ライフサイエンスコーパス: early endosome

1 found that both of them are localized in the early endosome.

2 ulting in an accumulation of the TfR1 in the early endosome.

3 the plasma membrane or lysosome, but not the early endosome.

4 ment of actin in regulating processes at the early endosome.

5 thin the cell, for example the ER, golgi and early endosome.

6 nding of PE molecules in the membrane of the early endosome.

7 ggesting an important role for TSPAN9 in the early endosome.

8 docytosis and low-pH-triggered fusion in the early endosome.

9 d to only partially inhibit ASLV fusion with early endosomes.

10 s, and LPS is released into the cytosol from early endosomes.

11 cking to Rab7-labeled late endosomes but not early endosomes.

12 lays long lifetimes, all features typical of early endosomes.

13 b5-GTP, and its recruitment to Rab5-positive early endosomes.

14 tine, unlike retromer components that act on early endosomes.

15 the cytoplasmic domain of beta1 integrin in early endosomes.

16 -operate to support bi-directional motion of early endosomes.

17 traffic of HAS3 from the plasma membrane to early endosomes.

18 ng Hook protein as general motor adapters on early endosomes.

19 periphery and reduced virion localization to early endosomes.

20 zed with both NOD1 and RIP2 in EEA1-positive early endosomes.

21 of the synaptobrevin-like v-SNARE Snc1 from early endosomes.

22 s essential for in vitro homotypic fusion of early endosomes.

23 sosomes because of a failure to recycle from early endosomes.

24 microtubule-based long-distance motility of early endosomes.

25 t the MHC-II-Ii complex away from March-I(+) early endosomes.

26 AP3 localized to the trans-Golgi network and early endosomes.

27 te receptor to become trapped in clusters of early endosomes.

28 sorted into recycling tubules emerging from early endosomes.

29 the apical cell surface and moves rapidly to early endosomes.

30 ggesting that cathepsin L cleavage occurs in early endosomes.

31 crotubules, but were generally distinct from early endosomes.

32 isms deliver cargo into different subsets of early endosomes.

33 ated structures and the no-insert isoform on early endosomes.

34 fficient recycling of Rab7 from lysosomes to early endosomes.

35 ellular trafficking of both mitochondria and early endosomes.

36 and appeared conjointly with alpha-toxin in early endosomes.

37 ondrial quality control mediated by Rab5 and early endosomes.

38 leading to its accumulation in EEA1-positive early endosomes.

39 upports the formation of F-actin networks on early endosomes.

40 egulating the formation of branched actin on early endosomes.

41 ork, whereas others suggested an origin from early endosomes.

42 PN-1 greatly reduced Lifeact accumulation on early endosomes.

43 cropinosomes often interacting with EEA-1(+) early endosomes.

44 tive trafficking between plasma membrane and early endosomes.

45 ion of DISLL enhances the exit of BACE1 from early endosomes, a pathway mediated by GGA1 and retromer

46 d that retrograde cargo TGN-38 is trapped in early endosomes after depletion of SNX-3 (a retromer com

47 APPL1, but not early endosome Ag 1, deficiency impairs IRF3 target gene

48 lmitoylated peptide also passed rapidly from early endosome Ag-1-positive endosomes to RAS-related GT

49 cipates in the trafficking and tubulation of early endosomes along microtubules.

50 here that peroxisomes move by hitchhiking on early endosomes, an organelle that directly recruits the

51 both an increased stability at the pH of the early endosome and efficient degradation at lower pH in

52 enin also prolonged TNF association with the early endosome and enhanced caspase-8 activation in apop

53 w glucose variation-induced stress regulated early endosome and lysosome formation via endocytosis of

54 s accumulate abnormal endosomes positive for early endosome and recycling endosome markers that are n

55 ized in the Golgi stack, trans-Golgi network/early endosome and tonoplast.

56 mannose-phosphate receptor-positive tubular early endosomes and a reduction in Notch signaling capac

57 iptional regulator RNF11, which localizes to early endosomes and appears additionally in the cell nuc

58 USP2a localizes to early endosomes and associates with EGFR, stabilizing th

59 ermal growth factor receptor (EGFR) from the early endosomes and degradation of EGFR after EGF stimul

60 ARRDC3 primarily localizes to EEA1-positive early endosomes and directly interacts with the beta2AR

61 fter activation, receptors are trafficked to early endosomes and either recycled or sorted to lysosom

62 by finding that F13 was largely confined to early endosomes and failed to colocalize with B5 in the

63 by tubular-vesicular carriers that bud from early endosomes and fuse with a corresponding acceptor c

64 transport in which peroxisomes hitchhike on early endosomes and identify PxdA as the novel linker pr

65 rs from the TGN, perinuclear accumulation of early endosomes and impaired transferrin endocytosis.

