ライフサイエンスコーパス: eIF2 kinase

1 aromyces cerevisiae expressing only a single eIF2 kinase.

2 distinct functions in the regulation of this eIF2 kinase.

3 ose translational expression is regulated by eIF2 kinases.

4 in the coordinate gene expression induced by eIF2 kinases.

5 Schizosaccharomyces pombe expresses a third eIF2 kinase, a Gcn2p ortholog.

6 This study indicates that loss of GCN2 eIF2 kinase activity shifts the normal maintenance of pr

7 of this portion of PEK blocked induction of eIF2 kinase activity.

8 ef of an inhibitory region and activation of eIF2 kinase activity.

9 nt limitation, leading to activation of this eIF2 kinase and translational control.

10 of this study were to assess the role of the eIF2 kinases and protein kinase R-like endoplasmic retic

11 get that integrates signaling from different eIF2 kinases and their respective stress signals, the eI

12 This is of fundamental importance because eIF2 kinases can induce the expression of genes involved

13 stress response pathway, the composition of eIF2 kinases differs, with mammals containing four disti

14 These results demonstrate that eIF2 kinases direct the translational expression of mult

15 Because there are multiple mammalian eIF2 kinases, each responding to different stress arrang

16 wn-regulating the activity of the pancreatic eIF2 kinase/eukaryotic initiation factor 2alpha (eIF2alp

17 e eIF2 kinase gene or deleted for the entire eIF2 kinase family.

18 ytic domain enhanced autophosphorylation and eIF2 kinase function in vivo.

19 e presence of constitutive expression of the eIF2 kinase GCN2 or in cells that have two initiator tRN

20 etion by the eukaryotic initiation factor 2 (eIF2) kinase GCN2.

21 Treating mice deleted for the eIF2 kinase, GCN2, with the E. coli enzyme showed eIF2 p

22 AC) genes whose transcription depends on the eIF2 kinase, Gcn2.

23 ed S. pombe strains expressing only a single eIF2 kinase gene or deleted for the entire eIF2 kinase f

24 Herein we describe that mice lacking the eIF2 kinase, general control nonderepressible 2 (GCN2) f

25 We find that Hri2p is the primary activated eIF2 kinase in response to exposure to heat shock, arsen

26 have mechanisms of coordinate activation of eIF2 kinase in their stress remediation responses.

27 insults, this study supports involvement of eIF2 kinases in the coordination of gene expression in r

28 Gcn2p serves as the primary eIF2 kinase induced during a nutrient downshift, treatme

29 show that activating EIF2 signaling through EIF2 kinase inhibition mitigated stress-induced behavior

30 terested in the mechanisms by which multiple eIF2 kinases interface with complex stress signals and e

31 Second, this eIF2 kinase is activated by select uncharged tRNAs, whic

32 he regulation of protein translation through eIF2 kinases is associated with development, 2) eIF2alph

33 Given its importance to pathogenesis, eIF2 kinase-mediated stress responses may provide opport

34 Furthermore, we have characterized novel eIF2 kinases; one in the endoplasmic reticulum and a lik

35 ulation and translational control allows the eIF2 kinase pathway to selectively repress or activate k

36 central regulatory proteins targeted by the eIF2 kinase pathway.

37 ino acid starvation by a mechanism requiring eIF2 kinases PEK (Perk or EIF2AK3) and GCN2 (EIF2AK4), r

38 tic initiation factor-2 (eIF2) by pancreatic eIF2 kinase (PEK), induces a program of translational ex

39 gnate upstream stress signals, the mammalian eIF2 kinases PERK and GCN2 repress translation of most m

40 is that coincided with activation of another eIF2 kinase PKR-like endoplasmic reticulum kinase (PERK)

41 Both eIF2 kinases, protein kinase-like endoplasmic reticulum

42 that in addition to two previously described eIF2 kinases related to mammalian HRI, designated Hri1p

43 Deletion of these eIF2 kinases renders S. pombe more sensitive to many of

44 Central to the eIF2 kinase response is the preferential translation of

45 riptional activator of genes targeted by the eIF2 kinase stress pathway.

46 c organisms characterized to date contain an eIF2 kinase stress response pathway, the composition of

47 ubunit implicated in feedback control of the eIF2 kinase stress response.

48 there is activation of alternative secondary eIF2 kinases, suggesting that eukaryotes have mechanisms

49 tes protein synthesis by inhibiting PKR, the eIF2 kinase that is regulated by double-stranded RNA.

50 he importance of eIF2Balpha in mediating the eIF2 kinase translation-inhibitory activity and may prov

51 To delineate the roles of each eIF2 kinase, we constructed S. pombe strains expressing