ライフサイエンスコーパス: dysregulation

1 n (PCR) were used to examine transcriptional dysregulation.

2 hat most antidepressants may counteract this dysregulation.

3 phenotype that was not associated with gene dysregulation.

4 crobiome as a driver of this systemic immune dysregulation.

5 rve as a marker of this IFN-gamma-associated dysregulation.

6 onset obesity, growth defects, and metabolic dysregulation.

7 le immune deficiency with features of immune dysregulation.

8 vered dozens of loci that influence glycemic dysregulation.

9 her retinopathies associated with complement dysregulation.

10 causality between the mutation and oncogene dysregulation.

11 ention in patients suffering from complement dysregulation.

12 ed to increased epithelial cell beta-catenin dysregulation.

13 es, with SERPINA3 showing the most prominent dysregulation.

14 onkeys resembled RTT patients in immune gene dysregulation.

15 ettings of infection, vaccination, or immune dysregulation.

16 eir physiological functions and pathological dysregulation.

17 osed in the literature may modulate striatal dysregulation.

18 ctivity assessed ex vivo and improved immune dysregulation.

19 rbidities and hypothalamic-pituitary-gonadal dysregulation.

20 ponents of the ubiquitin system cause immune dysregulation.

21 nd effects on lymphoproliferation and immune dysregulation.

22 ons mediate cisplatin-induced energy balance dysregulation.

23 AML) is a disease associated with epigenetic dysregulation.

24 ces with specific hormonal and immunological dysregulations.

25 te hypothalamic-pituitary-adrenal (HPA) axis dysregulation, a key feature of affective disorders.

26 evere intestinal inflammation and epithelial dysregulation, accompanied by excessive necroptotic cell

27 ive rise to overlapping phenotypes of immune dysregulation and autoimmunity, with dramatically increa

28 ing to increased cell death, transcriptional dysregulation and cell-type-specific molecular pathology

29 esponses, reverses both aging-related Ca(2+) dysregulation and cognitive impairment.

30 to provide a topographical map of this dual dysregulation and explore potential cellular and circuit

31 cers; however, the mechanisms underlying its dysregulation and functions in carcinogenesis remain obs

32 ommunication and repetitive behavior, immune dysregulation and gastrointestinal issues are common com

33 of disordered breathing patterns, autonomic dysregulation and increases in incidence of arrhythmia i

34 found that DENV infection induced metabolic dysregulation and inflammatory responses and affected th

35 there are gaps in knowledge regarding VEGF-D dysregulation and its cellular origin in lymphangioleiom

36 tation triggers IRF3-independent immune cell dysregulation and lung disease in mice.

37 ehavioural inflexibility, reflect underlying dysregulation and malfunction in specific neural circuit

38 is linked with cardiovascular and metabolic dysregulation and morbidity.

39 y pathologic mechanism for driving glutamate dysregulation and neuronal hyperactivity during AD.SIGNI

40 of synj1 rescues blast-induced phospholipid dysregulation and prevents development of Tau hyper-phos

41 The barrier dysregulation and spontaneous skin inflammation in Il17r

42 l response to insulin through IRS-1 and PTEN dysregulation and suggest that, in Alzheimer's disease,

43 ate a causal relationship between complement dysregulation and systemic angiopathy and suggest that c

44 able to acute stress, leading to progressive dysregulation and the onset of psychosis.

45 Because Neu5Gc(-/-) mice exhibit glycemic dysregulations and pancreatic beta-cell dysfunctions, we

46 icrobiome in the pathogenesis of CVID immune dysregulation, and describe the possible immunologic mec

47 tive disorders are associated with autophagy dysregulation, and drugs modulating autophagy have been

48 disorders, such as cancer, fibrosis, immune dysregulation, and neurodegenerative diseases.

49 f FMRP in neural function from developmental dysregulation, and that PFC function can be restored in

50 vations implicate a critical role for T cell dysregulation as a central problem in rheumatoid arthrit

51 olymorphism, suggesting NRG3 transcriptional dysregulation as a molecular mechanism of risk.

