ライフサイエンスコーパス: durable

1 ent responses to sorafenib treatment that is durable.

2 h makes for an instrument that can be highly durable.

3 To achieve a durable adaptive immune response, lymphocytes must under

4 requiring a multispecies community to form a durable adhesion phenotype.

5 ourse early in life is sufficient to lead to durable alterations to the murine intestinal microbiota,

6 Ideally, SOCs should perform well, be durable and be inexpensive, but there are often competit

7 DC/CoAT induced durable and complete remissions of large subcutaneous tu

8 Herein, a highly durable and efficient carbide-based bifunctional catalys

9 Complementarily, these more durable and efficient dentitions could be selected to co

10 oduce plants with multiple R genes providing durable and environmentally safe protection against path

11 s can resist some antibiotics because of its durable and impermeable cell envelope.

12 gent and combination regimens, have produced durable and long-lasting clinical responses in a subset

13 Purpose Durable and long-term responses to the poly (ADP-ribose)

14 t protective HLA class I alleles may be more durable and mediated by CD8(+) T cell-independent mechan

15 However, responses are not durable and resistance develops within months.

16 s, which may support the development of more durable and successful cancer immunotherapy approaches i

17 Electric eel-skin-inspired mechanically durable and super-stretchable nanogenerator is demonstra

18 nt due to its great potential for generating durable and synergistic antitumor response.

19 ) and commercial superglue is combined and a durable and ultrarobust antifouling zwitterionic (DURA-Z

20 moricidal effects to harness tumor-specific, durable, and systemic antitumor immunity with minimal to

21 or the development of even more powerful and durable antibiotics.

22 301S tau transgenic mice results in high and durable antibody expression, primarily in neurons.

23 h NP TLR L adjuvants in promoting robust and durable antibody responses against HIV in the next gener

24 ulated TLR ligands (NP) to induce potent and durable antibody responses that last a lifetime in mice.

25 ival of bone marrow-derived plasma cells and durable antibody responses to multiple virus and vaccine

26 /m(2) is a safe therapy with encouraging and durable anticancer activity in patients with R/R NHL.

27 Such antibiotics are expected to display durable antimicrobial activity not prone to rapidly acqu

28 ected) immune checkpoint blockade results in durable antitumor activity in many advanced malignancies

29 Purpose Pembrolizumab provides durable antitumor activity in metastatic melanoma, inclu

30 in dosages and thereby produces a strong and durable antitumor effect.

31 t antibodies can lead to tumor clearance and durable antitumor immunity.

32 MEK inhibitors in vivo to elicit potent and durable antitumor responses, including by a vaccine-like

33 system can be activated to induce long-term, durable antitumor responses.

34 ated HER2-targeted phagocytosis and produced durable antitumour immune responses against HER2-express

35 This effective and durable antiviral response probably participates in a vi

36 surfaces that are stable under pressure and durable at elevated temperatures.

37 HIV vaccines capable of inducing potent and durable B-cell responses have been unsuccessful until no

38 We found superior and durable B-cell responses in macaques vaccinated with an

39 d consequently a lack of strong, robust, and durable B-memory responses.

40 n cancer patients, the response is often not durable because tumor cells develop resistance to the dr

41 Conclusion Olaparib has durable benefit for patients with ovarian cancer beyond

42 n why T-cell-based immunotherapy can provide durable benefits with relatively infrequent escape.

43 as inexpensive and effective means to create durable, biologically active biomaterials.

44 c bypass surgery resulted in substantial and durable bodyweight reduction and cardiometabolic benefit

45 velopment is an ability to elicit strong and durable broadly neutralizing antibody (bNAb) responses.

46 nd uses is construction decisions for highly durable buildings made under weak institutions.

47 e been shown to induce substantial levels of durable, but primarily T-cell-biased responses against t

48 a great need for cost effective, active and durable catalyst materials to replace the precious plati

49 Developing a low cost, highly active, durable cathode towards an oxygen reduction reaction (OR

50 se results demonstrate that obesity produces durable changes in HSC function and phenotype and that e

51 er training regimens (FTM or LTM) can induce durable changes in the parameters of locomotion.

