ライフサイエンスコーパス: dwell time

1 patient has lived with the precursor (i.e., dwell time).

2 pore conductance and a prolonged fusion pore dwell time.

3 lity for infection increased with additional dwell time.

4 reby account for lower limits of attentional dwell time.

5 externalization exceeding 20% at >5 years of dwell time.

6 0 mum by 110 mum with a highly uniform pixel dwell time.

7 as hardness number decreasing with increased dwell time.

8 echnical success of retrieval increases with dwell time.

9 ation can be used to estimate a patient's BE dwell time.

10 fide bridges that decreased the channel open dwell time.

11 d reverses for leads with <40 years expected dwell time.

12 d mean open dwell times and shortened closed dwell times.

13 ft the laser beam sample volume during large dwell times.

14 burst durations and shorter mean interburst dwell times.

15 udes every experimental data point, not only dwell times.

16 is less mechanosensitive and has longer open dwell times.

17 ole ICP-MS system using a sufficiently short dwell time (0.1 ms).

18 II-restricted TCRs require a shorter antigen dwell time (0.2 s) to initiate negative selection compar

19 s (SEP) or interlaced lines (INT), different dwell times (2.5-75 micros), and repetition numbers (10

20 was achieved in all patients (mean catheter dwell time, 28 days; range, 3-99 days), with two minor c

21 portion of long bursts), and enhanced closed dwell times (3- to 6-fold increase)].

22 Optimized GC-qMS parameters (dwell time 70 ms, 2 most abundant ions) resulted in stan

23 ,12-DHET dose-dependently increased the open dwell times, abbreviated the closed dwell times, and dec

24 Dwell time analysis indicated that about three hidden st

25 A detailed dwell time analysis of the fluorescence and FRET traject

26 Dwell time analysis reveals that PNU introduces two nove

27 Indeed, channel dwell-time analysis indicates that CHS and EtOH exert op

28 Dwell-time analysis of fluorescence trajectories recorde

29 Dwell-time analysis showed that the affinity of MAP65-1

30 nts for each pathway have been determined by dwell-time analysis, revealing that intramolecular trans

31 In contrast to dwell-time analysis, which is the current standard metho

32 With a 5 ms dwell time and 200 mus settling time, the size detection

33 hy-mass spectrometry acquisition with a 3-ms dwell time and a 1.55-s duty cycle time.

34 Prolonged dwell time and catheter insertion under emergent conditi

35 isplay a linear relationship between average dwell time and dNTP concentration.

36 receptors can be targeted to modulate T cell dwell time and inflammation at effector sites, revealing

37 y useful because EAC risk may change with BE dwell time and it is generally not known how long a pati

38 li MscL, plays a major role in both the open dwell time and mechanosensitivity of the channel.

39 ation, and TNF inhibition reduced neutrophil dwell time and ROS production, as well as renal injury.

40 ed that E2 treatment selectively reduced the dwell time and thereby decreased the confinement of GABA

41 the formed adhesion cluster as a function of dwell time and thereby determine the precise size of the

42 Dwell times and accelerations can be adjusted independen

43 Specifically, their event mean dwell times and amplitudes were sufficiently distinct to

44 stematic comparison of the conductance state dwell times and apparent activation energies for a serie

45 ity (P(o)) than WT, with prolonged mean open dwell times and shortened closed dwell times.

46 ho-dependent termination by increasing pause dwell times and the kinetic window for Rho action.

47 The closed conformation minimized TCR dwell times and thereby prevented activation by membrane

48 sen for data collection (i.e., scan time and dwell time) and the necessary limits of detection requir

49 are able to measure the binding statistics (dwell times) and binding energies of the initial RAG bin

50 t the promoter, resulting in longer promoter dwell time, and an increase in the steady-state populati

51 Data, including efficacy, adverse reactions, dwell time, and catheter type, were collected over a 5-m

52 in (BSA) sample provided narrow peaks, short dwell time, and good peptide coverage.

53 ded on the magnitude of the applied voltage, dwell time, and writing speed.

