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1 o noxious stimulation alone and/or together (dyads).
2 hat GH5_pMut bound to the nucleosome off the dyad.
3 on from experiments on a fullerene-porphyrin dyad.
4 modated in pockets remote from the catalytic dyad.
5 e "built-in" guanidine/guanidinium catalytic dyad.
6  for a covalently linked porphyrin-fullerene dyad.
7 ts as novel functional groups binding to the dyad.
8  effect on the dynamics of CS and CR in this dyad.
9 distance of the PAM site from the nucleosome dyad.
10 stem or a HORMA domain-PCH2-like AAA+ ATPase dyad.
11 extrusion of 10-30 bp of DNA near the pseudo-dyad.
12 g of inhibitors and protons localized at the dyad.
13 ains such an interacting tyrosine-tryptophan dyad.
14 d Asp38 and Asp104 as an essential catalytic dyad.
15  was especially important within the marital dyad.
16 gina were collected for each maternal-infant dyad.
17 ses are studied primarily as a host-pathogen dyad.
18           Analyses included 752 mother-child dyads.
19 ary intake between sex-specific mother-child dyads.
20  a clinical birth cohort of 40 mother-infant dyads.
21   The authors enrolled 1,016 caregiver-child dyads.
22 er behavioral performance than female/female dyads.
23  a national, large sample of caregiver-child dyads.
24 eness of contemplative practice performed in dyads.
25 ons are not based on trust, or bonds, within dyads.
26 ncluded 26 parent-infant (aged 10-16 months) dyads.
27 cant coherence was not observed in mixed-sex dyads.
28 domized controlled study of 97 mother-infant dyads.
29 l evidence that they appropriately target to dyads.
30 V-infected and HIV-uninfected mother-newborn dyads.
31 ed compared to HIV-uninfected mother-newborn dyads.
32 t of allergic and non-allergic mother/infant dyads.
33 ncinnati, Ohio, area among 398 mother-infant dyads.
34 e white-tailed deer (Odocoileus virginianus) dyads.
35 and in bad weather compared with the control dyads.
36 he 13-13' linked chlorin and bacteriochlorin dyads.
37 MHC relatedness in male-male and male-female dyads.
38 inical convenience sample of 80 mother-child dyads.
39 ction is localized on the carotenoid in both dyads.
40 ns compared to HIV-uninfected mother-newborn dyads.
41  in mother-daughter dyads than in mother-son dyads.
42  outcomes for 157,145 (99.7%) mother-newborn dyads.
43 of standardized case scenarios of caregiving dyads.
44 ural contingencies exist within adult-infant dyads.
45 d (1.49 [0.12] sessions) and the perspective dyad (1.06 [0.12] sessions) and increased over time for
46 ss increased during a session for the affect dyad (1.49 [0.12] sessions) and the perspective dyad (1.
47 ized, single-blind, clinical trial among 217 dyads (1 parent: 1 teenaged learner's-permit holder) to
48 .43] sessions) and was higher for the affect dyad (10.11 [0.46] sessions) than the perspective dyad (
49                  Among the 40 patient-parent dyads (22 female children and 18 male children; mean [SD
50 tion (3.63 [0.20] sessions), and perspective dyad (3.24 [0.18] sessions).
51 ss meditation (3.78 [0.18] sessions), affect dyad (3.59 [0.14] sessions), observing-thoughts meditati
52 bstantial longevity, in which one particular dyad [4(bpyP)] exhibits the highest activity, generating
53                   Of the 129 patients in the dyads, 68 were boys, and 61 girls; of the 129 parents, 1
54                  Data were available from 77 dyads (74% of enrolled).
55 (10.11 [0.46] sessions) than the perspective dyad (8.41 [0.46] sessions).
56             We re-enrolled 1302 mother-child dyads (87% of the 1489 dyads in the original enrolment)
57  meditation (11.20 [0.40] sessions) than the dyads (9.26 [0.43] sessions) and was higher for the affe
58 its persistence of about 50-60 ns makes this dyad a potential electron-transporting catalyst to carry
59 enediimide radical anion (Re(I)-bpy-PDI(-*)) dyad, a prototype model system for artificial photosynth
60 ternans, wherein the probabilistic nature of dyad activation and recruitment was constrained.
61 tus and pregnancy outcomes in maternal-child dyads affected by gestational diabetes (GDM).
