ライフサイエンスコーパス: eIF-2alpha kinase

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1 identified that regulate the activity of the eIF-2alpha kinases.

2 614 with an alanine completely abolished the eIF-2alpha kinase activity, whereas the mutant PEK was s

3 This HRI was an active autokinase and eIF-2alpha kinase, and its kinase activities were inhibi

4 UPR, including PERK, the ER stress-specific eIF-2alpha kinase; ATF4, an ER stress-induced transcript

5 eement with the hypothesis that K3L inhibits eIF-2alpha kinases by functioning as a pseudosubstrate,

6 includes BiP and XBP-1, and another that is eIF-2alpha kinase-dependent, which includes ATF4 and GAD

7 ort the concept that pPKR is a member of the eIF-2alpha kinase family.

8 -2alpha peptide, a key characteristic of the eIF-2alpha kinase family.

9 indicate that K3L is a specific inhibitor of eIF-2alpha kinases from mammals and yeast and suggest th

10 er K3L can inhibit the activity of the yeast eIF-2alpha kinase GCN2.

11 ionally substituted for the endogenous yeast eIF-2alpha kinase, GCN2, by a process requiring the seri

12 In yeast, an eIF-2alpha kinase, GCN2, functions in translational cont

13 gether, our studies identify a new mammalian eIF-2alpha kinase, GCN2, that can mediate translational

14 of protein synthesis and the presence of an eIF-2alpha kinase has not been demonstrated in higher pl

15 heme-regulated eukaryotic initiation factor (eIF)2alpha kinase (HRI) was aligned to sequences in the

16 egulating the activity of the heme-regulated eIF-2alpha kinase (HRI) in hemin-supplemented rabbit ret

17 The heme-regulated eIF-2alpha kinase (HRI) is activated not only in heme-de

18 elates with the activation of heme-regulated eIF-2alpha kinase (HRI), which blocks the initiation of

19 n directly on the homogeneous heme-regulated eIF-2alpha kinase (HRI), which is activated during heme

20 gulated eukaryotic initiation factor 2alpha (eIF-2alpha) kinase (HRI) interacts with hsp90 in situ in

21 unit of eukaryotic initiation factor-2alpha (eIF-2alpha) kinase (HRI).

22 lates protein homeostasis through inhibiting eIF-2alpha kinases including double-stranded RNA-depende

23 ion is carried out in part by three distinct eIF-2alpha kinases including mammalian double-stranded R

24 PEK, which shares common features with other eIF-2alpha kinases including phosphorylation of eIF-2alp

25 new related kinase, which we term pancreatic eIF-2alpha kinase, or PEK.

26 ence and structural features conserved among eIF-2alpha kinases, PEK contains a distinctive amino-ter

27 osphorylation was shown to be carried out by eIF-2alpha kinases PKR and HRI.

28 RNA-activated eukaryotic initiation factor (eIF)-2alpha kinase (PKR).

29 ding mammalian double-stranded RNA-dependent eIF-2alpha kinase (PKR) and heme-regulated inhibitor kin

30 fer fish Fugu rubripes, suggesting that this eIF-2alpha kinase plays an important role in translation

31 WT SV5 was a poor activator of the eIF-2alpha kinase protein kinase R (PKR).

32 polypeptides into an active heme-regulatable eIF-2alpha kinase that exhibited slower electrophoretic

33 and cDNA clones homologous to the yeast GCN2 eIF-2alpha kinase (yGCN2) were isolated from Drosophila

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