ライフサイエンスコーパス: dysregulated

1 functions, can disrupt genome integrity when dysregulated.

2 Nkx2-5 (NK2 homeobox 5), Tbx3, and Tbx5 are dysregulated.

3 Es; however, only KLK7 was transcriptionally dysregulated.

4 rtant pathway that causes disease when it is dysregulated.

5 g via this interaction can be detrimental if dysregulated.

6 treating diseases in which PAD2 activity is dysregulated.

7 cs, and mitochondrial protein synthesis were dysregulated.

8 thology when upstream activating signals are dysregulated.

9 tributes to cardiac disease progression when dysregulated.

10 teins involved in cell cycle regulation were dysregulated.

11 hat immune-related genes are the most highly dysregulated.

12 autoimmunity or neoplasia if misdirected or dysregulated.

13 iants are also more likely to be silenced or dysregulated.

14 specific diseases in which PAD2 activity is dysregulated.

15 eq analysis demonstrated that S-(+)-fipronil dysregulated a higher level of genomic DNA methylation t

16 Dysregulated activation of the CDK4/6 kinases is a hallm

17 bowel disease patients, and this results in dysregulated activation of the NLRP3 inflammasome and pr

18 on and schizophrenia, may arise in part from dysregulated activity of ventral tegmental area dopamine

19 Dysregulated adipocyte physiology leads to imbalanced en

20 e numbers of RNA binding proteins (RBPs) are dysregulated and that RBP dysregulation is associated wi

21 alizing with CKD-associated variation can be dysregulated and therefore, considered as CKD candidate

22 These findings show that dysregulated angiogenic precursors link coronary anomali

23 the urea cycle and nitric oxide pathways are dysregulated at early stages in HD.

24 t the expression of inflammasome sensors was dysregulated at the mRNA level except for the NLRP12.

25 Its development involves dysregulated autophagy and unresolved inflammation, demo

26 Dysregulated autophagy might promote the inflammatory re

27 apeutic target for diseases characterized by dysregulated B cell activity.

28 lating diverse brain structural processes is dysregulated by aging and restored by FKBP1b overexpress

29 It is dysregulated by behavioral stress in animal models of de

30 pt is that the RNA editing process itself is dysregulated by brain pathologies.

31 s a powerful tool to identify genes that are dysregulated by DNA methylation in disease.

32 We identified 578 miRNAs dysregulated by eCig exposure in NHBE, and 125 miRNA aff

33 To investigate the extent of gene expression dysregulated by HPV E7-induced DNA methylation, we analy

34 Dopamine neurotransmission is highly dysregulated by the psychostimulant methamphetamine, a s

35 Under pathological conditions of dysregulated Ca(2+) cycling, mitochondrial Ca(2+) overlo

36 rough a mechanism involving vulnerability to dysregulated calcium metabolism and the combination of f

37 The mechanism for increased mortality may be dysregulated cardiomyocyte Ca(2+) handling because of re

38 Dysregulated catecholamine signaling has long been impli

39 This dysregulated cell cycle mechanism may contribute to para

40 Oncogenic transformation leads to dysregulated cell proliferation, nutrient deficiency, an

41 TBK1 suppresses mTORC1 activity, leading to dysregulated cellular metabolism.

42 Dysregulated cellular signaling results in a shift from

43 ressive disorder, an illness associated with dysregulated circadian rhythms and a high incidence of s

44 clude an understanding of fear conditioning, dysregulated circuits, memory reconsolidation, epigeneti

45 These observations demonstrate that dysregulated CO and H2S signaling in the CB leads to apn

46 with mutations or autoantibodies leading to dysregulated complement activation.

47 Accumulating evidence suggests a dysregulated complement pathway among the pathogenic pro

48 ar memory, hyperarousal, generalization, and dysregulated corticosterone in stress-susceptible male m

49 unction through phosphorylation, which, when dysregulated, could lead to oncogenesis.

50 Subsequent studies examined the influence of dysregulated CRF and FAAH systems in altering excitatory

51 e glutamatergic transmission in the CeA, and dysregulated CRF-FAAH facilitates stress-induced increas

52 of the hepatic growth factor (HGF) caused by dysregulated cross talk between pulmonary endothelium an

53 Dysregulated crosstalk between the vasculature and retin

54 s infection, potentially contributing to the dysregulated cytokine response that is a hallmark of Ebo

55 D8(+) double-positive thymocytes resulted in dysregulated development and proliferation of invariant

56 eukemic state with enhanced self-renewal and dysregulated differentiation.

