ライフサイエンスコーパス: early embryo

1 e adult and alter correct development in the early embryo.

2 selecting target genes for activation in the early embryo.

3 its role in regulating BMP signaling in the early embryo.

4 increased efficiency of wound repair in the early embryo.

5 quiescent oocytes to dynamic exchange in the early embryo.

6 igand, Trunk, are expressed uniformly in the early embryo.

7 ively regulates aph-1(zu147) activity in the early embryo.

8 how that their differentiation starts in the early embryo.

9 cytial blastoderm nuclear cycle phase of the early embryo.

10 e in the primitive streak and tailbud of the early embryo.

11 curate automated cell tracking in the entire early embryo.

12 ies all cells with hematopoietic fate in the early embryo.

13 temporal regulation of their function in the early embryo.

14 shed by those same signaling pathways in the early embryo.

15 t arise from cartilaginous precursors in the early embryo.

16 tivities to generate sharp boundaries in the early embryo.

17 ating anterior endoderm transcription in the early embryo.

18 dynamic morphogenetic events that shape the early embryo.

19 -RK family and is broadly transcribed in the early embryo.

20 o maintain DE-cadherin protein levels in the early embryo.

21 on the ventral-to-dorsal BMP gradient in the early embryo.

22 that regulates centrosome positioning in the early embryo.

23 limits the activity of both pathways in the early embryo.

24 s along the anteroposterior (AP) axis of the early embryo.

25 expressed in early developing endosperm and early embryo.

26 ces drive the movement of tissues within the early embryo.

27 to promote cleavage furrow formation in the early embryo.

28 the totipotent and pluripotent cells of the early embryo.

29 ld1 transcripts are uniformly distributed in early embryo.

30 he activation of the protease cascade in the early embryo.

31 ell cycle and checkpoint requirements in the early embryo.

32 ment to specific locations in the oocyte and early embryo.

33 s coordinated with cell specification in the early embryo.

34 he maternal contribution of ribosomes to the early embryo.

35 ved understanding of neural induction in the early embryo.

36 or Pol II binding and gene activation in the early embryo.

37 ovulation, the SCMC proteins persist in the early embryo.

38 rrors and thus approximately constant in the early embryo.

39 umber of primordial germ cells (PGCs) in the early embryo.

40 quired for cleavage furrow ingression in the early embryo.

41 regulating regions of open chromatin in the early embryo.

42 nstrates paternal-specific expression in the early embryo.

43 s for regulation of lineage decisions in the early embryo.

44 enuates pMad and Dpp signalling range in the early embryo.

45 le progression in the Caenorhabditis elegans early embryo.

46 ar characteristics of the totipotent egg and early embryo.

47 itioning cells to the inner cell mass of the early embryo.

48 gans caudal homolog, to the posterior of the early embryo.

49 robust regulation in the quickly developing early embryo.

50 lated at their 3' ends in mature oocytes and early embryos.

51 ring mitotic cycles in frog-egg extracts and early embryos.

52 attern similar to that in migratory PGCs and early embryos.

53 pment originates from lineage segregation in early embryos.

54 de cell polarization and axis orientation in early embryos.

55 l for two separate cell-cell interactions in early embryos.

56 he establishment of the pluripotent state in early embryos.

57 ity and defects in chromosome segregation in early embryos.

58 which is normally present at high levels in early embryos.

59 ome-wide DNA demethylation in germ cells and early embryos.

60 maintain genome stability in stem cells and early embryos.

61 anules are cytoplasmic bodies in oocytes and early embryos.

62 ly regulate multiple developmental events in early embryos.

63 ntral (DV) axes and midline determination in early embryos.

64 an capture up to 75% more genes expressed in early embryos.

65 growth from the poles in mitotic spindles of early embryos.

66 RNAs that are abundant in animal gonads and early embryos.

67 structures important for mitotic fidelity in early embryos.

68 spindle alignment in Caenorhabditis elegans early embryos.

69 CDC-25.1, are asymmetrically distributed in early embryos.

70 e, results in spindle orientation defects in early embryos.

71 ateral membrane in both epithelial cells and early embryos.

72 al migration of the primordial germ cells in early embryos.

73 those operating in primordial germ cells and early embryos.

74 inucleotides in the hypomethylated genome of early embryos.

75 3, are also expressed throughout the soma of early embryos.

76 the rga locus, which is highly expressed in early embryos.

77 In the early embryo, a myosin II-dependent contraction of the c

78 eviously in unstaged embryos, revealing that early embryos accumulate poised Pol II and that poising

79 nase inhibitor, normally undetectable in the early embryos, accumulates at high levels in the absence

80 Polarization of early embryos along cell contact patterns--referred to i

81 t regulate nos translation in the oocyte and early embryo also regulate nos in the PNS.

