ライフサイエンスコーパス: early

1 Methane concentrations stabilized in the early 2000s and began increasing again in 2007.

2 f additional founding nests in late 2016 and early 2017.

3 tivity), specific (90%-95% specificity), and early (3-4 years in advance on average) prediction of pa

4 the rRNA can assemble simultaneously during early 60S assembly and underscore the enormous complexit

5 ndently associated with a lower incidence of early acute respiratory distress syndrome.

6 nsidered in individuals with risk factors in early adulthood to inform discussions about primary prev

7 ristic of schizophrenia do not appear before early adulthood.

8 es than the wild-type, and the generation of early-after-depolarisations promoted unidirectional patt

9 e 19 years was significantly associated with early age at sensitization.

10 nt activation of apoptotic cell death during early age correlated well with the differential regulati

11 undergoing cardiac surgery with evidence of early AKI to receive intra-aortic MSCs (AC607; n=67) or

12 ntially through modulating susceptibility to early allergic sensitization, upper respiratory tract co

13 d sample; 2137 had no signs of AMD, 2209 had early AMD, and 150 had late AMD, of whom 104 had nvAMD.

14 Early anatomic imaging may show that a tumor has increas

15 Here we sequence the genomes of an Early and End Neolithic dog from Germany, including a sa

16 ifferent susceptibility to the inhibition of early and immediate early viral gene expression.

17 ator ESRRA was highlighted for an especially early and important regulatory role.

18 Finally, to dissect early and late events following interspecific hybridizat

19 therapeutic RNA interference (RNAi) in both early and late presentations.

20 o stages corresponding to the arrival of the early and late proteins at the plasma membrane.

21 s, 62 (28.6%) and 155 (71.4%) presented with early and late/very late ST, respectively.

22 ancreatic cancer, exploring the influence of early and midlife exposures will further advance our und

23 -selective temporal area in individuals with early and profound deafness.

24 ETHODS AND At gestational age mean 32 weeks (early) and mean 37 weeks (late), we compared the fetal c

25 phils were recognized as key contributors in early animal models of GN, at a time when the prevailing

26 and reproductive cell differentiation during early anther development in Arabidopsis (Arabidopsis tha

27 f bacterial infection is essential to ensure early appropriate administration of antibiotics to save

28 Early AR (HR = 1.77, P < .001) and elevated Cr at Day 90

29 terns in their spontaneous head movements as early as 1-2 months after birth, relative to HR infants

30 ng and excluding HA + ROCK and its effect on early attachment rates and proliferation was studied on

31 In 2 randomized trials in Guinea-Bissau of early BCG-Denmark (Statens Serum Institut) given to low-

32 lanning in 52 of 270 patients (19%) with PCa early BCR (PSA < 1.0 ng/mL).

33 entral complex, and tools for characterizing early-born neurons in central complex function.

34 ontrolled trial, patients with HER2-positive early breast cancer were randomly assigned to receive tr

35 Remains of early Cambrian arthropods showed the external lattices o

36 te animal phyla, radiated rapidly during the early Cambrian period (approximately 535-520 million yea

37 Bivalve molluscs are descendants of an early-Cambrian lineage superbly adapted to benthic filte

38 associated molecules could be beneficial for early cancer diagnosis, monitoring and surveillance.

39 analysis revealed that transcriptomes during early cardiomyocyte differentiation were highly concorda

40 f major morbidity/mortality were similar for early-career (<15 years from medical school, approximate

41 lity of findings suggests that the status of early-career academic cardiologists remains challenging;

42 r development grants, only a small number of early-career American College of Cardiology members have

43 Female-biased BCL6 targets were enriched for early cGH derepression.

44 romatin state in male liver generally showed early cGH responses; genes in an inactive chromatin stat

45 with individual virulent serotypes, both in early challenge and after 5 months of challenge without

46 Similarly, early changes in strain and Ea were associated with wors

47 rmation of the foregut and heart tube in the early chick embryo.