66 overexpression reduced NTR1 localization in early endosomes and increased expression of proteins rel

67 tination, promoted BACE1 accumulation in the early endosomes and late endosomes/lysosomes, and decrea

68 endocytic trafficking, causing clustering of early endosomes and leading to the accumulation of endoc

69 ation-induced stress-stimulated formation of early endosomes and lysosomes.

70 e proteins, IFITMs), on the pH regulation in early endosomes and on the efficiency of acid-dependent

71 PACS-2 co-localizes with ADAM17 on early endosomes and PACS-2 knockdown decreases the recyc

72 osphate (PIP3) on B cell receptor-containing early endosomes and proper sorting into the MHC class II

73 mine/siRNA polyplexes initially appearing in early endosomes and rapidly moving to other compartments

74 multivesicular body pathway, retained APP in early endosomes and reduced Abeta(40) production.

75 RNAs are internalized by a specific class of early endosomes and show preferential association with e

76 2A, whereupon it quickly translocates to the early endosomes and subsequently routes to the lysosomes

77 PTH) stimulation, the PTHR internalizes into early endosomes and subsequently traffics to the retrome

78 hat KIF13A and KIF13B bind preferentially to early endosomes and that KIF1A and KIF1Bbeta bind prefer

79 We localized AFTPH to early endosomes and the trans-Golgi network (TGN) in uns

80 now show that HCMV is initially retained in early endosomes and then moves sequentially to the trans

81 d activation of Rab5 to cause enlargement of early endosomes and to disrupt retrograde axonal traffic

82 ), suggesting brief receptor localization in early endosomes and transfer to late endosomes.

83 pathway used, all these viruses converge in early endosomes and use multivesicular bodies for cell e

84 resent in all endocytic compartments between early endosomes and vacuoles, shares features of Vam3p a

85 ation by two Sec1/Munc-18 proteins, Vps45 in early endosomes and Vps33 in early and late endosomes/va

86 ssemblies of clathrin and caveolin, Rab5a in early endosomes, and alpha-actinin, often in relationshi

87 due to delayed transit time of EGFR through early endosomes, and cells preferentially proliferate.

88 Both FhipA and FtsA associate with early endosomes, and interestingly, while FtsA-early end

89 the Golgi/trans-Golgi network (TGN), in the early endosomes, and on the plasma membrane, yet the cel

90 rins, attenuates integrin translocation into early endosomes, and reduces delayed mitogen-activated p

91 ed NTR1 traffics from the plasma membrane to early endosomes, and then recycles.

92 At CCVs, CvpB binding to early endosome- and autophagy-derived PI(3)P and the con

93 t complex after stimulation with EGF, as was early endosome antigen 1 (EEA1), a factor responsible fo

94 n HSP, Mecp2 KO neurons have lower levels of early endosome antigen 1 (EEA1), a protein involved in A

95 ed colocalization of G. bethesdensis with an early endosome antigen 1 (EEA1)-positive compartment, fo

96 A with VEGFR-2 is localized within the EEA1 (early endosome antigen 1) endosomal compartment.

97 27a), and, to some extent, early endosomes (early endosome antigen 1), indicating a lack of integrit

98 or in early endosomes associated with EEA-1 (early endosome antigen 1).

99 th transferrin and EGF receptors (EGFRs) and early endosome antigen 1, but not with LAMP1 protein.

100 es transient oxidation on or close to RAB5+/ early endosome antigen 1- endosomes.

101 ero-oligomers including Bax, Troponin C, and Early Endosome Antigen 1.

