ライフサイエンスコーパス: ear

1 Analysis of 30 ears from 23 patients shows that severe neuronal loss co

2 on the temple (RR, 2.82; 95% CI, 1.72-4.63), ear (RR, 2.33; 95% CI, 1.67-3.23), or lip (RR, 2.28; 95%

3 the biological basis of normal and abnormal ear development.

4 ustic pure tones in a contralateral acoustic ear.

5 -acoustic stimulation, or EAS) and/or across ears (bimodal listening).

6 ficiently combined within rather than across ears, and that tonotopic mismatch should be minimized to

7 ARs) by GGA3 (Golgi-localized, gamma-adaptin ear domain homology, ADP ribosylation factor-binding pro

8 daptors, Gga (Golgi-localized, gamma-adaptin ear homology, Arf-binding) proteins and the AP-1 (assemb

9 efficiently transduce sensory cells in adult ears while maintaining normal cochlear function.

10 s the fundamental process for hearing in all ears across the animal kingdom.

11 Millimeter-scale differences among ear, cob, and kernel traits that ranged more than 2.5-fo

12 Mice also received an ear punch for evaluating wound healing.

13 e systematically seen by a stomatologist, an ear, nose, and throat specialist, and a urologist; women

14 eased fatigue (three [11%] vs two [4%]), and ear pain (six [21%] vs 15 [28%]).

15 The electrocardiogram and finger and ear photoplethysmograms were recorded simultaneously und

16 anges frequently overlapped between leaf and ear.

17 patient has chronic refractory otorrhea and ear granulation tissue.

18 ensities of KCs were higher on the scalp and ear in men compared with women, and on the upper arm in

19 gments distributed over frequency, time, and ear of presentation is reduced in older listeners-even f

20 ents distributed across frequency, time, and ear of presentation.

21 m or a vehicle control cream to the face and ears twice daily for 2 to 4 weeks for a total of 28 to 5

22 placement and first dispensing of antibiotic ear drops.

23 nd shapes arise in biological organs such as ears, guts, hearts, brains and even entire organisms.

24 Relative to the better ear, bimodal benefits remained strong for sentence recog

25 us (BtAdV) recovered from a Rafinesque's big-eared bat (Corynorhinus rafinesquii) in Kentucky, USA, w

26 lated with those obtained with an Evans blue ear test and negatively correlated with the Ca(2+) influ

27 The relative arrival times of sounds at both ears constitute an important cue for localization of low

28 arrival time of low-frequency sounds at both ears.

29 ontrast, cells that are excitatory from both ears (EE cells) show no evidence of frequency-specific p

30 ce detectors that fire when inputs from both ears arrive near simultaneously.

31 rgery maintained normal-like input from both ears, but this did not support significant effects of bi

32 Even with CIs in both ears, they have difficulty making full use of subtle dif

33 ophageal symptoms, such as those provoked by ear, nose, throat, or respiratory disorders.

34 y tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheum

35 ning experience (CI plus HA in contralateral ear) completed a questionnaire that focused on attitudes

36 continue to use the HA in the contralateral ear postimplantation in order to determine whether or no

37 nerve afferent synapses in the contralateral ear.

38 The mechanically-coupled ears of Ormia ochracea are specialized for hyperacute di

39 nsmission of GBS, as determined by culturing ear, umbilicus, and nasal swabs, and (iii) the distribut

40 isms that regulate neuronal survival in deaf ears.

41 ation-mediated neuronal loss in the deafened ear, suggesting a key role for inflammation in the long-

42 Dimensionless ear and kernel shape traits that may interrelate yield c

43 clinically characterized by the discharging ear, hearing deficit, fever and otalgia.

44 ble in assessment of chronically discharging ears, especially to look for bone erosion and the integr

45 single, matched-frequency channels from each ear.

46 hlear implants working independently in each ear do not fully overcome deafness-related binaural proc

47 tween tones of disparate frequencies in each ear.

48 edicted from the frequency tuning for either ear, and the actual best difference.

49 y: the difference in travel time from either ear to the MSO neuron.

50 a difference in the travel times from either ear to the MSO.