48 lems in adulthood may be rooted partially in early childhood exposure to unpredictable events and env

49 25(OH)D deficiency in early childhood is associated with increased risk for pe

50 Symptoms of ASD typically occur during early childhood, whereas most symptoms characteristic of

51 We compared the early clinical outcomes in patients undergoing RA using

52 ascular remodeling in hypoxic PH involves an early compartment-independent activation of lung macroph

53 ical pathway (CP) inhibition at the level of early component C1.

54 ntal changes in the way attention alters the early cortical responses that support selective informat

55 emperature application but generally fail by early cracking with limited plasticity at room temperatu

56 realopelta markmitchelli gen. nov., from the Early Cretaceous of Alberta, which preserves integumenta

57 ve to immune-based therapies; in addition to early cytokine therapy, newer checkpoint inhibition ther

58 s were estimated for the association between early death and demographic, clinical, and socioeconomic

59 l morphogenesis in placodal neurons and that early defects are associated with ASD-associated mutatio

60 ther, these results strongly suggest that an early deficiency in beta-cell number in infants with CF

61 onic ambient temperature extremes may affect early delivery risk.

62 The baseline characteristics, development of early dermatologic reactions, and cause of treatment dis

63 ing evidence and potential benefit gained by early detection and appropriate management.

64 onitoring technology is already facilitating early detection and improved visual outcomes for patient

65 osensor paves a fascinating platform towards early detection of cancer tumour and is anticipated to b

66 (18)F-FDG PET/CT is a valuable technique for early detection of metastatic infectious foci, often lea

67 Early detection would save many lives, but current fluor

68 surveillance in these populations to enhance early detection, management, and control in future HPAI

69 eterogeneity in cell function emerges during early development and how structural patterning goes han

70 of the somatic and neural elements following early development of the central nervous system.

71 n overlapping function that is essential for early development.

72 Cs must transiently silence their genome, an early developmental process that requires Nanos activity

73 of L1-80 contribute to brain development at early developmental stages.

74 es in ASD mouse models, especially during an early developmental time when experience-dependent plast

75 pis brachynotus gen. nov.) from the Pragian (Early Devonian) of South China, which preserves a unique

76 ging appearance is essential to arrive at an early diagnosis and also to obviate biopsy in cases with

77 ncer diagnosis may significantly improve the early diagnosis and subsequent treatment.

78 Clinical breast examination may improve early diagnosis directly by finding breast cancers at ea

79 , and potentially screen individuals for the early diagnosis of cancer.

80 To develop an algorithm for accurate and early diagnosis of CJD by using the RT-QuIC assay on CSF

81 pplement current screening modalities to aid early diagnosis of high-risk populations and assist the

82 molecular level and has a high potential on early diagnosis.

83 reover, ECV was strongly correlated with the early diastolic strain rate (r = -0.782, p < 0.001) and

84 Our results show that early diet specialization may be reinforced by the eleva

85 disability that should be considered in the early differential diagnosis when screening results are

86 es in amyotrophic lateral sclerosis from the early disease stage.

87 about these basic aspects of cell biology in early-diverging Apicomplexan parasites, which do not div

88 iated with transcriptionally active genes in early-diverging fungal lineages.

89 value for both selective drain placement and early drain removal for PD.

90 CNE1 is displaced within the channel's cleft early during activation, or that conformational changes

91 mography, we find that centrioles degenerate early during ciliogenesis.

92 ction of proteasome activity in CD8+ T cells early during differentiation resulted in acquisition of

93 st and that many mutations become fixed very early during the adaptation process.

94 from east to west Eurasia must have occurred early during the Iron Age.

95 iver for malignant transformation, occurring early during the pathogenesis of cancers such as lung an

96 Greater levels of late/early ejection-phase MWS were associated with reduced LA

97 the transcription elongation complex during early elongation within 500 base pairs of the transcript

98 It is essential for differentiation and early embryonic development in mice.

99 in early human embryos, our understanding of early embryonic somatic mutations is very limited.