102 ed, the transit time of EGF receptor through early endosomes are accelerated, mitogenic MAPK-ERK1/2 s

103 We exploit the ease with which highly motile early endosomes are distinguished from static late endos

104 Early endosomes are essential for regulating cell signal

105 Early endosomes are transported bidirectionally by cytop

106 ed to nascent dense granules from contiguous early endosomes as MKs mature or functions in dense gran

107 fficking of plasma membrane receptors to the early endosomes as well as inhibit phagocytosis of the b

108 subcellular localization of the receptor in early endosomes associated with EEA-1 (early endosome an

109 imultaneous time-lapse imaging, we find that early endosome-associated PxdA localizes to the leading

110 A (A. nidulans FTS homologue) disrupts HookA-early endosome association and inhibits early endosome m

111 association requires FhipA and HookA, FhipA-early endosome association is independent of HookA and F

112 ith early endosomes, thus differing from the early endosome association of the cargo adapter HookA (H

113 rly endosomes, and interestingly, while FtsA-early endosome association requires FhipA and HookA, Fhi

114 in endothelial cells, possibly by fusing in early endosomes at higher pH or by other, unknown mechan

115 s of vezA causes an abnormal accumulation of early endosomes at the hyphal tip, where microtubule plu

116 early endosome clustering, and Rab5-positive early endosomes become smaller and scattered.

117 interaction between dynein-dynactin and the early-endosome-bound HookA is significantly decreased.

118 P21 dynamically localizes with EEA1-positive early endosomes but is also found in EEA1-negative endos

119 with the model that VSV initiates fusion in early endosomes but releases its core into the cytosol a

120 ansports various cellular cargoes, including early endosomes, but how dynein binds to its cargo remai

121 which plays an important regulatory role in early endosomes, but not on Rab7, which is associated wi

122 osome-related organelles obtain cargoes from early endosomes, but the fusion machinery involved and i

123 loss of VezA, HookA associates normally with early endosomes, but the interaction between dynein-dyna

124 EGFR-AMSH was efficiently internalized into early endosomes, but, importantly, the rates of ligand-i

125 t a model proposing that traffic jams in the early endosome can act as an upstream pathogenic hub in

126 some maturation appears to control a pool of early endosomes capable of fusing with autophagosomes wh

127 nein is able to physically interact with the early endosome cargo, but dynein-mediated early endosome

128 Strip knockdown disturbs the early endosome clustering, and Rab5-positive early endos

129 atients also accumulated large RAB5-positive early endosomes compared to controls.

130 Our data suggest that TSPAN9 modulates the early endosome compartment to make it more permissive fo

131 ed in the accumulation of EEA1/Rab5-positive early endosomes concomitant with a decrease in Rab7-posi

132 X, an increased amount of ZAP70 localized to early endosomes consistent with the role of monoubiquiti

133 TSPAN9 was localized to early endosomes containing internalized alphavirus, and

134 cells resulted in prolonged EGFR activity in early endosomes, delayed EGFR degradation, increased EGF

135 hemocytes and nephrocytes, and localizes to early endosomes despite the lack of a clear Vps3 homolog

136 pergillus nidulans, as a factor critical for early endosome distribution.

137 genome-wide screen for mutants defective in early-endosome distribution.

138 d binding protein 27a), and, to some extent, early endosomes (early endosome antigen 1), indicating a

139 ssociated with the trans-Golgi network (TGN)/early endosome (EE) and tracked along filamentous actin,

140 s required for maturation of TLR3 containing early endosome (EE) into LE, the compartment that fuses

141 ssential for kinesin-3- and dynein-dependent early endosome (EE) motility in the fungus Ustilago mayd

142 rt between the trans-Golgi network (TGN) and early endosome (EE) requires Drs2, a phospholipid transl

143 TGN) to the cell surface and to and from the early endosomes (EE) requires active protein sorting dec

144 We show that shortly after uptake into early endosomes (EE), CpG and siRNA parts of the conjuga

145 Unlike B2AR, which traffics to early endosomes (EE), LHR internalizes to distinct pre-e

146 rn to the plasma membrane (PM) directly from early endosomes (EE; fast recycling) or they can traffic

147 n caused significant accumulation of ASOs in early endosomes (EEs) and reduced localization in LEs an

148 , and the endoplasmic reticulum (ER) rely on early endosomes (EEs) for intracellular movement in a fu

149 ow that long-distance retrograde motility of early endosomes (EEs) is necessary to trigger transcript

150 Early endosomes (EEs) mediate protein sorting, and their

151 PS-ASOs exited early endosomes (EEs) rapidly after internalization and

152 enetic ablation of the Hook complex adapting early endosomes (EEs) to dynein but absolutely requires

153 tein implicated in translocation of Hsc70 to early endosomes for clathrin removal during retrograde t

154 f CD74 is to translocate HLA-DR molecules to early endosomes for reloading with peptides prior to rec

155 Hook homologues were found to link dynein to early endosomes for their transport.

156 n of the protein from the plasma membrane to early endosomes, for tubule formation, and for CaMV infe

157 ither for membrane scission (shibire) or for early endosome formation (Rab5, Vps45, and Rabenosyn-5).

