ライフサイエンスコーパス: early event

1 is a V600E substitution in BRAF, which is an early event.

2 of basal forebrain cholinergic neurons is an early event.

3 e-1-specific substrate to allow study of the early events.

4 for declining treatment assignment and other early events.

5 -1 mouse cardiomyocytes to investigate these early events.

6 In grafts surviving at least 90 days, early events (acute rejection [AR] and delayed graft fun

7 lthough there is a good understanding of the early events after birth that lead to the rapid increase

8 Hras(G12V) knock-in allele to elucidate the early events after Hras activation, and to evaluate the

9 ction factors in primary cells or during the early events after SIV infection and suggest that the le

10 amyloid-beta peptide (Abeta) in brain is an early event and hallmark of Alzheimer's disease (AD).

11 amyloid-beta (Abeta) peptide in brain is an early event and hallmark pathology of Alzheimer's diseas

12 We hypothesized that MC activation is an early event and now find by histology that exocytosis of

13 Axon degeneration is an early event and pathological in neurodegenerative condit

14 c proinflammatory pattern is associated with early events and active retinochoroidal lesion, whereas

15 Secondary outcomes were early events and major adverse cardiac and cerebrovascul

16 onship between NK and CD4 cells, we analyzed early events and selective depletion of T regulatory cel

17 r alterations in EGFR and CDKN2A/B/p14ARF as early events, and aberrations in PDGFRA and PTEN as late

18 g comparison of risk of DCGF associated with early events (AR, DGF, baseline serum Cr >2.0 mg/dL) to

19 These early events are associated with impairment of parasite

20 These early events are driven by the epithelial MyD88-signalin

21 various models of asymmetry can be unified: early events are needed to initiate LR asymmetry, and la

22 pillary perfusion, which suggests that these early events are not mediated by oxidants.

23 Inactivation of HR appears to be an early event, as 62.5% of tumours showed a LOH pattern su

24 iously responded to immunochemotherapy is an early event associated with a poor outcome that may dese

25 r, our results provide new insights into the early events associated with acute SIV pathogenesis and

26 To investigate early events associated with antigen exposure, we first

27 ology and glutamatergic synaptic loss may be early events associated with cognitive impairment, we co

28 raction and highlight the modulation of this early event by the DNA sequence.

29 neural stem cell (eNSC) model to understand early events contributing to sexually dimorphic brain de

30 These results suggest that thrombin supports early events coupled to inflammation-mediated tumorigene

31 RUNX1 mutations can be early events, creating preleukemic stem cells that expan

32 oth muscle cell (VSMC) phenotype change were early events, detected by week 4 and before AMC.

33 0 days, neither clinical characteristics nor early events distinguished those who subsequently did or

34 lomerase expression in senescent cells is an early event during cancer progression in humans.

35 e checkpoint that can lead to polyploidy, an early event during cervical carcinogenesis that predispo

36 identified as being B cell-intrinsic and an early event during hematopoiesis.

37 An early event during homology-dependent repair is resectio

38 that myelin phagocytosis by astrocytes is an early event during lesion formation and leads to astrogl

39 in the draining lymph node was an important early event during the antiviral response and that B cel

40 Early events during dengue virus (DENV) infection remain

41 eview, we seek to provide an overview of the early events during Lm infection that dictate or regulat

42 stomata and apoplast are the most important early events during plant-bacteria interactions.

43 Early events during retroviral infection play a critical

44 mass controls are similarly coordinated with early events during the differentiation of pluripotent s

45 histological, and biochemical studies of the early events during the infection of maize (Zea mays) wi

46 lignant lesions suggests that they represent early events during tumor progression and additional alt

47 already in 2005, but an in-depth analysis of early events during virus infection had not been perform

48 To investigate the early events following acquisition of this mutation in m

49 olved in plant embryogenesis, especially the early events following fertilization are largely unknown

50 s of plant biologist for many years, yet the early events following water uptake, during which metabo

51 generative diseases is commonly viewed as an early event in a continuum that ultimately results in ne

52 Furthermore, EndMT is an early event in a JAK2-V617F knock-in mouse model of prim

53 PRs) leads to cytosolic Ca(2+) elevation, an early event in a signaling cascade that activates immune

54 tical importance of Abeta accumulation as an early event in AD pathogenesis, multiple lines of eviden

55 beta (Abeta) protein has been proposed as an early event in AD pathogenesis.