100 s reminiscent of local activation of Toll in early embryonic ventral hypoderm, consistent with the hy

101 es transient oxidation on or close to RAB5+/ early endosome antigen 1- endosomes.

102 venger receptors and subsequently escape the early endosome through a pH-triggered disassembly mechan

103 pathways including apoptosis, DNA repair and early estrogen response that were differentially regulat

104 rmany, including a sample associated with an early European farming community.

105 between recruited APC and TC may occur as an early event promoting allergic airway inflammation.

106 In grafts surviving at least 90 days, early events (acute rejection [AR] and delayed graft fun

107 ction factors in primary cells or during the early events after SIV infection and suggest that the le

108 fficiently at centromeres during G1, mediate early events in centromere establishment at an ectopic c

109 onse of badlands to erosion such that in the early evolution stages, vegetation removal results in gu

110 The authors present compelling evidence that early exposure to tanning beds advances the date of diag

111 nonlinear mixed-effects models showed small early favorable changes in the first few months post-TAV

112 ction and aggressive macrophage activity are early features in the pathogenesis of type 1 diabetes (T

113 uring patient recuperation starting from the early febrile to the defervescence and convalescent stag

114 INTERPRETATION: Early feeding of babies with their own mother's milk and

115 Early floral stages constitutively accumulate greater am

116 oss-of-function of FRS7 and FRS12 results in early flowering plants with overly elongated hypocotyls

117 ced by vernalization, in contrast to the Ku (early-flowering) parent, which showed constitutively hig

118 Early fluoroquinolone (FQ) use was defined as receiving

119 Loss of Sin3a in mouse early foregut endoderm led to a specific and profound de

120 rand breaks are crucial to the modulation of early gene expression, which provides a mechanistic link

121 and, in most cases, expression of immediate early genes.

122 n of these de novo mutations occurred during early germ cell development.

123 ssociated with mortality differences between early goal-directed therapy and control included Acute P

124 ate core regulatory mechanisms unique to the early Golgi Arf-GEFs.

125 preformed DSA demonstrated elevated risks of early graft failure, whereas those with de novo DSA expe

126 We find the transcription factor early growth response 3 (EGR3) is increased in D1 recept

127 novelty is baseline specific and, during the early-Holocene, was mitigated by the rapid spread of pla

128 somal abnormalities are remarkably common in early human embryos, our understanding of early embryoni

129 Early humans inherited activating KIR2DS4 and an inhibit

130 serine 10 or 28 and expression of immediate-early (IE) genes.

131 ociations between body size and MM originate early in life and are driven largely by height and birth

132 sociation was found for antibiotics exposure early in life and objective atopy measurements including

133 channel (K2P) subunits, largely dispensable early in life, are necessary for terminating contraction

134 Barcoding of DNA template molecules early in next-generation sequencing (NGS) library constr

135 not need or want palliative care involvement early in the disease trajectory.

136 phobic spacer peptide (SP) at its C-terminus early in the maturation process, which is progressively

137 se results suggest an archaic human diaspora early in the Middle Pleistocene.

138 At a site early in the Salmonella flgM gene, the effects on transl

139 d that most regulatory genes are upregulated early in the season when the cork cambium becomes active

140 The appearance of wings in insects, early in their evolution [1], has been one of the more c

141 K) repeats in the glutaminases were acquired early in their evolution.

142 ynamics and to engage in research activities early in their scientific career.

143 Although early in vitro enzyme assays showed that recombinant BAR

144 ody 1 year after discontinuation might be an early indicator of a protolerogenic mechanism.

145 that virulence factors are only utilized in early infection to initiate the insect-bacterial associa

146 de C envelope (Env)-pseudotyped viruses from early infection.

147 se data demonstrate MyD88 signaling mediates early inflammatory responses in the joint but also contr

148 TIGIT expression increased over time despite early initiation of ART.

149 rs after 600 mg/kg dose of APAP, resulted in early initiation of liver regeneration in a dose-depende

150 sceptibility is warranted to inform targeted early intervention and prevention efforts.