82 t immediate post-fertilization expression of early embryo and (or) endosperm development.

83 we describe its widespread expression in the early embryo and adult tissues.

84 in the context of cells residing within the early embryo and cells propagated in vitro.

85 during fertilization, which could influence early embryo and endosperm development.

86 e gene FAC1, both of which are essential for early embryo and endosperm development.

87 ough preferential maternal expression in the early embryo and endosperm.

88 or inhibiting Xist and X-inactivation in the early embryo and in cultured stem cells of extra-embryon

89 ch Chk1 blocks cell-cycle progression in the early embryo and is an essential function of Chk1 at the

90 patiotemporal expression of ash genes in the early embryo and larval stages suggests that they regula

91 sion drive both global reorganization of the early embryo and local remodeling during organogenesis.

92 that lead to cell elongation defects in the early embryo and markedly reduced suspensor length.

93 served spatiotemporal dynamics of Cic in the early embryo and might explain RTK-dependent control of

94 inst full trisomy of some chromosomes in the early embryo and provides data for estimation of recurre

95 imary function of Delta40p53 in cells of the early embryo and stem cells, which are the only normal c

96 e-versus-outside positioning of cells in the early embryo and stochastic expression of key transcript

97 -type cyclin in cell cycle regulation in the early embryo and suggest that CYB-3 asymmetry helps esta

98 or Chk1 in normal proliferating cells of the early embryo and suggest the potential for diverse effec

99 protein is present in all blastomeres of the early embryo and that its abundance oscillates with the

100 aturally during mammalian development in the early embryo and the developing germ line, and artificia

101 Global DNA demethylation occurs in the early embryo and the germ line, and may be mediated by T

102 stablished prior to gastrulation in the very early embryo and, because it is systemic, can be assesse

103 cy is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vi

104 o accumulate stably at the cell periphery in early embryos and at the apical surface in pharyngeal an

105 H3K27ac is present at high levels in early embryos and declines after 4 hours as H3K27me3 inc

106 that, in mice, is expressed specifically in early embryos and embryonic germ cells.

107 ental contributions to the transcriptomes of early embryos and endosperm.

108 ey differentially regulate the heart rate of early embryos and equally facilitate heart function in o

109 alyzed the planar cell divisions in ascidian early embryos and found that spindles in every cell tend

110 amily of pluripotent cell lines derived from early embryos and from germ cells, and compare them with

111 a gene that is expressed in the notochord of early embryos and in multiple epithelia during later dev

112 es place in primordial germ cells (PGCs) and early embryos and is linked with pluripotency.

113 red gene expression of metabolic pathways in early embryos and islets of F1 offspring, which was unre

114 domain organization is remarkably similar in early embryos and L3 larvae, with conservation of 85% of

115 ive hAgo2 is required to elicit RNAi in both early embryos and oocytes using either siRNA or endogeno

116 to the DNA mutational processes occurring in early embryos and the mechanisms underlying them.

117 hat some of them are actively transcribed in early embryos and the proper regulation of retrotranspos

118 ambiae embryogenesis, first in the serosa of early embryos and then again during late stages as seen

119 Here, we use chromatin state analyses in early embryos and third-larval stage (L3) animals to inv

120 domain protein Elba2, which is expressed in early embryos and was hypothesized to have insulator-spe

121 iched in nuclear extracts from late, but not early, embryos and that it contains three insulator prot

122 ons that are transcribed in the germline and early embryo, and ectopic transcription of genes in a mu

123 terization of starch turnover during flower, early embryo, and silique development in Arabidopsis (Ar

124 programming occurs in primordial germ cells, early embryos, and embryonic stem cells where reciprocal

125 nally for egg laying, mitotic progression in early embryos, and embryonic survival.

126 ammalian primordial germ cells (PGCs) and in early embryos, and is important for the erasure of impri

127 -specific DNA methylomes from mouse gametes, early embryos, and primordial germ cell (PGC), as well a

128 lationally repressed properly in oocytes and early embryos, and then correctly translated only in the

129 Methylome data from human early embryos appear to support this finding.

130 The commitment to the cell cycle in the early embryo appears to preclude many other cellular pro

131 system begins when pluripotent cells of the early embryo are directed to acquire a neural fate.

132 Totipotent cells in early embryos are progenitors of all stem cells and are

133 ms controlling retrotransposon expression in early embryos are still not well understood.