56 tion of intracellular Abeta42 peptides is an early event in AD progression.

57 (VHL) tumor suppressor gene is mutated as an early event in almost all cases of clear cell renal cell

58 osomal-lysosomal membranes may constitute an early event in Alzheimer's disease (AD) pathogenesis.

59 et enriched conformations was proposed as an early event in Alzheimer's Disease (AD).

60 One early event in AMI is the increased cardiac expression o

61 hat altered calcium homeostasis may be a key early event in basal toxicity or narcosis induced by lip

62 Although dissemination is an early event in breast cancer, extended periods of cancer

63 Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of

64 Endothelial dysfunction is an early event in cardiovascular disease and characterized

65 indicating that ALIS formation represents an early event in cellular adjustment to altered proteostas

66 s due to promoter hypermethylation and is an early event in cervical oncogenesis.

67 l effectors of ciliary vesicle formation, an early event in ciliogenesis.

68 ell renewal and aberrant WNT signaling is an early event in colorectal cancer (CRC) development.

69 on of adenomatous polyposis coli (APC) is an early event in colorectal cancer (CRC) progression that

70 increased whole-body protein breakdown is an early event in development of PDAC.

71 Podocyte injury is an early event in diabetic kidney disease and is a hallmark

72 titute the outer layer of capillaries, is an early event in diabetic retinopathy; however, the relati

73 Therefore, endothelial dysfunction is an early event in disease processes including atheroscleros

74 revealing altered RT of the TP63 gene as an early event in disease progression of both HGPS and RTS.

75 glomerular endothelial cells representing an early event in DKD progression, and suggest that cross t

76 In conclusion, MYC rearrangement is an early event in DLBCL.

77 r results indicate that HuR activation is an early event in FAP-adenoma but is not present in IBD-dys

78 ns therefore implicate CREBBP mutation as an early event in FL evolution that contributes to immune e

79 Collapse of unfolded protein chains is an early event in folding.

80 so found that peripheral degeneration was an early event in FUS as well as C9ORF72 repeat expansion m

81 pulation and corresponding FGP formation, an early event in gastric carcinogenesis, as well as antral

82 IDH mutation is an early event in gliomagenesis and has significant implica

83 assembly suggests that core formation is an early event in granule assembly.

84 ggesting that deficient protein import is an early event in HD.

85 (CICR), and its structural disruption is an early event in heart failure.

86 IV and dendritic cells (DCs) is an important early event in HIV-1 pathogenesis that leads to efficien

87 proteins, most notably including AQP2, is an early event in hypokalemia-induced NDI.

88 -dependent helicase unloading as a critical, early event in ICL repair.

89 onfirming that cohesin mutations occur as an early event in leukemogenesis, facilitating the potentia

90 e data suggest that miRNA deregulation is an early event in liver carcinogenesis and the later global

91 Axonal degeneration is a critical, early event in many acute and chronic neurological disor

92 ctivated protein kinase (MAPK) pathway is an early event in many different cancers and a key driver o

93 Cancer cell migration is an early event in metastasis, the main cause of breast canc

94 l distal processes has been identified as an early event in multiple sclerosis (MS) lesion developmen

95 polyploidization and suggest that this is an early event in NAFLD that may contribute to HCC developm

96 ggests that the IER3-dependent pathway is an early event in pancreatic tumorigenesis.

97 trocytic Dlp1 likely represents a relatively early event in PD pathogenesis.