54 the open dwell times, abbreviated the closed dwell times, and decreased the transition rates from ope

55 um with respect to unitary conductance, open dwell times, and responses to ryanodine and ruthenium re

56 oximately 27), the unitary current, the open dwell-times, and the intraburst closures were all only w

57 change in channel amplitude or open-channel dwell times; and (4) the SUR activator ("KATP channel op

58 types, the pore-blocking current and inverse dwell time are shown to scale linearly at low electric f

59 concentrations of two ligands with different dwell times are adjusted to equalize the level of LAT ph

60 angle, higher-grade perforation, and longer dwell times are associated with complicated IVC filter r

61 are recorded as a discrete time series, the dwell times are quantized.

62 Deposition rates (spot dwell time) are determined by the chromatographic resolu

63 mma(j)) of the main open state, reduced open dwell time at +/-40 mV, and absence of a long-lived subs

64 CLIP-170-EB1 complex also indicates a short dwell time at growing plus-ends, an observation inconsis

65 inding of dNTP to captured complexes affects dwell time at higher dNTP concentrations.

66 hen initially captured predominantly affects dwell time at low dNTP concentrations.

67 nding to microtubules, implying an increased dwell time at microtubule plus ends.

68 o individual synapses increases alpha7-nAChR dwell time at presynaptic sites.

69 orylation is associated with a longer pol II dwell time at start sites and reduced transcriptional po

70 within this pause region and found that the dwell time at the pause sequence decreased with increasi

71 e retention of MinD and MinE and explain its dwell time at this region of bacterial cells.

72 (P=0.0024) but that slope conductance, open dwell times at 0 mV, and distribution between 2 open sta

73 We also show that dwell times at intersections depend on the angle between

74 ttributable to extraction of leads with high dwell time because of infection, recall, or subsequent l

75 tistical analysis did not suggest an optimal dwell time, because this parameter did not significantly

76 The average rate-limiting dwell time between rotation events observed at the satur

77 olecules exhibit a marked alternation in the dwell times between sequential steps, causing these moto

78 A kinetic analysis of the dwell times between steps shows that the 17-nm steps alt

79 reversed by the L224A mutation with reduced dwell times between T cells and DCs.

80 hibited a pronounced difference in mean open dwell-time between redox conditions.

81 the frequency of LCC reopening and the open dwell time, both of which are modulated by Ca(2+) influx

82 rease in hysteresis of "up" and "down" state dwell times, but intrinsic bistability was not observed.

83 Increasing qdots' illuminated dwell time by 10-fold during FCS did not change the frac

84 onged retrievable inferior vena cava filters dwell time by determining the inflection point when the

85 Remarkably, extending CB1R dwell times by preventing endocytosis substantially incr

86 The distribution of discrete dwell times, collected from an "ensemble" of 300 single

87 ions for each conductance level required two dwell-time components, indicating that at each conductan

88 of the receptor complexes displayed multiple dwell-time components.

89 etics at the bilayer surfaces on the channel dwell time, concluding that the change would have to be

90 We show that dwell time contributes significantly to the quality of d

91 ith defined conformations, we found that TCR dwell times controlled Zap70 activity.

92 -1-FAK1 decreased T-cell-dendritic cell (DC) dwell times dependent on LAT-Y171, leading to reduced DO

93 nd IPSA2-0, identical to IPSA2 but without a dwell-time deviation constraint.

94 e; IPSA1-0, identical to IPSA1 but without a dwell-time deviation constraint; IPSA2, without a constr

95 The dwell time distribution of all observable pauses was ind

96 tives of one-dimensional and two-dimensional dwell-time distribution functions and employed the gradi

97 s that make significant contributions to the dwell-time distribution remain.