62                    Forty percent (72/180) of dyads allocated to iCST completed at least two sessions
63 Sterically imposed nonplanar geometry of the dyad allows the access of nonparallel arrangement of the
64 sectional study in which 836 caregiver-child dyads among 3 race/ethnic groups completed the questionn
65                                      The CpG dyad, an important genomic feature in DNA methylation an
66 ort on 41 fragments binding to the catalytic dyad and adjacent specificity pockets.
67 e H1 globular domain contacts the nucleosome dyad and both linkers, associating more closely with the
68 idue H3(T118) is located near the nucleosome dyad and can be phosphorylated.
69 ned team members observed each nurse-patient dyad and completed the Nurse-Patient Bonding Instrument.
70 omal DNA 1 to 1.5 turns from the nucleosomal dyad and in doing so, it positions the SET domain for ca
71 to obtain covalently linked azaBODIPY-BODIPY dyads and azaBODIPY-(BODIPY)2 triads.
72 end such experimentation drastically, beyond dyads and beyond laboratory walls, to identify neural ma
73 lude effects and covariates for individuals, dyads and populations, which can be constant or variable
74                                          The dyads and triads were characterized in detail by HR-MS,
75 aw general rules for the design of PDI-based dyads and triads with proper self-assembling properties
76 their independent characteristic features in dyads and triads.
77 fer from BODIPY unit(s) to azaBODIPY unit in dyads and triads.
78 nction in both humans (n = 128 mother/infant dyads) and rats (n = 12 dams; 28 adolescents).
79 tinctive configurations (i.e. hilate monads, dyads, and permanent tetrads).
80 le residues in BACE-1 including its aspartyl dyad are computed and compared between apo and inhibitor
81           Three amidoquinoline-naphthalimide dyads are designed and synthesized in 67-73% overall yie
82                    Stress levels in stranger dyads are higher than in cagemate dyads or isolated mice
83                             Cis and trans AA dyads are proposed to arise when A reacts with anti-MA i
84 scopic and electrochemical properties of the dyads are the sum of the individual chromophores (Bodipy
85 the delivery of such a homogeneous molecular dyad as designed (e.g., optimal molar ratio) is extremel
86 alysis revealed a highly conserved catalytic dyad as well as conserved substrate and cation-binding s
87 close contact with DNA around the nucleosome dyad as well as extranucleosomal DNA.
88                In the hypothalamus-pituitary dyad as well as the rest of the brain, the majority of T
89 ontagion of pain in mouse and human stranger dyads, as did a shared gaming experience (the video game
90  how to create covalently bound nanoparticle dyad assemblies on a colloidal template and studies phot
91  study was conducted among 40 patient-parent dyads at a pediatric dermatology clinic at the Children'
92 ect is asymmetric relative to the nucleosome dyad axis and is regulated by histone modifications.
93 ection of nucleosomal DNA on one side of the dyad axis during chromatin remodeling.
94 T=(m)CG CPDs over a full helical turn at the dyad axis of a nucleosome and find that whereas photopro
95 adjacent DNA gyre 1.5 helical turns from the dyad axis of symmetry.
96 nding asymmetry in MNase protection near the dyad axis, suggesting that the loss of DNA contacts arou
97 stone-DNA contact points with respect to the dyad axis.
98            Heavy atom-free BODIPY-anthracene dyads (BADs) generate locally excited triplet states by
99                              Compared to the dyad binders, bulkier fragments occupy these regions.
100  is different from the recently reported off-dyad binding mode of Drosophila linker histone H1.
101                                       The on-dyad binding mode of the H5 globular domain is different
102 ular domain of H5, are consistent with an on-dyad binding mode.
103  magnitude compared to that in the reference dyads Bodipy-NDI and TAPD-Ru, as it passes from about 3
104 etrad lies higher than that in the reference dyads (Bodipy-NDI and TAPD-Ru), leading to the energy ef
105 the excited-state dynamics of donor-acceptor dyads, but their involvement could never be unambiguousl
106 6 home visits delivered to 220 mother-infant dyads by specially trained community health workers.