57 s bulimia nervosa has been associated with a dysregulated dopamine system and catecholamine depletion

58 Genes that were dysregulated due to NOTCH1 haploinsufficiency in mice wi

59 also found that, unlike many host processes dysregulated during Toxoplasma infection, the induction

60 , motility, and immune responses, and can be dysregulated during tumor development and progression.

61 doption of a fast life-history strategy, and dysregulated-eating behaviors.

62 ches for the treatment of diseases that have dysregulated energy metabolism.

63 raise the question of the potential role of dysregulated epigenetic modifiers in normal aging hemato

64 and serine peptidase inhibitors as the most dysregulated esophagus-specific protein families in pati

65 Many studies support the contribution of dysregulated, exaggerated inflammation in scar formation

66 throid progenitors resulting in anemia, with dysregulated expression of Cebpa and Gata1, myeloid/eryt

67 Here we show that dysregulated expression of Cyp1a1 in mice depletes the r

68 K14CreERT;DLX3(fl/fl) skin exhibited dysregulated expression of differentiation-associated ge

69 Transcriptomics revealed the dysregulated expression of many genes (e.g. placental pr

70 Here, we determined whether dysregulated expression of the gap junction protein conn

71 he relationship of tumor pathophysiology and dysregulated expression of the NOTCH pathway transcripti

72 , these effects were in part mediated by the dysregulated expression of the scaffold protein IQGAP2,

73 ithm of metabolic disorders characterized by dysregulated fatty acid metabolism, including nonalcohol

74 Given that dysregulated fear levels characterize anxiety disorders,

75 egulating synaptic strength and learning, is dysregulated following traumatic brain injury (TBI), sug

76 Dysregulated Foxp3(+) Treg cells with distinct character

77 Dysregulated Foxp3(+) Treg functions result in uncontrol

78 ng's immune system, which in turn results in dysregulated function.

79 The family of diseases generated by dysregulated fusion tyrosine kinase (TK) genes is recogn

80 ciation of differential gene expression with dysregulated gBcyt-mediated fusion.

81 not restored survival fitness, rectified the dysregulated gene expression and thymocyte maturation in

82 g tissue-specific allergic disease, involves dysregulated gene expression in esophageal epithelial ce

83 Moreover, dysregulated gene expression in SMYD5 cancer cells was a

84 Dysregulated gene expression in the absence of TET1 caus

85 ud and heart development (LBH) gene as a key dysregulated gene in RA and other autoimmune diseases.

86 We identified dysregulated gene sets in blood that replicated in the i

87 in fragile X syndrome cells, and identified dysregulated gene- and network-level correlates of fragi

88 ric AML microRNA (miRNA) samples to identify dysregulated genes and assess the utility of miRNAs for

89 formatics analysis predicts that many of the dysregulated genes are regulated by common transcription

90 d patients with Alagille syndrome identified dysregulated genes encoding proteins enriched at the api

91 gene expression, with a larger proportion of dysregulated genes in the atrial chambers.

92 factor-binding site motifs of differentially dysregulated genes uncovered distinct MEF2A co-regulator

93 These dysregulated genes were enriched for telomere-contacting

94 ITE is able to identify novel subnetworks of dysregulated genes.

95 sses crucial for renal function, identifying dysregulated geranylgeranyl diphosphate biosynthesis as

96 knock-out mice are not readily explained by dysregulated Gi/o signaling.

97 Dysregulated Gp1 mGluR signaling has been observed in nu

98 sis complex (TSC) is a pediatric disorder of dysregulated growth and differentiation caused by loss o

99 e altered gene expression is associated with dysregulated H3K27ac and H3K4me1/2.

100 eregulated PU.1 gene expression is linked to dysregulated hematopoiesis and the development of leukem

101 ased serum concentrations of natural IgM and dysregulated homeostasis of B-2 cells; this caused the s

102 hodologies is advancing understanding of the dysregulated host immune response to infection in sepsis

103 specific sepsis therapeutics that target the dysregulated host response are highly desirable.

