ライフサイエンスコーパス: dysfunctional

1 ts in which the endothelium is challenged or dysfunctional.

2 dysfunctional, and at follow-up CMR 19% were dysfunctional.

3 gens are detected in cancer patients but are dysfunctional.

4 t CD4(+) T cells in chronic HCV patients are dysfunctional.

5 eling, irritability would be associated with dysfunctional activation in the amygdala and other tempo

6 contributor to insulin resistance and other dysfunctional adaptations in adipose tissue.

7 st a relationship between obesity-associated dysfunctional adipose tissue (AT) and HFpEF.

8 dominant contributors to the pathogenesis of dysfunctional adipose tissue (AT) in obesity: unresolved

9 However, the impact of dysfunctional adipose tissue has not been fully elucidat

10 1-USP8 mitophagy complex is destabilized and dysfunctional after lenalidomide treatment as well as af

11 ur-specific CD8 T cells in solid tumours are dysfunctional, allowing tumours to progress.

12 he default-mode network (DMN) is known to be dysfunctional, although correlation with level of consci

13 ion in naive adults, but are lost and become dysfunctional among children repeatedly exposed to malar

14 et specific threat processes associated with dysfunctional amygdala-insula connectivity that are not

15 We observed that SLE MACs are dysfunctional and secrete pro-inflammatory cytokines.

16 Nbeal2-deficient NK cells were also dysfunctional and showed reduced degranulation.

17 At acute CMR 32% of segments were dysfunctional, and at follow-up CMR 19% were dysfunction

18 n MDA-MB-231-bearing nude mice, H3L2 induced dysfunctional angiogenesis and tumor cell apoptosis and

19 n and endothelial proliferation resulting in dysfunctional angiogenesis in tumors.

20 ts with two mutated ANKZF1 alleles result in dysfunctional ANKZF1, as shown by an increased level of

21 a was noted in 5 of 6 bleeding patients with dysfunctional aortic prostheses and in 3 of 5 bleeding p

22 o, mean (range) 0.94 (0.84-0.99) compared to dysfunctional aortic valve replacement, 0.78 (0.73-0.87)

23 mean (range) 92 (82-112) seconds compared to dysfunctional aortic valve replacement, 139 (122-177) se

24 r aortic valve replacement, 24 patients with dysfunctional aortic valve replacement, 36 patients with

25 nts or repairs but were abnormal in 20 of 24 dysfunctional aortic valve replacements and in 14 of 19

26 eover, lymphatic vessels collapse and become dysfunctional as melanomas progress.

27 macytoid dendritic cells (pDCs) are rendered dysfunctional, as measured by their decreased capacity t

28 th HD may be triggered, at least in part, by dysfunctional astrocytes, thereby providing details of a

29 sults suggest that seizure onset regions are dysfunctional at baseline, and support the idea that int

30 In conclusion, the type I IFN pathway is dysfunctional at the epigenetic level in systemic sclero

31 activation in the cognitive control network, dysfunctional auditory-limbic connectivity, and deaffere

32 Dysfunctional autophagy contributes to many diseases.

33 y; hence, histaminergic ligands might reduce dysfunctional aversive memories and improve the efficacy

34 the prefrontal and temporal cortex, but such dysfunctional behaviors are typically measured by explic

35 hypothalamic development is associated with dysfunctional behavioural and neuroendocrine stress resp

36 GRK2) is upregulated in HF patients, causing dysfunctional beta-adrenergic receptor signaling.

37 Increased HMGA1 in PAECs resulting from dysfunctional BMPR2 signaling can transition endothelium

38 tant epilepsy, focal seizures originating in dysfunctional brain networks will often evolve and sprea

39 er (ADHD) have revealed various ADHD-related dysfunctional brain regions, with heterogeneous findings

40 eep apnoea, vocal cord dysfunction, obesity, dysfunctional breathing and anxiety/depression.