134 which are resistant to demethylation in the early embryo, are resistant to vitamin-C-induced DNA dem

135 nse, increased recombination-based repair in early embryos as determined by plasmid-based reporters.

136 and regulation of protein trafficking in the early embryo, as well as serve as a tool for manipulatin

137 critical features of the methylome of human early embryos, as well as its functional relation to the

138 echnology (ART) involves the manipulation of early embryos at a time when they may be particularly vu

139 K genes causes an analogous phenotype in the early embryo before the onset of hematopoietic stem/prog

140 ints on splicing were likely to exist in the early embryo, being splicing avoidance a possible explan

141 The virus was injected into the very early embryo (blastodisc stage) to target the primordial

142 island promoters--that are maintained in the early embryo but are lost upon specification and absent

143 as loss of end-3 halves ELT-2 levels in the early embryo but levels fully recover by the time of hat

144 t of polarity axes in the developing egg and early embryo, but has no known somatic functions or expr

145 t plays essential roles in mouse oocytes and early embryos, but the functional role of individual ami

146 Mitotic spindles specify cleavage planes in early embryos by communicating their position and orient

147 that we have previously shown to be bound in early embryos by the maternally deposited transcription

148 tones in later development, may be shared in early embryos by weakly homologous proteins, such as Big

149 ate decisions because of the ease with which early embryos can be recovered and the availability of a

150 Furthermore, overexpression of Mtrm in the early embryo caused aberrant nuclear divisions and devel

151 Moreover, overexpression of Grh in the early embryo causes defects in cell division, phenocopyi

152 Subsequent entry into the cytosol of early embryos causes gene silencing in progeny.

153 are most prominent in large oocyte, egg and early embryo cells.

154 n turnover in mitotic spindles of Drosophila early embryos, characterized by diffusional interactions

155 igh levels of many of these rab genes in the early embryo, chemical inhibitors of Rab functions rescu

156 three-dimensional computational model of the early embryo, consisting of pseudoelastic plates represe

157 ctivation of a DNA checkpoint operational in early embryos contributes significantly to the nopo phen

158 equired for cytokinesis in the nematode worm early embryo (CYK-1) and fission yeast (Cdc12p).

159 ed in complete female infertility because of early embryo death.

160 be epigenetic differences in the gametes or early embryos derived from couples undergoing treatment

161 e first movies and targeted manipulations of early embryos developing inside cultured seeds.

162 trotransposition in somatic cells, excluding early embryo development and some malignancies.

163 d in active demethylation of H3K27me3 during early embryo development and that this mark plays an imp

164 We propose that GPT1 is necessary for early embryo development because it catalyses import int

165 Germline and early embryo development constitute ideal model systems

166 he mitochondrial matrix and is essential for early embryo development in Arabidopsis (Arabidopsis tha

167 ly play a minor role in the initial steps of early embryo development in maize.

168 tives on DNA methylation heritability during early embryo development that extend beyond conventional

169 data reveal a novel function of PADI1 during early embryo development transitions by catalyzing histo

170 Consistent with this observation, early embryo development was also arrested at the 4-cell

171 onally significant role in ESC self-renewal, early embryo development, and reprogramming.

172 at both calcium regulators are essential for early embryo development, and that knockdown of PmTPCs l

173 ion is an important epigenetic marker during early embryo development, cellular differentiation, and

174 domains and grouped them into three groups (early embryo development, late embryo development, and e

175 rkable effects on both oocyte maturation and early embryo development, which in turn can have lifelon

176 tabilization of cyclin A2 mRNA and mammalian early embryo development.

177 in 5 (K5)-Cre gene construct is expressed in early embryo development.

178 ted specifically within the suspensor during early embryo development.

179 gotic genome activation and is essential for early embryo development.

180 lation of PKA localisation during oocyte and early embryo development.

181 in PKA localisation occur during oocyte and early embryo development.

182 tions that drive egg activation and initiate early embryo development.

183 tivated specifically in the suspensor during early embryo development.

184 one after anthesis, during fertilization and early embryo development.

185 ture of the uterine environment in which the early embryo develops is not well understood.

186 Here, we show that in the early embryo dFMRP associates specifically with Caprin,

187 in mammalian development is how cells of the early embryo differentiate into distinct cell types.