52 Utilizing models of Ras dysregulation as well as inhibitors of the MAPK and PI3K

53 s a heritable disorder characterized by mood dysregulation associated with brain functional dysconnec

54 icted to preventing blood loss in hemostatic dysregulation because of poor efficacy and adverse effec

55 s are not due to gene expression variance or dysregulation, but emerge from the nonlinearity of the g

56 te a rate-limiting checkpoint against B cell dysregulation by MYD88(L265P) and provide an explanation

57 nt plays a key role in host defense, but its dysregulation can cause autologous tissue injury.

58 Quantitative approaches that describe these dysregulations can provide guidance in the design of nov

59 naling and localization, whereas Na/K-ATPase-dysregulation caused by retinoschisin deficiency could r

60 n the brain, it is not surprising that miRNA dysregulation causes neurodegeneration in animal models.

61 at DENV infection strongly induced metabolic dysregulation, complement signaling, and inflammation.

62 e cell's growth and metabolic state, and its dysregulation contributes to a variety of diseases, incl

63 ased susceptibility to mitochondrial calcium dysregulation contributes to dendritic injury in mutant

64 interesting question regarding how chromatin dysregulation contributes to different diseases.

65 critical role in health and lifespan and its dysregulation contributes to inflammation, cancer and ag

66 e data suggest that cortico-striatal circuit dysregulation drives maladaptive decision making in psyc

67 Metabolic dysregulation drives tumor initiation in a subset of gli

68 gene modulations associated with cell cycle dysregulation during HIV-1 infection in CD4(+) T cells,

69 cal diseases connected with neurotransmitter dysregulation, e.g. attention deficit hyperactivity diso

70 ion, associated pathology and transcriptomic dysregulation even after substantial motor dysfunction a

71 , under disease-associated, context-specific dysregulation, exacerbates disruption of dopaminergic ne

72 A circuit dysregulation framework focuses more broadly on aberrant

73 issociating dysfunction due to developmental dysregulation from dysfunction due to the continued abse

74 role in many biological processes and their dysregulation has a significant impact on important cell

75 es these dynamic modifications assume, their dysregulation has been associated with cancer and many o

76 diator of the inflammatory response, and its dysregulation has been associated with immune-related ma

77 isorders, where previously only lysosomal pH dysregulation has been described, massive reduction of l

78 Immune dysregulation has been linked to occlusive vascular remo

79 al autoimmune encephalomyelitis (EAE), miRNA dysregulation has been mainly related to immune system d

80 Its dysregulation has been proposed as a core factor in the

81 Epigenetic dysregulation has emerged as a recurring mechanism in th

82 t a universally beneficial mechanism because dysregulation has neurotoxic consequences.

83 fic functional defects resulting from TDP-43 dysregulation have not been well described.

84 d the potential role of Asb1-mediated immune dysregulation in anxiety disorders.

85 porting the hypothesis of systemic elemental dysregulation in ASD.

86 tory bowel disease (IBD) is characterized by dysregulation in both cytokines and responses to intesti

87 ry of transcriptionally mediated immune cell dysregulation in CFS and ADCLS, at least outside of peri

88 n the maintenance of inflammation and immune dysregulation in CVID, and suggest research strategies t

89 rther support the emerging role for synaptic dysregulation in epilepsy.

90 ZIKV infections showed dysregulation in expression of 929 genes.

91 biological and clinical significance of VGLL dysregulation in human breast cancer pathogenesis remain

92 Here we link metabolic dysregulation in human BTICs to a nexus between MYC and

93 There is widespread transcriptional dysregulation in Huntington's disease (HD) brain, but an

94 However, evidence for leptin dysregulation in major depressive disorder (MDD) is conf

95 ogenesis modulation that contributes to bone dysregulation in metabolic disorders.

96 Endoplasmic reticulum (ER) stress elicits EC dysregulation in metabolic syndrome.

97 characterized by chronic hyperglycaemia and dysregulation in metabolism, is unclear.

