ライフサイエンスコーパス: early gene

1 ession of ICP27, a multifunctional immediate-early gene.

2 with the in vivo expression pattern for each early gene.

3 and, in most cases, expression of immediate early genes.

4 IE expression but not the transactivation of early genes.

5 s examined and differed from other immediate early genes.

6 hin the virion, another being the product of early genes.

7 quantifying mRNA levels for other immediate early genes.

8 cRE multiplicity is a general feature of the early genes.

9 t mechanism governs the hormonal response of early genes.

10 ls expressing immediate-early genes (IE) and early genes.

11 lso essential for the transcription of HAdv5 early genes.

12 units on transcriptional activation of HAdv5 early genes.

13 exclusively) the Shine-Dalgarno sequences of early genes.

14 The first wave includes conserved immediate early genes.

15 pression of VSV protein and MHV-68 immediate-early genes.

16 nes and the ubiquitously expressed immediate-early genes.

17 lue required for inhibition of expression of early genes.

18 ranscription of plasticity-related immediate early genes.

19 ion by targeting the expression of immediate-early genes.

20 ctivation of a subset of viral genes, termed early genes.

21 eactivation requires expression of immediate early genes.

22 eviously demonstrated that TGFbeta Inducible Early Gene-1 (TIEG1), also known as KLF10, plays importa

23 2 (transforming growth factor-beta-inducible early gene 2) and MODY VII (maturity onset diabetes of t

24 as transforming growth factor-beta-inducible early gene 2) between the brains of 18 human subjects wi

25 gulates cellular proliferation and immediate early gene activation, CaMKII-mediated signaling to H3 i

26 und dosage-dependent activation of immediate early genes after 1 h.

27 Immediate early gene analysis and single unit recordings from VMHv

28 d the promoters for 10 Chlamydia trachomatis early genes and found that they could be separated into

29 esponded to fight outcome included immediate early genes and genes involved in neuroplasticity and ep

30 , activated ERK1/2 is recruited to immediate early genes and phosphorylates INTS11, the catalytic sub

31 Insulin-stimulated expression of immediate early genes and proliferation were also potently reduced

32 gh cell adhesion also can regulate immediate early genes and proliferation, the mechanism for this ef

33 functionally deleted for all five immediate-early genes and the 15-kb internal repeat region.

34 ndent recruitment of Integrator at immediate early genes and their enhancers.

35 idespread changes in expression of immediate early genes and their targets, supporting the likely inv

36 r to the stimuli, predominantly at immediate-early genes, and identified specific TF ensembles that c

37 viral entry, normal expression of immediate early genes, and viral DNA replication.

38 relation between expression of the immediate-early gene Arc (activity-regulated, cytoskeleton-associa

39 The immediate early gene Arc (also Arg3.1) produces rapid changes in s

40 Experience-induced expression of immediate-early gene Arc (also known as Arg3.1) is known to be imp

41 GCs), many of which upregulate the immediate-early gene Arc after male-male social experience.

42 Here, we report that the immediate early gene Arc is required for activity-dependent genera

43 how that the plasticity-associated immediate-early gene Arc is selectively expressed in IGCs from res

44 Visualization using the immediate early gene Arc revealed sparser and more robust odor rep

45 detection of the expression of the immediate-early gene Arc, used as a marker of neuronal activation.

46 expressing the plasticity-related immediate early gene Arc.

47 and IC based on activation of the immediate early gene Arc; however, we found that infusion of the N

48 endent manner from the loci of the immediate early genes Arc and Fos.

49 nes included altered levels of the immediate early genes arc, fosB, and nr4a3, as well as genes invol

50 nt increases in mRNA expression of immediate early genes (Arc, Egr1), Bdnf and its receptor (Trkb), g

51 that induces transcription of the immediate early genes, Arc and c-Fos.

52 The early genes are a key group of ecdysone targets that fun

53 At the molecular level, immediate early genes are among the synaptic plasticity genes that

54 pregulate midcycle genes, but the effects on early genes are not known.