98 dy binding kinetics, rotational freedom, and dwell time distributions of a Cy5-labeled OTD (L1Cy5-7OT

99 Analysis of the dwell time distributions of single channels suggested th

100 Single-molecule dwell time distributions reveal two, well-differentiated

101 extracted from the images and combined into dwell time distributions that are fitted by kinetic func

102 hannel kinetics were well modeled by fitting dwell time distributions to biliganded activation and in

103 exhibit fast kinetics and single exponential dwell time distributions, with average dwell times of hu

104 bility to use a single kinetic scheme to fit dwell-time distributions arising from a variety of exper

105 This efficient method can be used to study dwell-time distributions for a broad class of molecular

106 based on a simultaneous fit of the observed dwell-time distributions for all conductance levels, usi

107 Analysis of single-molecule dwell-time distributions for each state reveals that for

108 ing boundary method allows global fitting of dwell-time distributions for enzymes subject to differen

109 Statistical analysis of dwell-time distributions from single molecule trajectori

110 e able to use a single kinetic scheme to fit dwell-time distributions observed under different ligand

111 ed the absorbing boundary method to simulate dwell-time distributions of complex kinetic schemes, whi

112 ed absorbing boundary method to experimental dwell-time distributions of single-headed myosin V, and

113 ishable from their retinal counterparts; the dwell-time distributions of the open and closed states i

114 s regular, producing narrow and well-behaved dwell-time distributions that fit a simple drift-diffusi

115 lo were evaluated by fitting two-dimensional dwell-time distributions using maximum likelihood techni

116 The conductance properties and the dwell-time distributions were adequately described by mo

117 Fitting dwell-time distributions with sums of exponentials is wi

118 the impact of undetected transitions on the dwell-time distributions, and by introducing an improved

119 mining how well these described the observed dwell-time distributions, open-shut correlation, and sin

120 Dwell-time distributions, waiting-time distributions, an

121 ental observables such as protein number and dwell-time distributions.

122 Longer dwell times do not correlate with pneumothorax and shoul

123 leads in young patients (>40-year estimated dwell time) driven by high aggregate anticipated risk of

124 ion regression analysis demonstrated that if dwell time exceeded 7 months, the risk of standard techn

125 The optimal dwell time for 40-80 nm particles, limiting both incompl

126 n optimal recording conditions the mean open dwell time for all three mammalian InsP3R isoforms is 7-

127 an alpha-hemolysin nanopore, we measured the dwell time for complexes of DNA with the Klenow fragment

128 is negatively correlated with the respective dwell time for different SH2 domains and the dwell time

129 speed, the forward/backward step ratio, and dwell times for both forward and backward steps.

130 d activation of the UPR while allowing short dwell times for initiation of this response.

131 Mean dwell times for pMHC:TCR molecular binding of 5 and 54 s

132 ay discriminate among ligands with different dwell times for receptor binding through a mechanism cal

133 The analysis of run lengths and dwell times for the two-motor complex, which has only on

134 ) or nonergodic with a broad distribution of dwell times for traps (continuous-time random walk).

135 inating between undocking and fusion events, dwell times for vesicle fusion after vesicle docking to

136 the number of cytoplasmic MTs and prolonged dwelling times for MTs after reaching the hyphal apex.

137 the cycling double-ring system, and thus of "dwell time" for the folding protein in the cis cavity, p

138 distribution functions of the CW and the CCW dwell times have been measured for different CW biases.

139 xist for analysis of the data, including the dwell-time histogram fittings and the full maximal-likel

140 An analysis of dwell time histograms indicated the presence of two clos

141 Open and closed dwell time histograms were fitted by the sum of two and

142 dividual open time constants determined from dwell time histograms, but increased the mean open time

143 Dwell-time histograms are often plotted as part of patch

144 tting of one-dimensional and two-dimensional dwell-time histograms.

145 le inferior vena cava filters with prolonged dwell times; however, there is no precise definition of

146 receptor to an open state and increases its dwell time in an intrinsically occurring closed conforma

147 in reductions in neutrophil recruitment and dwell time in glomerular capillaries and in reactive oxy

148 tigen-presenting DCs and naive T cells whose dwell time in LNs was synchronized.

149 The longer prerigor dwell time in MR may be clinically relevant not only for

150 The dwell time in one of these orientations was significantl

151 e time in their null mode and with increased dwell time in one or more closed states.

152 , we show that BDNF prolonged the average MT dwell time in spines and that this effect was dependent

153 ccounting for long pulses (comparable to the dwell time in t(1)) and short rotation periods.