51 elop increased CHS characterized by elevated ear thickening, mono/MPhi-dominated dermal inflammation,

52 ith MCs protected Sash mice from exacerbated ear swelling after repeated oxazolone challenge.

53 t of the inflammatory response, and examined ear swelling, SK activity, vascular permeability, leukoc

54 xpressivity and severity, including external ear anomalies, abnormal branchial arch derivatives, hear

55 ve field stimulation (PENFS) in the external ear to modulate central pain pathways.

56 gastrointestinal infections (64 [8%]), eye, ear, nose, and throat infections (55 [7%]), urinary trac

57 ility, and defects involving the brain, eye, ear, heart, and kidney.

58 RNA sequencing data from both human fetal ear and mouse second branchial arch tissue confirmed tha

59 maize (Zea mays), 94 RNA-seq libraries from ear, tassel, and leaf of the B73 public inbred line were

60 econd counts individual kernels removed from ears, including those in clusters.

61 ce liquid chromatography analyses of hamster ear extracts showed that OG treatment increased ACC leve

62 -2-furoic acid significantly reduced hamster ear sebaceous gland size, indicating that this pro-drug

63 coordinating reproduction and typically have ears tuned to the dominant frequency of their vocalizati

64 m a specific direction by movements of head, ears, or eyes.

65 In field experiment, plant height, ear length, ear weight/plot, grain yield/plot and 100 gr

66 We show that in healthy adult human ears, deeper tissue penetration of SWIR light allows bet

67 n quinolone and neomycin plus hydrocortisone ear drop-exposed children.

68 lammatory response as assessed by changes in ear thickness, myeloid cell infiltration, and cytokine a

69 tion of Channelrhodopsin (ChR2) expressed in ear and lateral line hair cells and acquired high-speed

70 showed strong evidence of genes involved in ear development and syndromes with auricular phenotypes.

71 Included ear drops were quinolones (ofloxacin, ciprofloxacin plus

72 skin inflammation in both the IL-23-induced ear swelling model and the topical imiquimod model, and

73 treatment successfully dampened PMA-induced ear edema, proinflammatory cytokine production, reactive

74 ring development and diminished VEGF-induced ear angiogenesis and tumor angiogenesis.

75 ne and chemokine genes in vDeltaK1L-infected ears.

76 pression was decreased in vDeltaK1L-infected ears.

77 lations were decreased in vDeltaK1L-infected ears.

78 (gastrointestinal illness, sinus infections, ear infections, infected wounds).

79 T cell infiltration was reduced in inflamed ear tissue, whereas CTLA-4(+)Foxp3(+) Treg frequencies w

80 In an LPS-induced inflamed ear murine model, HA-treated MSC demonstrated a signific

81 e reveal the regulatory logic that initiates ear formation and highlight the hierarchical organisatio

82 tinocytes both ex vivo and in IL-23-injected ears of mice.

83 ry brainstem response thresholds in injected ears than in uninjected ears or ears injected with contr

84 Inner ear hair cells detect sound through deflection of stereo

85 hes in mice, the authors show that (1) inner ear dysfunction due to either Tbx1 or Slc12a2 mutations

86 Furthermore, we show that (1) inner ear dysfunction due to the tissue-specific loss of Tbx1

87 The abnormal inner ear phenotype of MRL- Atp6v1b1vtx/vtx mice was lost when

88 to form the neurons that innervate all inner ear sensory regions.

89 g loss occur at the cellular level and inner ear cells are very sensitive to autolysis.

90 gs highlight a biological link between inner ear dysfunction and behavioral disorders and how sensory

91 ediction, analysis of developing chick inner ear revealed that ligand-producing hair cell precursors

92 re we tested SOX2's requirement during inner ear neuronal specification using a conditional deletion

93 are coordinately oriented within each inner ear sensory organ to exhibit a particular form of planar

94 most of the syndromic defects, exhibit inner ear defects and hyperactivity.

95 new gene interactions responsible for inner ear development and for the segregation of the otic line

96 ng optokinetic reflex compensation for inner ear dysfunction.

