ライフサイエンスコーパス: dysregulate

1 functions, can disrupt genome integrity when dysregulated.

2 Nkx2-5 (NK2 homeobox 5), Tbx3, and Tbx5 are dysregulated.

3 Es; however, only KLK7 was transcriptionally dysregulated.

4 rtant pathway that causes disease when it is dysregulated.

5 g via this interaction can be detrimental if dysregulated.

6 treating diseases in which PAD2 activity is dysregulated.

7 cs, and mitochondrial protein synthesis were dysregulated.

8 thology when upstream activating signals are dysregulated.

9 tributes to cardiac disease progression when dysregulated.

10 teins involved in cell cycle regulation were dysregulated.

11 hat immune-related genes are the most highly dysregulated.

12 autoimmunity or neoplasia if misdirected or dysregulated.

13 specific diseases in which PAD2 activity is dysregulated.

14 eq analysis demonstrated that S-(+)-fipronil dysregulated a higher level of genomic DNA methylation t

15 Dysregulated activation of the CDK4/6 kinases is a hallm

16 bowel disease patients, and this results in dysregulated activation of the NLRP3 inflammasome and pr

17 on and schizophrenia, may arise in part from dysregulated activity of ventral tegmental area dopamine

18 Dysregulated adipocyte physiology leads to imbalanced en

19 e numbers of RNA binding proteins (RBPs) are dysregulated and that RBP dysregulation is associated wi

20 alizing with CKD-associated variation can be dysregulated and therefore, considered as CKD candidate

21 the urea cycle and nitric oxide pathways are dysregulated at early stages in HD.

22 t the expression of inflammasome sensors was dysregulated at the mRNA level except for the NLRP12.

23 Its development involves dysregulated autophagy and unresolved inflammation, demo

24 Dysregulated autophagy might promote the inflammatory re

25 Although it is known that METH dysregulates both dopamine transmission and dopamine reu

26 lating diverse brain structural processes is dysregulated by aging and restored by FKBP1b overexpress

27 pt is that the RNA editing process itself is dysregulated by brain pathologies.

28 s a powerful tool to identify genes that are dysregulated by DNA methylation in disease.

29 We identified 578 miRNAs dysregulated by eCig exposure in NHBE, and 125 miRNA aff

30 To investigate the extent of gene expression dysregulated by HPV E7-induced DNA methylation, we analy

31 Dopamine neurotransmission is highly dysregulated by the psychostimulant methamphetamine, a s

32 Under pathological conditions of dysregulated Ca(2+) cycling, mitochondrial Ca(2+) overlo

33 The mechanism for increased mortality may be dysregulated cardiomyocyte Ca(2+) handling because of re

34 Dysregulated catecholamine signaling has long been impli

35 This dysregulated cell cycle mechanism may contribute to para

36 Oncogenic transformation leads to dysregulated cell proliferation, nutrient deficiency, an

37 TBK1 suppresses mTORC1 activity, leading to dysregulated cellular metabolism.

38 Dysregulated cellular signaling results in a shift from

39 ressive disorder, an illness associated with dysregulated circadian rhythms and a high incidence of s

40 clude an understanding of fear conditioning, dysregulated circuits, memory reconsolidation, epigeneti

41 These observations demonstrate that dysregulated CO and H2S signaling in the CB leads to apn

42 with mutations or autoantibodies leading to dysregulated complement activation.

43 Accumulating evidence suggests a dysregulated complement pathway among the pathogenic pro

44 ar memory, hyperarousal, generalization, and dysregulated corticosterone in stress-susceptible male m

45 unction through phosphorylation, which, when dysregulated, could lead to oncogenesis.

46 of the hepatic growth factor (HGF) caused by dysregulated cross talk between pulmonary endothelium an

47 Dysregulated crosstalk between the vasculature and retin

48 s infection, potentially contributing to the dysregulated cytokine response that is a hallmark of Ebo

49 D8(+) double-positive thymocytes resulted in dysregulated development and proliferation of invariant

50 eukemic state with enhanced self-renewal and dysregulated differentiation.

51 s bulimia nervosa has been associated with a dysregulated dopamine system and catecholamine depletion

52 expression, a common occurrence in cancers, dysregulates DSB repair, enhancing efficiency of likely

53 Genes that were dysregulated due to NOTCH1 haploinsufficiency in mice wi

54 also found that, unlike many host processes dysregulated during Toxoplasma infection, the induction

55 , motility, and immune responses, and can be dysregulated during tumor development and progression.