98 We propose that axonal injury may be an early event in presymptomatic Alzheimer's disease, causi

99 other methods, reveal abnormal TP63 RT as an early event in progeroid disease progression, and sugges

100 MP synthase enzyme complex that catalyzes an early event in pyrimidine nucleotide biosynthesis.

101 that PKCalpha translocation may occur as an early event in radiation-induced bystander responses and

102 ribe ligand-mediated receptor assembly as an early event in receptor signaling and its application to

103 Virion uncoating is an essential early event in reovirus infection.

104 An early event in skeletal joint development is the specifi

105 n samples, to identify NOTCH1 mutation as an early event in squamous cell carcinogenesis.

106 Our data suggest that BBB breakdown is an early event in the aging human brain that begins in the

107 utopsy, suggesting that this mutation was an early event in the clonal evolution of resistance.

108 Attention deficit is an early event in the cognitive impairment of patients with

109 A key early event in the DDR is the phosphorylation of histone

110 nent mitochondrial dysfunction as a critical early event in the delayed degeneration of CA1 neurons a

111 led by endothelial junction stability, is an early event in the deterioration of vascular integrity i

112 An early event in the development of an effective T cell re

113 apoptosis induced by oxidative stress is an early event in the development of atherosclerosis.

114 ependent inflammation and fibrosis may be an early event in the development of ccRCC.

115 alterations in NF-kappaB signaling may be an early event in the development of cSCC.

116 ated with meniscal degeneration, which is an early event in the development of osteoarthritis and cor

117 of the cartilage proteoglycan aggrecan is an early event in the development of osteoarthritis, and a

118 ts indicate that Braf mutation is a frequent early event in the development of rat gliomas caused by

119 is considered as an important factor and an early event in the etiology of Alzheimer's disease (AD).

120 Atg-16L-positive vesicles represents a very early event in the generation of the phagophore and in t

121 t of recurrent collateral synapses may be an early event in the initiation process of SE and that TRP

122 e viral life cycle affected revealed that an early event in the life cycle is inhibited.

123 titutes both a genetic hallmark and critical early event in the natural history of follicular lymphom

124 logy points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infecti

125 Thus, a potentially early event in the normal human aging process is microsa

126 hypothesize that microglial activation is an early event in the Parkinson's disease (PD) spectrum and

127 Amyloid beta (Abeta) accumulation is an early event in the pathogenesis of Alzheimer's disease (

128 esulting in mitochondrial dysfunction are an early event in the pathogenesis of Alzheimer's disease (

129 e hypothesis that SOX2 deregulation is a key early event in the pathogenesis of bronchial dysplasia;

130 Retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy

131 Retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy

132 le-negative state appears to be an important early event in the pathogenesis of lymphoproliferation i

133 dependent Kupffer cell (KC) activation as an early event in the pathogenesis of PNALI.

134 dothelial cells (MVECs) injury is a critical early event in the pathogenesis of systemic sclerosis (S

135 ant survival mechanism that appears to be an early event in the pathogenesis of the disease.

136 mpairment of mitochondrial respiration is an early event in the pathogenesis, but the exact mechanism

137 g that abnormal mitochondrial dynamics is an early event in the pathogenic process.

138 in the KRAS2 proto-oncogene thought to be an early event in the progression of disease.

139 It appears that miR-21 up-regulation is an early event in the transformation from normal pancreatic

140 r to dissipate mitochondrial potential as an early event in their antimalarial action and therefore m

141 An early event in this process is monocyte recruitment thro

142 nt in retinal vessels near the ON head is an early event in TON and the CXCL10/CXCR3 axis has a criti

143 howed that reduced ESE3/EHF expression is an early event in tumorigenesis, frequently occurring indep

144 f tumor suppressor genes is thought to be an early event in tumorigenesis.

145 is common in cancer and often considered an early event in tumorigenesis.