97 otransporter and is also necessary for inner ear function, causes hyperactivity; (2) vestibular rathe

98 The use of viral vectors for inner ear gene therapy is receiving increased attention for tr

99 as well as regenerative mechanisms for inner ear repair.

100 s a novel and atraumatic technique for inner ear transgene delivery in early postnatal mice.

101 for translation to humans with genetic inner ear disorders.

102 Because the human inner ear cannot be visualized during life, histopathological

103 Histopathologic study of the human inner ear continues to emphasize the need for non- or minimall

104 m should facilitate the study of human inner ear development and research on therapies for diseases o

105 The human inner ear has an intricate spiral shape often compared to shel

106 The derivation of human inner ear tissue from pluripotent stem cells would enable in v

107 mouse neonatal inner ear, primarily in inner ear resident macrophages, which outnumber the hair cells

108 er 2 months, the vesicles develop into inner ear organoids with sensory epithelia that are innervated

109 The mammalian inner ear (IE) subserves auditory and vestibular sensations vi

110 ter hair cells (OHCs) of the mammalian inner ear and is required for cochlear amplification, a mechan

111 lance organs of the neonatal mammalian inner ear have the capacity to generate new hair cells after d

112 aims of this study were to manipulate inner ear connexin expression in vivo using BAAV vectors, and

113 n of kidney and intestinal microvilli, inner ear stereocilia, immune synapses, endocytic patches, adh

114 -skinned individuals tend to have more inner ear melanin, and cochlear melanocytes are important in g

115 d from three compartments of the mouse inner ear - the vestibular and cochlear sensory epithelia and

116 Here in vivo clonal analysis of mouse inner ear cells during development demonstrates clonal relatio

117 protein between the frog and the mouse inner ear hair cells.

118 system faithfully recapitulates mouse inner ear induction followed by self-guided development into o

119 hout postnatal maturation of the mouse inner ear, cochlear hair cells display at least two types of m

120 ogenitor populations from the neonatal inner ear differentiate to cell types associated with their or

121 binase in the Gfi1(Cre) mouse neonatal inner ear, primarily in inner ear resident macrophages, which

122 have facilitated the emergence of new inner ear organs and their functional diversification in the c

123 tely activate genes crucial for normal inner ear function and acid-base regulation in the kidney.

124 is required for acquisition of normal inner ear structure and function.

125 chanisms underlying inherited forms of inner ear deficits has considerably improved during the past 2

126 d be used to investigate mechanisms of inner ear development and disease as well as regenerative mech

127 Maintenance of the composition of inner ear fluid and regulation of electrolytes and acid-base h

128 ta represent unprecedented recovery of inner ear function and suggest that biological therapies to tr

129 at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' i

130 defects in Xenopus and misalignment of inner ear hair cells in mouse.

131 ciliary bundle, the sensory antenna of inner ear hair cells, and in the mechanoelectrical transductio

132 Specification of inner ear progenitors is initiated by FGF signalling.

133 rganoids that morphologically resemble inner ear vestibular organs.

134 eplacement as a strategy for restoring inner ear functions in a mouse model of Usher syndrome type 1G

135 nterplay between alternative splicing, inner ear development, and auditory function.

136 the growth of transducing stereocilia.Inner ear hair cells detect sound through deflection of stereo

137 ts effects in vivo, we discovered that inner ear hair cells are much more vulnerable to loss of Atoh1

138 alized sensory hair cells (HCs) in the inner ear (IE) to convey information about sound, acceleration

139 t versus efferent circuits between the inner ear and the brain.

140 teristics of DA fibers innervating the inner ear and the hindbrain auditory efferent nucleus in the p

141 of the distinct sensory organs of the inner ear and the non-sensory domains that separate them are s

142 f an extracellular tissue found in the inner ear demonstrating a mechanism of frequency separation in

143 The vestibular system of the inner ear detects head position using three orthogonally orien

144 Vestibular hair cells in the inner ear encode head movements and mediate the sense of balan

145 sed on the morphology, dynamics of the inner ear fluids, and membranous labyrinth deformability.

146 to introduce viral particles into the inner ear have been described, presumed physiological barriers

147 Mechanoelectrical transduction in the inner ear is a biophysical process underlying the senses of he

148 The inner ear is a complex vertebrate sense organ, yet it arises f

149 itch information is extracted from the inner ear itself.