104 develop secondary infections revealed a more dysregulated host response during the first 4 days after

105 fe-threatening organ dysfunction caused by a dysregulated host response to an infection leading to sy

106 s is a common and deadly syndrome in which a dysregulated host response to infection causes organ fai

107 is life-threatening organ dysfunction due to dysregulated host responses to infection.

108 mic hypoglycaemia, insulin secretion becomes dysregulated (ie, uncoupled from glucose metabolism) so

109 he mucosal barrier integrity, as well as how dysregulated IEL responses can contribute to pathology.

110 n patients whose tumors are characterized by dysregulated IFNalpha signaling.

111 These results provide new insights into the dysregulated IgG4 response in patients with IgG4-RD.

112 Increasing evidence implicates dysregulated ILC responses as drivers of disease pathoge

113 nic inflammatory diseases is associated with dysregulated immune activation and production of tissue

114 chronic inflammatory disease resulting from dysregulated immune activation associated with a large l

115 nflammatory disease of the airways caused by dysregulated immune balance in the lungs with incomplete

116 chronic liver disorders are characterized by dysregulated immune responses and hepatocyte death.

117 the relationship between AH development and dysregulated immune responses that might be ameliorated

118 predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors

119 vels of virus replication and dissemination, dysregulated immune responses, extensive virus- and host

120 , and environmental factors that result in a dysregulated immune system.

121 tuned homeostatic function and contribute to dysregulated immune-responses.

122 hma is a complex disease that is promoted by dysregulated immunity and the presence of many cytokine

123 173 miRNAs were significantly dysregulated in 45 BC versus 17 normal adjacent breast t

124 is essential for cellular homeostasis but is dysregulated in a number of diseases, including myocardi

125 or myeloid differentiation and is frequently dysregulated in acute myeloid leukemia.

126 t in the airways of healthy subjects but are dysregulated in adults with asthma, with a reduced diver

127 reported that this splicing event is highly dysregulated in aggressive forms of breast cancers, whic

128 dulate alpha-synuclein neuropathy and/or are dysregulated in Alzheimer's disease, understanding this

129 85% of the kinome has been identified to be dysregulated in at least one disease or developmental di

130 tial to identify genes and pathways that are dysregulated in autism spectrum disorder as well as frag

131 suppression by regulatory T cells (Tregs) is dysregulated in autoimmune diseases and cancer.

132 PI3K/Akt cell survival signalling pathway is dysregulated in both systems.

133 ins are important signalling hubs frequently dysregulated in cancer and in a group of developmental d

134 The tumor suppressor p53 is widely dysregulated in cancer and represents an attractive targ

135 ors (CKIs), the expression of which is often dysregulated in cancer cells.

136 developmental pathways in embryogenesis are dysregulated in cancer, we aim to unravel the role of FS

137 A-derived small RNAs, hereafter "tsRNAs") is dysregulated in cancer.

138 ty of cellular functions, and are frequently dysregulated in cancer.

139 dition, Chlamydia-specific Ab responses were dysregulated in CCR7-deficient mice, displaying an unexp

140 These two miRNAs were also found dysregulated in childhood and adult PA patients' cohorts

141 hat hepatic targets of PPARalpha and FXR are dysregulated in chronic undernutrition.

142 The CDK4/6 pathway is frequently dysregulated in cutaneous melanoma.

143 ss important in normal development and often dysregulated in disease.

144 mately 600 genes - we previously found these dysregulated in dying and surviving rat hippocampal neur

145 and the RNA editing pathway were found to be dysregulated in EC.

146 results suggest that RNABPs TTP and HuR are dysregulated in endometriotic lesions compared to matche

147 pathways and cytoskeleton related genes were dysregulated in EPHA2 knockdown HLE cells.

148 We identified parathyroid miRNAs that were dysregulated in experimental hyperparathyroidism, includ

149 ere we demonstrated that the MCU complex was dysregulated in hepatocellular carcinoma (HCC) cells and

150 ression of long non-coding RNAs (lncRNAs) is dysregulated in hepatocellular carcinoma (HCC).

151 ic target of rapamycin (mTOR) is prominently dysregulated in high-grade glial brain tumors, blockade

152 ast 20 members, most of which are frequently dysregulated in human malignancies including breast canc

153 proach to identify genes whose expression is dysregulated in human prostate cancers.