98 in a hypoxia-dependent manner that led to a dysregulation in mitochondrial iron balance, enhanced re

99 ogical determinant of the onset of metabolic dysregulation in offspring predisposed to altered beta-c

100 Here, we link metabolic dysregulation in patient-derived brain tumor-initiating

101 Immune dysregulation in patients with PHTS included lymphopenia

102 hese findings provide a broad view of immune dysregulation in PTSD and demonstrate inflammatory pathw

103 Neurovascular dysregulation in putaminal and pallidal regions is thoug

104 yield a new topography for the dopaminergic dysregulation in schizophrenia.

105 demonstrate a VCP mutation/knockdown-induced dysregulation in the adenine nucleotide translocase, whi

106 linical and immunological entities caused by dysregulation in the innate immune system.

107 pharmacological experiments suggest that PKA dysregulation in the mPFC underlies cognitive dysfunctio

108 ated an essential role of mitochondrial iron dysregulation in the pathogenesis of IBD.

109 Findings have converged to suggest early dysregulation in the striatum, especially in the rostral

110 A dysregulation in this wound healing process leads to fib

111 apy in parallel with other markers of immune dysregulation, including soluble IL-2 receptor alpha cha

112 SD to test whether fetal and postnatal metal dysregulation increases ASD risk.

113 Transcriptional dysregulation induced by aberrant transcription factors

114 s disease (CD) involves immune and microbial dysregulation, induced by environmental factors in genet

115 d by related but distinct profiles of immune dysregulation, inflammation, and endogenous autoantibodi

116 vascular cellular dysfunction and structural dysregulation, iron status, and coagulation.

117 MicroRNA (miRNA) dysregulation is a hallmark of cutaneous T-cell lymphoma

118 f MAPK signaling via CRAF overexpression and dysregulation is a mechanism for vemurafenib resistance

119 Consequently, Cu dysregulation is associated with fatal neonatal disease,

120 roteins (RBPs) are dysregulated and that RBP dysregulation is associated with poor prognosis.

121 tant cofactor in one-carbon metabolism whose dysregulation is associated with various clinical condit

122 n a range of biological functions, and their dysregulation is central to numerous diseases, including

123 c-Myc dysregulation is hypothesized to account for the 'stemne

124 centrosome structural genes and genes whose dysregulation is implicated in inducing CA.

125 post-status epilepticus (SE) evoked chloride dysregulation is important for the remodeling of aberran

126 n highlighted by reports indicating that EMC dysregulation is linked to neurodegenerative diseases.

127 to neurotransmitter imbalance and metabolite dysregulation, leading to the release of pro- or anti-ap

128 a vital role in cellular processes and their dysregulation leads to a range of diseases such as cysti

129 Such dysregulations led to defects in conduction velocity and

130 ent infections, as well as associated immune dysregulation manifesting as autoimmunity or allergic in

131 ences is critical for mental health, and its dysregulation may lead to psychopathologies.

132 tments effectively targeting immunometabolic dysregulations may benefit patients with depression and

133 Sox6-overexpression induces dysregulation of 64 proteins, involved in cytoskeleton r

134 play increased cell proliferation because of dysregulation of a beta-catenin/BRN2 transcriptional cas

135 s is closely associated with the age-related dysregulation of a large set of highly expressed and agg

136 Our results support a causal link between dysregulation of a miRNA target and SCZ-related deficits

137 had less accumulation of retinyl esters and dysregulation of a striking array of genes, including ge

138 HIV-associated dysregulation of adaptive immunity by depletion of CD4 T

139 Bipolar disorder (BD) is characterized by a dysregulation of affect and impaired integration of emot

140 Chronic dysregulation of alternative complement pathway activati

141 tors are critical for synaptic strength, and dysregulation of AMPA receptor-mediated signalling is li

142 Mutations in or dysregulation of ANTs is associated with progressive ext

143 Dysregulation of apoptosis is associated with several hu

144 hronic antigenic stimulation, which promotes dysregulation of apoptosis, mainly due to constitutive a

145 Dysregulation of autophagy and inflammasome activity con

146 o massive melanoma cell death due to a major dysregulation of autophagy, suggesting that alpha-synucl

147 , the formation of the inflammasome, and the dysregulation of autophagy.

148 o mTOR activation and cancer progression via dysregulation of basal DDIT4 gene expression.