150 and that lack of HGF signaling in the inner ear leads to profound hearing loss in the mouse.

151 pment of the sensory hair cells in the inner ear led to therapeutic efforts to restore these cells in

152 Ps into both zebrafish embryos and the inner ear of live mice to achieve specific, DNA-free base edit

153 by the adenoassociated virus 8 to the inner ear of newborn mutant mice reestablishes the expression

154 we delivered wild-type Ush1c into the inner ear of Ush1c c.216G>A mice using a synthetic adeno-assoc

155 ect that genetic background has on the inner ear phenotype of Atp6v1b1 mutant mice provides insight i

156 lution to obtain information about the inner ear prior to performing surgery.

157 s) are the mechanoreceptors within the inner ear responsible for our sense of hearing.

158 are specialized sensors located in the inner ear that enable the transduction of sound, motion, and g

159 ithin mechanosensory hair cells of the inner ear that have been implicated in hearing and balance dis

160 owing to the inability of cells in the inner ear to proliferate and replace lost sensory receptors.

161 shows how minute balance organs in the inner ear transformed at the same time.

162 Because dimension control of the inner ear's stereocilia is particularly precise, we studied th

163 In the inner ear, at least two systems regulate the planar polarity o

164 uction of a complex sensory organ, the inner ear, by imaging zebrafish embryos in vivo over an extend

165 rn the sensorineural components of the inner ear, its role in middle ear development has been less cl

166 ic Ganglion (SAG), which innervate the inner ear, originate as neuroblasts in the floor of the otic v

167 toxicity.SIGNIFICANCE STATEMENT In the inner ear, sensory hair cells signal reception of sound.

168 ably, vestibular sensory organs of the inner ear, the maculae, exhibit a line of polarity reversal (L

169 on of iron within the labyrinth of the inner ear, which might indirectly tune a magnetic sensor that

170 rged endolymphatic compartments of the inner ear.

171 ictly limited to hair cells within the inner ear.

172 ir cells, the sensory receptors of the inner ear.

173 cule, the main hearing endorgan of the inner ear.

174 c vesicle, the embryonic anlage of the inner ear.

175 earch on therapies for diseases of the inner ear.

176 cells for cell-based therapies of the inner ear.

177 enhance mechanical oscillation in the inner ear.

178 overall development of HCs within the inner ear.

179 letion/reporter gene activation in the inner ear.

180 cer (MET) channel in hair cells of the inner ear.

181 are specialzed bipolar neurons in the inner ear.

182 iating human pluripotent stem cells to inner ear organoids that harbor functional hair cells.

183 hyperactivity or anxiety coexist with inner ear dysfunction.

184 yperactivity or anxiety co-occurs with inner ear dysfunction.

185 ith valve dysplasia, and deafness with inner ear malformations.

186 Inner ears from two mass strandings of long-finned pilot whale

187 ir hearing sensitivity range and their inner ears are partly undeveloped, which accounts for their la

188 p link filaments convey force and gate inner-ear hair-cell transduction channels to mediate perceptio

189 However, in intradermally inoculated ears, vDeltaK1L replicated to levels nearly identical to

190 ced infiltration of innate immune cells into ears.

191 Its ear canal has a fully ossified tubular ectotympanic, a d

192 field experiment, plant height, ear length, ear weight/plot, grain yield/plot and 100 grain weight w

193 This system for measuring maize ear, cob, and kernel attributes is being used by multipl

194 stream of FGF by systematic analysis of many ear factors combined with a network inference approach.

195 cm critically protects hearing in the mature ear.

196 There was no evidence of a middle ear lesion, nor was there a Schwartz sign.

197 to cause both nasal colonization and middle ear infection.

198 in the region of the jugular bulb and middle ear.

199 She had normal bilateral middle ear pressure at tympanometry.

200 y peptide-encoding gene in chinchilla middle ear effusions.

201 mass for biofilms grown on chinchilla middle ear epithelial cells.

202 the transition from acute to chronic middle ear inflammation, and a potential molecular target.