158 lasma membrane to the lysosomal membrane via early endosome formation.

159 ly binds to and activates Rabex-5, promoting early-endosome formation.

160 l imaging suggests that MoVps17 can regulate early endosome fusion and budding as well as endocytosis

161 Phagosome-early endosome fusion required PI(3)P, yet did not depen

162 lized endosomal compartments, beginning with early endosomes harboring Rab5 and its effector EEA1.

163 Different subpopulations of early endosomes have been described, raising the questio

164 brane, although the TGN also functions as an early endosome in plants.

165 t from the Golgi and the trans-Golgi network/early endosome in the seed coat epidermis.

166 elevation of external pH can raise the pH in early endosomes in a cell type-dependent manner and ther

167 nd dissociation of signalling molecules from early endosomes in a dense cytoplasm with single-molecul

168 of poly(I:C) to effect signaling by TLR3 in early endosomes in a mechanism that involves FPRL1.

169 have demonstrated that RME-8 associates with early endosomes in a phosphatidylinositol 3-phosphate (P

170 t SNX27 binds several beta integrin tails in early endosomes in a PI3 (phosphatidylinositide 3)-kinas

171 n organelle distribution: Golgi outposts and early endosomes in distal dendritic branches are reduced

172 8aa transmembrane smORF peptide localised to early endosomes in Drosophila macrophages.

173 ndosomal trafficking through somatodendritic early endosomes in L1-mediated axon growth.

174 uggesting that dense granules originate from early endosomes in MKs.

175 nteraction between dynein and the Hook-bound early endosomes in vivo.

176 le in cargo sorting and vesicle budding from early endosomes, in most cases leading to cargo fusion w

177 y showed a dissociation of payloads from the early endosome indicating translocation of the chimeric

178 e interaction occurs independently of dynein-early endosome interaction and requires the C-terminal d

179 h dynein and dynactin independently of HookA-early endosome interaction but dependent on the N-termin

180 HookA is a novel linker important for dynein-early endosome interaction in vivo.

181 HookA-early endosome interaction occurs independently of dynei

182 d loss of HookA significantly weakens dynein-early endosome interaction, causing a virtually complete

183 mechanism that initiates PAR1 sorting at the early endosome is not known.

184 bility of RME-8 to associate with PI(3)P and early endosomes is largely abolished when residues Lys(1

185 ors of beta1/beta2-integrin recycling in the early endosome, is decreased in Klf5(Delta/Delta) haemat

186 t pHs characteristic of the plasma membrane, early endosome, late endosome, and lysosome.

187 CLN3-positive early endosomes, late endosomes and cholesterol/sphingol

188 nto phagolysosomes by sequential fusion with early endosomes, late endosomes, and lysosomes.

189 ires sequential fusion of the phagosome with early endosomes, late endosomes, and lysosomes.

190 argos, including mitochondria, Rab5-positive early endosomes, late endosomes/lysosomes, and TrkA-, Tr

191 r bacterium Ehrlichia chaffeensis resides in early endosome-like vacuoles and circumvents lysosomal f

192 in PxdA that is necessary and sufficient for early endosome localization and peroxisome distribution

193 cted contribution of the trans-Golgi network/early endosome-localized V-ATPase to vacuolar pH.

194 an cells without affecting other organelles (early endosomes, lysosomes, the Golgi apparatus, the end

195 we observed that C5b-9 colocalizes with the early endosome marker EEA1 and that, in the presence of

196 ized GPRC6A was mainly co-localized with the early endosome marker Rab5 and the long loop recycling e

197 We identify a specific stage of early endosome maturation that is regulated by beclin 1,

198 As early endosomes mature, the SAND-1/CCZ-1 complex acts as

199 under mildly acidic conditions mimicking the early endosome, mature virions release pentons and perip

200 plasma membrane as expected, but also in the early endosome membrane, and that internalized receptors

201 s and colocalizes with the Golgi membrane or early endosome membrane.

202 on of TSPAN9 inhibited virus fusion with the early endosome membrane.