56 doption of a fast life-history strategy, and dysregulated-eating behaviors.

57 ches for the treatment of diseases that have dysregulated energy metabolism.

58 raise the question of the potential role of dysregulated epigenetic modifiers in normal aging hemato

59 use ER stress regardless of their ability to dysregulate ER Ca(2+) inhibit PCSK9 secretion, thereby r

60 and serine peptidase inhibitors as the most dysregulated esophagus-specific protein families in pati

61 Many studies support the contribution of dysregulated, exaggerated inflammation in scar formation

62 throid progenitors resulting in anemia, with dysregulated expression of Cebpa and Gata1, myeloid/eryt

63 Here we show that dysregulated expression of Cyp1a1 in mice depletes the r

64 K14CreERT;DLX3(fl/fl) skin exhibited dysregulated expression of differentiation-associated ge

65 Transcriptomics revealed the dysregulated expression of many genes (e.g. placental pr

66 Here, we determined whether dysregulated expression of the gap junction protein conn

67 he relationship of tumor pathophysiology and dysregulated expression of the NOTCH pathway transcripti

68 , these effects were in part mediated by the dysregulated expression of the scaffold protein IQGAP2,

69 Elevations in CRF-CRF1 signaling dysregulate FAAH activity, and this genotypic difference

70 ithm of metabolic disorders characterized by dysregulated fatty acid metabolism, including nonalcohol

71 Given that dysregulated fear levels characterize anxiety disorders,

72 egulating synaptic strength and learning, is dysregulated following traumatic brain injury (TBI), sug

73 Dysregulated Foxp3(+) Treg cells with distinct character

74 Dysregulated Foxp3(+) Treg functions result in uncontrol

75 ng's immune system, which in turn results in dysregulated function.

76 The family of diseases generated by dysregulated fusion tyrosine kinase (TK) genes is recogn

77 ciation of differential gene expression with dysregulated gBcyt-mediated fusion.

78 not restored survival fitness, rectified the dysregulated gene expression and thymocyte maturation in

79 g tissue-specific allergic disease, involves dysregulated gene expression in esophageal epithelial ce

80 Moreover, dysregulated gene expression in SMYD5 cancer cells was a

81 Dysregulated gene expression in the absence of TET1 caus

82 ud and heart development (LBH) gene as a key dysregulated gene in RA and other autoimmune diseases.

83 We identified dysregulated gene sets in blood that replicated in the i

84 in fragile X syndrome cells, and identified dysregulated gene- and network-level correlates of fragi

85 ric AML microRNA (miRNA) samples to identify dysregulated genes and assess the utility of miRNAs for

86 formatics analysis predicts that many of the dysregulated genes are regulated by common transcription

87 d patients with Alagille syndrome identified dysregulated genes encoding proteins enriched at the api

88 gene expression, with a larger proportion of dysregulated genes in the atrial chambers.

89 factor-binding site motifs of differentially dysregulated genes uncovered distinct MEF2A co-regulator

90 These dysregulated genes were enriched for telomere-contacting

91 ITE is able to identify novel subnetworks of dysregulated genes.

92 sses crucial for renal function, identifying dysregulated geranylgeranyl diphosphate biosynthesis as

93 knock-out mice are not readily explained by dysregulated Gi/o signaling.

94 en symptoms of many psychiatric disorders by dysregulating glutamatergic function within the prefront

95 Dysregulated Gp1 mGluR signaling has been observed in nu

96 sis complex (TSC) is a pediatric disorder of dysregulated growth and differentiation caused by loss o

97 e altered gene expression is associated with dysregulated H3K27ac and H3K4me1/2.

98 eregulated PU.1 gene expression is linked to dysregulated hematopoiesis and the development of leukem

99 Using GEM microarray model, we found ARF dysregulates Hippo and Wnt pathways.

100 ased serum concentrations of natural IgM and dysregulated homeostasis of B-2 cells; this caused the s

101 hodologies is advancing understanding of the dysregulated host immune response to infection in sepsis

102 specific sepsis therapeutics that target the dysregulated host response are highly desirable.