203 The diminutive middle ear ossicles (malleus, incus, stapes) housed in the tymp

204 the role of CCL3 in OM, we evaluated middle ear (ME) responses of ccl3(-/-)mice to nontypeable Haemo

205 CT) and MRI are helpful in evaluating middle ear pathologies, usage being indication specific.

206 llance, all OM episodes submitted for middle ear fluid culture in children <3 years from 2004 through

207 features that are likely critical for middle ear functions and related to OM susceptibility.

208 ponents of the inner ear, its role in middle ear development has been less clear.

209 ng in patterning the stapes and incus middle ear bones derived from the equivalent pharyngeal arches

210 reviously identified in any mammalian middle ear, and the morphology of each auditory bone differs fr

211 ia in the epithelium of the mammalian middle ear, thus illustrating novel structural features that ar

212 e earliest known definitive mammalian middle ear.

213 ed to be for gliding and a mandibular middle ear with a unique character combination previously unkno

214 The understanding of middle ear cilia properties that are critical to OM susceptibil

215 Studies in the chinchilla model of middle ear infection demonstrated that VP1 is a virulence deter

216 light allows better visualization of middle ear structures through the tympanic membrane, including

217 line the posterior dorsal pole of the middle ear cavity which was previously thought to contain only

218 orifice at the ventral region of the middle ear cavity, consisting mostly of a lumen layer of multi-

219 The middle ear conducts sound to the cochlea for hearing.

220 ive otitis media (CSOM) refers to the middle ear inflammation which is clinically characterized by th

221 ctories, functional properties of the middle ear of AMHs and Neandertals are largely similar.

222 t have evolved independently from the middle ear structures of monotremes and therian mammals.

223 ated OFF and remained OFF, within the middle ear.

224 diagnosed with OM and had undergone a middle-ear fluid culture.

225 nterferometer, designed to serve as a middle-ear microphone for totally implantable cochlear- or midd

226 Incidence of OM necessitating middle-ear fluid culture (predominantly complex OM including re

227 for totally implantable cochlear- or middle-ear hearing aids.

228 ion of acoustical response of sheep's middle-ear ossicles.

229 ng the sensing optical fiber into the middle-ear and its aiming at the incus was investigated and des

230 aring inflammatory cell activation in a 4 mm ear injury during regeneration (Acomys cahirinus) and sc

231 Using a 4-mm ear punch assay across multiple mammalian species, here

232 ergistically in the croton oil-induced mouse ear edema model at low doses.

233 s of IDR-1002 in vivo, the PMA-induced mouse ear inflammation model was used.

234 s pathogenic in intradermally infected mouse ear pinnae.

235 ced RNA transcriptomic analysis on the mouse ear transcriptome revealed that IDR-1002 reduced sterile

236 hen it was intradermally injected into mouse ears and induced ADSC differentiation, characterized by

237 ion of ADSCs along with BA-DEG-BA into mouse ears markedly enhanced the adipogenic differentiation of

238 ave injected viral suspensions into neonatal ears, via the round window membrane.

239 Nine ears in eight adult CI listeners with Advanced Bionics H

240 Using two mouse models of ear skin inflammation (histamine- and IgE-mediated passi

241 Three models of ear-level devices were selected based on the quality of

242 nsertion of TT, adenoidectomy, and number of ear drop prescriptions was used to compare the rate of p

243 depends on the sizes, shapes, and numbers of ears and the kernels they bear.

244 predominantly around the snout, eyes, and on ears.

245 egral to ILD processing (excitatory from one ear, inhibitory from the other: EI cells) compare ILDs s

246 s attended to spoken digits presented to one ear and ignored tightly synchronized distracting digits

247 in injected ears than in uninjected ears or ears injected with control complexes that targeted an un

248 ed distracting digits presented to the other ear.

249 s, corresponding mainly to the natural outer ear canal gain.

250 l cavity, whereas others innervate the outer ear.

251 ng showed that OG applied onto Yorkshire pig ears accumulated in sebaceous glands relative to the sur

252 oduction, and neutrophil influx and prevents ear swelling.

253 ilies accordingly when prescribing quinolone ear drops.