146 and subsequent NK cell activation may be an early event in viral containment and may support inducti

147 ecretoglobin Scgb3a2 and Notch activation as early events in a program of secretory cell fate determi

148 and mitochondrial dysfunction are also among early events in AD.

149 mpen, whereas circulating monocytes promote, early events in allergic lung inflammation.

150 onsider in this study a rule-based model for early events in BCR signaling that encompasses membrane-

151 To evaluate early events in C4 evolution, we compared leaf anatomy,

152 That prothrombin is linked to early events in CAC was strongly inferred by the observa

153 t imperative to develop new tools to measure early events in cell death.

154 fficiently at centromeres during G1, mediate early events in centromere establishment at an ectopic c

155 cate that the regions of CENP-A required for early events in centromere establishment differ from tho

156 ious regions unique to CENP-A to investigate early events in centromere establishment.

157 oroplasts to supplement PTOX activity during early events in chloroplast biogenesis.

158 e in the neural progenitors is essential for early events in corticogenesis, and help to understand t

159 Spodoptera littoralis, little is known about early events in defense signaling and their link to down

160 s a general and effective route to study the early events in enzyme-substrate reactions.

161 y (CFM) used to supplement information about early events in fibrillogenesis.

162 Although early events in IL-4 signal transduction (i.e., activati

163 n opportunity to study the clinically silent early events in infection.

164 Here we analyzed the early events in influenza B virus infection and interfer

165 outcomes of ATG5 activity, and shed light on early events in innate immunity that are required to reg

166 dies confirm that cell-based QCMs can detect early events in intrinsic apoptosis and reveal unique ki

167 Conversely, adverse early events in life may have consequences later in life

168 way field has been postulated as a model for early events in lung cancer pathogenesis.

169 cular circadian rhythms that are relevant to early events in lung injury.

170 pithelial tissues principally by influencing early events in malignant transformation.

171 We present a model of the early events in mast cell signaling mediated by Fcepsilo

172 subpopulations, few are suited for studying early events in neural crest development.

173 Dok7, LRP4, and Wnt11r are involved in these early events in neuromuscular junction formation.

174 ra as an exceptional model in which to study early events in organellogenesis, and suggests that prot

175 To explain this observation we re-examined early events in pancreas formation.

176 KRAS mutation and alterations in CDKN2A are early events in pancreatic tumorigenesis.

177 ylation, ubiquitination, or internalization, early events in PKCalpha desensitization.

178 tility of hyperpolarized NMR for quantifying early events in polymerization reactions.

179 g the time that would have been required for early events in primordial chemistry before the advent o

180 the environment and may be representative of early events in protein folding and structure stabilizat

181 assay makes it ideally suited for studies of early events in pure lipid bilayer fusion or fusion assi

182 and CRT-1 act in the same pathway to promote early events in regeneration and that CED-3 might act do

183 We discuss how the various early events in SL signalling could result in the observ

184 n signaling pathway, which occur commonly as early events in sporadic CRC.

185 Early events in T cell receptor signaling can distinguis

186 to and exocytosis at the contact region, are early events in TCR-driven, but not chemokine-driven TEM

187 richment in the PrP(C) monomer as one of the early events in the conversion of PrP(C) into PrP(Sc).

188 ation that exerts significant influence over early events in the developing immune response.

189 these mutations may represent characteristic early events in the development of hematologic cancers.

190 amplification of the CXCR4 gene locus may be early events in the development of HGSOC, and associated

191 One of the early events in the development of liver cancer is a neu

192 urrent mutations and genomic instability are early events in the disease.

193 Furthermore, little is understood about the early events in the establishment of chronic infection i

194 To identify the early events in the establishment of totipotency, we mon

195 unfolding rates and specifically modulating early events in the folding process, stabilizing formati

196 heat stress to investigate specifically the early events in the heat stress and recovery response.

