyperplasia in which normal liver parenchyma is

84 iate into hepatocytes and underwent atypical ductular hyperplasia, exhibiting epithelial metaplasia a

85 patocytes and alternatively induced atypical ductular hyperplasia.

86 Acinar tissue destruction and ductular inflammation were common features, with less fr

87 g genetic component characterized by biliary ductular inflammation with eventual liver cirrhosis.

88 apacity may contribute to the development of ductular injury in postischemic livers.

89 nsistent with differentiation along the bile ductular lineage.

90 In contrast, both bile ductular metaplasia and proliferation were observed in b

91 s that in BA excessive Hh activation impedes ductular morphogenesis and enhances fibrogenesis by prom

92 Although the control of biliary ductular morphogenesis has received some attention parti

93 n of factors that regulate hyperplastic bile ductular morphogenesis, cell proliferation, and polarize

94 ese findings indicate that for human biliary ductular morphogenesis, epithelial cell-cell interaction

95 ries of dacryops that implicate a failure of ductular "neuromuscular" contractility must therefore be

96 islets, eight of which showed intra-insular ductular or cyst formation as seen in the pancreas of ha

97 rrounding cytoplasmic EpCAM(+)/HNF-4alpha(-) ductular oval cells.

98 hepatocytes, biliary epithelial cells, and (ductular) oval cells.

99 obis (2-oxopropyl)amine (BOP)-induced ductal/ductular pancreatic cancers in the hamster model develop

100 The ductular progenitor cells are less numerous, may prolife

101 t genes, and markers of mesenchymal cells or ductular progenitors.

102 der and prepuberty were also associated with ductular proliferation (P < 0.05), increased numbers of

103 ase in biliary epithelial cells, evolving to ductular proliferation and a decrease in the density of

104 e injury, which is repaired through atypical ductular proliferation and oval cells and their subseque

105 Although mechanisms for bile ductular proliferation are unknown, recent evidence sugg

106 Ductular proliferation decreased in 92%.

107 Bile ductular proliferation in biliary atresia, however, was

108 -positive cells, indicating greater atypical ductular proliferation in KO, which coincided with incre

109 y may mediate pathologic alterations in bile ductular proliferation in other cholangiopathic conditio

110 , M70 ameliorated the hepatosplenomegaly and ductular proliferation that are associated with cholangi

111 Loss of NTPDase2 may mediate the bile ductular proliferation typical of obstructive cholestasi

112 Despite ductular proliferation vanishing and lobular zonation re

113 onclude that portal fibroblasts inhibit bile ductular proliferation via expression of NTPDase2 and bl

114 th interface hepatitis, portal fibrosis, and ductular proliferation without duct damage or loss.

115 came inflamed, with hepatocellular necrosis, ductular proliferation, and fibrosis; hepatocellular car

116 decreases in alkaline phosphatase, atypical ductular proliferation, and periportal inflammation comp

117 was associated with autoimmune markers, bile ductular proliferation, and portal infiltrates, which pr

118 Ductular proliferation, metabolic zonation, sinusoid cap

119 C) results in hepatobiliary injury, atypical ductular proliferation, oval cell appearance, and limite

120 giopathies" characterized by disordered bile ductular proliferation.

121 actors are up-regulated on BEC during active ductular proliferation.

122 AT) (n = 4), CK-19 and HEA-125 immunostained ductular proliferative cells that tended to form finely

123 onalcoholic steatohepatitis (NASH), and bile ductular proliferative reactions in a number of liver di

124 onic liver diseases it has been shown that a ductular reaction (DR) appears early, correlates with fi

125 ture cholangiocytes and by the appearance of ductular reaction (DR) as the results of hepatic progeni

126 We hypothesized that a bile acid-induced ductular reaction (DR) drives fibrogenesis.

127 located mainly in the cytokeratin 19-labeled ductular reaction (DR) in human cirrhotic livers and in

128 atory infiltrate and its relationship to the ductular reaction (DR), a second portal phenomenon impli

129 To address this issue, liver inflammation, ductular reaction (DR), and fibrosis were induced in C57

130 elial cells, collectively referred to as the ductular reaction (DR).