188 pose that, unlike more cohesive tissues, the early embryo dissipates tensile forces required by const

189 We show that, in Xenopus laevis oocytes and early embryos, double-stranded exogenous siRNAs cannot f

190 characteristic of specific cells within the early embryo (e.g., epiblast cells) and of certain cells

191 length TET1 isoform (TET1e) is restricted to early embryos, embryonic stem cells (ESCs), and primordi

192 om neoblasts: they express unique cohorts of early embryo enriched transcripts and behave differently

193 We therefore propose that the early embryo environment restricts the fate choice of ep

194 enopus laevis, including oocyte, egg, sperm, early embryo equivalent (pronuclei incubated in egg extr

195 tored predeposition histones in the egg, the early embryo equivalent pronuclei, cultured somatic cell

196 activation of cre/lox based gene excision in early embryo extraembronic trophoblast tissues as well.

197 In early embryos, Fibroblast growth factor (FGF) maintains

198 Once the program is activated in early embryos, Fli1 then takes over to sustain the proce

199 ought that the bilateral heart fields in the early embryo fold directly towards the midline, where th

200 d by its requirement in the posterior of the early embryo for abdomen formation [2].

201 that Drosophila FMRP (dFMRP) is required in early embryos for cleavage furrow formation.

202 ystematically profile the methylome of human early embryos from the zygotic stage through to post-imp

203 stone tail citrullination, which facilitates early embryo genome transactivation.

204 How transcription is silenced in early embryos has long been a mystery.

205 or anterior-posterior (AP) patterning in the early embryo, have uncovered two distinct ways of scalin

206 In germ cells and early embryos, however, epigenetic reprogramming occurs

207 a window(s) of opportunity in the zygote and early embryo; (ii) there is no statistical variation of

208 lizes asymmetrically to the posterior of the early embryo in a PKC-3-dependent manner, and functions

209 n to be necessary for the development of the early embryo in mammals, but the molecular processes aff

210 However, whole-transcriptome analysis of early embryos in flowering plants has been hampered by t

211 supplied mRNAs encode proteins that pattern early embryos in many species.

212 cing of a small number of transcripts in the early embryo, including the pre-mRNA that encodes the ap

213 evelopmental promoters that are repressed in early embryos, including many bivalent (H3K4me3/H3K27me3

214 Edn2 overexpression in the early embryo inhibits vascular development at midgestati

215 , it prevents the ectopic differentiation of early embryos into trophoblast.

216 actomyosin structures during wound repair in early embryos involves disassembly of the actomyosin net

217 nction is disrupted, furrow formation in the early embryo is completely abolished.

218 The duration of S phase in early embryos is often short, and then increases as deve

219 ablishing X chromosome inactivation (XCI) in early embryos, is conditionally deleted from Xi in somat

220 entrosomes and also with cleavage furrows in early embryos, is required for cleavage furrow assembly.

221 inase localized asymmetrically in C. elegans early embryos, is symmetrically localized in the one-cel

222 In early embryos, it was primarily nuclear, whereas later i

223 Because maturing oocytes and early embryos lack appreciable transcription, posttransc

224 Knockdown in the early embryo led to abnormal atrial septal development a

225 Matr3(Gt-ex13) homozygotes are early embryo lethal, but Matr3(Gt-ex13) heterozygotes ex

226 Endothelial depletion of Pak2 leads to early embryo lethality due to flawed blood vessel format

227 ssues, and Cubn gene inactivation results in early embryo lethality most likely due to the impairment

228 nsistent with impaired cell division causing early embryo lethality.

229 dria are often asymmetrically distributed in early embryos, little is known about how they contribute

230 In the Drosophila early embryo, maternally deposited TE-derived PIWI-inter

231 es originating in two different areas of the early embryo meet.

232 A substantial fraction is resistant to early embryo methylation reprogramming, which may have a

233 crotubules of mixed polarity, differing from early-embryo mitotic spindles.

234 ession to read the sex chromosome karyotype, early embryos must remain gender-naive; our findings sho

235 In the early embryo NF-kappaB/RelA regulates twist, snail2, and

236 In the Drosophila melanogaster early embryo, Nuf (Nuclear fallout), a Rab11 effector wh

237 In the early embryo of many species, comparatively small spindl

238 yment of the cuticle biosynthesis pathway in early embryos of A. gambiae.

239 Early embryos of Caenorhabditis elegans polarize radiall

240 Early embryos of some metazoans polarize radially to fac

241 n of distinct H2A.X variants in the eggs and early embryos of the frog Xenopus laevis that contain a

242 centa directly conveys the Zika virus to the early embryo or fetus.