151 practices for a genetics-driven approach to early intervention in at-risk relatives.

152 is who received social recovery therapy plus early intervention services.

153 These data provide a framework for early intervention studies to facilitate safer applicati

154 ng with clinical correlation, which includes early involvement of ACTH and TSH and a relatively rapid

155 uman islets to develop a detailed profile of early ischemia induced changes and targets for intervent

156 Otherwise, no early laboratory or clinical features distinguished the

157 ehavioral effects of miRNA regulation in the early larva.

158 dinosaurs were relatively common during the early Late Cretaceous.

159 Delays in early learning developmental trajectories in HR infants

160 her study as to how fish tolerate what is an early lethal mutation in mammals could facilitate improv

161 t of family financial resources available in early life influences child health and development.

162 Installation of a water softener in early life may be able to prevent AD development.

163 The number of early life risk factors, including high levels (extreme

164 pond with differences in body composition in early life, a known contributor to obesity risk.

165 ate the development of cytokine responses in early life, and that cytokine responses to specific micr

166 ht have increased intestinal permeability in early life.

167 Early-life OM episodes historically associated with vacc

168 terization of imaging correlates elicited by early-life social stress is lacking.

169 Here, we test for the first time how early-life stress drives developmental programming and t

170 generational effects of maternal exposure to early-life stress on several phenotypic traits in their

171 about how genes are specifically affected by early malnutrition and the implications for males and fe

172 egulated as seeds mature: 99% of them during early maturation were down-regulated, and preferentially

173 Specifically, early measurements of thermally activated vortex motion

174 l body composition and thus may be among the early mechanisms modulating later susceptibility to diab

175 Early microbiological cure on culture is a predictor of

176 Early Miocene (18-20 Ma) corals exhibit the same nitroge

177 t is thus important to understand underlying early molecular events.

178 of GRP78 maintained normal sizes during the early months, with reduced proliferation and suppression

179 olved in oligodendrocyte differentiation and early myelination, but is not necessary for myelin maint

180 tion reduces myoblasts growth by inducing an early myogenesis -related gene expression pattern which

181 ns, but with some additional dilution of the Early Neolithic ancestry.

182 k gene TCF4 enhances NMDA receptor-dependent early network oscillations.

183 Using light-sheet microscopy, early neural development is here followed in vivo in rea

184 rk cycle to constant darkness and aroused in early night or late night.

185 he world, (2) why shamanism professionalizes early, often in the absence of other specialization, and

186 ionally representative British population in early old age, statin use was associated with lower limb

187 gas concentrations during the late Eocene to early Oligocene, and does not represent a single respons

188 cases, 4,001 controls), the most severe and early onset form of periodontitis.

189 A subset of patients with early onset formed hallucinations (n=21) had reduced hig

190 (rs11206510), which has been identified for early onset myocardial infarction (MI), modified the ass

191 ted with glomerular disease characterised by early onset proteinuria and ultrastructural thickening a

192 entification and study of inherited forms of early-onset AD and genetic risk factors that provide ins

193 Patients from a large family with early-onset pain symptoms were evaluated by clinical exa

194 Patients presented with early-onset sensorineural deafness and distal renal tubu

195 le based mainly on missing, insufficient, or early or late baseline laboratory data.

196 activation of the LT and Wnt pathways during early- or late-onset allergic airway inflammation and to

197 The low detection rate of early oral SCC is a considerable clinical issue.

198 score for decision making and assessment of early outcome in patients eligible for transcatheter aor

199 The mouthparts of early oxyporines, including enlarged mandibles and great

200 he Great Oxidation Event (GOE), began in the early Paleoproterozoic in association with global glacia

201 rly symptom-related causes, attitudes toward early palliative care integration, and patient-parent co

202 olumes were associated with a higher risk of early pancreas graft failure at 3 months.