103 develop secondary infections revealed a more dysregulated host response during the first 4 days after

104 fe-threatening organ dysfunction caused by a dysregulated host response to an infection leading to sy

105 s is a common and deadly syndrome in which a dysregulated host response to infection causes organ fai

106 is life-threatening organ dysfunction due to dysregulated host responses to infection.

107 mic hypoglycaemia, insulin secretion becomes dysregulated (ie, uncoupled from glucose metabolism) so

108 he mucosal barrier integrity, as well as how dysregulated IEL responses can contribute to pathology.

109 n patients whose tumors are characterized by dysregulated IFNalpha signaling.

110 These results provide new insights into the dysregulated IgG4 response in patients with IgG4-RD.

111 Increasing evidence implicates dysregulated ILC responses as drivers of disease pathoge

112 nic inflammatory diseases is associated with dysregulated immune activation and production of tissue

113 chronic inflammatory disease resulting from dysregulated immune activation associated with a large l

114 chronic liver disorders are characterized by dysregulated immune responses and hepatocyte death.

115 the relationship between AH development and dysregulated immune responses that might be ameliorated

116 predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors

117 vels of virus replication and dissemination, dysregulated immune responses, extensive virus- and host

118 , and environmental factors that result in a dysregulated immune system.

119 tuned homeostatic function and contribute to dysregulated immune-responses.

120 hma is a complex disease that is promoted by dysregulated immunity and the presence of many cytokine

121 rolled enhancer, promotes atherosclerosis by dysregulating immunometabolism towards a chronic inflamm

122 173 miRNAs were significantly dysregulated in 45 BC versus 17 normal adjacent breast t

123 is essential for cellular homeostasis but is dysregulated in a number of diseases, including myocardi

124 or myeloid differentiation and is frequently dysregulated in acute myeloid leukemia.

125 t in the airways of healthy subjects but are dysregulated in adults with asthma, with a reduced diver

126 reported that this splicing event is highly dysregulated in aggressive forms of breast cancers, whic

127 dulate alpha-synuclein neuropathy and/or are dysregulated in Alzheimer's disease, understanding this

128 85% of the kinome has been identified to be dysregulated in at least one disease or developmental di

129 tial to identify genes and pathways that are dysregulated in autism spectrum disorder as well as frag

130 suppression by regulatory T cells (Tregs) is dysregulated in autoimmune diseases and cancer.

131 PI3K/Akt cell survival signalling pathway is dysregulated in both systems.

132 The tumor suppressor p53 is widely dysregulated in cancer and represents an attractive targ

133 ors (CKIs), the expression of which is often dysregulated in cancer cells.

134 A-derived small RNAs, hereafter "tsRNAs") is dysregulated in cancer.

135 dition, Chlamydia-specific Ab responses were dysregulated in CCR7-deficient mice, displaying an unexp

136 These two miRNAs were also found dysregulated in childhood and adult PA patients' cohorts

137 hat hepatic targets of PPARalpha and FXR are dysregulated in chronic undernutrition.

138 The CDK4/6 pathway is frequently dysregulated in cutaneous melanoma.

139 ss important in normal development and often dysregulated in disease.

140 mately 600 genes - we previously found these dysregulated in dying and surviving rat hippocampal neur

141 and the RNA editing pathway were found to be dysregulated in EC.

142 results suggest that RNABPs TTP and HuR are dysregulated in endometriotic lesions compared to matche

143 pathways and cytoskeleton related genes were dysregulated in EPHA2 knockdown HLE cells.

144 We identified parathyroid miRNAs that were dysregulated in experimental hyperparathyroidism, includ

145 ere we demonstrated that the MCU complex was dysregulated in hepatocellular carcinoma (HCC) cells and

146 ression of long non-coding RNAs (lncRNAs) is dysregulated in hepatocellular carcinoma (HCC).

147 ic target of rapamycin (mTOR) is prominently dysregulated in high-grade glial brain tumors, blockade

148 proach to identify genes whose expression is dysregulated in human prostate cancers.

149 GJA5, SLAMF7 and ETV1, which were frequently dysregulated in human squamous cell carcinomas, highligh

150 research has shown that miRNA expression is dysregulated in IDC and that these changes are already p

151 regulation is a prominent biological process dysregulated in individuals with OGID.

152 bitory plasticity in auditory cortex that is dysregulated in Mecp2(het).

153 onserved, essential survival mechanism often dysregulated in neuropsychiatric disorders.

