ライフサイエンスコーパス: dystrophic neurite

1 ary tangles and not with neuropil threads or dystrophic neurites.

2 bsence of PHF/tau-positive plaque-associated dystrophic neurites.

3 accumulation of LC3-GFP positive puncta and dystrophic neurites.

4 brain in diffuse deposits and in a subset of dystrophic neurites.

5 TN3, but not RTN1, is abundantly enriched in dystrophic neurites.

6 plaque growth and attenuates plaque-related dystrophic neurites.

7 e deposition, and reduced tau immunoreactive dystrophic neurites.

8 d was associated with a ninefold increase of dystrophic neurites.

9 n Abeta levels, Abeta plaque deposition, and dystrophic neurites.

10 were unable to detect the majority of these dystrophic neurites.

11 -amyloid fibrils, microglia, astrocytes, and dystrophic neurites.

12 d neocortex, and a decrease in the number of dystrophic neurites.

13 ctivation, age-related amyloid deposits, and dystrophic neurites.

14 nd over time, accumulated in cell bodies and dystrophic neurites.

15 of AD, including A beta-amyloid deposits and dystrophic neurites.

16 gnificantly fewer immunoreactive plaques and dystrophic neurites.

17 ne deletion resulted in a marked increase in dystrophic neurites (2- to 3-fold higher than APP/PS1 Gf

18 of ERC lesion, numbers of APP-immunoreactive dystrophic neurites and Abeta burden were significantly

19 Plaques are associated with synapse loss, dystrophic neurites and altered neurite trajectories.

20 unimmunized AD, but lacked plaque-associated dystrophic neurites and astrocyte clusters; (iii) in som

21 Dystrophic neurites and astroglia showed no M-CSFR label

22 i-hAPP- and antineurofilament-immunoreactive dystrophic neurites and astroglial cells.

23 Amyloid deposition is associated with dystrophic neurites and extensive gliosis.

24 Alzheimer disease (AD), are associated with dystrophic neurites and glial responses, both astrocytic

25 served in small numbers of plaque-associated dystrophic neurites and in focal regions of pyramidal ne

26 ases show accumulation of alpha-synuclein in dystrophic neurites and in Lewy bodies.

27 r abundance, morphology, and distribution of dystrophic neurites and neuronal cytoplasmic inclusions

28 neurofilament immunostaining revealed a few dystrophic neurites and neurons, choline acetyltransfera

29 ous A beta 42-reactive plaques, many bearing dystrophic neurites and reactive glia.

30 o decreased the numbers of ubiquitin-labeled dystrophic neurites and the percentage area per plaque o

31 unded by large, swollen axons and dendrites (dystrophic neurites) and activated glia.

32 as reactive astrocytes, activated microglia, dystrophic neurites, and a few NFTs.

33 ents with HD, both in the cytoplasm, forming dystrophic neurites, and in the nucleus, forming intranu

34 by senile plaques, neurofibrillary tangles, dystrophic neurites, and reactive glial cells.

35 These data suggest that PHF/tau-positive dystrophic neurites are a common component of all subtyp

36 ed helical filament (PHF)/tau immunoreactive dystrophic neurites are a common pathological feature in

37 dy, we investigated whether PHF/tau-positive dystrophic neurites are located in all subtypes of plaqu

38 en reported that phosphorylated tau-positive dystrophic neurites are observed in transgenic mice over

39 this system suggest that amyloid-associated dystrophic neurites are relatively stable structures in

40 Dystrophic neurites are swollen dendrites or axons recog

41 Dystrophic neurites are thought to disrupt neuronal func

42 or CD40 deficiency reduces the mean ratio of dystrophic neurite area to congophilic plaque area and t

43 0 days after immunotherapy, there were fewer dystrophic neurites around each plaque, a recovery of sy

44 a variety of noxious stimuli (ubiquitinated dystrophic neurites, astrocytosis, and microglial infilt

45 parenchymal plaque burden, astrogliosis, and dystrophic neurites at doses 10- to 50-fold lower than u

46 intraneuronal and extraneuronal tangles and dystrophic neurites), but does not seem to bind to a sig

47 hore methoxy-X04, and individual YFP-labeled dystrophic neurites by their inherent fluorescence.

48 alpha-Syn immunoreactive dystrophic neurites contained numerous electrodense lami

49 and presence of neurofibrillary tangles and dystrophic neurites containing hyperphosphorylated tau.

50 ulation not only in Lewy bodies, but also in dystrophic neurites decorating Abeta plaques.

51 produce a virtual phenocopy of Abeta-induced dystrophic neurites, dendritic simplification, and dendr

52 Dystrophic neurites displayed intense immunoreactivity d

53 brains include mitochondrial dysfunction and dystrophic neurites (DNs) in areas surrounding amyloid p

54 neuronal intranuclear inclusions (NIIs) and dystrophic neurites (DNs) in the HD cortex and striatum,

55 ely in degenerated neurons, and localizes to dystrophic neurites during Alzheimer's progression.

56 plaque-centered quantification of SMI312(+) dystrophic neurites, GFAP(+) reactive astrocytes, and IB

57 co-localization of PS1 with NFTs and plaque dystrophic neurites implicates a role for PS1 in the div

58 any alpha-synuclein-positive Lewy bodies and dystrophic neurites in 50% of amygdala samples from Down

59 PHFtau was evident in dystrophic neurites in 55% of cases with AD, 34% with no

60 alpha-Synuclein was present in dystrophic neurites in 7 cases, 6 of which also had cere

61 s Abeta levels, amyloid plaque deposits, and dystrophic neurites in a mouse transgenic AD model.