131 direct target of miR-133b, is crucial in the ductular reaction (DR)/oval cell (OC) response for gener

132 001), hepatocyte ballooning (P = 0.004), the ductular reaction (i.e., numbers of gli2+/sox9+ cells; P

133 reduced hepatocyte proliferation and reduced ductular reaction 72 hours after BDL compared to wild ty

134 naling in WT mice also resulted in defective ductular reaction after BDL.

135 ibrosis stage, microvesicular steatosis, and ductular reaction among other findings, whereas eosinoph

136 able to restore PC2 expression and to reduce ductular reaction and fibrosis may represent a new thera

137 y the progressive onset of liver injury with ductular reaction and fibrosis.

138 CCN1 induces cholangiocyte proliferation and ductular reaction and identify CCN1/alphavbeta5/NF-kappa

139 This is recognized histopathologically as a ductular reaction and leads to gradual distortion of the

140 atitis C and E, immunohistochemistry for the ductular reaction and malignant liver tumors and several

141 Ductular reaction and portal inflammation were quantifie

142 Biliary atresia (BA) is notable for marked ductular reaction and rapid development of fibrosis.

143 ment of these mice with soluble JAG1 rescued ductular reaction and reduced hepatic necrosis and morta

144 om biliary epithelial cells constituting the ductular reaction and the regenerated peripheral IHBDs.

145 In chronic hepatitis C, the ductular reaction appears to be a major factor associate

146 We found that ductular reaction cells in human cirrhotic livers expres

147 could have beneficial effects by preventing ductular reaction development.

148 nf6(flox/flox)Rbpj(flox/flox) mice mounted a ductular reaction extending through the hepatic tissue a

149 Ductular reaction has been associated with chronic alcoh

150 ort a role for LPS-TLR4 pathway in promoting ductular reaction in AH.

151 Both the ductular reaction in humans and hepatic progenitor cells

152 The ductular reaction in nonalcoholic steatohepatitis appear

153 in hepatocytes with liver injury triggered a ductular reaction of cholangiocyte origin, with approxim

154 ve stress-related changes, but had increased ductular reaction protoporphyrin-IX accumulation, and MD

155 on-skin type fibrotic lesions and pronounced ductular reaction starting from 4 weeks of age.

156 of HPCs also determines the appearance of a ductular reaction that has been correlated with progress

157 human diseased liver and mouse models of the ductular reaction that Notch and Wnt signaling direct sp

158 The ductular reaction to acute submassive necrosis was studi

159 ls to modulate virtually every aspect of the ductular reaction to injury.

160 The mechanisms mediating this so-called 'ductular reaction' need to be better understood to impro

161 icient mice develop focal liver necrosis and ductular reaction, accompanied by impaired Atg14L-linked

162 The HDC/histamine/histamine receptor axis, ductular reaction, and biliary senescence were evaluated

163 Fibrosis, ductular reaction, and ductopenia were significantly mor

164 ess hepatocyte proliferation, an exaggerated ductular reaction, and more advanced disease compared wi

165 PC2 expression and significantly reduced the ductular reaction, fibrosis, and phosphorylated ERK1/2.

166 her hepatic and serum bile acid levels, bile ductular reaction, increased pericellular fibrosis, and

167 ind alphavbeta5/alphavbeta3 were impaired in ductular reaction, leading to massive hepatic necrosis a

168 and other pathologic conditions that trigger ductular reaction, proliferating cholangiocytes acquire

169 lso mediates cholangiocyte proliferation and ductular reaction, which are repair responses to cholest

170 -13 in fibrosis, steatosis, cholestasis, and ductular reaction.