197 provide insight into mechanisms controlling early events in the metastatic process and suggest that

198 ing evolution and metastatic spread are very early events in the natural history of urothelial carcin

199 for disease therapy and tool for unraveling early events in the onset of polyQ diseases.

200 Although early events in the pathogenesis of acute lung injury (A

201 n the MCK-betaAPP mice and may represent key early events in the pathogenesis of inclusion body myosi

202 ld of cancerization, providing insights into early events in the pathogenesis of NSCLC that may compr

203 This has been associated with early events in the pathogenesis of several disorders th

204 In this review, we focus on the early events in the process of fibroblast spreading on f

205 The early events in the retrovirus assembly pathway, particu

206 Although our simulations represent the early events in the self-assembly process of chitosan, w

207 n, and provide structural information on the early events in this important secretion process.

208 Thus, early events in thymic T cell development and repertoire

209 To study the kinetics of early events in trypanosome division, we employed an "AE

210 found that tandem duplications appear to be early events in tumor evolution, especially in the genes

211 hat EGFR amplification and rearrangement are early events in tumorigenesis and EGFRvIII follows a mod

212 that contributed to this GnT-V regulation of early events in tumorigenesis, microarray analysis was p

213 If amplification and rearrangement are early events in tumorigenesis, this implies that they sh

214 To further investigate early events in vaccine-induced antibody responses again

215 rom rodent optic nerve and characterised the early events in Wallerian degeneration using an unbiased

216 coating by the long non-coding RNA XACT are early events in XCI erosion and, therefore, may play a r

217 Early events include caspase activation, cleavage of ant

218 Known early events include opening of the blood-brain barrier

219 Early events initiating the pathophysiological outcomes

220 Although some of the early events involved in this pathology have been identi

221 However, the early events involving HIV-1 epitope presentation to CD8

222 In lytic infection, an important early event is the colocalization of ICP0 to nuclear dom

223 We analyzed early events leading to apoptosis of human endothelial c

224 vide evidence that caspase-9 facilitates the early events leading to autophagosome formation; that it

225 sequences play crucial roles in biasing the early events leading to frustration in the folding of Ch

226 Early events leading to intrauterine infection and fetal

227 ipocyte differentiation, less is known about early events leading to lineage commitment and cell fate

228 unctional integrin-beta1 is required for the early events leading to renal cystogenesis in ADPKD and

229 nism of macrophage-dependent coordination of early events leading to stable tolerance.

230 at the IL-2 receptor activation, among other early events, leads to activation of PKCtheta.

231 These early events likely help dictate the outcome of infectio

232 enesis the onset of Nrf2 mutations is a very early event, likely essential for the clonal expansion o

233 ecruitment of mannosidase-II vesicles was an early event mediated by focal exocytosis and coincided w

234 ry receptor, EGFR, in CD34(+) HPCs initiates early events necessary for successful latent infection o

235 tional connectivity (FC) is thought to be an early event occurring in diseases with cerebral amyloido

236 Here, we focused on the early events occurring after the interaction between Wnt

237 y patients with BE and EAC and indicate that early events occurring even in histologically NE cells m

238 These results define early events occurring in an inhalational macaque monkey

239 within 24 h after AS01, suggesting that the early events occurring postinjection were required for t

240 ty of piceatannol was largely limited to the early event of adipogenesis.

241 Here, we report that an immediate-early event of Arg-auxotrophic response involves reactiv

242 ion, which might play important roles in the early event of KS tumor development.

243 rotic and apoptotic cell death, mimicking an early event of liver infection by HBV.

244 twork fragmentation was also confirmed as an early event of replicative aging.

245 o the vascular subendothelium constitutes an early event of the atherogenic process.

246 umour and reveal that clonal expansion is an early event of tumorigenesis.

247 They also suggest that early events of adherens junction assembly involve inter

248 Finally, we examine whether these early events of axon/dendrite formation involve local au

249 lls and the impact of CD23 expression on the early events of B-cell receptor (BCR) activation using C

250 uggests that Rictor positively regulates the early events of BCR signaling.