254 Patients exposed to quinolone ear drops had a higher risk of perforation, with an adju

255 Exposure of children with TT to quinolone ear drops is associated with increased risk of perforati

256 This study investigated whether quinolone ear drops, with or without corticosteroids, increase the

257 In a rabbit ear model, PUT induced a 68.5% reduction in blood perfus

258 Regular firing in spinal motoneurons of red-eared turtles (Trachemys scripta elegans, either sex) ev

259 conserved DM domain gene, Dmrt1, in the red-eared slider turtle Trachemys scripta (T. scripta), whic

260 , face psychosocial disorders and rheumatic, ear-nose-throat, neurocognitive, and ophthalmologic comp

261 ctric hearing to be combined within the same ear (electric-acoustic stimulation, or EAS) and/or acros

262 nd electric hearing was combined in the same ear.

263 organs, including the craniofacial skeleton, ear, branchial arches, heart, lungs, diaphragm, gut, kid

264 ects (three of whom discontinued the study): ear discomfort (n=6; three in the PENFS group, three in

265 ntial development of ovary cohorts along the ear and to the timing of silk emergence.

266 tical transmission to layer 4 as well as the ear and eye opening.

267 question of how pitch is represented in the ear has been debated for over a century.

268 Here, we show that occluding the ear causes synapses at the very first stage of the audit

269 s from the relatively stable position of the ear canal with respect to vital organs.

270 cochlear nucleus following occlusion of the ear canal.

271 , 5.65; 95% CI, 1.76-18.20), location on the ear (RR, 4.67; 95% CI, 1.28-17.12) or lip (RR, 4.55; 95%

272 n((R)) loaded with PPE, applied daily on the ear, while eight received placebo EPIT (Placebo).

273 reception of the resultant sound through the ear.

274 r example, otitis media reduces sound to the ear, which can cause long-lasting deficits in language s

275 nal location and flies localized towards the ear with better signal detection.

276 violin was considered the loudest under the ear by players, and on average, violins that were quiete

277 l-despite seeming relatively quiet under the ear of the player-compared with new violins.

278 average, violins that were quieter under the ear were found to project less well.

279 examination revealed nodular lesions in the ears and a lump in the subcutaneous tissue of the left a

280 s release, and neutrophil recruitment in the ears of CD1 mice.

281 t reduced inflammatory lesions formed in the ears of Leishmania-infected C57BL/6 and Tlr3/7/9(-/-) mi

282 y young ages, even before the opening of the ears.

283 ain multielectrode arrays left in place, the ears were pharmacologically deafened and electrical stim

284 tortions caused by modern digital behind-the-ear HAs using a variety of stimuli and HA program settin

285 us monocytes migrating toward full-thickness ear wounds we found that Arpc2(-/-) monocytes maintain c

286 lection for FGF3 and FGF11, genes related to ear and tooth development and hypoxia, respectively.

287 ation of circRNA-circ1690 and was related to ear height, potentially through the interplay between ci

288 display an enhanced inflammatory response to ear skin 12-O-tetradecanoylphorbol-13-acetate treatment.

289 omach and all side ports inside it: [nose-to-ear-to-xiphisternum - 50]cm/2+50cm]; [gender-weight and

290 The nose-to-ear-to-xiphisternum and Hanson method should no longer b

291 Four studies found nose-to-ear-to-xiphisternum was most likely to result in a tube

292 t and nose-umbilicus-flat]; [xiphisternum-to-ear-to-nose+10cm]; [earlobe to xiphisternum to umbilicus

293 es, which receive segregated inputs from two ears and display rapid and compartment-specific reorgani

294 e differences in the sounds reaching the two ears [interaural time difference (ITD)] to identify wher

295 intensity of the sound that reaches the two ears by integrating ipsilateral excitation and contralat

296 ences of the sound waves arriving at the two ears.

297 h recognition performance in the unimplanted ear between the two groups, we recommend that unilateral

298 resholds in injected ears than in uninjected ears or ears injected with control complexes that target

299 cutaneously by painting HDM on unmanipulated ear skin or under an occlusive tape.

300 In one case, a juvenile animal, whose ears were fixed within 4 hours of death, revealed that m