243 otent stem cells are derived from culture of early embryos or the germline and can be induced by repr

244 sential for establishment and maintenance of early embryo polarity and their homologs in other organi

245 rked by an initial auxin maximum, suggesting early embryo proper establishment in the absence of a ba

246 we find that, in the Drosophila melanogaster early embryo, reduced levels of the protein kinase Akt r

247 Our data indicate early embryos regulate and stabilise endocytosis as a me

248 ex1 and apex2 are both strongly expressed in early embryos relative to adults, these data indicate th

249 Telomere position in early embryos required the NE protein SUN-1, the single-

250 Exponential increase of cell numbers in early embryos requires large amounts of DNA precursors (

251 e have previously shown that the oocyte- and early embryo-restricted maternal effect gene Mater (Nlrp

252 The phenotype has a rapid onset in early embryos, resulting in vessel defects by 48 h and d

253 Conversely, ectopic expression of ttv in early embryos results in severe germ-cell migration defe

254 er an initial expansion along the midline of early embryos, shh was elevated in the oral-pharyngeal r

255 Third, the analysis of cultured Steel-null early embryos shows that Steel factor is required for no

256 timulus DNA damage is actively suppressed in early embryos so that P lineage cell divisions may occur

257 ression templates from a cohort of zebrafish early embryos spanning 6 developmental stages from 4 to

258 down-regulation of Cdx2 transcripts from the early embryo stage results in defects in TE specificatio

259 BPs are enriched in posterior regions of the early embryo, suggesting their general importance in pos

260 in-bound levels of PCNA in both S2 cells and early embryos, suggesting that the Enok complex may inte

261 of genes that are normally not expressed in early embryos, suggesting that Zld controls the genome-w

262 er abundance of transcripts, indicating that early embryos tend to retain higher residual methylation

263 polarity defects are more apparent in par-2 early embryos than in par-1 or par-4, except for strd-1(

264 sun is much higher in Drosophila ovaries and early embryos than in testes, we herein sought to determ

265 sistent with a repair event occurring in the early embryo that is more efficient in females, perhaps

266 We purified a factor from semi-synchronized early embryos that binds to an end-1 cis regulatory regi

267 In the Drosophila early embryo, the centrosome coordinates assembly of cle

268 maternal origin are distributed uniformly in early embryos, this pattern changes as development proce

269 eted to the posterior pole of the oocyte and early embryo through translational repression of unlocal

270 pre-patterning that persists in zygotes and early embryos through the morula stage.

271 ecific genes in germline function and in the early embryo, through overexpression or RNA interference

272 The cell cycles of the early embryo titrate out these factors, leading to zygot

273 s revealed distinct expression patterns from early embryo to adult stages in An. stephensi.

274 new miRNAs, revealed distinct patterns from early embryo to adult stages in An. stephensi.

275 that the mir-35 family microRNAs act in the early embryo to function as a developmental timer that p

276 nd function of C. elegans intestine from the early embryo to mature adult.

277 e of the natural adherence properties of the early embryo to position them in a single layer on a pol

278 This hastened cell cycle allows the early embryo to rapidly grow.

279 processes ranging from specification of the early embryo to terminal differentiation.

280 ng the responses of pluripotent cells in the early embryo to the signals that regulate germ layer spe

281 LICs in human cell lines and Xenopus laevis early embryos to dissect the LICs' role in cell division

282 antagonizes btl transcription, re-sensitize early embryos to hypoxia, indicating that their relative

283 inearity is observed in the time course from early embryos to late larvae.

284 ssues, from the separation of tissues in the early embryo, to turnover in the homeostasis of the gast

285 published Arabidopsis thaliana endosperm and early embryo transcriptomes generated in these studies.

286 ntal contributions to both the endosperm and early embryo transcriptomes.

287 We describe two alternative early embryo transduction protocols (removal of zona pel

288 tion of a prototypic 4D atlas for vertebrate early embryos, using multicolor fluorescence in situ hyb

289 resent uniformly throughout all cells of the early embryo, vasa protein accumulates selectively in th

290 GTPases in polarization and division of the early embryo, we constructed a fluorescent biosensor to

291 te the processes that generate forces within early embryos, we developed a novel gel-based sensor to

292 solution maps of oxidized cytosine bases for early embryos, we report the existence of 5hmC and 5fC i

293 uring transcript levels in single cells from early embryos, we show that CHD4 influences the frequenc

294 NA, and 86 putative porcine miRNA in MII and early embryos were detected.

295 The process starts in the endoderm of the early embryo where precursors of endocrine cells and ent

296 for heterochromatin assembly, likely in the early embryo, where piRNA pathway components are abundan

297 We find that wound closure is faster in early embryos, where, in addition to a purse string arou

298 high threshold target gene expression in the early embryo, while expression of a Mad linker mutant in

299 confocal microscopy and explants cultures of early embryos with ERK-specific inhibitors suggest an im

300 ults in the dissolution of P granules in the early embryo, with an apparent submicromolar phase bound