149 Dysregulation of BCL-2 has long been known to be a cruci

150 Dysregulation of beta1-integrin underlies Kindler syndro

151 Sustained dysregulation of blood glucose (hyper- or hypoglycemia)

152 the innate myeloid cell lineage displayed a dysregulation of bone marrow cells with a rapid decline

153 In Smith-Magenis syndrome (SMS), the dysregulation of both sleep-wake behavior and melatonin

154 to antidepressants supports the concept that dysregulation of brain arousal is a possible predictor o

155 Dysregulation of BRD4 function has been implicated in th

156 Reduced SERCA activity underlies dysregulation of Ca(2+) homeostasis under atmospheric O2

157 Downstream of mGluR1, dysregulation of calcium homeostasis has been hypothesiz

158 Dysregulation of cAMP metabolism is a consistent finding

159 Dysregulation of cell cycle machinery is implicated in a

160 data identify a critical role of CAF1 in the dysregulation of cell invasion and motility phenotypes s

161 Together, these findings suggest that dysregulation of ceramide pathways and calcium sensitive

162 itical pathway in the hyperglucidic-mediated dysregulation of chondrocytes.

163 Extensive dysregulation of chromatin-modifying genes in clear cell

164 iologic and transcriptome analyses implicate dysregulation of ciliogenesis, nuclear translocation, an

165 : In maize seedlings, severe cold results in dysregulation of circadian pattern of gene expression ca

166 Furthermore, dysregulation of CLOCK disrupts coexpressed networks of

167 However, dysregulation of complement can serve as a trigger for a

168 of the retinal pigment epithelium (RPE) and dysregulation of complement have been implicated in its

169 changes in their activity, along with severe dysregulation of cortical temporal organization and stat

170 AAH), although it is unclear whether chronic dysregulation of CRF systems induces maladaptive changes

171 desensitization and provide insight into the dysregulation of CXCR4 observed in patients with various

172 olleagues (pp. 1122-1133) demonstrate severe dysregulation of developmentally regulated alternative s

173 hypothesis that genetically determined local dysregulation of dietary vitamin C or antioxidants trans

174 onsequent reductions in soluble DISC1 led to dysregulation of DISC1-PDE4 complexes, aberrantly increa

175 at the sigma receptor has a key role in METH dysregulation of dopamine release and dopamine-related b

176 Dysregulation of eIF2B activity is associated with a num

177 function as a chloride channel, resulting in dysregulation of epithelial fluid transport in the lung,

178 The dysregulation of fatty acid oxidation has been related w

179 ltaami1 mutant cells to separate also led to dysregulation of FtsZ ring bundling.

180 control of enhancer activity cause extensive dysregulation of gene expression.

181 trate reduced proliferation with concomitant dysregulation of genes including Cdkn2a (p16), Cdkn2b (p

182 in vitro experiments, we showed significant dysregulation of genes involved in MAPK/Wnt signalling p

183 Dysregulation of genes with reported driver mutations an

184 ulin receptor (IR) signaling that results in dysregulation of glucose homeostasis.

185 olysis in heritable PAH BOECs, corrected the dysregulation of glycolytic genes and lactate production

186 d PTPB1 and PKM2 expression, and significant dysregulation of glycolytic genes in the rat SUGEN-hypox

187 Recent metabolomic reports connect dysregulation of glycosphingolipids, particularly cerami

188 and excitation-transcription coupling in the dysregulation of heart and jaw morphogenesis.

189 eptor-alpha (PPARalpha)-regulated genes, and dysregulation of hepatic lipid homeostasis.

190 These data indicate that dysregulation of ILC2s and TH2 cells attenuates DEP-enha

191 aled global DNA hypomethylation and enriched dysregulation of imprinted genes in Naa10p-knockout embr

192 or the host's defense against pathogens, but dysregulation of inflammasomes may contribute to the pat

193 resolution receptors in health, disease, and dysregulation of inflammation in type 2 diabetes.

194 ction in the liver and further supports that dysregulation of insulin signaling is associated with HC

195 uent refibrillation, partially by mitigating dysregulation of intracellular Ca(2+).