41 associated with beiging in white AT and with dysfunctional brown AT.

42 MF is a key domain of dysfunctional but viable myocardium among others (eg, mi

43 Rendering adult nephrocytes dysfunctional by disrupting their endocytic function or

44 PDI can become dysfunctional by post-translational modifications, inclu

45 Moreover, dysfunctional Ca(2+)and glutamate signaling that was obs

46 Dysfunctional capillaries with no flow, a result of tumo

47 IP (Raf kinase inhibitor protein), triggered dysfunctional cardiomyocyte energetics and the expressio

48 development and homeostasis and the way that dysfunctional caspase-8 may contribute to the developmen

49 occur in aging and stroke, will give rise to dysfunctional CBF regulation and may result in subsequen

50 Chronic chagasic patients (CCPs) have dysfunctional CD8(+) T cells that are characterized by i

51 Dysfunctional cellular lipid metabolism contributes to c

52 f CSF is evolving to models that incorporate dysfunctional cerebral pulsations, brain compliance, and

53 d to arise from bacterial ascension across a dysfunctional cervical mucus plug.

54 The presence of dysfunctional CFTRs in enteric ganglia could, to a certa

55 t scaling down in input integration leads to dysfunctional changes in BG output, which is seen as red

56 tid-to-nucleus retrograde signals emitted by dysfunctional chloroplasts impact photomorphogenic devel

57 ary switches, which when disrupted result in dysfunctional cilia, yet how ARLs are activated remain e

58 ture studies that will shed further light on dysfunctional circuits mediating diseases of the nervous

59 urvival and death, the former by eliminating dysfunctional components in the cell, the latter by prog

60 es in demyelinated axons, may underlie their dysfunctional conduction akin to muscle weakness in mult

61 ('biotypes') defined by distinct patterns of dysfunctional connectivity in limbic and frontostriatal

62 ns, and they describe, for the first time, a dysfunctional consequence of tau-ribosome associations t

63 ng retaliation/reactive aggression and, when dysfunctional, contributes to reactive aggression, indep

64 inhibition balance in the caudate leading to dysfunctional corticostriatal circuits.

65 to correct maladaptive plasticity underlying dysfunctional decision-making related to neuropsychiatri

66 ghts into psychopathologies characterized by dysfunctional decision-making, such as addiction and pat

67 First, patients with schizophrenia had dysfunctional delta rhythms between 1-4 Hz in the medial

68 The 26S proteasome was dysfunctional despite normal function of the core 20S su

69 This dysfunctional development includes altered maturation/di

70 ons have correlated these abnormalities with dysfunctional DNA damage response.

71 Results strengthen the assumption that dysfunctional dorsolateral prefrontal and limbic brain r

72 c threat circuitry when punishing others and dysfunctional down-regulation of the ventromedial prefro

73 ognize cancer cells, they are often rendered dysfunctional due to an immunosuppressive microenvironme

74 lipid droplet formation but also results in dysfunctional elevated lipogenesis and lipolysis activit

75 Research points to dysfunctional emotion regulation in MS, whereas findings

76 Indeed, the immature endothelium resembles dysfunctional endothelial cells, and retention or re-eme

77 have accelerated cardiovascular disease and dysfunctional endothelial repair mechanisms.

78 ndings show that nitrosative stress leads to dysfunctional ER stress signaling, thus contributing to

79 associated with loss of neuronal structures, dysfunctional excitation-transcription coupling, and cog

80 A significantly larger repertoire of dysfunctional (exhausted) HSV-specific CD8(+)T cells wer

81 ant phase of tumorigenesis, TST cells became dysfunctional, exhibiting phenotypic, functional, and tr

82 trated by increased triglyceride content and dysfunctional expression of enzymes and transcription fa

83 a major global problem, and consequences of dysfunctional feeding patterns carry over into infancy a

84 We report that mice with a dysfunctional FN-synergy motif (Fn1(syn/syn)) suffer fro

85 argue that proposed policies will lead to a dysfunctional future of policy failure and widely disper

86 Dysfunctional GABAA receptor signaling that results in m

87 with hippocampal hyperactivity, arising from dysfunctional GABAergic interneurons.