203 AVE/SCAR and Arp2/3 regulate endocytosis and early endosome morphology in diverse tissues of C. elega

204 ements require ATP and involve bidirectional early endosome motility, indicating that microtubule-ass

205 he early endosome cargo, but dynein-mediated early endosome movement away from the hyphal tip occurs

206 kA, as a factor required for dynein-mediated early endosome movement in the filamentous fungus Asperg

207 equency but not the speed of dynein-mediated early endosome movement.

208 pA complex are important for dynein-mediated early endosome movement.

209 ion, causing a virtually complete absence of early endosome movement.

210 ookA-early endosome association and inhibits early endosome movement.

211 s in dynein-mediated nuclear positioning and early endosome movement.

212 inding of SNX31 with beta1 integrin tails in early endosomes occurs between the FERM domain and the m

213 f function, thus affecting actin dynamics in early endosomes of BLOC-1-deficient cells.

214 pletion did not alter the delivery of SFV to early endosomes or change their pH or protease activity.

215 occur minimally in EEA-1-positive (EEA-1(+)) early endosomes or LAMP-1(+) late endosomes/lysosomes.

216 long-range movement of peroxisomes, but not early endosomes or nuclei.

217 , Strip acts as a molecular platform for the early endosome organization that has important roles in

218 tely 5,000-fold, whereas transferrin uptake, early endosome organization, and dynein-dependent moveme

219 the phosphatidylinositol-3-phosphate pool in early endosomes; phosphatidylinositol-3,4-biphosphate an

220 a dense granule defect in mice, to show that early endosomes play a direct role in dense granule biog

221 somes (EE), LHR internalizes to distinct pre-early endosomes (pre-EEs) for its recycling.

222 ediated fusion between Golgi-derived SGs and early endosomes precedes the maturation of the SGs, as r

223 internalizing surface pMHC-II in March-I(+) early endosomes promotes degradation of "old" pMHC-II an

224 (a) detection of the enzyme in EEA1-positive early endosomes, Rab7-positive late endosomes/multivesic

225 ure has ever been identified at the level of early endosomes, raising a question about their role.

226 The bidirectional movement of early endosomes randomly distributes polysomes, which ma

227 ex and uncovered a new function for Vps13 in early endosome recycling and Neo1 localization.

228 We further show that the early-endosome recycling route and its control though th

229 In MDCK 3D cultures, CLIC4 is expressed on early endosome, recycling endosome and apical transport

230 that once internalized, M1 mAChRs traffic to early endosomes, recycling endosomes and late endosomes.

231 1 was recruited to the cell surface from the early endosome-recycling complex pathway, its knockdown

232 - and branched actin-mediated trafficking on early endosome regulates apical delivery during early lu

233 and alters the subcellular enrichment of the early endosome regulator RAB-5.

234 lised into early endosomes, where the master early endosome regulator Rab5b promotes STAT5 phosphoryl

235 , IFITM2 and IFITM3 localize to the late and early endosomes, respectively, as well as the lysosome.

236 Membrane microcompartments of the early endosomes serve as a sorting and signaling platfor

237 ed infection by several viruses that fuse in early endosomes (SFV, SINV, CHIKV, and vesicular stomati

238 cargo from the plasma membrane into specific early endosome subpopulations is required for its approp

239 n and caused prolonged TLR4 retention at the early endosome, suggesting that TLR4 transport from earl

240 ns in dense granule biogenesis directly from early endosomes, suggesting that dense granules originat

241 Apm2 and Apm1 colocalize at Golgi/early endosomes, suggesting that they do not associate w

242 suggested that TRAM and TLR2 co-localize in early endosomes, supporting the hypothesis that signalin

243 NG gene, which encodes a trans-Golgi network/early endosome (TGN/EE)-localized E3 ubiquitin ligase.

244 ole required neither the trans-Golgi network/early endosome (TGN/EE)-localized vacuolar H(+)-ATPase a

245 r its recognition at the trans-Golgi network/early endosomes (TGN/EE) for vacuolar targeting.

246 In plants, the trans-Golgi network and early endosomes (TGN/EE) function as the central junctio

247 Thus FhipA is more directly linked to early endosomes than HookA and FtsA.

248 owth factor receptor (EGFR) occurs from APPL early endosomes that mature into early EEA1 endosomes.