154 he intrinsic pumping rates but increased the dwell time in the active pumping state.

155 lly incorrect structures produced during the dwell time in the cis cavity.

156 rfere with DNA gate dynamics and shorten the dwell time in the closed state.

157 ected by a mechanism that involves prolonged dwell time in the DZ where selected cells undergo accele

158 ect to symmetrical 1 M KCl, while the duplex dwell time in the nanopore remained acceptable for pulse

159 meation characteristics but with a very long dwell time in the open state.

160 ism for RNAP II pausing in which a prolonged dwell time in the pre-translocated state increases the l

161 We propose a "dwell time in the target zone" model to explain the effe

162 Ca2+ have both easier access to, and longer dwell time in, the Ca2+ binding locus in the pore when t

163 ceptor and its cofactors affect each other's dwell times in an asymmetric manner.

164 ients and allowed for sustained (>10-minute) dwell times in an upper-body perfusion circuit.

165 closed state of the DNA gate and to measure dwell times in each state.

166 oach brought on by the advent of microsecond dwell times in single particle ICP-MS allows for the det

167 , yielding insights into the distribution of dwell times in the paired complex and the propensity for

168 The median device dwell time (in d) differed across cannulation sites (p <

169 sitors and scan sampling showed substantial 'dwell times' in the Centre by common zoo standards and t

170 direction (P < .0001), while perforation and dwell time increased risk of a complicated retrieval by

171 Average nanopore dwell time increased without saturating as a function of

172 tics show even stronger dependence, with the dwell time increasing about 20-fold.

173 With dwell time increasing from 5 sec to 6x10(4) sec, the har

174 as a sigmoidal relationship to the crossover dwell time, indicating a strong bias for longer-lived cr

175 ignalling, whereas those eliciting prolonged dwell times induce robust signalling.

176 This has pushed pixel dwell times into the time domain of nanoseconds, resulti

177 This dwell time is 100-fold shorter than previously reported

178 n InsP3R isoforms is 7-8 ms, the mean closed dwell time is approximately 10 ms; 4), InsP3R2 has the h

179 dwell time for different SH2 domains and the dwell time is positively correlated with the local densi

180 n one G protein molecule because the odorant dwell-time is very brief.

181 Longer dwell times (mean, 29 minutes; range, 12-66 minutes) did

182 We analyzed these dwell time measurements in the framework of a two-state

183 5% versus 68%; P=0.05), and had shorter lead dwell time (median, 3.0 versus 4.0 years; P<0.0001) and

184 the signal passes to second messengers, the dwell time no longer regulates the signal.

185 during reorientation were illustrated using dwell time normalized visual maps.

186 y explain the long and widely distributed LN dwell times observed in vivo.

187 38%-56%; P<0.0001), and emergency department dwell time of </=20 minutes (33%-43%; P<0.0001).

188 nges rapidly at microtubule plus-ends with a dwell time of <1 s, indicating that single EB1 molecules

189 e externalized leads, 0%, 13%, and 26% had a dwell time of <3 years, 3 to 5 years, and >5 years, resp

190 Central venous catheters with a median dwell time of 11 days were examined.

191 A spatial resolution of 4 nm and a pixel dwell time of 20 micros were obtained.

192 ed successfully to all patients, with a mean dwell time of 3.0+/-0.4 minutes.

193 The optimum dwell time of 80 ms yielded a measured 201Hg/202Hg isoto

194 ate constant of the order of 0.04 s(-1): the dwell time of a given stator in the motor is only approx

195 In reversible adhesion events, the dwell time of cells at the surface before departing was

196 h lower than in noninfected strains, and the dwell time of cryparin within the cell after labeling wa

197 important to find conditions under which the dwell time of cyclodextrins in the lumen of the pore is

198 gs to block translocation and to prolong the dwell time of EF-G on the ribosome.

199 is that the S670G point mutation reduces the dwell time of glutamate in its binding site.

200 e in proteostasis whereby Aha1 regulates the dwell time of Hsp90 with client.

201 the diffusion coefficient and decreases the dwell time of KCC2 at excitatory synapses.