88 Schizophrenia patients exhibit dysfunctional gamma oscillations in response to simple a

89 We sought to define how dysfunctional gene transcription is causally linked to t

90 Dysfunctional glycinergic inhibitory transmission underl

91 ecting newborn children and usually involves dysfunctional glycinergic neurotransmission.

92 , but the possibility that airway nerves are dysfunctional has not been fully explored.

93 rity of congenital muscular dystrophies when dysfunctional, has a function at postsynaptic sites rest

94 the secretion of VEGFA to locally repair the dysfunctional heart.

95 show that Paris SR drive is a consequence of dysfunctional HP1D2 alleles that fail to prepare the Y c

96 he Wnt5a-haploinsufficient niche regenerates dysfunctional HSCs, which do not successfully engraft in

97 plasticity, resulting in the accumulation of dysfunctional IFNgamma(+) Th1/Tregs that may permit furt

98 troviral therapy era, we found evidence that dysfunctional immune activation and chronic inflammation

99 troviral therapy era, we found evidence that dysfunctional immune activation and chronic inflammation

100 AH patients also had more activated yet dysfunctional immune cells as monocytes, T cells, and B

101 with variable/high levels of antibody and a dysfunctional immune response.

102 shift poses, little is known about how such dysfunctional immune states are initiated.

103 immunodeficiency diseases are outcomes of a dysfunctional immune system and represent 2 sides of the

104 Dysfunctional, impaired effector differentiation also oc

105 atory T cells (Treg), previously shown to be dysfunctional in APECED.

106 it excised from oligomeric FP, which is also dysfunctional in bacteriolysis but binds the AP proconve

107 GC synthesis, and GC receptor expression is dysfunctional in both nonlesional and lesional psoriatic

108 of Ca(2+)-mediated CaMKII activation that is dysfunctional in C3KO mice, leading to reduced transcrip

109 ion by secreting HCO3(-), a process which is dysfunctional in CF airway epithelium leading to ASL aci

110 We further investigate mutants dysfunctional in chromatin assembly factor-1 (CAF-1) (fa

111 activating transcription factor 4 (ATF4), is dysfunctional in HD because of oxidative stress contribu

112 eadily available and contains cells that are dysfunctional in HD, could act as a surrogate for brain

113 ry B-cells become quantitatively reduced and dysfunctional in patients with cirrhosis through poorly

114 , the region believed to be most prominently dysfunctional in schizophrenia.

115 Our findings suggest that ANXA1 signaling is dysfunctional in SIV infection, and may contribute to ch

116 icrotubule-severing enzyme spastin, which is dysfunctional in some forms of upper motor neuron diseas

117 regs recovered from atherosclerotic mice are dysfunctional in suppression assays.

118 CREB signaling is dysfunctional in the brains of mouse models of Alzheimer

119 a subpopulation of progenitor cells that is dysfunctional in the diabetic state, and normalizes diab

120 esponse to TBI and that the ApoE4 isoform is dysfunctional in this process.

121 he kynurenine pathway-which is implicated as dysfunctional in various psychiatric disorders-toward en

122 thesis or modification genes, rendering them dysfunctional; inconclusive serotyping results due to no

123 esponse-based choices.SIGNIFICANCE STATEMENT Dysfunctional interactions between orbitofrontal cortex

124 insulin-expressing stage led to immature and dysfunctional islet beta cells carrying abnormal chromat

125 ts in protein alterations that contribute to dysfunctional learning and reward processing.

126 cantly increased in T2DM patients because of dysfunctional left ventricle (LV).