154 GJA5, SLAMF7 and ETV1, which were frequently dysregulated in human squamous cell carcinomas, highligh

155 research has shown that miRNA expression is dysregulated in IDC and that these changes are already p

156 regulation is a prominent biological process dysregulated in individuals with OGID.

157 is a key process during wound healing and is dysregulated in lung diseases.

158 S-stimulated prostaglandin-E2 production was dysregulated in macrophages, demonstrating the substrate

159 bitory plasticity in auditory cortex that is dysregulated in Mecp2(het).

160 onserved, essential survival mechanism often dysregulated in neuropsychiatric disorders.

161 rentiation, morphogenesis, and function were dysregulated in newborn Jag1(Ndr/Ndr) mice, with aberrat

162 We report that inflammation after SCI is dysregulated in part due to inappropriate synthesis of p

163 ses were used to identify molecular pathways dysregulated in patients with these disorders.

164 ppressor of invasive phenotypes that becomes dysregulated in primary and metastatic prostate cancer.

165 peckle-type POZ protein (SPOP) is frequently dysregulated in prostate adenocarcinoma (PC), via either

166 activating proteins (GAPs) is differentially dysregulated in response to OGD/ischemia in hippocampal

167 CHGA is dysregulated in several cardiovascular diseases, but the

168 so a tumor suppressor, and its expression is dysregulated in several human cancers.

169 lation of cognitive control processes and is dysregulated in several neuropsychiatric disorders.

170 ar remodeling maintains bone homeostasis, is dysregulated in skeletal disease, and may represent an a

171 The inhibitory properties of BECs are dysregulated in stable LTx recipients, which could sugge

172 iRNA, miR-124-3p, whose expression is highly dysregulated in stressed rodents, and identified a set o

173 sive studies, some key cellular pathways are dysregulated in the ALS-FTD spectrum disorder, including

174 cal pathway analysis of genes preferentially dysregulated in the atria and ventricles revealed distin

175 rated fatty acid metabolism is significantly dysregulated in the brains of patients with varying degr

176 Here, we demonstrate that Cx43 is dysregulated in the hearts of HIV-infected individuals.

177 extracellular matrix, Mmrn1, were temporally dysregulated in the placentas.

178 Secretion of this hormone is dysregulated in type 2 diabetes mellitus but the mechani

179 mune processes and their metabolism is often dysregulated in ulcerative colitis, a major category of

180 ine may block the Wnt pathway which is often dysregulated in various cancers.

181 Angiogenesis is dysregulated in various pathologies, including age-relat

182 ry miRNAs could successfully be confirmed as dysregulated in vivo with 10 upregulated (let-7c-5p, miR

183 , we identify 15 NLRs that are significantly dysregulated, including significant downregulation of NL

184 ging from periodic fever syndromes caused by dysregulated inflammasome-mediated production of the cyt

185 brosis in organ systems or diseases in which dysregulated inflammation and HA intersect.

186 ) phenotype to F4/80(hi)CD206(-) may lead to dysregulated inflammation during helminth infection.

187 monstrated an increased bacterial burden and dysregulated inflammation in the lungs.

188 Dysregulated inflammation is implicated in the pathobiol

189 Furthermore, the concept of dysregulated inflammation resolution in atherosclerosis

190 idity in patients after severe injury due to dysregulated inflammation, which is believed to be drive

191 severe disease in humans characterized by a dysregulated inflammatory response and elevated cytokine

192 is is a life-threatening condition caused by dysregulated inflammatory response to infection with no

193 and signaling to monocytes may contribute to dysregulated inflammatory syndromes in older adults.

194 tors, and altered gut microbiota, leading to dysregulated innate and adaptive immune responses.

195 n Network Analysis on PTSD, and identified a dysregulated innate immune module associated with PTSD d

196 Increasing evidence has linked dysregulated interleukin (IL)-10 production by IL-10(+ve

197 -/-) HFD mice are susceptible to obesity via dysregulated leptin/Ob-R signaling, whereas the lack of

198 as an interventional candidate to attenuate dysregulated lesional inflammation and to restore functi

199 have complex roles in neurodevelopment, and dysregulated levels may be indicative of genetic differe

200 Dysregulated lipid and carbohydrate metabolism resulting

201 tivity in late pregnancy in association with dysregulated lipid and glucose handling by the dam.

