ライフサイエンスコーパス: dysfunction

1 dysfunction and cardiomyocyte/mitochondrial dysfunction).

2 f the genetic landscape involved in auditory dysfunction.

3 , two abnormalities contributing to vascular dysfunction.

4 atory/inhibitory imbalance and dopamine (DA) dysfunction.

5 l strain (GLS) is a marker of subclinical LV dysfunction.

6 ling may be useful to counteract endothelial dysfunction.

7 gnosis, especially in individuals with renal dysfunction.

8 inflammatory cytokines induced by epidermal dysfunction.

9 ger term in STEMI patients complicated by LV dysfunction.

10 haracterized by blood stasis and endothelial dysfunction.

11 tients (29%) met the definition of diastolic dysfunction.

12 n the setting of inflammatory cardiovascular dysfunction.

13 dative stress, inflammation, and endothelial dysfunction.

14 ed later than cardiovascular and respiratory dysfunction.

15 en diffuse myocardial fibrosis and diastolic dysfunction.

16 vestigate the genome-scale effects of DNMT3B dysfunction.

17 quent epithelial disorders and mitochondrial dysfunction.

18 tion of protein aggregates and mitochondrial dysfunction.

19 (SLE) is a known risk factor for endothelial dysfunction.

20 , and other molecules associated with T cell dysfunction.

21 athologies involving prefrontal cortex (PFC) dysfunction.

22 in Abeta-induced mitochondrial and synaptic dysfunction.

23 uchs membrane and retinal pigment epithelium dysfunction.

24 hrotic syndrome is characterized by podocyte dysfunction.

25 tress, as well as mitochondrial and synaptic dysfunction.

26 sis in an efficient way to minimize systolic dysfunction.

27 ing antisense technology to treat vestibular dysfunction.

28 results in debilitating cognitive and motor dysfunction.

29 ophy of cardiac myocytes and overall cardiac dysfunction.

30 44% (9-91%) larger probability of cognitive dysfunction.

31 cascade of events can trigger immunological dysfunction.

32 tory insufficiency but typically not cardiac dysfunction.

33 pathways by which they contributed to muscle dysfunction.

34 ely unknown but could contribute to neuronal dysfunction.

35 ect recognition task, suggesting hippocampal dysfunction.

36 reased oxidative stress due to mitochondrial dysfunction.

37 E) can cause brain damage and lead to neural dysfunction.

38 immune diseases that are accompanied by Treg dysfunction.

39 al deficits resulting from midbrain dopamine dysfunction.

40 ne of the main reasons for a general retinal dysfunction.

41 or function, indicative of spinal inhibitory dysfunction.

42 of which have been associated with cancer or dysfunction.

43 ked cough responses consistent with neuronal dysfunction.

44 promote neurodevelopment and prevent mental dysfunction.

45 o-vagal imbalance, arrhythmias and diastolic dysfunction.

46 exposure, we found that hypoxia caused heart dysfunction.

47 es and other chronic disorders related to PN dysfunction.

48 ow WRN deficiency leads directly to telomere dysfunction.

49 nts into cohorts by severity of rod and cone dysfunction.

50 nts could relate to a greater extent of cone dysfunction.

51 d when characterizing diastolic function and dysfunction.

52 reduced ATP production, and flight and motor dysfunction.

53 sease that causes neuromuscular transmission dysfunction.

54 o behavioral deficits in AS, including motor dysfunction.

55 ation myocardial infarctions resulting in LV dysfunction.

56 precursors of type 2 diabetes and cognitive dysfunction.

57 basis, and methods for assessing attentional dysfunctions.

58 al proteins that are involved in lal(-/-) EC dysfunctions.

59 or amelioration of neurodegenerative-related dysfunctions.

60 th Abeta binding and Abeta-mediated synaptic dysfunctions.

61 for transcription factor-related hematologic dysfunctions.

62 nd aberrant GC action is linked to metabolic dysfunctions.

63 omplicated by left ventricular (LV) systolic dysfunction; (2) an age- and sex- matched hyper-control

64 Age, B-type natriuretic peptide level, renal dysfunction, 24-h AHI, CAI, and time with oxygen saturat

65 tigated whether PLK2 contributes to podocyte dysfunction, a characteristic change in the development

66 lymicrobial sepsis in mice causes myocardial dysfunction after generation of the complement anaphylat

67 he writhing assay and without inducing motor dysfunction after sc administration in mice.