127 AND Across 10 US centers, 27 patients with a dysfunctional LVOT conduit were evaluated in the cathete

128 TPVR in dysfunctional LVOT conduits is feasible but associated w

129 ntaining interstitial fluid homeostasis, and dysfunctional lymphangiogenesis contributes to various p

130 deposition, impaired lymphangiogenesis, and dysfunctional lymphatic pumping.

131 acellular accumulation of lipids and swollen dysfunctional lysosomes are linked to several neurodegen

132 Dysfunctional lysosomes give rise to lysosomal storage d

133 in kappaLC accumulation within enlarged and dysfunctional lysosomes, alteration of cellular dynamics

134 pment of nanomedicines to efficiently target dysfunctional macrophages can strengthen the effectivene

135 Dysfunctional macrophages have significant pathophysiolo

136 This review discusses the specific roles of dysfunctional macrophages in various diseases and summar

137 he recruitment, activation and regulation of dysfunctional macrophages represents a promising therape

138 ostics for treating diseases associated with dysfunctional macrophages.

139 We investigated how and when dysfunctional MCT8 can induce brain lesions associated w

140 n to drive-differentiation of monocytes into dysfunctional mDCs.

141 Mutations result in dysfunctional melanosome biogenesis and macromelanosome

142 luding increases in endothelial cells and in dysfunctional mesenchymal and osteoblastic populations,

143 a primary immunodeficiency characterized by dysfunctional microbicidal activity and chronic inflamma

144 Overall, our data suggest that dysfunctional microglia might play a causative role in t

145 Furthermore, dysfunctional mitochondria accumulated in the cytoplasm,

146 The ablation of BCO2 causes dysfunctional mitochondria and altered energy metabolism

147 Dysfunctional mitochondria and generation of reactive ox

148 Dysfunctional mitochondria appear to be involved in many

149 In hypoxic cells, dysfunctional mitochondria are selectively removed by a

150 ogy: healthy mitochondria are thin and long; dysfunctional mitochondria are thick (swollen) and short

151 bserved an unexpected defect in clearance of dysfunctional mitochondria at specific stages during ery

152 n the retina, the removal of the damaged and dysfunctional mitochondria by a double-membrane autophag

153 Mitophagy, the selective engulfment of dysfunctional mitochondria by autophagasomes, is importa

154 ly, IL-10 promotes mitophagy that eliminates dysfunctional mitochondria characterized by low membrane

155 Dysfunctional mitochondria contribute to the development

156 The accumulation of dysfunctional mitochondria has been implicated in aging,

157 logy, which is linked to the accumulation of dysfunctional mitochondria in aged flight muscle.

158 Generating dysfunctional mitochondria in MSCs using rhodamine 6G pr

159 y orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological

160 In several neurological disorders, dysfunctional mitochondria show significant changes in g

161 ment in the selective degradation of damaged/dysfunctional mitochondria through mitophagy may play a

162 drial dynamics is the removal of damaged and dysfunctional mitochondria through mitophagy, which is d

163 ochondrial biogenesis and removal of damaged/dysfunctional mitochondria via mitophagy.

164 police mitochondrial fidelity by binding to dysfunctional mitochondria via PTEN (phosphatase and ten

165 1 and pink-1 mutants show an accumulation of dysfunctional mitochondria with age, which leads to acti

166 n pdr-1 and pink-1 cause the accumulation of dysfunctional mitochondria, which activates the mitoUPR

167 is associated with biogenesis and removal of dysfunctional mitochondria.

168 ess that selectively removes damaged, old or dysfunctional mitochondria.

169 uced to eliminate damaged portions or entire dysfunctional mitochondria.

170 otility as an early step in the clearance of dysfunctional mitochondria.

171 ised in AD, resulting in the accumulation of dysfunctional mitochondria.