52 Cefoxitin treatment resulted in complete and durable clearance of ETBF colonization.

53 is interim analysis show that venetoclax has durable clinical activity and favourable tolerability in

54 ion and provides additional evidence for the durable clinical activity of immune checkpoint inhibitor

55 igand 1 (PD-L1) with atezolizumab can induce durable clinical benefit (DCB) in patients with metastat

56 an melanoma, most patients do not experience durable clinical benefit.

57 een approved for treating human cancers with durable clinical benefit.

58 Conclusion The durable clinical efficacy and safety of MR imaging-guide

59 Low-dose IL-2 provides durable clinical improvement in active cGVHD and extende

60 utochthonous tumor debulking and resulted in durable clinical remission.

61 Antibodies targeting PD-1 elicit durable clinical responses in patients with multiple tum

62 med cell death 1 ligand 1) have demonstrated durable clinical responses in patients with non-small-ce

63 n 1/programmed death-ligand 1 have displayed durable clinical responses in various cancers.

64 Ls with CTLA-4 blockade is safe and produces durable clinical responses, likely reflecting both enhan

65 its receptor PD-1 has produced unparalleled, durable clinical responses, with highest likelihood of r

66 Marked and durable CMV-specific T-cell responses were also detected

67 veloped to create a new highly efficient and durable cobalt-based electrocatalyst for the oxygen evol

68 settlements allowed house mice to establish durable commensal populations that expanded with human s

69 n Patients with metastatic melanoma can have durable complete remission after discontinuation of pemb

70 mphoproliferative syndrome (ALPS) achieved a durable complete response (CR), including rapid improvem

71 objective response (20%), including 1 with a durable complete response.

72 Identification of low cost, highly active, durable completely noble metal-free electro-catalyst for

73 Treatments aimed at mitigating the durable consequences of early-life cocaine use may benef

74 testinal microbiome and highlight unexpected durable consequences of treatment for the world's most c

75 assessments of adult patients implanted with durable continuous-flow LVADs as bridge to transplant, d

76 Eight patients (16%) had durable control of disease for > 12 months.

77 ity of utilizing RNA interference to achieve durable correction of hair structural phenotypes through

78 The mechanisms underlying durable CR require further investigation.

79 results in frequent infections and a lack of durable cross-protection.

80 LAIV boosts durable, cross-reactive T-cell responses in children and

81 umors ultimately arise for which there is no durable cure.

82 sis, compared with patients who will achieve durable cure.

83 ne checkpoint inhibitor biologics to produce durable cures in mouse models of glioblastoma in which s

84 on resultant from brief DCS application into durable DCS-LTD.

85 Conclusion Everolimus may induce durable disease control in a high percentage of patients

86 creased the proportion of patients achieving durable disease control with excellent results, as measu

87 nomodulatory antibodies offer the promise of durable disease control.

88 ll enable delivery of improved diagnosis and durable disease-control strategies.

89 s to improve broad-spectrum, and potentially durable, disease resistance in crops.

90 This effect was durable during the follow-up year.

91 ation; however, these regimens do not have a durable effect on long-term graft survival owing to a co

92 wed a statistically significant, robust, and durable effect on pain intensity, indicating that MBCT m

93 ions of 15d-PGJ2 in the cream showing a more durable effect up to 8h.

94 ll-directed immunotherapy might lead to more durable efficacy, T cell responses are themselves at lea

95 vel cobalt alloy-based coronary stent with a durable elastomeric polymer eluting the antiproliferativ

96 article form of Env (VLP) induces potent and durable Env-specific antibody responses in the serum and

97 Durable expression of GUCY2C, guanylin, and uroguanylin

98 oaches for more selective and therefore more durable Fe-N-C catalysts.

99 r mechanical energy harvesting by creating a durable ferroelectret energy harvester/nanogenerator (FT

100 d in later retrieval, formed memories appear durable for at least 48 h.