68 ion symptom mapping approach, since cortical dysfunction after stroke can arise from cortical damage

69 ion in an animal model of corneal epithelial dysfunction after surgical transplantation.

70 lammation, oxidative stress, and endothelial dysfunction, all of which may perpetuate a noxious micro

71 by the loss of motor neurons, but astrocyte dysfunction also contributes to the disease in mouse mod

72 associated with the development of systolic dysfunction among moderate-severe traumatic brain injury

73 use appears to be associated with myocardial dysfunction and accelerated coronary atherosclerosis.

74 Islet beta-cell dysfunction and aggressive macrophage activity are early

75 Alveolar epithelial cell (AEC) mitochondrial dysfunction and apoptosis are important in idiopathic pu

76 of toxic glucose metabolites, mitochondrial dysfunction and apoptosis.

77 ighlight a biological link between inner ear dysfunction and behavioral disorders and how sensory abn

78 multiple RTT-like features, including motor dysfunction and breathing irregularities, in both male a

79 e myocardium among others (eg, microvascular dysfunction and cardiomyocyte/mitochondrial dysfunction)

80 t impaired mitophagy contributes to synaptic dysfunction and cognitive deficits by triggering Abeta a

81 ventricular remodeling, along with systolic dysfunction and comparable intra-cardiac fibrosis.

82 as associated with progressive mitochondrial dysfunction and consequent exacerbation of oxidative str

83 inflammation in cytokine-mediated beta-cell dysfunction and death in type 1 diabetes mellitus, altho

84 rome (SIRS) and sepsis at low risk for organ dysfunction and death is a major clinical challenge.

85 y genes for diabetes contribute to beta cell dysfunction and death.

86 etic knockdown of PIP4K ameliorated neuronal dysfunction and degeneration as assessed using motor per

87 models recreate the progressive adult-onset dysfunction and degeneration of a neuronal network that

88 er the occurrence of age-related endothelial dysfunction and diminished distensibility.

89 ese patients also has coronary microvascular dysfunction and evidence of inflammation.

90 er transplant candidates with advanced renal dysfunction and HCC may be considered for SLK.

91 t, fibrosis causes mechanical and electrical dysfunction and in the kidney, it predicts the onset of

92 ileum, those lacking Mdr1 displayed mucosal dysfunction and induced Crohn's disease-like ileitis fol

93 ignificantly to the development of metabolic dysfunction and inflammation.

94 ersed metabolic abnormalities, mitochondrial dysfunction and kidney pathology.

95 a new pathway to noninvasively image kidney dysfunction and local injuries at the anatomical level.

96 tion of many drugs, and highly vulnerable to dysfunction and loss in neurodegenerative disease.

97 tion, a mechanism likely to contribute to PN dysfunction and loss in SCA2.

98 receptors, ultimately resulting in synaptic dysfunction and loss.

99 s) is evidenced by clear links between their dysfunction and multiple diseases where autoimmunity and

100 er's disease may contribute to neurovascular dysfunction and neurodegeneration associated with human

101 ltiple sclerosis (MS), contributes to axonal dysfunction and neurodegeneration.

102 to prevent or treat postoperative cognitive dysfunction and other forms of cognitive decline related

103 c dysregulation even after substantial motor dysfunction and pathology were observed.

104 tases, minimum age, HIV infection, and organ dysfunction and prior and concurrent malignancies) to de

105 ia, trigger a fetal origin of cardiovascular dysfunction and programme cardiovascular disease in late

106 st common genetic risk factors for cognitive dysfunction and schizophrenia, we found that goal-orient

107 ein, leading to neuromuscular junction (NMJ) dysfunction and spinal motor neuron (MN) loss.

108 ing HTRA2 and PINK1-associated mitochondrial dysfunction and suggesting that TRAP1 acts downstream of

109 feron response and improved left ventricular dysfunction and survival.

110 prior studies suggest biventricular cardiac dysfunction and vascular impairment in baboons who were

111 ss of insulin production caused by beta-cell dysfunction and/or destruction.