154 rentiation, morphogenesis, and function were dysregulated in newborn Jag1(Ndr/Ndr) mice, with aberrat

155 We report that inflammation after SCI is dysregulated in part due to inappropriate synthesis of p

156 ses were used to identify molecular pathways dysregulated in patients with these disorders.

157 ppressor of invasive phenotypes that becomes dysregulated in primary and metastatic prostate cancer.

158 peckle-type POZ protein (SPOP) is frequently dysregulated in prostate adenocarcinoma (PC), via either

159 CHGA is dysregulated in several cardiovascular diseases, but the

160 so a tumor suppressor, and its expression is dysregulated in several human cancers.

161 ar remodeling maintains bone homeostasis, is dysregulated in skeletal disease, and may represent an a

162 The inhibitory properties of BECs are dysregulated in stable LTx recipients, which could sugge

163 iRNA, miR-124-3p, whose expression is highly dysregulated in stressed rodents, and identified a set o

164 sive studies, some key cellular pathways are dysregulated in the ALS-FTD spectrum disorder, including

165 cal pathway analysis of genes preferentially dysregulated in the atria and ventricles revealed distin

166 rated fatty acid metabolism is significantly dysregulated in the brains of patients with varying degr

167 Here, we demonstrate that Cx43 is dysregulated in the hearts of HIV-infected individuals.

168 extracellular matrix, Mmrn1, were temporally dysregulated in the placentas.

169 Secretion of this hormone is dysregulated in type 2 diabetes mellitus but the mechani

170 mune processes and their metabolism is often dysregulated in ulcerative colitis, a major category of

171 ine may block the Wnt pathway which is often dysregulated in various cancers.

172 Angiogenesis is dysregulated in various pathologies, including age-relat

173 ry miRNAs could successfully be confirmed as dysregulated in vivo with 10 upregulated (let-7c-5p, miR

174 , we identify 15 NLRs that are significantly dysregulated, including significant downregulation of NL

175 ging from periodic fever syndromes caused by dysregulated inflammasome-mediated production of the cyt

176 brosis in organ systems or diseases in which dysregulated inflammation and HA intersect.

177 ) phenotype to F4/80(hi)CD206(-) may lead to dysregulated inflammation during helminth infection.

178 monstrated an increased bacterial burden and dysregulated inflammation in the lungs.

179 Dysregulated inflammation is implicated in the pathobiol

180 Furthermore, the concept of dysregulated inflammation resolution in atherosclerosis

181 idity in patients after severe injury due to dysregulated inflammation, which is believed to be drive

182 severe disease in humans characterized by a dysregulated inflammatory response and elevated cytokine

183 is is a life-threatening condition caused by dysregulated inflammatory response to infection with no

184 and signaling to monocytes may contribute to dysregulated inflammatory syndromes in older adults.

185 e to impinge the ability of P. gingivalis to dysregulate innate immunity by repressing gingipain-asso

186 tors, and altered gut microbiota, leading to dysregulated innate and adaptive immune responses.

187 Increasing evidence has linked dysregulated interleukin (IL)-10 production by IL-10(+ve

188 MIA may confer increased risk for ASD by dysregulating key aspects of fetal brain gene expression

189 -/-) HFD mice are susceptible to obesity via dysregulated leptin/Ob-R signaling, whereas the lack of

190 as an interventional candidate to attenuate dysregulated lesional inflammation and to restore functi

191 have complex roles in neurodevelopment, and dysregulated levels may be indicative of genetic differe

192 Dysregulated lipid and carbohydrate metabolism resulting

193 tivity in late pregnancy in association with dysregulated lipid and glucose handling by the dam.

194 Obesity is associated with dysregulated lipid metabolism and adipokine secretion.

195 of biological functions, it is evident that dysregulated lipid metabolism signifies a key element in

196 ll renal cell carcinoma cells (ccRCC) have a dysregulated lipid-mediated checkpoint due in part to de

197 musculoskeletal soft tissues may result from dysregulated LM-SPM production, and that inhibition of 1

198 e employed RNA sequencing analysis to reveal dysregulated lncRNAs in lung cancer utilizing 461 lung a

199 FAM83H-AS1, one of the top dysregulated lncRNAs, was found to be overexpressed in t

200 IL-33 dysregulated lung Treg cells and impaired immunologic to

201 actors adversely affecting v-ATPase function dysregulate lysosomal acidification in other LSDs and co