196 ost devoid of Dock7, resulting in a profound dysregulation of its signaling pathway, leading to defec

197 Dysregulation of kinase signaling has frequently been re

198 Defective microtubule assembly and dysregulation of KIT-MAPK signaling also feature as recu

199 The underlying dysregulation of Kv1.1 expression was attributable to cA

200 Obesity-related dysregulation of leptin signaling (e.g., hyperleptinemia

201 Dysregulation of lipid metabolism is associated with man

202 Dysregulation of local translation is associated with ma

203 Disruption of endothelial KLF2 results in dysregulation of lung microvascular homeostasis and cont

204 Notably, dysregulation of MAFB and SELENBP1 was common to ZIKV, d

205 Loss of Islet1 results in dysregulation of mesenchymal genes important for morphog

206 The dysregulation of metabolic pathways leading to abundance

207 We observed dysregulation of metabolic processes during early persis

208 Many lines of evidence also indicate that dysregulation of microglia contributes to the pathogenes

209 Dysregulation of microRNAs (miRNAs) plays an important r

210 Dysregulation of miRNAs is important in breast cancer in

211 ent acylcarnitine accumulation and lipotoxic dysregulation of mitochondria.

212 d that this dysfunction may be the result of dysregulation of mitochondrial proteins.

213 We observed global dysregulation of mRNA levels in H3K36R animals that corr

214 Taken together, dysregulation of mRNA translation is emerging as a unify

215 strate prominent MIA-induced transcriptional dysregulation of mTOR and EIF4E-dependent signaling.

216 Dysregulation of mTOR signalling is associated with a va

217 t differentiation and fusion associated with dysregulation of myogenic transcription factors and disr

218 n deficit (IED) may be due to stress-induced dysregulation of neural circuits involved in extinction

219 Following peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in d

220 In inflammatory arthritis, the dysregulation of osteoclast activity by proinflammatory

221 Indeed, a large body of work has shown that dysregulation of p53 and its E3 ligase MDM2 by the ubiqu

222 her genetic and environmental factors, cause dysregulation of PAK3 leading to synaptic deficits in SC

223 rovascular pressure reactivity represent the dysregulation of pathways directly involved in traumatic

224 V cells to EGF and TGFbeta and resulted in a dysregulation of phospho-protein expression in HaCaT cel

225 It is characterized by dysregulation of physiological remodeling, activation of

226 that at clinical stages of prion infection, dysregulation of respiratory chain proteins may lead to

227 ression in early brain development featuring dysregulation of RNA processing, chromatin remodeling an

228 Dysregulation of RPE- and podocyte-derived VEGF is assoc

229 + and Zc3h14Deltaex13/Deltaex13 mice reveals dysregulation of several pathways that are important for

230 e-specific HIF1/HIF2-dependencies as well as dysregulation of several pathways.

231 The dysregulation of Shh signaling is associated with a shor

232 The model suggests that dysregulation of signalling by these mutants in tumours

233 timulated whole-body glucose disposal; thus, dysregulation of skeletal muscle metabolism can strongly

234 ice without functional mGluR5 exhibit severe dysregulation of sleep-wake homeostasis, including lack

235 s is impaired during atherogenesis caused by dysregulation of so-called eat me ligands, which govern

236 Oxidative stress may result from dysregulation of systems typically affected in schizophr

237 ermediate filament subtype switching induced dysregulation of the actin cytoskeleton and reduced the

238 Alcohol use disorder has been linked to dysregulation of the brain stress systems, producing a n

239 ns interacting with Nbeal2 and points to the dysregulation of the canonical signaling pathway of Dock

240 dynamic of cancer is intimately linked to a dysregulation of the cell cycle and signalling pathways.

241 holesterol sensor in prostate cells and that dysregulation of the CYP27A1/27HC axis contributes signi

242 the retrieval of remote memories through the dysregulation of the endocannabinoid system in the PFC.

243 One such factor involves dysregulation of the immune system, which has been linke

244 Dysregulation of the lipid-mediated checkpoint forces th

245 Dysregulation of the pathway from the prelimbic (PrL) co

246 The dysregulation of the RNA editing pathway was further inv

247 % of adults worldwide and is associated with dysregulation of the skin barrier.