202 Ps and rNTPs diminished the average nanopore dwell time of KF-DNA complexes in a concentration-depend

203 The average nanopore dwell time of KF-DNA complexes increased as a function o

204 ing within the PSD may modulate the synaptic dwell time of many TM proteins important for synaptic fu

205 that disrupted the pause hairpin reduced the dwell time of RNA polymerase at the pause site dramatica

206 We found that the dwell time of SH2 modules within the TIR illumination fi

207 hat MinK enhances blockade by increasing the dwell time of TEA on its pore site from approximately 70

208 with the H5 region helping to determine the dwell time of the channel in the open state.

209 the mean velocity, mean run length, and mean dwell time of the kinesin-1 motors decreased upon increa

210 Dwell time of the polymerase at this pause site was sign

211 The dwell time of the substate, which is inversely related t

212 f DPN to control feature size by varying the dwell time of the tip on the surface, and variation of t

213 counted for entirely by the prolonged thymic dwell time of Tregs.

214 ion, single-molecule studies showed that the dwell time of ubiquitin conjugates at the proteasome was

215 tio accuracy and precision were evaluated at dwell times of 10, 20, 40, 80, and 160 ms using SRM 3133

216 o an applied force of 110 pN, we measure the dwell times of 1647 unfolding events of individual ubiqu

217 the specimen surface at a load of 10 N with dwell times of 5 sec to 6x10(4) sec.

218 The beta1-subunit increased the open dwell times of all three isoforms and decreased the clos

219 The dwell times of different macromolecular structural or fu

220 a comprehensive analysis on the intranuclear dwell times of four steroid receptors and a number of kn

221 ntial dwell time distributions, with average dwell times of hundreds of milliseconds.

222 all three isoforms and decreased the closed dwell times of MANG and MDAL but increased the closed dw

223 es of MANG and MDAL but increased the closed dwell times of MSSN.

224 to "limp", i.e., exhibit alternation in the dwell times of successive steps.

225 erpretations of FDAP/FRAP data have revealed dwell times of tau on MTs in the range of several second

226 ecomes large compared to the open and closed dwell times of the channel, that is, on average the chan

227 Different dwell times of the FRET states were found for the distin

228 his analysis, we fit the fluctuations in the dwell times of the packaging motor of the bacteriophage

229 tes, through reducing the occurrence and the dwelling time of the long closed states whilst increasin

230 ysis, we have quantitatively measured RAG1/2 dwell time on 12RSS, 23RSS, and non-RSS DNA, confirming

231 ore, a systematic study of the dependence of dwell time on DNA length reveals a single power-law scal

232 This indicates that tau's dwell time on microtubules is sufficiently long to influ

233 but not the control condition, also altered dwell time on socially threatening faces not used in tra

234 Dwell time on socially threatening faces was assessed du

235 rget, but instead function by increasing the dwell time on target RNA.

236 aperonin, trapping experiments show that its dwell time on the complex is only 20 seconds.

237 only do the adducts influence the polymerase dwell time on the DNA but also its binding position and

238 alkylating agents, they will have increased dwell time on the topoisomerase II-DNA complex and incre

239 but not the control condition, also reduced dwell time on threat, which partially mediated clinical

240 We analyze single-protein dwell times on DNA for different flow rates and conclude

241 n naive cell correlated with the TCR-p:MHCII dwell time or the amount of p:MHCII.

242 both undamaged and damaged DNA show multiple dwell times over three orders of magnitude: 0.3-0.8, 8.1

243 d a lower number of fixations and normalized dwell time per ROI compared with others, suggesting a mo

244 The dwell time per sample and the number of samples to colle

245 Deubiquitinases reduce polyubiquitin dwell times preferentially on clients that dissociate mo

246 We assessed patient age/sex, filter dwell time, procedural technical success, the use of adv

247 Agonists inducing short endocytic dwell times produce little or no beta-arrestin signallin

248 ange of TCR-pMHC interaction.This restricted dwell-time range is consistent with the exclusion of eit

249 t T cell activation occurs within an optimal dwell-time range of TCR-pMHC interaction.This restricted