251 tion, and functional studies, we uncover the early events of C. elegans brain assembly.

252 These are shown to be early events of catch-up growth that are independent of

253 We have analyzed the early events of CD4 T-cell activation by IL-7.

254 The early events of cholesterol crystal development were inv

255 bust and faithful experimental system of the early events of epigenetic reprogramming and regulation

256 ve embryonic stem cells and characterize the early events of epigenetic reprogramming during the form

257 erexpression perturbs both nuclear shape and early events of HIV infection.

258 However, almost no information exists on the early events of human pancreatic specification in the di

259 The early events of IFNgamma-induced tumour ischaemia resemb

260 ing methods, Ritter et al. (2015) define the early events of immunological synapse formation and gran

261 reaction can lead to systemic shock, but the early events of its development in lung tissues have not

262 that P55 plays no important role during the early events of M. bovis infection.

263 infection and offer important insights into early events of M. tuberculosis infection.

264 ellular matrix, has an essential role in the early events of myelination.

265 The molecular interactions governing the early events of osteolytic lesion formation are currentl

266 r, a genetic system that permits tracing the early events of PNEC transformation has not been availab

267 es, and protein contents associated with the early events of postharvest physiological deterioration

268 by demonstrating helix-dipole effects in the early events of self-assembly.

269 Early events of specific immunotherapy (SIT) are inducti

270 in2 (TbCen2) and T. brucei 3 (TbCen3) in the early events of T. brucei procyclic cell cycle.

271 oited by C. neoformans to interfere with the early events of the afferent responses that support Th1

272 results provide better understanding of the early events of the BR signaling pathway.

273 ndancy and efficiently support the postentry early events of the mammalian-retrovirus replication cyc

274 rs a new and unique opportunity to study the early events of tumor invasion, metastasis and drug resp

275 thin host cells; however, the role of ROS in early events of viral entry and the induction of signali

276 between recruited APC and TC may occur as an early event promoting allergic airway inflammation.

277 Pollen-pistil interactions are critical early events regulating pollination and fertilization an

278 , the molecular mechanisms accompanying this early event remain unclear.

279 at the ensuing signaling regulates important early events required for successful infection of CD34(+

280 ishment/clearance research, and transmission/early-event studies.

281 ge incipient atherosclerosis is based on the early events taking place at the endothelial level.

282 understanding of the role of Slug in ADM, an early event that can eventually lead to pancreatic cance

283 molecule expression in large arteries is an early event that coincides with diet-induced obesity and

284 immune response during injury is a critical early event that determines whether the outcome of tissu

285 y, endothelial inflammatory activation is an early event that occurs coincident with the development

286 disease pathophysiology (in particular, the early events that condition its onset), better definitio

287 intaining whole-body energy balance might be early events that contribute to weight gain and obesity

288 patic stellate cells (HSCs) in promoting the early events that could culminate in cancer, as well as

289 Early events that govern granuloma formation were studie

290 differences are fundamental to understanding early events that lead to immune dysregulation and might

291 Delineating the key early events that lead to the development of broadly neu

292 a better systems level understanding of the early events that occur during the development of OA in

293 Mutations in GNAQ and GNA11 are early events that promote cell proliferation, and these

294 gs reveal an essential role for Siah2 in the early events that signal undifferentiated progenitor cel

295 To identify these early events, we have evaluated both phenotypic and gene

296 These early events were followed by a progressive mitochondria

297 sion identified TERT promoter mutation as an early event, whereas FGF3, FGF4, FGF19 or CCND1 amplific

298 BCL2 translocations and CREBBP mutations are early events, whereas MLL2 and TNFRSF14 mutations probab

299 To identify early events which might later determine why EBV infecte

300 The characterization of these early events, which are similar to those encountered in