55 Vaccinia virus early genes are transcribed immediately upon infection.

56 5-HT2c receptor (5-HT2cR), and an immediate early gene associated with neuronal plasticity, zif268,

57 iated mRNAs were detected for most annotated early genes at 2 h and for most intermediate and late ge

58 A sequences were detected for most annotated early genes at 2 h and for most intermediate and late ge

59 e PCR and NGS revealed the activation of key early genes at 6 h and transition to late gene activatio

60 e found that EUO, which is expressed from an early gene, binds to two sites upstream of the late oper

61 coordinate the all-or-nothing expression of early genes, but also over a longer time course integrat

62 OCV RNAs mapped to homologs of orthopoxvirus early genes, but few did so to homologs of intermediate

63 transcription factors, which are products of early genes, but not for late transcription factors.

64 stic insights on the regulation of immediate early genes by anesthesia and hypothermia.

65 did not bind to either of the EBV immediate early genes BZLF1 and BRLF1.

66 ctivating expression of both EBV immediately early genes, BZLF1 and BRLF1.

67 with vehicle-pretreated rats, the immediate early gene c-Fos (a marker of neuronal activation) was u

68 was measured by expression of the immediate early gene c-Fos [c-Fos-like immunoreactivity (Fos-LI)].

69 t 1 assessed the expression of the immediate-early gene c-fos in rats that discriminated novel from f

70 and NTS also showed expression of immediate early gene c-FOS in the hindbrain in AMN+LEP-treated rat

71 e first compared expression of the immediate-early gene c-Fos in the medial (VP-m) and lateral (VP-l)

72 nal activation of mPeriod1 and the immediate early gene c-Fos in the SCN in response to a phase-delay

73 ht, and enhances expression of the immediate early gene c-fos in the SCN, which is involved in photic

74 otein was under the control of the immediate early gene c-fos promoter as well as time-lapse two-phot

75 euronal activity mapping using the immediate early gene c-fos reveals the engagement of distinct brai

76 s indicated that expression of the immediate-early gene c-fos was aberrantly elevated in the Bdnf(+/-

77 d expression of the product of the immediate-early gene c-Fos were assessed by immunohistochemistry f

78 is of neuronal activity, using the immediate early gene c-fos, demonstrated a reduced neuronal activi

79 s was detected by staining for the immediate-early gene c-fos, thus supporting earlier findings that

80 ion of the protein products of the immediate early genes c-fos and arc in new and mature granule neur

81 term changes in activity-dependent immediate early genes c-Fos and Arc/Arg3.1 in auditory and neighbo

82 f the learning- and memory-related immediate early genes c-Fos and Egr-1 were normalized or upregulat

83 produced widespread reductions in immediate-early gene (c-fos) expression in a network of memory-rel

84 al magnetic resonance imaging, and immediate early gene (c-fos) expression to assess the hypoxic vent

85 with extracellular recordings and immediate-early gene (c-Fos) expression.

86 nditioning drove expression of the immediate early genes cFos and Nr4a2 in the hippocampus, which coi

87 , encoded by genes present at the end of the early gene cluster in their respective phage genomes and

88 ZIC2 localized at immediate early and early gene cluster regions of the KSHV genome and contri

89 motif discovery tool (FIRE), we identify two early gene clusters whose promoters show significant enr

90 markers, retrograde tracings, and immediate early gene colocalizations.

91 c signaling induces Arc/Arg3.1, an immediate early gene crucial for synaptic plasticity.

92 tumor suppressor, is induced as an immediate-early gene during hepatic stellate cell (HSC) activation

93 d in decreased expression of viral immediate early genes during infection.

94 Chromatin remodeling of early genes during the inflammatory response in vivo is

95 cial aptazymes into the adenoviral immediate early gene E1A enables small-molecule-triggered, dose-de

96 The adenovirus immediate early gene E1A initiates the program of viral gene trans

97 previously found that one of the Drosophila early genes, E75, harbors multiple functional ecdysone r

98 The immediate-early gene early growth response 3 (Egr3) is associated

99 associated with nuclear translocation of the early gene Egr-1 In conclusion, specific and strictly or

100 We report activation of the immediate-early gene Egr-1 in the lateral amygdala (LA), hippocamp

101 P) kinase signaling but not on the immediate early gene EGR-1.

102 fied as a downstream target of the immediate early gene Egr1.