101 Cs from poorly controlled patients to induce durable GAD65-specific T cell hyporesponsiveness was rev

102 ch, education, environmental assessments, or durable goods integral to home environmental interventio

103 CIST (version 1.1); however, 17 (33%) showed durable (>/= 4 months) stable disease, including seven (

104 ION: Pegylated interferon alfa-2a can induce durable haematological and molecular responses in patien

105 The weighted probability of durable HBeAg seroconversion was 91.9% and 88.0% at 12 a

106 nsplantation for chronic hepatitis B, with a durable HBsAg seroclearance rate of 92%, an undetectable

107 t of C57BL/6 mice permitted establishment of durable hematopoietic chimerism when the mice were given

108 vide phenotypic and mechanistic insight into durable hematopoietic dysregulations resulting from obes

109 Durable, highly efficient, and economic sound electrocat

110 ible SiCl4 cross-linking chemistry to create durable hybrid solid-electrolyte interphases (SEIs) on m

111 imod and establishment of tumor-specific and durable immune memory.

112 tionized the treatment of cancer by inducing durable immune responses and clinical remissions in pati

113 -based nanoparticles (NPs) induce robust and durable immune responses in mice and macaques.

114 Overcoming the immune response to establish durable immune tolerance in type 1 diabetes remains a su

115 ttenuated vaccines typically offer rapid and durable immunity but have reduced safety when compared t

116 reversal at 3 years, reflecting a lack of a durable immunologic effect.

117 ified effectively with therapy and generated durable immunologic memory.

118 Treatment with CN-105 was associated with a durable improvement in functional outcomes as assessed b

119 PDP enabled these durable improvements by targeting multiple tumor compart

120 recent progress, results after treatment are durable in half of patients, and therapy can be associat

121 This hydrophilic hybrid muscle is physically durable in solution and responds to electric field stimu

122 Engraftment was durable in the majority of chimeras and increased over t

123 SVR appears durable in the majority of patients at 5 years post-trea

124 Although responses have been durable in the majority of patients, relapses do occur,

125 adventitial delivery of resveratrol produces durable inhibition of all three pro-restenotic pathologi

126 whereas virus-specific exhaustion imparts a durable inhibitory imprint on cell function.

127 ctivation in skeletal muscle induced robust, durable, insulin-independent glucose uptake and glycogen

128 hen acquiring and then effectively retaining durable knowledge that is associated to preexisting know

129 ted B-cell responses proved to be remarkably durable, lasting more than 60 weeks postimmunization.IMP

130 ment, a 30-min practice break also disrupted durable learning on a non-native phonetic classification

131 Time-course studies demonstrated that durable leukemia remission required CAR T-cell persisten

132 These studies demonstrate that durable levels of protective antitoxin immunity exist in

133 ped in the lubricating liquid to result in a durable, liquid-repellent surface.

134 of patients with metastatic GIST experiences durable, long-term overall survival with imatinib treatm

135 adverse kidney events (death, dialysis, and durable loss of renal function [chronic kidney disease])

136 nduced by a typical American diet reflects a durable loss of taxa that is replenished only when dieta

137 Durable LVADs included 108 Heartmate II (HM II) and 105

138 ies of neighboring endogenous microglia in a durable manner.

139 g CLTS were less likely to be constructed of durable materials than pre-existing latrines, but were e

140 ory VAs, including heart transplantation and durable mechanical circulatory support, may be required

141 Responses were durable (median response duration 12.0 months [95% CI 3.

142 These findings highlight how durable memories are formed.

143 the neuronal predictors for the formation of durable memories largely unknown.