202 However, dysregulated macrophage function impairs wound healing a

203 Dysregulated mammalian target of rapamycin (mTOR) promot

204 Whereas BRAF fusions primarily dysregulate MAPK signaling, the CRAF fusions QKI-RAF1 an

205 RNAseq analysis revealed dysregulated metabolic functions and signs of muscle atr

206 Hypoxia and dysregulated metabolism are defining features of solid t

207 Dysregulated metabolism can broadly affect therapy resis

208 In total, 398 and 368 dysregulated metabolites in the BAL fluid and plasma of

209 were perturbed in patients with T1R, with 71 dysregulated metabolites mapping to pathways for lipid m

210 bly, Lebanese BC patients had 21 exclusively dysregulated miRNA (e.g. miR-31, 362-3p, and 663) and 4

211 r the first time the involvement of LC based dysregulated miRNA network in disrupting cellular pathwa

212 roarray data revealed a potential role of 51 dysregulated miRNA regulating 719 tumor suppressive or o

213 To identify dysregulated miRNAs in lung tissue of patients with chro

214 Focusing on the most dysregulated miRNAs, we found miR-199 and miR-214 to be

215 A mouse liver we identified 14 significantly dysregulated miRNAs.

216 , the complexity of diseases associated with dysregulated MMP expression necessitates the imaging of

217 rity, corresponded to the most significantly dysregulated modules in the HD caudate, the most promine

218 mitters that are potentially responsible for dysregulated motor impulsivity following long-term alcoh

219 Additionally, a cholinergic dysregulated mouse model overexpressing a miR refractory

220 vated by microbial translocation through the dysregulated mucosal barrier in colon adenomas, facilita

221 onstitutive increases in CRF1 signaling that dysregulate N-arachidonoylethanolamine signaling mechani

222 Disorders of dysregulated negative emotion such as depression and anx

223 trol cells, suggesting that IE2 concurrently dysregulates neural stem cell maintenance in the VZ and

224 Tobacco use disorder is associated with dysregulated neurocognitive function in the right inferi

225 The majority of anthelmintics dysregulate neuromuscular function, a fact most prominen

226 haracterized by swellings/varicosities), and dysregulated neuronal excitability (decreased firing at

227 bE)/beta-thalassemia patients to investigate dysregulated neutrophil activity.

228 RATIONALE: Dysregulated neutrophil functions with age and sepsis ar

229 euronal chloride cotransporters indicated by dysregulated NKCC1 and KCC2 protein expression levels.

230 ew, we discuss rare human diseases caused by dysregulated nucleic acid sensing, focusing primarily on

231 phenotypic effects that were associated with dysregulated nucleotide metabolic processes in the male

232 itiation gene, EIF4E, is one of the most MIA-dysregulated of all ASD-associated genes and targeted ne

233 to understand how these genes contribute to dysregulated oncogenic pathways.

234 Dysregulated oncogenic serine/threonine kinases play a p

235 so contribute to a host of disease states if dysregulated or chronic.

236 he Human Protein Atlas, to identify commonly dysregulated pathways and biliary markers.

237 -driven variable selection method, to select dysregulated pathways and crucial proteins related to th

238 h, investigation of therapeutics that target dysregulated pathways or processes, rather than single t

239 Other dysregulated pathways such as signal transducer and acti

240 obesity during puberty leads to persistently dysregulated patterns of sleep and wakefulness by blunti

241 calvarium development in the mouse and that dysregulated PDGFRalpha activity causes craniosynostosis

242 Loss of functional Lyst leads to dysregulated phagosomal maturation, resulting in a failu

243 an cancers and that this alteration leads to dysregulated PI3K signaling.

244 Atherothrombosis is a process mediated by dysregulated platelet activation that can cause life-thr

245 This suggests that dysregulated Pol I transcription is essential for the ma

246 ic miRNA capable of simultaneously targeting dysregulated polyamine metabolism in cancer, thereby pro

247 ously delivering miR-34a mimic and targeting dysregulated polyamine metabolism in cancer.

248 m is regulated by reversible acetylation and dysregulated polyamine metabolism is associated with neo

249 ve focused on impaired threat processing and dysregulated prefrontal-cortex-amygdala circuitry.