203 This early pattern of Abeta accumulation is already evident i

204 ar role for the chemokine CXCL12 secreted in early PDAC and for its receptors CXCR4/CXCR7 on SC in th

205 Early perturbations in tissue-wide gene expression, as o

206 Global IL-6 inhibition in the early phase after fracture reduced systemic inflammation

207 earch strategy yielded 11 studies (9 smaller early-phase and 2 larger outcome trials).

208 Some are making the transition into early-phase patient trials, but the lack of validated bi

209 ta-galactosidase activity, oxidative stress, early phosphorylation of mitogen-activated protein kinas

210 neural circuits in vivo This work describes early postnatal developmental abnormalities in visual an

211 ccessing newborn infants at birth and in the early postnatal period underscores the limitations of ta

212 Minor early postoperative complications, such as graft infecti

213 ity, recent interpersonal violence, pre- and early postpartum stress, gestational age at birth, infan

214 Metabolic adaptations in early pregnancy are uncoupled from the circadian clock,

215 level, cohabitation with a partner, height, early pregnancy body mass index, smoking, year of delive

216 -specific GATA2/GATA3 function could lead to early pregnancy failure.

217 en hemoglobin concentrations are measured in early pregnancy.

218 h pre-60S subunits, resulting in turnover of early preribosomes, before the ITS1 spacer can be remove

219 rgistically activating the two EBV immediate early promoters (Zp and Rp).

220 During the early pupal period (P6-P48) these primordia grow in size

221 tients presenting with their first STEMI and early QW in the ECG had smaller myocardial salvage index

222 arthralgia, undifferentiated arthritis (UA), early RA, and established RA cohorts in comparison with

223 tes them, is the target of autoantibodies in early RA.

224 apeutic potential of alpha7nAChR agonists in early re-programming of microglia in neonates exposed to

225 Comparing the early receptor current amplitude and action spectra betw

226 retinal imaging biomarkers are important for early recognition and monitoring of inflammation and neu

227 l metabolic tumor volume (TMTV) could detect early relapse or refractory disease.

228 data and safety monitoring board recommended early reporting of the study results because of safety c

229 with WDTC treated with RAI had an increased early risk of developing AML and CML but no other hemato

230 rement of lactate levels may have utility in early risk stratification of pediatric sepsis.

231 g in Arabidopsis during seed germination and early seedling development.

232 a that cross-modal plasticity in the case of early sensory deprivation relates to the original functi

233 or induce a systemic resistance that shares early signaling components with the root iron-uptake mac

234 mportant to be able to detect CVD biomarkers early so that patients can be diagnosed properly and beg

235 rate that lung gammadelta T cells provide an early source of innate IL-17, which promotes antimicrobi

236 unity phenologies differed strongly, with an early spring peak followed by decline in forests, and a

237 or patients with symptom debut in the winter/early spring.

238 individuals at risk of developing AD and/or early stage AD for which current therapies may be more b

239 vestigations to explore the role of miRNA in early stage BC in young women, including ethnic specific

240 a manganese oxidizing complex, and describe early stage formation of its mineral products.

241 lengths were measured repeatedly during the early stage of growth.

242 ne frontal cortex, becomes active during the early stage of learning a novel vocabulary.

243 is review, we describe speculative ideas and early stage research concerning the flow of genetic info

244 rentially methylated gene regions (DMGRs) in early stage tumors across eleven genes (AGRN, C1orf170,

245 Cytotoxicity at the early stage was investigated on twenty types of polymers

246 Patients and Methods Early-stage (I-III) AABCS were randomly assigned to a 6-

247 r an estradiol vaginal ring in patients with early-stage BC receiving an AI; secondary objectives inc

248 examine change in the percent uninsured and early-stage diagnosis among nonelderly patients with new

249 s documented, 45 (48.4%) were diagnosed with early-stage disease (American Joint Committee on Cancer

250 tigates tumor heterogeneity and evolution in early-stage non-small cell lung cancer.