144 For durable memory encoding, we found increased activation i

145 ic MET exon 14 mutants, which propagate more durable MET signals due to a defect in receptor degradat

146 uch as Mg, Ti, and Zr are lightweight and/or durable metals with critical structural applications in

147 All patients achieved durable MGFA complete stable remission with no residual

148 recipient regulatory T (Treg) cells promotes durable mixed hematopoietic chimerism and allograft tole

149 he ZIKV outbreak in 2013 elicited potent and durable neutralizing antibody responses in mice and non-

150 antinib demonstrated clinically significant, durable objective response activity in patients with RAI

151 with diffuse large B-cell lymphoma achieved durable objective responses (two complete responses at 1

152 heckpoint blockade has led to remarkable and durable objective responses in a number of different tum

153 Durable objective responses show the potential of nivolu

154 Long-term follow-up is needed to establish durable oncologic efficacy and survival relative to comp

155 HER2 V777_G778insGSP mutation and achieved a durable partial response.

156 his suggests that the requisite practice for durable perceptual learning is integrated throughout eac

157 The durable performance of these strains confirms the potent

158 Moreover, the vaccine effects proved to be durable, persisting for over eight months.

159 Our discovery identifies a new type of durable plant resistance gene conferring quantitative di

160 with shorter follow-up, this therapy elicits durable plateaus of long-term OS and progression-free su

161 Durable platelet response rates with romiplostim by age

162 The primary endpoint, durable platelet response, was defined as achievement of

163 lack-supported cost-effective, efficient and durable platinum single-atom electrocatalyst with carbon

164 eloped to overcome the limitation of current durable polymer drug-eluting stents eluting amorphous si

165 tent sirolimus-eluting stent compared with a durable polymer drug-eluting stents has not been investi

166 nt group and 41 (10%) of 427 patients in the durable polymer everolimus-eluting stent group met the 1

167 ymer sirolimus-eluting stent compared with a durable polymer everolimus-eluting stent in a broad pati

168 ble polymer sirolimus-eluting stent over the durable polymer everolimus-eluting stent in a complex pa

169 rolimus-eluting stent is non-inferior to the durable polymer everolimus-eluting stent was 100% (Bayes

170 sorbable polymer sirolimus-eluting stent and durable polymer everolimus-eluting stent with Bayesian m

171 able polymer sirolimus-eluting stent or to a durable polymer everolimus-eluting stent.

172 polymer sirolimus-eluting stents (n=884) or durable polymer everolimus-eluting stents (n=450).

173 mer stent (MiStent) or an everolimus-eluting durable polymer stent (Xience).

174 t was non-inferior to the everolimus-eluting durable polymer stent for a device-oriented composite cl

175 Lack of availability of durable, potent drugs in child-friendly formulations in

176 re perishable, dried extracts emerge as more durable products and their quality control must include

177 Collectively, these data suggest durable protection against homologous and heterologous P

178 not succeed in raising safe, effective, and durable protection against human Zika virus infections o

179 indings suggest that PfSPZ Vaccine conferred durable protection to malaria through long-lived tissue-

180 subsets that together provide immediate and durable protection.

181 of these NP adjuvants to promote robust and durable protective immune responses against SIV in nonhu

182 cleoside-modified mRNA-LNP elicits rapid and durable protective immunity and therefore represents a n

183 ated ablation produced rapid, efficient, and durable PV isolation.

184 py)3](2+)-GO electrodes exhibit superior and durable redox properties compared to the pristine carbon

185 These data demonstrate that SPX-101 promotes durable reduction of ENaC membrane concentration, leadin

186 These findings suggest significant and durable reductions of inpatient use and cost of health c

187 f PD-1 in humans has resulted in impressive, durable regression responses in select tumor types.

188 points PD-1 and CTLA-4, induced complete and durable regressions (>1 year) of established TNBC tumors

189 A single dose of SGN-CD19B induced durable regressions at 300 mug/kg (3 mug/kg drug equival

190 panel of malignant B-cell lines and induced durable regressions in mice bearing xenografts derived f

191 n anti-PD-1 nonresponders led to a complete, durable rejection of essentially all injected tumors and

192 hat target the inflammasome may lead to more durable remission and resolution.

193 High rates of durable remission were observed, with recovery of B cell

194 Durable remissions associated with improved renal surviv

195 ate of peripheral neuropathy resolution, and durable remissions in a subset of patients with relapsed

196 Currently, therapies capable of providing durable remissions in relapsed/refractory TP53- or ATM-d

197 Ibrutinib produces high response rates and durable remissions in Waldenstrom macroglobulinemia (WM)

198 ic leukemia (ALL) is critical for sustaining durable remissions; accuracy of self-reported 6MP intake

199 ance genes, have promise for providing broad durable resistance in crop species.