202 Obesity is associated with dysregulated lipid metabolism and adipokine secretion.

203 of biological functions, it is evident that dysregulated lipid metabolism signifies a key element in

204 ll renal cell carcinoma cells (ccRCC) have a dysregulated lipid-mediated checkpoint due in part to de

205 musculoskeletal soft tissues may result from dysregulated LM-SPM production, and that inhibition of 1

206 e employed RNA sequencing analysis to reveal dysregulated lncRNAs in lung cancer utilizing 461 lung a

207 To delineate dysregulated lncRNAs in lung cancer, we analyzed RNA-Seq

208 FAM83H-AS1, one of the top dysregulated lncRNAs, was found to be overexpressed in t

209 IL-33 dysregulated lung Treg cells and impaired immunologic to

210 However, dysregulated macrophage function impairs wound healing a

211 Dysregulated mammalian target of rapamycin (mTOR) promot

212 RNAseq analysis revealed dysregulated metabolic functions and signs of muscle atr

213 Hypoxia and dysregulated metabolism are defining features of solid t

214 Dysregulated metabolism can broadly affect therapy resis

215 In total, 398 and 368 dysregulated metabolites in the BAL fluid and plasma of

216 were perturbed in patients with T1R, with 71 dysregulated metabolites mapping to pathways for lipid m

217 The underlying molecular mechanisms of how dysregulated microRNAs (miRNAs) cause neurodegeneration

218 bly, Lebanese BC patients had 21 exclusively dysregulated miRNA (e.g. miR-31, 362-3p, and 663) and 4

219 r the first time the involvement of LC based dysregulated miRNA network in disrupting cellular pathwa

220 roarray data revealed a potential role of 51 dysregulated miRNA regulating 719 tumor suppressive or o

221 To identify dysregulated miRNAs in lung tissue of patients with chro

222 Focusing on the most dysregulated miRNAs, we found miR-199 and miR-214 to be

223 A mouse liver we identified 14 significantly dysregulated miRNAs.

224 , the complexity of diseases associated with dysregulated MMP expression necessitates the imaging of

225 rity, corresponded to the most significantly dysregulated modules in the HD caudate, the most promine

226 mitters that are potentially responsible for dysregulated motor impulsivity following long-term alcoh

227 Additionally, a cholinergic dysregulated mouse model overexpressing a miR refractory

228 vated by microbial translocation through the dysregulated mucosal barrier in colon adenomas, facilita

229 Disorders of dysregulated negative emotion such as depression and anx

230 Tobacco use disorder is associated with dysregulated neurocognitive function in the right inferi

231 haracterized by swellings/varicosities), and dysregulated neuronal excitability (decreased firing at

232 bE)/beta-thalassemia patients to investigate dysregulated neutrophil activity.

233 RATIONALE: Dysregulated neutrophil functions with age and sepsis ar

234 euronal chloride cotransporters indicated by dysregulated NKCC1 and KCC2 protein expression levels.

235 ew, we discuss rare human diseases caused by dysregulated nucleic acid sensing, focusing primarily on

236 phenotypic effects that were associated with dysregulated nucleotide metabolic processes in the male

237 itiation gene, EIF4E, is one of the most MIA-dysregulated of all ASD-associated genes and targeted ne

238 to understand how these genes contribute to dysregulated oncogenic pathways.

239 Dysregulated oncogenic serine/threonine kinases play a p

240 so contribute to a host of disease states if dysregulated or chronic.

241 he Human Protein Atlas, to identify commonly dysregulated pathways and biliary markers.

242 -driven variable selection method, to select dysregulated pathways and crucial proteins related to th

243 h, investigation of therapeutics that target dysregulated pathways or processes, rather than single t

244 Other dysregulated pathways such as signal transducer and acti

245 obesity during puberty leads to persistently dysregulated patterns of sleep and wakefulness by blunti

246 calvarium development in the mouse and that dysregulated PDGFRalpha activity causes craniosynostosis

247 Loss of functional Lyst leads to dysregulated phagosomal maturation, resulting in a failu

248 an cancers and that this alteration leads to dysregulated PI3K signaling.

249 Atherothrombosis is a process mediated by dysregulated platelet activation that can cause life-thr

250 This suggests that dysregulated Pol I transcription is essential for the ma

251 ic miRNA capable of simultaneously targeting dysregulated polyamine metabolism in cancer, thereby pro

252 ously delivering miR-34a mimic and targeting dysregulated polyamine metabolism in cancer.