107 inucleotide sequences relative to nucleosome dyads can be directly determined from genome-wide nucleo
108 tuents covalently linked to C60 , as a novel dyad capable of generating charge-separated states of hi
109 formation of charge-separated state in these dyads, capable of harvesting light energy from the near-
110  analytic approach focused on a mother-child dyad case-control design, but it also allowed analyzing
111 ing activity of DNA polymerase beta near the dyad center, with H3K14Ac exhibiting stronger inhibition
112 de gap at specific locations relative to the dyad center.
113 al correlations were found between genes and dyad characteristics, which may explain abnormalities re
114 ecember 2009 to March 2013, 172 parent-child dyads completed FBT and were then randomized to 8 months
115                                              Dyads completed self-report measures of mindfulness (Cog
116              A high potential donor-acceptor dyad composed of zinc porphyrin bearing three meso-penta
117                                          New dyads consisting of a strongly absorbing Bodipy (dipyrro
118 red calcium transient, which is initiated at dyads consisting of ryanodine receptors (RyRs) at sarcop
119 enylporphyrin free base tetraphenylporphyrin dyad constitutes the minimum extreme.
120  to use a histidine residue within a His-Asp dyad contained in a signature sequence as their catalyti
121                                              Dyads containing at least one male demonstrated signific
122                              Each of the new dyads contains either a bipyridine (bpy) or phenanthroli
123                   A total of 646 woman/fetus dyads contributed 1376 ultrasonographic scans to this an
124  catalyzing enzyme, peroxidasin, represent a dyad critical for tissue development, which is conserved
125 repulsion in naphthalimide-naphthalene (NIN) dyad destabilizes the planar geometry between the consti
126         A control group of 229 mother-infant dyads did not receive the intervention.
127 lcium spark propagation in relation to inter-dyad distances.
128 in living cells enables visualization of the dyads distribution, promising new imaging applications.
129 tween participants, are typically limited to dyads, do not investigate social dynamics across time, a
130 o have important impacts on the mother child dyad during pregnancy.
131 udy information flow between brains of human dyads during real-time social interaction in a joint att
132 three pairs of chimpanzees (mother/offspring dyads) during an experimentally induced turn-taking scen
133                               Donor-acceptor dyads, each containing a single anthranilamide moiety, d
134              Upon photoexcitation of the NIN dyad, electron transfer from naphthalene to the singlet
135                                Contemplative dyads elicited engagement similar to classical contempla
136 ctron tomography to produce en-face views of dyads, enabling a direct examination of RYR2 distributio
137     Mif2 contacts one side of the nucleosome dyad, engaging with both Cse4 residues and AT-rich nucle
138 ficantly with females, whereas the remaining dyads (F-F, M-M) overlapped significantly less.
139 , which is part of a highly conserved AspGlu dyad found in all dual domain PGTs, as the active-site n
140  performed simulations for each mother-child dyad from two studies in which maternal PFAS levels at d
141 IV)-uninfected and HIV-infected child-mother dyads from 2007 to 2009 (pre-PCV era), in 2010 (7-valent
142 ta on 3,139 female social network friendship dyads from 3 waves of the National Longitudinal Study of
143                               Maternal-fetal dyads from January 2001 through June 2014 were included.
144 his cohort study included 3033 mother-infant dyads from the Canadian Healthy Infant Longitudinal Deve
145 analysis included 918 mother-singleton child dyads from the Danish National Birth Cohort.
146 tant to know which specific GEF-small GTPase dyad functions in a given cellular process.
147 nt-dielectric constant dependence of Phif in dyads gives an opportunity to construct environmentally
148 s varying from <5% (M group, Mahale) to >30% dyads grooming (Kanyawara, Kibale), and in a large free-
149 ommunities, samples of at least 100 observed dyads grooming with raised hands showed PPC frequencies
150  sanctuary group, the frequency reached >80% dyads (group 1, Chimfunshi) [1, 2].
151  the part of the patients; patients in these dyads had the highest prevalence of hospitalizations for
152                       Sixty-seven percent of dyads harbored HPV.
153  of two isomeric carotenoporphyrin molecular dyads having different conformations and therefore diffe
154 tion of the characteristic His-Cys catalytic dyad (His(99) and Cys(136)), and an Asp (Asp(134)) in th
155 neole conversion is initiated by a catalytic dyad (histidine-502 and glutamate-249), acting as a base
156 nd implicate a previously unexamined Asp-Thr dyad in catalysis of the cyclodehydration reaction.
157 r mechanism implies a role for the beta2 Y-W dyad in electron transfer.