200 this novel allele as a strategy for breeding durable resistance in rice.

201 R genes in a crop, which might provide more durable resistance.

202 actory AChR+ MG, who were observed to have a durable response after treatment.

203 To determine mechanisms of durable response and resistance to olaparib therapy, we

204 mg being sufficient to consistently achieve durable response in MCL.

205 age by RNase H1 in vitro and provides a more durable response in mice than stereorandom ASOs.

206 onse rate was 50%, and 44% of patients had a durable response lasting >/= 6 months.

207 tients with advanced colon cancer, but their durable response rate remains low.

208 ERPRETATION: Atezolizumab showed encouraging durable response rates, survival, and tolerability, supp

209 , many patients do not achieve a complete or durable response suggesting an opportunity to improve up

210 d HDAC2 gene expression were associated with durable response to treatment.

211 rrent liposomal drug therapy, a complete and durable response was obtained using protocols for which

212 ere also noted for prevention of recurrence, durable response, and bowel movement urgency.

213 cell therapy with axi-cel had high levels of durable response, with a safety profile that included my

214 ty characterised by a high response rate and durable response.

215 itself, which correlated significantly with durable response.

216 ty characterised by a high response rate and durable response.

217 generally well tolerated and may result in a durable response.

218 patients treated with immunotherapy exhibit durable response; the integration of nanomedicine and im

219 therapy is reasonable in patients with prior durable responses (time to next therapy >/=3 years) and

220 labrutinib treatment provided a high rate of durable responses and a favourable safety profile in pat

221 INTERPRETATION: Nivolumab provided durable responses and disease control in pre-treated pat

222 reatment were analyzed for associations with durable responses and OS.

223 lumab was well tolerated and associated with durable responses and prolonged survival in patients wit

224 uration, chemotherapy-free regimen, inducing durable responses and with a favorable long-term toxicit

225 However, complete and durable responses are only seen in a fraction of patient

226 nclusion Nivolumab demonstrated higher, more durable responses but no difference in survival compared

227 Although durable responses can be achieved in some patients, many

228 lators on T cells-could provide improved and durable responses for patients with disease that is othe

229 However, durable responses have been elusive in ovarian cancer pa

230 In summary, sirolimus led to CR and durable responses in a majority of children with refract

231 mmune-checkpoint blockade is able to achieve durable responses in a subset of patients; however, we l

232 activation by checkpoint inhibitors leads to durable responses in a variety of cancers, but combinati

233 sion IMMU-132 was well-tolerated and induced durable responses in heavily pretreated patients with me

234 can was well tolerated and induced early and durable responses in heavily pretreated patients with me

235 n-to-treat population showed well-tolerated, durable responses in line with previous phase 2 data for

236 ecules such as CTLA-4 and PD-1 have achieved durable responses in melanoma, renal cancer, Hodgkin's d

237 tions in vitro, and resulted in complete and durable responses in neuroblastoma xenografts derived fr

238 b, allowing prolonged exposure and promising durable responses in pazopanib- and other VEGF inhibitor

239 Ibrutinib has induced durable responses in previously treated patients with Wa

240 ose dexamethasone have acceptable safety and durable responses in RRMM patients.

241 ade or adoptive T-cell transfer, can lead to durable responses in the clinic, but response rates rema

242 in treated cancers can either contribute to durable responses or drive relapse.

243 essing relapsed or refractory lymphomas have durable responses to single-agent brentuximab vedotin an

244 However, complete and durable responses to targeted therapy are rare in indivi

245 ion of MAPK pathway signaling, thus limiting durable responses to the current BRAF inhibitors.