103 Sap-1 decreased expression of the immediate early genes egr1 and fos and subsequent proliferation no

104 activity reduced the expression of immediate-early gene-encoded protein Arc/Arg3.1, effectors that ar

105 One of these immediate early genes encodes naked cuticle homolog 1 (NKD1), whic

106 ~85% of these neurons express the immediate early genes Erg-1 and c-Fos, indicating that they are fu

107 In the presence of ecdysone, early genes exhibit a highly characteristic rapid and po

108 f Bpifa2 in mice lacking Nur77, an immediate early gene expressed in the kidneys during AKI.

109 For 293T cells, it is known that MVA early gene expression activates extracellular signal-reg

110 e mutant gene is required for LVH or whether early gene expression acts as an immutable inductive tri

111 ination of pups' neural activity using c-Fos early gene expression and (14)C 2-deoxyglucose autoradio

112 howed a lack of activity-triggered immediate early gene expression and altered sensory-related behavi

113 Without A8 or A23, viral early gene expression and DNA replication occurred but i

114 , but it is subsequently deficient for viral early gene expression and DNA replication.

115 in the noncoding control region that control early gene expression and miRNA expression before genome

116 ed using brain mapping analyses of immediate-early gene expression and produced a robust silencing of

117 bronectin suppressed serum-induced immediate early gene expression and S phase entry.

118 OSMI-1, affects initiation of HSV immediate-early gene expression and viral replication.

119 HCMV pUL97 kinase regulates viral immediate early gene expression by phosphorylation-mediated disrup

120 IFN-gamma was important for the early gene expression changes in the islets.

121 Early gene expression changes were determined by low-den

122 ing-induced transient waves of Arc immediate early gene expression critical for synaptic plasticity.

123 hyroid hypoplasia in these mutants is due to early gene expression defects in the third pouch, wherea

124 tentials and for establishment of endogenous early gene expression domains in the anterior ectoderm,

125 E1a is important for activating early gene expression from the other viral early transcr

126 impaired behavioral stimulation of immediate-early gene expression in the mPFC, suggesting that chron

127 nalysis and in situ hybridization assays for early gene expression in the mutant revealed that severa

128 r ORF30 is required for immediately early or early gene expression or viral DNA replication, but each

129 Immediate early gene expression patterns were informative of signa

130 While the early gene expression profile induced by both growth fac

131 Analysis of immediate early gene expression revealed parallel up-regulation in

132 gene expression, acting after initiation of early gene expression to block viral DNA replication and

133 lular resolution through profiling immediate early gene expression using immunostaining and light-she

134 hCMV early gene expression was responsible, as ultraviolet-in

135 r conditioning, activity-dependent immediate early gene expression, and in vivo electrophysiology, we

136 endent on progression beyond viral immediate-early gene expression, but not dependent on viral DNA re

137 all interfering RNA enhances ERK activation, early gene expression, DNA synthesis, expression of neur

138 rand breaks are crucial to the modulation of early gene expression, which provides a mechanistic link

139 ever, the replication cycle is stopped after early gene expression.

140 preventing core entry into the cytoplasm and early gene expression.

141 osphorylation and the induction of immediate-early gene expression.

142 -1) to limit viral replication and immediate-early gene expression.

143 te receptors and singing-dependent immediate-early gene expression.

144 ne expression but also because it suppresses early gene expression.

145 ntially be involved in the regulation of HPV early gene expression.

146 ohistochemical methods to quantify immediate-early gene expression.

147 ry and enhanced by viral immediate-early and early gene expression.

148 Silencing of MSH2 appears to inhibit early gene expression.

149 effect on neuronal firing rate or immediate early gene expression.

150 ylation that coordinately regulate immediate early gene expression.

151 litates transcription-factor recruitment and early gene expression.

152 d2 (Per1 and Per2), as well as the immediate-early gene Fos in the SCN, dorsal hippocampus, and olfac

153 was increased and the DA-regulated immediate early gene Fos was upregulated.

154 l detection of the tracers and the immediate early gene Fos.