249 Within the small group of early endosomes that move away from the hyphal tip in th

250 the retromer complex, a sorting platform on early endosomes that promotes recycling of surface recep

251 ow demonstrate that polysomes associate with early endosomes that undergo kinesin 3- and dynein-depen

252 a) antibody to be localized to Rab5-positive early endosomes, the trans-Golgi network, and subsequent

253 ch shortens the transit time of EGFR through early endosomes, thereby limiting mitogenic MAPK signals

254 ings demonstrate that NOD1 detects PG within early endosomes, thereby promoting RIP2-dependent autoph

255 venger receptors and subsequently escape the early endosome through a pH-triggered disassembly mechan

256 In contrast, if antigens were delivered to early endosomes through CD40 or CD11c, BDCA1(+) DCs were

257 manner but are not obviously associated with early endosomes, thus differing from the early endosome

258 trafficking vesicles that dock and fuse with early endosomes, thus overriding the default pathway to

259 OC-1 to -3, mediate protein sorting from the early endosome to lysosomes and lysosome-related organel

260 he exocytosis (not endocytosis) of NHE3 from early endosome to plasma membrane.

261 in-3 complex, which transports TLRs from the early endosome to the late endolysosomal compartments.

262 fficking apparatus that sorts cargo from the early endosome to the trans-Golgi network.

263 mal acid hydrolases requires traffic through early endosomes to late endosomes followed by transient

264 lts is that ArfGAP3 regulates transport from early endosomes to late endosomes.

265 own about the regulators of Ag delivery from early endosomes to lysosomal compartments where the prop

266 Rab14 and PI(3)P to direct the maturation of early endosomes to Rab9/CD63-containing late endosomes.

267 th the AP-3 clathrin adaptor complex, act at early endosomes to sort components required for melanin

268 h enhanced recycling of VE-cadherin-positive early endosomes to the IEJ.

269 all Rab GTPase mediating fast recycling from early endosomes to the plasma membrane, and enhanced the

270 arly retromer-mediated retrieval of APP from early endosomes to the TGN, resulted in the accumulation

271 ided evidence that retrograde transport from early endosomes to the trans-Golgi network is required f

272 cifically blocking retrograde transport from early endosomes to the trans-Golgi network.

273 x2 and found that depletion of UNC50 blocked early endosome-to-Golgi trafficking and induced lysosoma

274 To identify host factors required for early endosome-to-Golgi trafficking of STx2, we performe

275 Early endosome-to-Golgi transport allows the toxins to e

276 A new study investigates why directed early endosome trafficking is so frequently interrupted,

277 onstrated that the IRT1 protein localizes to early endosomes/trans-Golgi network (EE/TGN) and is cons

278 Here we develop a mathematical model of early endosome transport in Ustilago maydis.

279 When early endosome transport is abolished, POs and LDs drift

280 enhanced localization of HIV-1 with TLR8(+) early endosomes, triggered a pro-inflammatory response,

281 CvpB association to early endosome triggers vacuolation and clustering, lead

282 Early endosomes undergo retrograde transport (clustering

283 We show that DTX3L localizes to early endosomes upon CXCR4 activation and interacts dire

284 ed with TLR4, CD14, and dynamin into Rab5(+) early endosomes upon LPS treatment.

285 tive intracellular staining of lysosomes and early endosomes via subtle changes in fluorescence emiss

286 n-dependent sequestration into Rab5-positive early endosomes via the ESCRT machinery.

287 RIN3 recruited CD2AP to RAB5a-positive early endosomes via these interaction sites.

288 irmed that while VP2 is shed from virions in early endosomes, virus particles still consisting of VP5

289 The rapid transit of BACE1 S498D from early endosomes was coupled with reduced levels of amylo

290 Albumin accumulation in early endosomes was independent of FcRn-binding affinity

291 SNX17 localizes to early endosomes where it directly binds NPX(Y/F) motifs

292 rimary, resting NK cells on endocytosis into early endosomes where its receptor, CD158d, resides.

293 RTM3 co-localizes with both APP and BACE1 in early endosomes, where BACE1 processing of APP occurs.

294 Prolactin is internalised into early endosomes, where the master early endosome regulat

295 internalize polymersomes by endocytosis into early endosomes, where they are disassembled by the low

296 inated by the E3 ubiquitin ligase March-I in early endosomes, whereas biosynthetically immature MHC-I

297 ose receptor targeted antibody conjugates to early endosomes, whereas DEC205 targeted antigen primari

298 However, 5-NT altered the distribution of early endosomes with a concomitant impairment of reoviru

299 ed in the accumulation of endocytosed APP in early endosomes with reduced APP processing.

300 arance of large TrkA puncta in enlarged Rab5-early endosomes within the cytoplasm, suggesting delayed