171 g fibrosis, Mallory body formation, and bile ductular reaction.

172 disease (NAFLD) with portal inflammation and ductular reaction.

173 compartment, Notch2 is capable of inducing a ductular reaction.

174 cholangiopathies) that are characterized by ductular reaction.

175 Ductular reactions (DRs) are observed in virtually all f

176 This induced ductular reactions (DRs) in healthy mice.

177 ctivation, which often occurs in the form of ductular reactions (DRs) when hepatocyte proliferation i

178 ar environment conducive to the formation of ductular reactions (DRs).

179 ressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fi

180 At P30, Jag1(+/-) mice show widespread ductular reactions and ductopenia in liver and a mild, b

181 Ductular reactions are primarily composed of oval cells

182 Ductular reactions containing both hepatic progenitor ce

183 staining of hepatocytes, cholangiocytes, and ductular reactions in all tissues, to the exclusion of a

184 The 3-dimensional structure of ductular reactions in massive necrosis suggests that the

185 We found more-active nuclear YAP in the bile ductular reactions of primary sclerosing cholangitis and

186 iver progenitor cell types of human atypical ductular reactions seen in chronic cholestasis, in regen

187 Because HAI-1 and -2 colocalized in ductular reactions sharing similar features to those obs

188 with overexpression of p27 and emergence of ductular reactions was detected.

189 cell marker, PROMININ-1 (PROM1), adjacent to ductular reactions within regions of periportal fibrosis

190 splantation, is associated with intrahepatic ductular reactions within regions of rapidly expanding p

191 a reservoir for the epithelial diversity of ductular reactions, appearance of hepatocytes in bile du

192 /gp-80 systems in the early phases of type I ductular reactions.

193 d proliferation of liver progenitor cells or ductular reactions.

194 nic liver injury (CCl(4)-induced), or during ductular reactions.

195 and -2 were coexpressed in cells involved in ductular reactions.

196 cells have been identified in human atypical ductular reactions: type I: primitive, has an oval shape

197 n to take place but inhibits efficiently the ductular response and extracellular matrix deposition.

198 chymal origin as the progenitor for the oval/ductular response in the rat.

199 tiple chronic liver disorders that display a ductular response such as alcoholic liver disease or scl

200 Chronic hepatic injury is accompanied by a ductular response that is strongly correlated with disea

201 her anti-inflammatory drugs can modulate the ductular response, we treated mice suffering from a stea

202 (2+) release channel in Ca(2+) signaling and ductular secretion in animal models of cholestasis and i

203 i)(2+) is in part responsible for regulating ductular secretion, these findings also may have implica

204 owever can instead be induced to form acinar/ductular structures akin to bile ductules (in the presen

205 underwent organotypic morphogenesis forming ductular structures and cysts.

206 he formation and proliferation of dysplastic ductular structures are observed from the onset of the p

207 Similar acinar/ductular structures are seen in embryonic liver when HGF

208 epatocytic morphology appeared near EpCAM(+) ductular structures in the livers of mice fed 3,5-dietho

209 Proliferation of bile ductular structures is influenced by specific molecules

210 roduced grossly visible organoids containing ductular structures that stained for CK18, CK19, and AFP

211 -) cells provide luminal space near expanded ductular structures to prevent deterioration of the inju

212 tinal type" of ChC than in hyperplastic bile ductular structures within either cholangiofibrotic or b

213 The formation of ductular structures within islets was also demonstrated

214 On Matrigel, HBC-3 cells form elaborate ductular structures, which are positive for gamma-glutam

215 at pads of isogenic mice formed well defined ductular structures.

216 DDC diet, we found LacZ(+)Sox9(+) cells near ductular structures.

217 n the luminal areas of secretory alveoli and ductular tissue, indicating that much of the bacterial g

218 rowth to form a small, irregularly branched, ductular tree.

219 ithelial-to-mesenchymal transitions (EMT) in ductular-type progenitors.