172 Dysfunctional mitochondrial dynamics, transport, homeost

173 NTS: Neurodegenerative disorders can exhibit dysfunctional mitochondrial respiratory chain complex IV

174 stheses and in 3 of 5 bleeding patients with dysfunctional mitral prostheses/repair.

175 ment or repair, 0.90 (0.86-0.93) compared to dysfunctional mitral valve replacement or repair, 0.78 (

176 nt or repair, 85 (74-96) seconds compared to dysfunctional mitral valve replacement or repair, 143 (1

177 alve replacement or repair, 19 patients with dysfunctional mitral valve replacement or repair, and 31

178 al aortic valve replacements and in 14 of 19 dysfunctional mitral valve replacements or repairs (P <

179 3, a zinc-finger transcription factor in the dysfunctional module, as a regulator of dysfunction, and

180 dopaminergic drive can result in increased, dysfunctional, motor switching, besides motor suppressio

181 the pathway by which cells sense and restore dysfunctional mRNA translation and how this is linked to

182 Dysfunctional myocardium may persist, in part, from ongo

183 immune-mediated diseases, in which excess or dysfunctional NET production, bacterial NET evasion, and

184 al pole has been identified as a node in the dysfunctional network of major depressive disorder.

185 RiSE task performance could help to specify dysfunctional neural circuits in schizophrenia that can

186 Our findings suggest that inflammation and dysfunctional neuron-microglia interactions are factors

187 uronal plasticity in LE and leads to chronic dysfunctional neuronal circuitry that mediates epilepsy.

188 c disorders requires selective modulation of dysfunctional neuronal pathways.

189 However, the ontogeny of dysfunctional neutrophil during septic colitis remain po

190 We report that the dysfunctional neutrophil may be derived by the suppressi

191 As aberrant p53beta expression and dysfunctional NMD are both implicated in cancers, our st

192 ed with systemic hypoxia is characterized by dysfunctional NPD.

193 these findings point to oxidative stress and dysfunctional NRF2 as contributors to PPK pathogenesis,

194 This dramatic gating deficit is not due to dysfunctional nucleotide binding domains (NBDs) as the m

195 ntenance of neuronal health and suggest that dysfunctional O-GlcNAc signaling may be an important con

196 ns and cancer often lead to the emergence of dysfunctional or 'exhausted' CD8(+) T cells, and the res

197 d mitochondrial quality control, which, when dysfunctional or diminished with age, might actively con

198 s selective labels on protein aggregates and dysfunctional organelles, thus promoting their autophagy

199 f toxic protein species, and accumulation of dysfunctional organelles, which are hallmarks of Alzheim

200 ed mortality risk, greater number of acutely dysfunctional organs, and lower adjusted in-hospital mor

201 inciple medium spiny neurons (MSNs), whereas dysfunctional output of NAc MSNs contributes to a variet

202 ignaling was required for the development of dysfunctional ovulation, classic polycystic ovaries, red

203 tional, and clinical diversity, all in which dysfunctional p53 plays a key role.

204 In PTSD patients, dysfunctional patterns in the neural circuitry underlyin

205 gulated by T cells upon PD-1 blockade and in dysfunctional PD-1(+)TIM-3(+) TA-specific CD8(+) T cells

206 We conclude that Tim-3 is a biomarker of dysfunctional pDCs and may negatively regulate IFN-alpha

207 echanism of several diseases associated with dysfunctional PDI.

208 ndings, it was suggested that animals with a dysfunctional PF-pDMS pathway might suffer a deficit in

209 suggest an actin-dependent mechanism of this dysfunctional phenotype and potential treatment targets

210 Cas9 genome editing to show that it drives a dysfunctional phenotype in CD8(+) TILs.

211 As a consequence of dysfunctional photosynthesis and energy dissipation, rea

212 Plants possessing dysfunctional plastids due to defects in pigment biosynt

213 in the fmr1(-/y) mouse and may contribute to dysfunctional prefrontal cortex processing in fragile X

214 Together, these data suggest that the dysfunctional prefrontal cortical systems underlying res

215 This dysfunctional process typically involves additional regu

216 in which the balance between functional and dysfunctional processes are regulated for this protein.