112 We analyzed the mechanisms of these dysfunctions and their relationships, and how these cont

113 cause myocardial damage, induce endothelial dysfunction, and alter cardiac conduction.

114 ll patients have recurrent infections, organ dysfunction, and at least half die within 1 year.

115 rs, impaired immune responses, mitochondrial dysfunction, and neuroinflammation.

116 ent eyes and optic nerves, attenuated visual dysfunction, and prevented retinal ganglion cell loss in

117 lobal illness severity, markers of end-organ dysfunction, and profiles of hemodynamic instability.

118 n, cytoskeletal rearrangement, mitochondrial dysfunction, and reduced type 1 collagen secretion and a

119 ology, as indicated by inflammation, barrier dysfunction, and visceral hypersensitivity (VH).

120 5% CI = 3.7-9.0), and proximal renal tubular dysfunction (aOR = 7.0; 95% CI = 4.9-10.2]).

121 y liver, oxidative stress, and mitochondrial dysfunction are key pathophysiological features of insul

122 ng age, shock severity, and persistent organ dysfunction are predictive of chronic critical illness.

123 determine the degree to which these process dysfunctions are specific to anxiety.

124 generation-associated changes, and cognitive dysfunction arising after sepsis recovery.

125 t therapeutic window may result in allograft dysfunction as subtherapeutic tacrolimus levels predispo

126 on thus identifies SCN2A mutation and NaV1.2 dysfunction as the most frequently observed ASD risk fac

127 opathy correlate with the severity of OXPHOS dysfunction, as indicated by the level of impaired O2 ex

128 on and suggest that severe respiratory chain dysfunction, as observed in few cells leading to a mosai

129 rventions that attenuate or reverse systemic dysfunction associated with age therefore have the poten

130 SIV-associated B cell dysfunction associated with the pathogenic SIV infection

131 e incidence of developing new neuroendocrine dysfunction at 5 years was significantly lower in patien

132 Together, these experiments define synaptic dysfunction at NMJs experiencing ALS-related degradation

133 ogated the molecular mechanisms of beta-cell dysfunction at the level of mRNA translation under such

134 h a greater prevalence of shock, major organ dysfunction, bacteremia, inflammatory markers, and lacti

135 hronically elevated glucose causes beta-cell dysfunction, but little is known about how cells handle

136 jury is often accompanied by orofacial motor dysfunction, but little is known about the structural su

137 the cardiac action potential, and how their dysfunction can lead to arrhythmias, and discusses K(+)

138 ons and to control oxidative stress, and its dysfunction can lead to hypoxia-dependent pathologies su

139 As such, PFOS-induced male reproductive dysfunction can possibly be managed through an intervent

140 the EC barrier and protected against barrier dysfunction caused by vasoactive peptide thrombin and pr

141 rditis) is the proximate cause of myocardial dysfunction, causing injury that can range from a fully

142 hy, supporting the notion that reward system dysfunction comprises an important neurobiological risk

143 mechanisms by which inflammation and BMPR-II dysfunction conspire to cause disease remain unknown.

144 Alveolar type II (AT2) cell dysfunction contributes to a number of significant human

145 port here that the HIV/SIV-associated B cell dysfunction (defined by loss of total and memory B cells

146 ith non-tremor dominant phenotype, autonomic dysfunction, depression, anxiety and probable behaviour

147 Autonomic dysfunction developed in 85 patients (mean [SD] time fro

148 e (22q11.2 DS) show cognitive and behavioral dysfunctions, developmental delays in childhood and risk

149 llular inflammatory signals to mitochondrial dysfunction during AKI partly via PPARGC1A signaling.

150 e developed cardiac hypertrophy and systolic dysfunction, evidenced by a 5-fold greater heart mass, 6

151 e with HF induced long-term left ventricular dysfunction, fibrosis, and hypertrophy in naive recipien

152 , a number of studies have documented visual dysfunction following injury.

153 LA dilation and dysfunction form a prothrombotic milieu characterized by

154 t is highly expressed in the brain and whose dysfunction has been linked to intellectual disability a

155 ent) remains unknown, although spastic motor dysfunction has been related to the hyperexcitability of

156 AD-related cellular dysfunctions have been linked to this ApoE4 misfolded st

157 ctively, high-fat diet-induced mitochondrial dysfunction, hepatosteatosis, and insulin resistance in

158 thways to ameliorate consequences of protein dysfunction; however, targeting the source of that dysfu

159 increased severity of sensory and executive dysfunctions (i.e. hypervigilance and impulse control de

160 y response syndrome, and hypoperfusive organ dysfunction) identified by a quality initiative.

