ライフサイエンスコーパス: dysbindin-1

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1 Dysbindin-1, a protein that regulates aspects of early a

2 ctional roles of the three major isoforms of dysbindin-1, (A, B, and C) remain unknown, we generated

3 an hippocampal formations revealed that both dysbindin-1 and snapin are concentrated in tissue enrich

4 trophysiological deficits related to reduced dysbindin-1 and the potential role of PV cells, we exami

5 Further studies of dysbindin-1 and the proteins with which it interacts can

6 ucleotide polymorphisms in the gene encoding dysbindin-1 at 6p22.3.

7 We explored in dysbindin-1-deficient mice (dys-/-) (1) schizophrenia-re

8 Dysbindin-1 disruption altered dopamine-related behavior

9 tions in the gene encoding the novel protein dysbindin-1 (DTNBP1) are among the most commonly reporte

10 The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been

11 ne-protein phosphatase-alpha (RPTPalpha) and dysbindin-1, each of which reduces Src activity via prot

12 The gene encoding dysbindin-1 has recently been implicated in susceptibili

13 ion of this gene and of its encoded protein, dysbindin-1, have been reported in the brains of schizop

14 ric diagnoses, suggesting a general role for dysbindin-1 in cognition.

15 In contrast to the role of dysbindin-1 in glutamatergic transmission, gamma-band ab

16 We found that reduced dysbindin-1 in mice yielded deficits in auditory-evoked

17 The function of dysbindin-1 in presynaptic, postsynaptic and microtubule

18 ate here that snapin is a binding partner of dysbindin-1 in vitro and in the brain.

19 Dysbindin-1 is best known as dystrobrevin-binding protei

20 nding, immunoelectron microscopy showed that dysbindin-1 is located in (i) synaptic vesicles of axosp

21 et al. show that, contrary to expectations, dysbindin-1 is located presynaptically in glutamatergic

22 oded protein dystrobrevin-binding protein 1 (dysbindin-1) is often reduced in excitatory cortical lim

23 ound between case-control differences in any dysbindin-1 isoform and the case-control differences in

24 ver, if the protein reductions encompass all dysbindin-1 isoforms or if they are associated with decr

25 How dysbindin-1 might affect glutamate release nevertheless

26 axon terminal loss or neuroleptic effects on dysbindin-1 or VGluT-1.

27 izophrenia populations displayed presynaptic dysbindin-1 reductions averaging 18-42% (P = 0.027-0.000

28 bindin-1C and known post-synaptic effects of dysbindin-1 reductions in the rodent equivalent of the D

29 Our findings indicate that presynaptic dysbindin-1 reductions independent of the dystrophin gly

30 Dysbindin-1 regulates D2-receptor trafficking and is imp

31 The dominant circuit impact of reduced dysbindin-1 was impaired inhibition, and PV cell immunor

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