155 d with increased expression of the immediate early genes Fos and FosB and the NMDA receptor subunit g

156 One subset of seven early genes had promoters that were transcribed in a sup

157 nd subset, represented in our study by three early genes, had supercoiling-dependent promoters that w

158 These changes are driven by the immediate early gene Homer1a and signaling from group I metabotrop

159 all percentage of cells expressing immediate-early genes (IE) and early genes.

160 neural activity in females, using immediate early gene (IEG) expression as a proxy for brain activit

161 shown that epigenetic changes and immediate-early gene (IEG) induction in stress-activated dentate g

162 ocal ablation) with singing-driven immediate-early gene (IEG) labeling to explore the network archite

163 Arc, an immediate-early gene (IEG) product involved in dendritic spine dyn

164 otein (APP) and TIAM1, and between immediate early gene (IEG) proteins and the HSA21 protein superoxi

165 Arc is a cellular immediate-early gene (IEG) that functions at excitatory synapses a

166 letal-associated protein (Arc), an immediate-early gene (IEG) whose expression is tightly linked to t

167 scription factors and promoters of immediate early genes (IEG) accessible to PARP1-bound phosphorylat

168 ncreases the expression of several immediate early genes (IEG) and the vasopressin gene.

169 Among these immediate early genes (IEG), members of the Early growth response

170 set of genes we identified several Immediate Early Genes (IEG), which were highly expressed in restin

171 binds to genomic loci of multiple immediate early genes (IEGs) (Fos, Fosb, Egr1, Egr2, Arc, and Bdnf

172 ely resemble the dynamics of known immediate-early genes (IEGs) and this enables a comprehensive comp

173 elevation in the expression of the immediate early genes (IEGs) Arc/Arg3.1 and Egr-1 in the lateral a

174 Immediate early genes (IEGs) are activated as a first line of defe

175 Immediate-early genes (IEGs) are rapidly activated after sensory a

176 creases the expression of multiple immediate early genes (IEGs) associated with growth and angiogenes

177 Profound induction of immediate early genes (IEGs) by neural activation is a critical de

178 nd the release of paused RNAPII at immediate early genes (IEGs) following transcriptional activation

179 Transcription of immediate early genes (IEGs) in neurons is highly sensitive to neu

180 r (NELF) complex upon induction of immediate early genes (IEGs) in neurons.

181 Transcription of immediate early genes (IEGs) in response to extrinsic and intrinsi

182 tor Elk-1 stimulates expression of immediate early genes (IEGs) in response to mitogens.

183 lternatively, post hoc staining of immediate early genes (IEGs) indicates highly active cells within

184 n induction of activity, including immediate early genes (IEGs) such as Fos, Arc and Egr1.

185 e expression of several members of immediate early genes (IEGs) which are known to control more delay

186 In addition and unlike mammalian immediate early genes (IEGs), fly ARGs do not have short gene leng

187 Here, we used the expression of immediate-early genes (IEGs), protooncogene, c-Fos, and zinc finge

188 sion patterns of JUN, FOS and EGR1 immediate early genes (IEGs), reflected by the presence or absence

189 ect how Erk activity is decoded by immediate early genes (IEGs).

190 ation of the serum response genes (immediate early genes [IEGs]) FOS, EGR1, and cJUN.

191 Using immediate early gene imaging (c-Fos), fiber-sparing excitotoxic le

192 ogical recordings, lesion studies, immediate-early gene imaging, transgenic mouse models, as well as

193 ctivation of a learning-associated immediate early gene in rat olfactory cortices is uninterrupted by

194 d in endothelial cells (ECs) as an immediate early gene in response to PH.

195 ed had expression of the EBV major immediate-early gene in the blood indicative of active EBV lytic i

196 ymerase II and drive expression of immediate-early genes in neurons.

197 is essential for all IL-17-induced immediate-early genes in primary mouse embryo fibroblasts, whereas

198 d with a striking up-regulation of immediate early genes in the prelimbic region of the medial prefro

199 RNA) reduced the expression of HSV immediate-early genes, in addition to reducing viral yields.

200 mined whether deletion of Narp, an immediate early gene induced by electroconvulsive seizures (ECS),

201 s a complex phenomenon involved in Immediate-early gene induction in metazoan eukaryotes.