161 gradation and rescued the muscle atrophy and dysfunction in a Duchenne muscular dystrophy mouse model

162 r hemodynamics recovery, and limiting kidney dysfunction in a vasopressinergic-dependent manner.

163 ng the default mode network and dopaminergic dysfunction in ADHD.

164 ilure Assessment (SOFA) score to grade organ dysfunction in adult patients with suspected infection.

165 eal optimal targets for addressing metabolic dysfunction in ALS.

166 tolic load has been shown to cause diastolic dysfunction in animal models.

167 xis dysfunction in patients with preexisting dysfunction in at least 1 axis at baseline was also sign

168 search for the regulatory origins of T cell dysfunction in chronic viral infection.

169 using serelaxin as a new treatment for renal dysfunction in cirrhosis, although further validation in

170 t with serelaxin prevented cardiac and renal dysfunction in DOCA-salt rats.

171 We show here that in mouse models PFC dysfunction in Fragile X Syndrome (FX) can be attributed

172 n the treatment of respiratory and autonomic dysfunction in heart failure.

173 ay underlie METH- exacerbated neurocognitive dysfunction in HIV-infected patients.

174 otential of this marker of spinal inhibitory dysfunction in human painful diabetic neuropathy.

175 provide a novel mechanism for mitochondrial dysfunction in lipotoxic cardiomyopathy.

176 vity can account for the endothelial dilator dysfunction in old arteries.

177 ysregulation in the mPFC underlies cognitive dysfunction in Ophn1-deficient mice, as assessed using a

178 tools for potentially normalizing executive dysfunction in patient populations.

179 shear stress further exacerbates endothelial dysfunction in patients with moderate-severe COPD, and (

180 oscillatory shear stress-induced endothelial dysfunction in patients with moderate-severe COPD.

181 ) while developing a new neuroendocrine axis dysfunction in patients with preexisting dysfunction in

182 attern of neural activity underlie cognitive dysfunction in PP-MS, and that CLs possibly play a role

183 at the complex nature of blood-brain barrier dysfunction in psychosis might be relevant to many aspec

184 x (DLPFC) appears to contribute to cognitive dysfunction in schizophrenia, whereas psychosis is assoc

185 ortical, connectivity contribute to auditory dysfunction in schizophrenia.

186 was sufficient to reverse the observed heart dysfunction in the double knockout mice.

187 leading to intellectual deficits and sensory dysfunction in the fragile X syndrome (FXS).

188 ly contributes to the development of cardiac dysfunction in this setting.

189 ed by an increase in insulin demand and/or a dysfunction in vesicular trafficking.

190 ked cardiac hypertrophy and left ventricular dysfunction in vivo, whereas genetic knockdown or pharma

191 hypertrophic response and attenuated cardiac dysfunction in vivo.

192 ce protected against cardiac hypertrophy and dysfunction in vivo.

193 Interestingly, both the renal injury and dysfunction in wild-type mice undergoing iAKI is signifi

194 However, it is known that dysfunctions in basal ganglia, including a reduced numbe

195 y flow for diagnosing coronary microvascular dysfunction; in certain diseases, the degree of coronary

196 ogen deprivation therapy (ADT) and cognitive dysfunction, including Alzheimer disease.

197 61+/-7 mm, P<0.0001), more right ventricular dysfunction, increased epicardial fat thickness (10+/-2

198 stingly, these cells exhibited mitochondrial dysfunction, indicated by reactive oxygen species expres

199 ubule exhibited generalized proximal tubular dysfunction indicative of Fanconi syndrome, characterize

200 decline, increasingly attributed to neuronal dysfunction induced by amyloid-beta oligomers (AbetaOs).

201 d lipid accumulation in the kidney and renal dysfunction, injury, inflammation, and fibrosis.