158                         The CD40/CD40 ligand dyad in endothelial cells (EC) has a central role in pro
159           Fluorescence quantum yield of each dyad in nonpolar solvent (toluene) is comparable with th
160 smic region, and that mutation of a cysteine dyad in this motif preserves protein localization, but s
161  placentas and cord blood of 90 mother-child dyads in association with the methylenetetrahydrofolate
162 cy virus (HIV)-infected pregnant woman/fetus dyads in Cape Town, South Africa.
163 ants and psychiatric populations engaging as dyads in multi-round exchanges such as a repeated trust
164 led 1302 mother-child dyads (87% of the 1489 dyads in the original enrolment) for assessment when the
165 IN1-induced microdomains recruits P-RyR into dyads, increasing the calcium transient while preserving
166 of how the sex composition of an interacting dyad influences the brain and behavior during cooperatio
167            Of 705 participating mother-child dyads interviewed at the end of the Thinking Healthy Pro
168          This type of high-energy harvesting dyad is expected to open new research in the areas of ar
169       At intermediate pH, when the catalytic dyad is monoprotonated, a binding-competent state is hig
170 ement of RYR2 tetramers within the mammalian dyad is neither uniform nor static.
171    Formation of a high percentage of A-alt-B dyads is proposed to rely on an inversion of chirality a
172 bstrate deprotonation, driven by the His/Asp dyad, is an essential requirement for its activation.
173                                Indeed in dog dyads it was also less likely that both members simultan
174 with ascorbic acid as an electron donor, the dyad linked to Pt-TiO2 via a phosphonate or carboxylate
175 g: the transporters are organized within the dyad, linking the transverse tubule and sarcoplasmic ret
176 nd that of the more competent member of each dyad matched closely, supporting the hypothesis that mer
177        This study recruited 172 parent-child dyads (mean [SD] age: parents 42.3 [6.4] years; children
178    Participants included 180 mother-daughter dyads; measures were mothers' reports of controlling fee
179                                     A simple dyad model can be used to predict which excitations are
180 tones bind to the nucleosome with on- or off-dyad modes, respectively.
181 zer (i.e., diiodo-distyryl-BODIPY) to form a dyad molecule (RET-BDP).
182 he study includes primiparous mother-newborn dyads (n = 291) and was conducted at the Penn State Milt
183                                  Teen-parent dyads (N=28) were recruited from the community, Emergenc
184 [SD] age, 24.0 [3.4] years]) investigated as dyads, neural coupling was found to be associated with d
185 ex, while significant coherence in male/male dyads occurred in the right inferior prefrontal cortex.
186 aves with the second oxidation of the phenol dyad occurring at larger positive potential than that of
187 ve Phe substitution in the His-Asp catalytic dyad of CurJ-DH to elucidate substrate-enzyme interactio
188 lar results were obtained when the catalytic dyad of PNPLA3 was inactivated by substituting the catal
189 fficient at translational positions near the dyad of strongly positioned nucleosomes in the yeast gen
190              The globular domain sits on the dyad of the nucleosome and interacts with both DNA linke
191                                              Dyads of 494 patients and their partners were randomly a
192                                           LL dyads of a male and a female spent significantly more ti
193                               A total of 229 dyads of asthmatic children and their parents enroled in
194 ools were administered to 129 patient-parent dyads of hospital-based pediatric oncology ambulatory cl
195  profound increase in social interactions in dyads of monkeys highly familiar with each other.
196 ent high-resolution map of distances between dyads of neighboring nucleosomes in Saccharomyces cerevi
197 onfiguration occurs between FOXA1 motifs and dyads of nucleosomes genome-wide.
198                   Among separate analyses of dyads of parents and their adult children and dyads of s
199     Interpersonal motor coordination between dyads of patients (n = 45) or healthy controls (n = 45),
200                                              Dyads of patients and their partners were randomly assig
201 yads of parents and their adult children and dyads of spouses, the concordance between the chronic di
202 Non-escalation was highest in RHP asymmetric dyads of the second contest, irrespective of experience.
203 ormone analysis, we test the hypothesis that dyads of three-spined stickleback fish (Gasterosteus acu
204 ldcare, and sick care) among 2,161 household dyads of Tsimane' horticulturalists, using Bayesian mult
205 tan veterans and in-depth assessments of 197 dyads of veterans and collateral informants.