202 ices in DH-compromised animals and immediate early gene induction profiles for amygdala-projecting pr

203 eptor populations up-regulate many immediate early genes involved in growth and differentiation.

204 MAMP-mediated regulatory programs to control early genes involved in the synthesis of defence peptide

205 t expression of these supercoiling-dependent early genes is upregulated by increased chlamydial super

206 eased along with the expression of immediate early genes like c-fos and Egr-1 by the disease mutants.

207 Since most of the EcREs within early gene loci are situated distantly from promoters, w

208 RNPK recruitment along a number of immediate early gene loci, including EGR1 and ZFP36, with the high

209 ns and loss of CTCF binding at the immediate early gene locus, suggesting that cohesins may be a dire

210 A whole brain immediate early gene mapping highlighted the dorsolateral bed nucl

211 Immediate early gene mapping using zif268 in situ hybridization re

212 d memory maintenance using ex vivo immediate-early gene mapping, in vivo neuronal recordings and vira

213 ession of c-Fos and C/EBPbeta, two immediate-early gene markers of neuronal activity.

214 the expression or activity of this immediate-early gene may also contribute to the pathophysiology of

215 The immediate early gene neuronal activity-regulated pentraxin (NARP)

216 The early genes NLRC5, RTP4, and RHOH, which were modulated

217 tic expression of the synaptogenic immediate early gene NPTX2 by pyramidal neurons.

218 genic mice expressing GFP from the immediate early gene Nr4a1 (Nur77) locus.

219 , abnormal expression of FosB, the immediate early gene of L-dopa induced dyskinesia (LID), was mitig

220 ssential for the expression of the immediate early genes of both herpes simplex virus (HSV) and varic

221 equired for transactivation of the immediate-early genes of herpes simplex virus (HSV).

222 Kruppel-like factor 2 and several immediate early genes of the AP1 and Egr family.

223 rning on expression of both of the immediate early genes of the virus, probably by directly acting up

224 ssion of the FosB, ARC, and Zif268 immediate-early genes only in rats experiencing abnormal involunta

225 m of the predicted promoter of the immediate early gene open reading frame 63 (ORF63).

226 C11R is an early gene present in MVA and other orthopoxviruses.

227 is modulated by expression of the immediate early gene product Arc.

228 th of functional importance as the immediate early gene product Arc.

229 tatory glutamatergic synapses, the immediate early gene product Arc/Arg3.1 couples synaptic activity

230 The pattern of expression of the immediate early gene product cFos was used to identify key brain r

231 ression of the activity-dependent, immediate-early gene product Fos in the brains of wild-type (Wt) a

232 oduction induced expression of the immediate early gene product Fos in trigeminal regions that receiv

233 Colocalization of TH with the immediate early gene product Fos, an indirect marker of neural act

234 Here, we report that the immediately early gene product of gammaHV68, replication transactiva

235 Polyoma small T antigen (PyST), an early gene product of the polyoma virus, has been shown

236 The EBV genome encodes an early gene product, BARF1, which contributes to pathogen

237 d capacity for gene expression restricted to early gene products and is considered a replicative dead

238 Consequently, induction of the immediate early gene products and transcription factors c-Fos and

239 on, representative viral immediate-early and early gene products as well as viral DNA accumulated suf

240 ect autoregulatory activity on virus-encoded early gene products is completely preserved.

241 A number of herpesvirus immediate early gene products play important roles in the regulati

242 ntative viral immediate-early gene products, early gene products, and viral DNA sufficiently but had

243 2 accumulated representative viral immediate-early gene products, early gene products, and viral DNA

244 ML-NBs is similar to that of viral immediate-early gene products, such as infected cellular protein 0

245 RNAs) that lie antisense with respect to the early gene products, the tumor (T) antigens.

246 tively spliced transcript expressed from the early gene region concomitant with an increase in the ab

247 PV types have evolved to recruit CTCF to the early gene region to control the balance and complexity

248 show that this miRNA and this novel mode of early gene regulation are conserved with the related BPC

249 Therefore, understanding of immediate early gene regulation might add insights into viral path

250 rmination of transcription of vaccinia virus early genes requires the virion form of the viral RNA po

251 y that in white-throated sparrows, immediate early gene responses in the auditory pathway of females

252 ar nucleus, and we used lesion and immediate-early gene studies to test our working hypothesis that t

253 show that after UV-C irradiation, immediate early genes such as activating transcription factor 3 (A

254 or promoters (EGF, UV and TPA) and immediate early genes, such as c-myc, c-jun and c-fos.