202 ional Fatigue Inventory), bladder and sexual dysfunction (International Prostate Symptom Score, Inter

203 ing studies increasingly suggest that immune dysfunction is a viable risk factor contributing to the

204 Diabetes-induced visual dysfunction is associated with significant neuroretinal

205 r order cognitive processing, and prefrontal dysfunction is believed to underlie many of the cognitiv

206 sults suggest that some degree of swallowing dysfunction is common (82%), worse with hard consistenci

207 Epithelial dysfunction is critical in the pathology of many respira

208 using imaging presence of right ventricular dysfunction is essential for triage; however, comprehens

209 r neural circuit function, and their loss or dysfunction is implicated in human neuropsychiatric dise

210 (ER) extends throughout axons and axonal ER dysfunction is implicated in numerous neurological disea

211 NMDAR dysfunction is involved in a variety of neurological and

212 ing circuit mechanisms that drive behavioral dysfunction is of critical importance for quantitative d

213 c link between the human pathology and NMDAR dysfunction is poorly understood.

214 use of infantile epilepsy in humans and KCC2 dysfunction is present in patients with both idiopathic

215 ients with more advanced cirrhosis and renal dysfunction is required.

216 D) is incompletely understood, mitochondrial dysfunction is thought to play a crucial role in disease

217 s (ECs), one of the hallmarks of endothelial dysfunction leading to cardiovascular disorders, but the

218 ltiple extracellular matrix proteins and its dysfunction leads to a form of muscular dystrophy freque

219 and older children-namely complex surfactant dysfunction, lung tissue inflammation, loss of lung volu

220 rillation (AF) and left ventricular systolic dysfunction (LVSD) frequently co-exist despite adequate

221 uces Abeta production, reduces mitochondrial dysfunction, maintains mitochondrial dynamics and enhanc

222 Encephalopathy, hepatic, and renal dysfunction manifested later than cardiovascular and res

223 in human disease, this work shows that niche dysfunction may also cause disease, with possible releva

224 in release and beta cell survival, and their dysfunction may contribute to the loss of functional bet

225 hough it has been speculated that proteasome dysfunction may contribute to the pathogenesis of Huntin

226 Endothelial dysfunction may underlie this; however, the association

227 Organ dysfunction measured by the pSOFA score, and sepsis and

228 reflux, obstructive sleep apnoea, vocal cord dysfunction, obesity, dysfunctional breathing and anxiet

229 In conclusion, intrinsic mitochondrial dysfunction observed in type 1 diabetes alters mitochond

230 both CM Tln1 and Tln2 and found that cardiac dysfunction occurred by 4 wk with 100% mortality by 6 mo

231 Since beta cell dysfunction occurs during diabetes development, it was n

232 uring sepsis and shock states, mitochondrial dysfunction occurs.

233 on of hydroperoxy-PE due to insufficiency or dysfunction of a selenoperoxidase, GPX4, leads to ferrop

234 ive rather than viewing it as related to the dysfunction of a single brain area.

235 systemic inflammatory response syndrome and dysfunction of at least 1 organ system of the renal, res

236 tter the regulation of channel openings, the dysfunction of CFTR in CF and the action of drugs that r

237 roles in various physiological processes and dysfunction of lncRNAs could be a prevalent cause in hum

238 y contribute to the progressive fibrosis and dysfunction of mdx(5cv) diaphragm.

239 Dysfunction of microglia is known to play an important r

240 ibitory cortical neurons show that selective dysfunction of neuronal cell types cannot account for th

241 e cellular and molecular mechanisms by which dysfunction of TDP-43 contributes to disease pathogenesi

242 Dysfunction of the fast-inactivating Kv3.4 potassium cur

243 onic cutaneous injury can lead to injury and dysfunction of the most distal part of small sensory fib

244 As a consequence, dysfunction of these processes in adipose tissue compart

245 rvival of midbrain dopaminergic neurons, the dysfunction of which contributes to various neurological

246 a role in regulating executive function, the dysfunction of which is a factor in attention-deficit/hy

247 LS) neuronal activity, normalizes the social dysfunctions of ELS mice.

248 multiple inotropes, severe right ventricular dysfunction on echocardiography, ratio of right atrial/p

249 patients with bradycardia due to sinus node dysfunction or atrioventricular block.

250 obable behaviour disorder, but not cognitive dysfunction or motor severity.

251 Losartan had no significant effect on RV dysfunction or secondary outcome parameters in repaired

252 iation between hemoglobin and brain or renal dysfunction, or ICU mortality.