62 s and, along with C5b-9 IR, was localized to dystrophic neurites in a subset of neuritic plaques, neu

63 In addition, in AD brain, large dystrophic neurites in a subset of senile plaques are co

64 synaptophysin that may resemble formation of dystrophic neurites in AD.

65 or of synapse density because it is found in dystrophic neurites in Alzheimer's disease-affected brai

66 Fs produced by eta-secretase are enriched in dystrophic neurites in an AD mouse model and in human AD

67 ng frequent neuronal cytoplasmic inclusions, dystrophic neurites in both grey and white matter and al

68 loss of dendritic spines and the presence of dystrophic neurites in both the hippocampi of transgenic

69 The immunophenotype of dystrophic neurites in conjunction with the results of h

70 We found abundant clusters of dystrophic neurites in layers 2 to 3 of the neocortex, t

71 Dystrophic neurites in plaques of PDAPP tg mouse and AD

72 Importantly, we show that the presence of dystrophic neurites in Tg-RTN3 mice causes impairments i

73 ral amyloid burden and BACE1 accumulation in dystrophic neurites in the absence of BACE1 S-palmitoyla

74 tment strongly resembled AVs that collect in dystrophic neurites in the AD brain and in an AD mouse m

75 urofibrillary tangles, neuropil threads, and dystrophic neurites in the AD brain.

76 (Abeta)-containing plaques are surrounded by dystrophic neurites in the Alzheimer's disease (AD) brai

77 showed the occurrence of RTN3-immunoreactive dystrophic neurites in the cortex.

78 cortical Lewy bodies, abnormal neurites, and dystrophic neurites in the plaques.

79 nsonism without Lewy bodies but demonstrated dystrophic neurites in the substantia nigra intensely st

80 aining pattern excluded neuropil threads and dystrophic neurites indicating that tyrosine phosphoryla

81 Dystrophic neurites (Kendall tau = 0.34, P = 0.001), rea

82 ) is accumulated in a distinct population of dystrophic neurites named as RTN3 immunoreactive dystrop

83 o mark a distinct and abundant population of dystrophic neurites named RTN3 immunoreactive dystrophic

84 ly transported in neurons and accumulates in dystrophic neurites near cerebral amyloid deposits in AD

85 Within neurofibrillary tangles and dystrophic neurites of Alzheimer's disease (AD), the cyt

86 In sporadic AD, PS1 appears in the dystrophic neurites of mature amyloid plaques and co-loc

87 noreactivity is also present in some swollen dystrophic neurites of neuritic plaques.

88 release and its prominent deposition in the dystrophic neurites of PD, alpha-synuclein localizes alm

89 dant in autophagic vacuoles, accumulating in dystrophic neurites of PS/APP mice similar to AD brains.

90 of astrocytosis (P = 0.6060), more embedded dystrophic neurites (P < 0.0001) and were more likely to

91 ivity and to play a role in the formation of dystrophic neurites present in Alzheimer brains.

92 ously that reticulon-3 (RTN3) immunoreactive dystrophic neurites (RIDNs) are abundantly present in th

93 es with the formation of RTN3 immunoreactive dystrophic neurites (RIDNs) in brains of Alzheimer's cas

94 ystrophic neurites named RTN3 immunoreactive dystrophic neurites (RIDNs) in patients' brains of Alzhe

95 rophic neurites named as RTN3 immunoreactive dystrophic neurites (RIDNs).

96 ly argentophilic because both populations of dystrophic neurites stained with silver stains.

97 tures in the alphaS- and betaS-labeled hilar dystrophic neurites suggests that synaptic dysfunction m

98 horylated at Tyr-297) are mainly detected in dystrophic neurites surrounding Abeta plaque cores, wher

99 -relevant tau pathologies: tau aggregates in dystrophic neurites surrounding Abeta plaques (NP tau),

100 uropil threads, neurofibrillary tangles, and dystrophic neurites surrounding and invading plaques.

101 Hyperphosphorylation of tau is found within dystrophic neurites surrounding beta-amyloid deposits in

102 is associated with neurofibrillary tangles, dystrophic neurites surrounding neuritic plaques, neurop

103 to result in the accumulation of lipofuscin, dystrophic neurites, tau- and ubiquitin-positive inclusi

104 ctivity is particularly conspicuous in large dystrophic neurites that also label with antibodies spec

105 otein (TDP)-43-positive neuropil threads and dystrophic neurites (type C), and is only rarely due to

106 Pathological signs include gliosis, dystrophic neurites, vacuolated mitochondria, and accumu

107 nificant reduction in the number and size of dystrophic neurites was seen 3 days after Abeta deposits

108 Phosphorylated tau-positive dystrophic neurites were exclusively associated with Con

109 p3-reactive dystrophic neurites were found both independent in the n

110 d ghost tangles with PBB3 and AV-1451, while dystrophic neurites were more clearly detected by PBB3 i

111 PHF/tau-positive dystrophic neurites were present in and around nearly al

112 Plaque-associated PHF/tau-positive dystrophic neurites were rare or absent in the hippocamp

113 In AD brains, BACE1 is accumulated within dystrophic neurites, which is thought to augment Abeta-i

114 Tyrosine hydroxylase (TH)-positive dystrophic neurites with rosette or grape-like cluster d

115 aque burden, and associated pathology (e.g., dystrophic neurites), with maximal effects attained with

116 ed with ubiquitin labeled neurons as well as dystrophic neurites within plaque regions.