250 Based upon dwell time (range = 15-30 s) of the calcium waveform, th

251 The dwell time ranged from 1.0 to 4.0 minutes, depending on

252 wever, this is difficult to reconcile with a dwell time recently measured by single-molecule analysis

253 f the transient fusion pore by measuring its dwell time, relation to vesicular size, flickering and d

254 y, distribution in the colon, prognosis, and dwell time required for progression from adenoma to carc

255 Our dwell-time resolution of 2.5 mus enables translocation t

256 Statistical analysis of the preceding dwell times reveals that multiple ATPs bind during each

257 ximum likelihood algorithm that extracts the dwell time sequence from noisy data, and estimates state

258 ood approaches that fit either the idealized dwell-time sequence or more ambitiously the noisy data d

259 lization of noisy recordings into continuous dwell-time sequences.

260 The dwell times showed a broad distribution, but were longer

261 aneous channel opening, with open and closed dwell times similar to those of maximally activated WT G

262 els exhibited only two open states with mean dwell times similar to those of the two shorter open sta

263 the results on the general properties of the dwell-time statistics and the mechanism for ultrasensiti

264 dissipative allosteric model that generates dwell-time statistics consistent with the experimental r

265 on a general result on the properties of the dwell-time statistics for all equilibrium models, we sho

266 quilibrium models, we show that the observed dwell-time statistics imply that the flagellar motor swi

267 ficant fraction of molecules (characteristic dwell time tau = 192 +/- 15 s and tau = 98 +/- 15 s for

268 axation is strongly limited kinetically by a dwell time that is much shorter than the relaxation time

269 tly to the quality of data, with the optimal dwell time that limits split particle events, particle c

270 sed of non-synchronized cells with different dwell times that display heterogeneous behaviour in mous

271 CB1R), we identify ligand-specific endocytic dwell times, that is, the time during which receptors ar

272 the need for these cell gases, as at shorter dwell times the proportion of signal attributed to a nan

273 /min AF4 channel flow rate, and 5 ms spICPMS dwell time, the AF4-spICPMS can detect and quantify 40-8

274 Dwell time, the time between pleural puncture and needle

275 elocity in nanotubes that limits the carrier dwell time; the high spin polarization in the manganite

276 predicts the observed differences in antigen dwell-time thresholds used by MHCI- and MHCII-restricted

277 phils and macrophages, yet have a sufficient dwell time to prey on pathogens.

278 between the barrier profiles as well as the dwell time to spin lifetime ratio are crucial factors fo

279 chromatography/mass spectrometry using short dwell times to accommodate fast-eluting chromatographic

280 We then derive a binomial distribution of dwell times to describe the stochastic dynamics of prote

281 As a result, the mapping of dwell times to logarithmically spaced bins is highly irr

282 exhibits much slower kinetics, extending the dwell times to tens of seconds.

283 companied by significantly increased overall dwell times, tripling for the most committed two thirds

284 ential fits to the distribution of unfolding dwell times under force-clamp.

285 heme in which particles in cages with random dwell times undergo correlated motions owing to interact

286 Selective RPE damage is feasible with dwell times up to 15 micros.

287 Dwell time was 2 hours.

288 Dwell time was also recorded.

289 ved analysis that identified that the safest dwell time was extended to the first 9 days for centrall

290 Newborns' average dwell time was negatively associated with childhood surg

291 The dwell time was shorter by orders of magnitude than that

292 The mean dwell time was slightly longer for SCV catheters (103 da

293 Logistic regression identified that dwell time was the only risk factor for failure of stand

294 erior tilt angle, degree of perforation, and dwell time were higher for the complicated versus non-co

295 Individual dwell times were long enough to discriminate pMHC half-l

296 d the appearance of flickers and reduced the dwell time when astrocytes were mechanically stimulated,

297 Syt1 reduced the dwell time when astrocytes were stimulated either mechan

298 ubclavian catheter placement had the longest dwell time with a median of 16 days (interquartile range

299 eptor can induce T-cell motility and shorten dwell times with dendritic cells (DCs).

300 subsets exhibited an increased steady state dwell time within splenic MZ areas.