253 levels suggests that mitochondrial metabolic dysfunction persists after surgery.

254 r potential role in post-operative cognitive dysfunction (POCD).

255 Diastolic dysfunction portends early mortality in SCA.

256 y infusion in patients with left ventricular dysfunction post STEMI.

257 nsory anomalies can contribute to widespread dysfunctions, presenting an additional aetiological mech

258 Patients suffer from early synaptic dysfunction prior to Tau aggregate formation, but the un

259 products of hemolysis that promote vasomotor dysfunction, proliferative vasculopathy, and a multitude

260 ng these, lipid metabolism and mitochondrial dysfunction proteins were overrepresented.

261 e broadly, underlie the neural computational dysfunction prototypical of schizophrenia.

262 n patients with HF-PH with right ventricular dysfunction, pulmonary vascular remodeling was not more

263 ative diseases, there is a spectrum of smell dysfunction ranging from severe loss, as seen in Alzheim

264 Thyroid dysfunction rates are increased in patients with CSU (st

265 All patients with early systolic dysfunction recovered in 1 week.

266 was unleashed, and this coincided with liver dysfunction reflected by a failure to maintain hydrogen

267 tor agonist exendin-4 reversed the lysosomal dysfunction, relieving the impairment in autophagic flux

268 However, enhancers/SEs mediating VSMC dysfunction remain uncharacterized.

269 increased risk of DCGF; however, later-onset dysfunction requiring IBx had far greater impact (HR = 1

270 hematopoiesis is critical, as hematopoietic dysfunction results from a range of ionizing radiation d

271 The Multiple Organ Dysfunction Score is a simple organ-based score, and thi

272 on analysis, the difference between erectile dysfunction scores before and after stroke was correlate

273 pSOFA scores and additional pediatric organ dysfunction scores were compared.

274 mpared with active surveillance, mean sexual dysfunction scores worsened by 3 months for patients who

275 ncidence of osteonecrosis of the jaw, kidney dysfunction, skeletal morbidity rate (mean number of ske

276 ied AEs of interest-muscle-related, erectile dysfunction, sleep disturbance, and cognitive impairment

277 signaling, impaired autophagy, mitochondrial dysfunction, stem cell exhaustion, epigenetic changes, a

278 igning drug therapies for human eye movement dysfunctions such as abducens nerve palsy.

279 for human disorders related to primary cilia dysfunctions, such as ciliopathies and certain types of

280 edisposed and is associated with endothelial dysfunction that is induced by oxidative stress.

281 ction; however, targeting the source of that dysfunction, the affected protein itself, seems most jud

282 alterations of neural circuits via synaptic dysfunction, the underlying molecular mechanisms remain

283 licated circuits, the contribution of RCrusI dysfunction to ASD remains unclear.

284 an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration

285 t kinase 2 (CDK2), couples primary beta-cell dysfunction to the progressive deterioration of beta-cel

286 l condition caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein.

287 reverse alcohol-induced endothelial barrier dysfunction using both cultured endothelial cell monolay

288 ctors of ventilator-induced diaphragm muscle dysfunction (VIDD), but the upstream initiator(s) of thi

289 Diaphragm dysfunction was associated with higher ICU and hospital

290 Glomerular endothelial mitochondrial dysfunction was associated with increased glomerular end

291 4, with higher scores indicating more severe dysfunction) was greater in the angiotensin II group tha

292 emic dysregulations and pancreatic beta-cell dysfunctions, we evaluated islet function and glucose me

293 Factors associated with dysfunction were analyzed with uni- and multivariate ana

294 Motor dysfunctions were chiefly associated with the anterior l

295 ical features, like dysphonia or respiratory dysfunction, were exclusively detected in this group.

296 resolution of the mechanisms underlying p53 dysfunction will better address the p53-targeted therapi

297 requiring covered stent (n=2), and acute RV dysfunction with flash pulmonary edema.

298 eter and Surgical Aortic Bioprosthetic Valve Dysfunction With Multimodality Imaging and Its Treatment

299 These disorders are correlated with dysfunction within areas 25 and 32 of the ventromedial p

300 ple consensus that preventing early synaptic dysfunction would be an effective therapeutic strategy f