217 arch for the investigation of functional and dysfunctional processes coupled with their genetic and p

218 enic material and endogenous cargo including dysfunctional proteins and organelles.

219 iding a strategy to replace old, damaged, or dysfunctional proteins.

220 In this study, we report that dysfunctional pulmonary endothelium, resulting from the

221 Each ADHD-related dysfunctional region resulting from the activation likel

222 ion and connectivity profile of ADHD-related dysfunctional regions consistently detected across studi

223 und to the catalytic (C)-subunit reveals the dysfunctional regions of the RIalpha subunit.

224 Additionally, ADHD-related dysfunctional regions were clustered based on their func

225 ging, stroke, or schizophrenia could lead to dysfunctional regulation of CBF and subsequent neuronal

226 microstructural organization likely lead to dysfunctional regulation of IHI, ultimately accounting f

227 low levels of callous-unemotional traits and dysfunctional regulatory activity in the ventromedial pr

228 s identified by screening to be at risk from dysfunctional relationships when one of their relatives

229 c-Jun, damage results in the formation of a dysfunctional repair cell, neuronal death and failure of

230 bial drug target or used as a substitute for dysfunctional respiratory complex I in neuromuscular dis

231 triggered defects in aortic structure and a dysfunctional response to these forces.

232 duced reward-related striatal activation and dysfunctional reward learning, putatively reflecting dec

233 ther develop the therapeutic manipulation of dysfunctional rhythmic activity subtending the symptoms

234 acement (TPVR) is an established therapy for dysfunctional right ventricular (RV) outflow tract condu

235 Exogenous IL-6 protects the dysfunctional RPE but IL-1beta causes enhanced cell deat

236 ore, IL-1beta toxicity is more pronounced in dysfunctional RPE cells showing reduced IRAK3 gene expre

237 infarct size and underestimates recovery of dysfunctional segments acutely post ST-segment-elevation

238 covery occurs in a substantial proportion of dysfunctional segments with SEE >75%.

239 creased with increasing SEE, although 33% of dysfunctional segments with SEE 76% to 100% improved.

240 neurodevelopmental hypothesis of MDD wherein dysfunctional self-regulation is potentially reflected b

241 ychiatric and movement disorders for which a dysfunctional signaling of the dopamine D3 receptor (Drd

242 urately distinguished people with normal and dysfunctional smell.

243 ely detect kidney dysfunction, report on the dysfunctional stages, and even reveal adaptive function

244 onal mechanisms that induce and maintain the dysfunctional state and highlight the heterogeneity of C

245 ugh two discrete chromatin states: a plastic dysfunctional state from which T cells can be rescued, a

246 om which T cells can be rescued, and a fixed dysfunctional state in which the cells are resistant to

247 The dysfunctional state of Irf4-deficient T cells was initia

248 This dysfunctional state was imprinted within 3 d of immuniza

249 Although the TST cell dysfunctional state was initially therapeutically revers

250 and fetal development, and reversal of this dysfunctional state, is crucial in understanding the eti

251 ression of these receptors exacerbating this dysfunctional state.

252 sion mechanisms, but also a T cell-intrinsic dysfunctional state.

253 eling changes shifted HDL particles toward a dysfunctional state.

254 tate, as a result of neurodegeneration, to a dysfunctional state.

255 hlighting differences between functional and dysfunctional states of tau.

256 SIGNIFICANCE STATEMENT: Dysfunctional stress responses are linked to a number of

257 ibition is a novel approach that targets the dysfunctional substrate metabolism of the failing heart.

258 id valve-in-valve implantation (TVIV) within dysfunctional surgical tricuspid valve (TV) bioprosthese

259 s NE mislocalization, which in turn triggers dysfunctional survival signaling and UPR/ER stress.