246 Rapid and durable responses were observed in a minority of patient

247 Durable responses were observed in association with seve

248 Deep, durable responses were observed in heavily treated patie

249 Durable responses were observed with nivolumab; 10 (37%)

250 Single-agent ibrutinib induced durable responses with a favorable benefit-risk profile

251 able safety, notable antitumor activity, and durable responses with promising OS in patients with mRC

252 PD-L1/PD-1, only a subset of people exhibit durable responses, suggesting that a broader view of can

253 only a subset of patients exhibit clear and durable responses, suggesting that other mechanisms must

254 stemic therapies rarely provide reliable and durable responses.

255 omide/dexamethasone resulted in rapid, deep, durable responses.

256 ler for treatment of HIV-associated FLA with durable results at 12 months.

257 ociated with the highest accuracy to predict durable segments (area under the curve=0.73).

258 nd depth, is the most accurate predictor for durable segments.

259 linical setting would require disposable and durable sensors to provide better therapies and quality

260 -GO1 resulted in potent, dose-dependent, and durable silencing of the mRNA encoding glycolate oxidase

261 en thermal and electrical energy by means of durable, silent and scalable solid-state thermoelectric

262 V and EEEV E2/E1 glycoproteins also provided durable, single-dose protection from lethal VEEV and EEE

263 e newly elected parliament must pursue for a durable solution.

264 m-positive bacterium Bacillus subtilis forms durable spores for survival.

265 reagents are "on-chip," and these chips show durable storage stability without cold storage.

266 Developing cheap yet durable substitutes of precious-metal catalysts, especia

267 This durable suppression was due in part to epigenetic change

268 Durable surveillance and programs that emphasize the jud

269 M performed by experienced surgeons provided durable symptomatic relief in 94% of patients with nonsp

270 tallographic imperfections renders them more durable than their bulk counterparts.

271 unotherapy will likely be required to impart durable therapeutic efficacy.

272 and p110alpha/beta may serve as a potent and durable therapeutic regimen for the treatment of HER2+,

273 cell death 1 ligand 1 (PD1/PD-L1) generates durable therapeutic responses in a significant subset of

274 ty profiles, are required for development of durable therapy for these currently intractable disorder

275 llergic immunity abrogated the potential for durable tolerance.

276 ultrasound (HIFU) is a safe, effective, and durable treatment option for the management of osteoid o

277 Robust, functional, and durable Triplex-driven expansions of CMV-specific T cell

278 High-dose SSRS provides durable tumor control when used either as definitive the

279 the same way also displayed more robust and durable tumor control.

280 ligand 1 (PD-L1) resulted in synergistic and durable tumor regression even where either agent alone w

281 ists have now produced a compound that shows durable tumor regression in a lymphoma xenograft model.

282 Cancer immunotherapy can result in durable tumor regressions in some patients.

283 ined inhibition of PI3K and mTOR resulted in durable tumor regressions in three of five PDXs, and the

284 Durable tumor regressions were observed in seven (70%) o

285 Furthermore, we demonstrated evidence of durable tumor-specific antitumor immunity.

286 ted powdery mildew fungus, thus regulating a durable type of defense that works in both host and nonh

287 Durable undetectability of HDV RNA is a valid surrogate

288 rcentage of persons in HIV care who achieved durable viral suppression (all VL results <200 copies/mL

289 Two-thirds of persons in HIV care had durable viral suppression during a 2-year period.

290 We examined durable viral suppression, cumulative viral load (VL) bu

291 care, antiretroviral therapy initiation, and durable viral suppression, will be important components

292 py (ART), and 90% of individuals on ART have durable viral suppression.

293 The pooled rates of durable VR remission were 51.4%, 39.3%, and 38.2% at 12,

294 Durable VR seems to be feasible in a substantial proport

295 Although most patients have durable weight loss after total gastrectomy, weights sta

296 sleeve gastrectomy, produce significant and durable weight loss in both humans and rodents.

297 ential to replicate the strong, instant, and durable wet adhesion of the marine sessile organism.

298 The durable whole-body responses reported, together with the

299 Responses were durable, with median progression-free survival and overa

300 ssential component of safe, efficacious, and durable Zika virus vaccines.