248 Dysregulation of the skin renin-angiotensin system is im

249 However, dysregulation of the TGF-beta pathway is responsible for

250 To better understand dysregulation of the TGFbeta pathway, we first generated

251 These mutants also exhibit dysregulation of the Toll pathway target transcripts Dro

252 coexpression of alphaS and ATFS-1-associated dysregulation of the UPR(MT) synergistically potentiate

253 Dysregulation of their catalytic activity is associated

254 n in dose-dependent fashion, and halted Nrf2 dysregulation of these antioxidants.

255 x (vmPFC), but a causal relationship between dysregulation of these areas and such symptoms has not b

256 Notably, dysregulation of these essential genes would significant

257 nues for cardiac pathologies associated with dysregulation of these mechanisms.

258 ay of astrocytes and neurons and discuss how dysregulation of these pathways may contribute to the pa

259 Dysregulation of these pathways was confirmed at the pro

260 PXR also contributes to the dysregulation of these processes in diseases states.

261 Dysregulation of these processes underlies diverse ion c

262 urthermore, upregulation, mutation, or other dysregulation of these PTPs has been positively correlat

263 Dysregulation of this DDT pathway in human cells leads t

264 velopment and functional maturation and that dysregulation of this function results in severe human d

265 Dysregulation of this mechanism leads to numerous human

266 Dysregulation of this pathway in tumor-infiltrating T ce

267 Dysregulation of this pathway might underlie a periphera

268 Dysregulation of this process can lead to fibrosis, and

269 This dysregulation of translation initiation via alteration o

270 Dysregulation of tumor necrosis factor (TNF) receptor si

271 ulate multiple critical cellular activities, dysregulation of which correlates with various human mal

272 c electrical and mechanical indices, and its dysregulation plays an important role in cardiac disease

273 Calcium dysregulation plays an important role in PD pathogenesis

274 BA dysregulation plays an important role in the development

275 nts of the mitochondrial matrix are prone to dysregulation, prompting the activation of a specific or

276 d the consequences of immediate or long-term dysregulation remain elusive.

277 mechanisms underlying sepsis-induced immune dysregulation remain poorly understood.

278 Host metabolism dysregulation represents an effective parasite mechanism

279 Leptin dysregulation (resistance) may represent an underlying m

280 chanistic insight into durable hematopoietic dysregulations resulting from obesity.

281 RvE1 rescues the dysregulation seen on neutrophil receptor profile and, f

282 bserved here, may underpin a profound immune dysregulation, setting the stage for disease manifestati

283 feature of this syndrome is primary vascular dysregulation, sometimes including vasospasm.

284 ling can also result in conditions of immune dysregulation, such as early-onset autoimmunity.

285 uired to inform understanding of such immune dysregulation syndromes.

286 In this study, we characterize a novel miR dysregulation that contributes to overexpression of the

287 neural circuit function, partly due to Kv1.1 dysregulation that leads to a dual dysfunction consistin

288 to infection and vaccination, as well as the dysregulation that occurs in disease.

289 at drive successful immune responses and the dysregulation that occurs with aging or disease.

290 consistent with the current model of immune dysregulation that ostensibly allows the organism to eva

291 both PD-L1 and PD-L2, preventing the immune dysregulation that otherwise occurs when T-cells encount

292 f circulating CXCL4 may contribute to immune dysregulation through the modulation of DC differentiati

293 various biological processes and that their dysregulation underlies a number of complex human diseas

294 Complement dysregulation underlies several inflammatory disorders,

295 Its dysregulation underlies the development of several cance

296 D) is thought to be mediated through emotion dysregulation via high trait anger.

297 RAS component dysregulation was recently found in some malignancies an

298 ed T cells of patients with CVID with immune dysregulation will offer new therapeutic avenues for thi

299 ith emerging evidence connecting cholesterol dysregulation with disturbed pulmonary homeostasis, we a

300 alance, ineffective erythropoiesis, and iron dysregulation, with several agents being evaluated in pr