255 ef2, as well as activity-regulated immediate-early genes, such as fos and jun.

256 hat was post-binding but took place prior to early gene synthesis for both PR772 and HAdV-2.

257 Our work defines TSP-1 as a novel immediate early gene that could be a potential therapeutic target

258 ociated protein (Arc/Arg3.1) is an immediate-early gene that has been widely implicated in synaptic p

259 of Arc (also known as Arg3.1), an immediate-early gene that is required for long-term memory.

260 CCN1 is a product of an immediate-early gene that is transcriptionally induced in ECs in r

261 Arc is an immediate early gene that is unique among neuronal mRNAs because i

262 ton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity underlying

263 ding Arc, also known as Arg3.1, an immediate early gene that plays a significant role in memory conso

264 ity causes the rapid expression of immediate early genes that are crucial for experience-driven chang

265 ep RNA sequencing allowed us to map 118 VACV early genes that are expressed before viral DNA replicat

266 rsally at active genes, except for immediate early genes that are strongly induced before Myc.

267 seizure activity and induction of immediate early genes that control hippocampal excitability.

268 The FGFR immediate early genes that were identified include those encoding

269 Multiple isoforms encoded by early genes then coordinate the activation of a larger g

270 e disease, recent clinical trials as well as early gene therapy trials have evaluated the use of sial

271 echanism underlying the distinct response of early genes to ecdysone.

272 he emphasis of gene expression switches from early genes to late genes in a highly regulated manner.

273 ly proteins is important for efficient viral early gene transcription and for changes in expression o

274 ly proteins is important for efficient viral early gene transcription and for changes in expression o

275 LCR) of human papillomavirus (HPV) regulates early gene transcription by interaction with several vir

276 e I (NPH I) is an essential component of the early gene transcription complex.

277 in herpes simplex virus 1 (HSV-1) immediate early gene transcription, our findings suggest that EBV

278 Glycolysis is necessary for early gene transcription, while glutaminolysis is necess

279 (MAPK) phosphorylation to regulate immediate early gene transcription.

280 equired for the repression of KSHV immediate early gene transcription.

281 ssion early in development, and in immediate early gene transcription.

282 arks and the activation of viral immediately early gene transcription.

283 h the roles of these proteins in intravirion early gene transcription.

284 ption, while glutaminolysis is necessary for early gene translation but not transcription.

285 onine import, leading to decreased immediate-early gene translation without significant toxicity.

286 LC, the transcription of the viral immediate early genes UL122 and UL123 and of the delayed early gen

287 rly genes UL122 and UL123 and of the delayed early gene UL50 is substantially lower than that in mLC.

288 For each early gene we detected chromatin loops that juxtapose th

289 After CO2 asphyxiation, several immediate early genes were expressed at lower levels in Abcc5(-/-)

290 ion domain (n208) efficiently activates many early genes, whereas late genes are poorly activated, an

291 Early genes, which include the viral RNAp gene, are tran

292 a robust expression of a panel of immediate early genes, which included the Nr4a subfamily of nuclea

293 Nur77 is an immediate early gene whose expression is rapidly upregulated by TC

294 uced expression of c-Fos and Egr2, immediate-early genes with promoter-proximally paused polymerases,

295 (as the expression pattern of the immediate early gene ZENK) during sleep in juvenile zebra finch ma

296 Thus, altered expression of the immediate early gene Zif268 may contribute to lower levels of GAD6

297 rons that depends on the inducible immediate early gene zif268, processes that are critical for their

298 g and in situ hybridization of the immediate early gene zif268, respectively.

299 factor ATF4 to the promoter of the immediate early gene zif268, which competitively inhibits its expr

300 of newborn neurons, the inducible immediate early gene zif268/egr1.