251 ed multiregion whole-exome sequencing on 100 early-stage NSCLC tumors that had been resected before s

252 rectly on brain function and/or treatment in early-stage psychosis populations are needed.

253 energic mechanisms, can substantially affect early-stage sensory signal processing and subsequent beh

254 ss the potential of a protein to be toxic at early stages of development.

255 In the early stages of endocytosis, fPlas-gold nanoparticles ap

256 Direct observation of nanoparticles in the early stages of growth with unobtrusive laser probes sho

257 blishes a new system with potential to study early stages of NBL oncogenesis, to functionally assess

258 Especially poorly understood are the very early stages of protein folding, which are likely define

259 ough EDTA had some inhibitory effects in the early stages of storage.

260 alterations in transcription rate during the early stages of stress response, indicating orthogonal t

261 ess fracture risk among T2DM patients in the early stages of the disease.

262 ations in South Africa, deposited during the early stages of the first rise in atmospheric oxygen on

263 situ and invasive cancers and may influence early stages of tumorigenesis.

264 gnificant difference was seen in the rate in early-start patients during this time period (-1.51 g/L

265 g/L per year to -1.63 g/L per year), thus in early-start patients the efficacy was sustained to month

266 sex ratio as a possible explanation for this early sterilizing effect.

267 jects without diabetes in the Progression of Early Subclinical Atherosclerosis (PESA) Study.

268 ults showed that the HFMD epidemic peaked in early summer and autumn.

269 Degree of perceived suffering from early symptom-related causes, attitudes toward early pal

270 All patients with early systolic dysfunction recovered in 1 week.

271 upts antigen presentation thereby preventing early T cell activation and interferes with diapedesis.

272 g of cytokine-induced beta-cell apoptosis in early T1D.

273 We therefore defined eyes as having early tears if they tore before the breakpoint (38/55 ey

274 Early thymic progenitors (ETPs) are endowed with diverse

275 e who had serum samples obtained at multiple early timepoints.

276 eases with time after CTC1 disruption and at early times net G-strand growth is apparent, indicating

277 A decreasing BMI from early to middle age and a low BMI in middle age may be p

278 rom adjuvant anthracyclines in patients with early TOP2A-normal breast cancer.

279 Early translational recovery and SG disassembly induced

280 DR was classified according to Early Treatment Diabetic Retinopathy Study Research Grou

281 t and at 6 months (or prior, in the event of early treatment failure).

282 implicit time and was lower in patients with Early Treatment of Diabetic Retinopathy Study (ETDRS) le

283 overy After an Initial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) study, a 34-site clu

284 Here we explore early trends in pediatric transplantation following KAS,

285 y, including checkpoint immunotherapies, and early tumor resection and (neo)adjuvant chemotherapy fai

286 For example, the recent detection of the early ultraviolet pulse of a peculiar, subluminous type

287 G1-G3 These dates suggest a co-occurrence of early Upper Paleolithic osseous artifacts, particularly

288 This finding was associated with an impaired early vascularization and stromal tissue growth as well

289 IT was a randomized clinical trial comparing early versus delayed interferon beta-1b treatment in 465

290 that the chaotic pattern was predominant in early VF, but the regular pattern emerges as VF progress

291 ity to the inhibition of early and immediate early viral gene expression.

292 In contrast, early visual areas generally manifest responses to indiv

293 eorganization in long-range connections from early visual areas to the face-selective temporal area i

294 Many of the neurons in early visual cortex are selective for the orientation of

295 Electrically stimulating early visual cortex results in a visual percept known as

296 ibuting to the transition in climate from an early, warm, wet environment to today's cold, dry atmosp

297 fference of deep delta(18)Oc likely reflects early warming of the deep northern North Atlantic by app

298 Early winter respiration was not well simulated by the E

299 Early withdrawal from repeated cocaine also produces dra

300 entional metallic drug-eluting stents in the early years after implantation.