260 A dysfunctional sympathetic-gut communication is associate

261 ise in mitochondrial bioenergetics result in dysfunctional synaptic plasticity and synapse loss in co

262 Reversing the dysfunctional T cell state that arises in cancer and chr

263 gain a deeper molecular understanding of the dysfunctional T cell state, we analyzed population and s

264 Our results open novel avenues for targeting dysfunctional T cell states while leaving activation pro

265 he transcriptional and spatial regulation of dysfunctional T cells and for the design of therapeutics

266 Dysfunctional T cells can mediate autoimmunity, but the

267 present a potential strategy to reinvigorate dysfunctional T cells for cancer treatment.

268 nal, and transcriptional features similar to dysfunctional T cells isolated from late-stage human tum

269 In dysfunctional T cells that have a decreased cytotoxic ca

270 programmable from non-reprogrammable PD1(hi) dysfunctional T cells within heterogeneous T cell popula

271 coexpression of LAG-3 and 4-1BB characterize dysfunctional T cells within tumors, and that targeting

272 iated EM CD45RA(+) cell subsets expressing a dysfunctional T-helper 1-like signature program in chron

273 We show that a single chromosomal dysfunctional telomere can fuse with diverse nontelomeri

274 myocytes from telomerase-deficient mice with dysfunctional telomeres (G3 Terc(-/-)) show precocious d

275 Dysfunctional telomeres activate DDR in ageing, cancer a

276 fter birth, resulting in cardiomyocytes with dysfunctional telomeres and anaphase bridges and positiv

277 ults demonstrate that tDDRNAs are induced at dysfunctional telomeres and are necessary for DDR activa

278 that long single-stranded lesions, formed at dysfunctional telomeres in budding yeast, are re-synthes

279 or ZRANB3 prevents the rapid accumulation of dysfunctional telomeres in RTEL1-deficient cells.

280 How TRF2 prevents MRN activation at dysfunctional telomeres is unclear.

281 NBS1(S432) dictates repair pathway choice of dysfunctional telomeres.

282 NBS1 determines the repair pathway choice of dysfunctional telomeres.

283 In summary, we provide evidence of dysfunctional TGF-beta signalling occurring at an early

284 ate that could be considered maladaptive or "dysfunctional." This laryngeal dysfunction can underpin

285 cell surface markers defining tumor-specific dysfunctional TILs, and PD-1 alone is not sufficient.

286 partial rescue of cytokine production by the dysfunctional TILs, with only limited changes in gene ex

287 eering is to repair, replace, and regenerate dysfunctional tissues to restore homeostasis.

288 e with normal TLR-4 and C3H/HeJ (Lps-d) with dysfunctional TLR4 (TLR4 deficiency) were treated withou

289 and extracellular vesicle trafficking and a dysfunctional trans-Golgi network phenotype in patient-d

290 evels, the defective vesicle trafficking and dysfunctional trans-Golgi network phenotypes were revers

291 s on exonucleolytic degradation to eliminate dysfunctional transcripts.

292 tion of coinhibitory signaling pathways, and dysfunctional Tregs may influence predisposition to hype

293 urface proteins LAG-3 and 4-1BB can identify dysfunctional tumor antigen-specific CD8(+) TIL.

294 Singer et al. characterize dysfunctional tumor infiltrating lymphocytes to reveal a

295 A gain or loss of function and suggests that dysfunctional UBE3A might affect additional proteins and

296 sed in dorsal root ganglion neurons, becomes dysfunctional upon calcineurin (CaN) inhibition.

297 The paradigm of disease resistance through a dysfunctional variant of an essential gene may be applic

298 l for channel function and are enriched with dysfunctional variants.

299 early childhood prevented the development of dysfunctional Vdelta2 T cells.

300 The literature views many African cities as dysfunctional with a hodgepodge of land uses and poor "c