253 m is regulated by reversible acetylation and dysregulated polyamine metabolism is associated with neo

254 ve focused on impaired threat processing and dysregulated prefrontal-cortex-amygdala circuitry.

255 These data indicate that dysregulated presynaptic mGluR2/3 signaling is a possibl

256 However, their dysregulated production and signaling can aggravate tiss

257 e regulation of dendritic cell activity, and dysregulated production of chemokines collectively favor

258 Immunity, Spath et al. (2017) show that the dysregulated production of GM-CSF rather than IL-17 indu

259 These dysregulated programs can cause cancer cells to become h

260 dependencies can develop as a consequence of dysregulated programs, and how these dependencies provid

261 oped an ICU-acquired infection showed a more dysregulated proinflammatory and vascular host response

262 ts with both AD and CD identified additional dysregulated proteins compared with subjects with either

263 resulted in aggravated NTN with selectively dysregulated renal and systemic Th1 responses.

264 Thus, our data suggest that nicotine causes dysregulated repair by inhibition of myofibroblast diffe

265 suggesting that nicotine is responsible for dysregulated repair during injurious responses.

266 Type 2 diabetes mellitus (T2D) arises from a dysregulated response to elevated glucose levels in the

267 robust protective host immune responses and dysregulated responses that promote immune pathology, ca

268 Inappropriate or dysregulated responses to RSV can be pathogenic, causing

269 n and off treatment, sJIA patients displayed dysregulated responses to TLR4, TLR8, and TLR7 stimulati

270 ons for cytoskeletal reconfiguration through dysregulated RhoA or Rac1, and they predict compensatory

271 trol metabolic disorders associated with its dysregulated secretion.

272 and host cell death that are associated with dysregulated septin cage-like formation, impaired autoph

273 cognitive changes typically associated with dysregulated serotonin (5HT) transmission in the medial

274 The association of cancer cells with dysregulated signaling pathways linked to RTKs represent

275 n (mTOR) pathway is one of the most commonly dysregulated signaling pathways that is linked to cancer

276 Kidney disease has been linked to dysregulated signaling via PKC in kidney cells such as p

277 rowing body of studies has demonstrated that dysregulated splicing profiles constitute pivotal mechan

278 AH patients were in a highly immune-dysregulated state, whereas HDC showed little evidence o

279 Despite ample evidence of dysregulated sympathetic control of the peripheral vascu

280 ABSTRACT: Despite ample evidence of dysregulated sympathetic control of the peripheral vascu

281 sed by STAT1 GOF mutations are the result of dysregulated T helper cell responses.

282 ell-specific overexpression of miR-27 harbor dysregulated Th1 responses and develop autoimmune pathol

283 The absence of CD40L dysregulated the macrophage transcriptome, which was imp

284 If this well-orchestrated response becomes dysregulated, the wound can become chronic or progressiv

285 Dysregulated Toll-like receptor (TLR)-4 activation is in

286 genetic alterations that invariably lead to dysregulated transcriptional programs.

287 Our analysis predicts distinct dysregulated transcriptional regulators downstream of so

288 s, with sufficient collective influence over dysregulated transcripts.

289 mediated in part by defective desmosomes and dysregulated transforming growth factor beta production

290 that is in action even at rest, implicating dysregulated triangular sensory-prefrontal-cortex-amygda

291 However, the causative link between dysregulated tryptophan metabolism and abdominal aortic

292 d world, millions of individuals suffer from dysregulated type 2 immunity, referred to clinically as

293 story strategy, in turn, was associated with dysregulated weight-management behaviors (i.e., eating e

294 lycerol are very significantly circadian and dysregulated when sleep is disrupted.

295 oordinating brain structural organization is dysregulated with aging and restored by FKBP1b.

296 The lipid metabolism was further dysregulated with increased triglyceride species and a s

297 ical aspects of embryonic development, while dysregulated Wnt signaling contributes to common disease

298 ther, we use the system to show that loss of dysregulated Wnt signaling is critical for the progressi

299 HTS is the result of dysregulated wound healing, where excessive collagen and

300 ported a novel crosstalk of ARF/beta-catenin dysregulated YAP in Hippo pathway and a new approach to