250 However, their dysregulated production and signaling can aggravate tiss

251 e regulation of dendritic cell activity, and dysregulated production of chemokines collectively favor

252 Immunity, Spath et al. (2017) show that the dysregulated production of GM-CSF rather than IL-17 indu

253 These dysregulated programs can cause cancer cells to become h

254 dependencies can develop as a consequence of dysregulated programs, and how these dependencies provid

255 oped an ICU-acquired infection showed a more dysregulated proinflammatory and vascular host response

256 ts with both AD and CD identified additional dysregulated proteins compared with subjects with either

257 Here we examine how MIA dysregulates rat fetal brain gene expression (at a time

258 resulted in aggravated NTN with selectively dysregulated renal and systemic Th1 responses.

259 Thus, our data suggest that nicotine causes dysregulated repair by inhibition of myofibroblast diffe

260 suggesting that nicotine is responsible for dysregulated repair during injurious responses.

261 Type 2 diabetes mellitus (T2D) arises from a dysregulated response to elevated glucose levels in the

262 robust protective host immune responses and dysregulated responses that promote immune pathology, ca

263 Inappropriate or dysregulated responses to RSV can be pathogenic, causing

264 n and off treatment, sJIA patients displayed dysregulated responses to TLR4, TLR8, and TLR7 stimulati

265 ons for cytoskeletal reconfiguration through dysregulated RhoA or Rac1, and they predict compensatory

266 and host cell death that are associated with dysregulated septin cage-like formation, impaired autoph

267 cognitive changes typically associated with dysregulated serotonin (5HT) transmission in the medial

268 The association of cancer cells with dysregulated signaling pathways linked to RTKs represent

269 n (mTOR) pathway is one of the most commonly dysregulated signaling pathways that is linked to cancer

270 Kidney disease has been linked to dysregulated signaling via PKC in kidney cells such as p

271 rowing body of studies has demonstrated that dysregulated splicing profiles constitute pivotal mechan

272 AH patients were in a highly immune-dysregulated state, whereas HDC showed little evidence o

273 Despite ample evidence of dysregulated sympathetic control of the peripheral vascu

274 sed by STAT1 GOF mutations are the result of dysregulated T helper cell responses.

275 ell-specific overexpression of miR-27 harbor dysregulated Th1 responses and develop autoimmune pathol

276 We examine how these fusion genes dysregulate the BCL-2 family of proteins, preventing act

277 e they share many genetic risk variants that dysregulate the expression of immune-related genes.

278 The absence of CD40L dysregulated the macrophage transcriptome, which was imp

279 that the oxidative stress induced by obesity dysregulates the expression of the transcription factor

280 pathology by hyperphosphorylating tau and by dysregulating the alternative splicing of tau exon 10 in

281 tor KO B cells after BCR stimulation through dysregulating the dephosphorylation of ezrin.

282 cytokine TNFalpha causes EC apoptosis while dysregulating the Notch pathway, a major contributor to

283 If this well-orchestrated response becomes dysregulated, the wound can become chronic or progressiv

284 integration within cortical microcircuits to dysregulate threat reactivity and promote aggression.

285 Dysregulated Toll-like receptor (TLR)-4 activation is in

286 genetic alterations that invariably lead to dysregulated transcriptional programs.

287 Our analysis predicts distinct dysregulated transcriptional regulators downstream of so

288 s, with sufficient collective influence over dysregulated transcripts.

289 mediated in part by defective desmosomes and dysregulated transforming growth factor beta production

290 that is in action even at rest, implicating dysregulated triangular sensory-prefrontal-cortex-amygda

291 However, the causative link between dysregulated tryptophan metabolism and abdominal aortic

292 d world, millions of individuals suffer from dysregulated type 2 immunity, referred to clinically as

293 story strategy, in turn, was associated with dysregulated weight-management behaviors (i.e., eating e

294 lycerol are very significantly circadian and dysregulated when sleep is disrupted.

295 oordinating brain structural organization is dysregulated with aging and restored by FKBP1b.

296 The lipid metabolism was further dysregulated with increased triglyceride species and a s

297 ical aspects of embryonic development, while dysregulated Wnt signaling contributes to common disease

298 ther, we use the system to show that loss of dysregulated Wnt signaling is critical for the progressi

299 HTS is the result of dysregulated wound healing, where excessive collagen and

300 ported a novel crosstalk of ARF/beta-catenin dysregulated YAP in Hippo pathway and a new approach to