206                                In all, seven dyads, one triad, and nine benchmarks in toluene and ben
207                        Finally, for same-sex dyads only, task-related inter-brain coherence was posit
208                      Although both a "simple dyad or a population of thousands" are groups, these are
209 ection of a new or recurrent melanoma by the dyad or physician.
210 n stranger dyads are higher than in cagemate dyads or isolated mice [2, 3], suggesting that stress mi
211 for surface trafficking, localization to the dyad, or adrenergic stimulation of CaV1.2 in adult cardi
212                       The porphyrin-perylene dyad P-PMI displays the most even spectral coverage from
213 05]), increasing more steeply for the affect dyad (P < .001).
214 ht.Data were available for 4689 mother-child dyads participating in Generation R, a prospective birth
215 y conjugated perylenediimide-bridge-perylene dyad (PDIPe) has been investigated in dichloromethane us
216 ransfer (RET) mechanism to construct a novel dyad photosensitizer which is able to dramatically boost
217 iction and the ability to predict nucleosome dyad positions is attributed to bending energy that is a
218         The model successfully predicted the dyad positions of nucleosomes assembled in vitro and the
219 it consisting of rod bipolar cells and their dyad postsynaptic targets, AII and A17 amacrine cells, w
220                    A rhodamine-naphthalimide dyad probe, 1, that selectively responds to the addition
221                   Half of the patient-parent dyads received a simple, 3-step instruction sheet on how
222 ion-to-treat analysis of 897 caregiver-child dyads receiving 1 y of INT.
223 major novelty of BOCTOPUS2 is the use of the dyad-repeat pattern of lipid and pore facing residues ob
224                                      The TDP dyads reported more practice in 5 of the 6 environments
225                                Contemplative dyads represent a new type of intervention targeting soc
226                                 This pair of dyads reproduces the characteristics of fast and slow T-
227                                Female/female dyad's exhibited significant inter-brain coherence withi
228 clinical programs that involve heart failure dyads should tailor strategies to take into consideratio
229 tion spectra and cyclic voltammograms of the dyads show that the spectroscopic and electrochemical pr
230          Prior to intentional imitation, the dyad shows mimicry behaviors, which are automatic, but d
231 (slope of 0.023 [0.004]) and the perspective dyad (slope of 0.006 [0.005]), increasing more steeply f
232 (slope of 0.016 [0.003]) and the perspective dyad (slope of 0.012 [0.003]).
233 ions) and increased over time for the affect dyad (slope of 0.016 [0.003]) and the perspective dyad (
234 isclosure increased over time for the affect dyad (slope of 0.023 [0.004]) and the perspective dyad (
235       Both the patient and the parent in the dyad spoke English, and all participating parents provid
236  of co-oligomers has been synthesized with a dyad structure (AD) or a triad structure (DAD and ADA) i
237                 An analysis of mother-infant dyads suggested that these variants act at the level of
238 localized binding to a sequence with partial dyad symmetry -20 and +38 relative to the sabA +1 site.
239 hich comprise 20 imperfect copies of a 30-bp dyad symmetry enhancer and an origin for DNA replication
240 ) proteins and have an alphaherpesvirus-like dyad symmetry Ori-Lyt domain.
241         Mutations to one of the sequences of dyad symmetry substantially reduced SaiR binding and Sai
242 or-Lst8 heterodimers assemble further into a dyad-symmetry dimer mediated by Tor-Tor interactions.
243  this activator binding site, disrupting the dyad-symmetry element, caused constitutive, B6 -independ
244 a > 1.2 ns) as compared to that of monomeric dyad (taucrm < 110 fs), monitored using femtosecond tran
245                    A porphyrin-fullerene C60 dyad (TCP-C60) substituted by carbazoyl groups was used
246 ded to be slightly higher in mother-daughter dyads than in mother-son dyads.
247 eration of a guanidine-guanidinium catalytic dyad that can act both intermolecularly and intramolecul
248 ne or both residues of the conserved Tyr-Ser dyad that has previously been implicated in KR-catalyzed
249  analysis of Fpn reveals a His-Cys catalytic dyad that is characteristic of C11-family cysteine prote
250 ed with characteristics of the breastfeeding dyad that may reflect changing infant needs.
251 dule), loving-kindness meditation and affect dyad (the affect module), and observing-thoughts meditat
252 bserving-thoughts meditation and perspective dyad (the perspective module).
253 ed (Pt-TiO2) so that the light absorber (the dyad), the electron conduit (TiO2), and the catalyst (at
254                                       In the dyad, the electronic transition dipole moment of the ele
255                                     In these dyads, the Bodipy dye is bonded directly to the benzened
256 APD-Ru, as it passes from about 3 ns in each dyad to 850 ns in the tetrad.
257 water-mediated proton transfer from aspartyl dyad to the substrate, as well as structural flexibility
258                   Among the 26 parent-infant dyads, toy type was associated with all outcome measures
259                            Upon aggregation, dyad TPEP forms a fluorescent nanoaggregate which was co
260 ing the perceived consonance of all possible dyads, triads, and tetrads within a single octave.
261 erences between associations among different dyad types and geographical locations.
262   The strong electronic coupling between the dyad units gives rise to a CT band.
263       Aggression was significantly higher in dyads using only their left antennae (LL) than it was in
264 ll showed that the tetramer packing within a dyad was nonuniform containing a mix of checkerboard and
265 ypertension and diabetes in the adult-parent dyads was statistically significantly negative (aOR = 0.
266                 Using baseline data from 482 dyads, we calculated prevalence ratios to evaluate candi
267                     In 176 patient-caregiver dyads, we found that worse caregiver mental health predi
268 sed hyperscanning in 111 same- and mixed-sex dyads, we identified significant behavioral and neural s
269  liking of vegetables in both members of the dyad.We conducted a randomized controlled study of 97 mo
270                Five donor-acceptor molecular dyads were constructed using zinc porphyrin and free bas
271 ramme randomised controlled trial, 584 (83%) dyads were enrolled.
272 e interviewed separately at baseline, and 15 dyads were interviewed again after at least 3 mo and ano
273                            Finally, 21.2% of dyads were labeled as expert and collaborative because o
274                                     56.4% of dyads were labeled as inconsistent and compensatory beca
275                                     22.4% of dyads were labeled as novice and complementary because p
276 ure self-care that was generally poor; these dyads were predominantly older adults with less severe h
277                   Half of the patient-parent dyads were randomized for a secondary analysis to receiv
278                            1302 mother-child dyads were re-enrolled between Jan 1, 2013, and March 31
279                    Twenty-five mother-infant dyads were recruited from the University Hospital at the
280                       Forty-one parent-child dyads were recruited to participate in this longitudinal
281  several photosensitizer-photochromic-switch dyads were reported as a potential means of the (1) O2 c
282                 A total of 752 infant-mother dyads were screened and 139 of 195 qualified neonates we
283                                     Overall, dyads where BODIPY is attached at the 10-position of chl
284 urrence of plant uses between individuals in dyads (which we define as their "shared knowledge" of pl
285 hat phenol oxidation is modulated within the dyad, which exhibits a splitting of one-electron waves w
286 ing the previously identified Tyr-19-His-132 dyad, which indicated an energetically unfavorable mecha
287 energy transfer (>0.90) is observed for each dyad, which is manifested by nearly exclusive emission f
288  also the synthesis of key intermediates and dyads, which appear useful for the understanding of the
289                         In contest 2 control dyads, which only had experience of one prior contest, a
290 ges of a spiropyran-merocyanine photochromic dyad, while drug quantification was enabled using a Fors
291                                 Mother-child dyads who participated in the Thinking Healthy Programme
292  an aniline-triazine electron donor-acceptor dyad with an alkyne spacer has been investigated using a
293 ultrasonographic scans to this analysis: 132 dyads with >/=25 weeks, 326 with 10-24 weeks, and 188 wi
294                                              Dyads with BODIPY attached at the 10-position of chlorin
295 ruction of highly substituted stereochemical dyads with excellent stereocontrol.
296 ly occurring archetypes of patient-caregiver dyads with respect to patient and caregiver contribution
297 idal sporangia containing monads formed from dyads with ultrastructure closer to that of higher plant
298 um as well as BM samples in 31 mother-infant dyads within the first 15 post-partum months utilizing p
299 localisation of these two structures to form dyads within which calcium-induced-calcium-release occur
300  a xanthene backbone is akin to the tyrosine dyad (Y730 and Y731) of ribonucleotide reductase.

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