ライフサイエンスコーパス: early phase

1 tion - the epitranscriptome - is still in an early phase.

2 e how networks and support evolve during the early phase.

3 ly induces type I interferon response in the early phase.

4 , are not predictive of reprogramming during early phases.

5 erize the oligomers that are produced in the early phases.

6 ysis of the stroke hazard rate identified an early phase (0-10 days; 4.1% of strokes) and a late phas

7 nical rationale was provided, the results of early phase 1 and 2 clinical trials have been quite disa

8 investigational new drug guidance describes early phase 1 exploratory approaches involving microdose

9 In comparison with glucose metabolism, early-phase (11)C-DED and (11)C-PiB perfusion appear to

10 In this multitracer PET study, early-phase (11)C-DED and (11)C-Pittsburgh compound B ((

11 We suggest that during the early phase (17.5-18 ka), wind-driven upwelling replenis

12 0.05) better in xenon-treated groups in the early phase (24 hr) and up to 4 days after injury.

13 Global IL-6 inhibition in the early phase after fracture reduced systemic inflammation

14 hages than the WT MDSC/BMP4/GFP cells in the early phase after injury.

15 he expected inflammatory response during the early phase after injury.

16 cilitate neutrophil extravasation during the early phase after MI.

17 redict an increased risk of rejection in the early phase after renal transplantation.

18 significantly more microsaccades during the early phase after the R peak in the ECG.

19 produces paradoxical behavioural responses: early-phase analgesia and late-phase mechanical allodyni

20 phasic decay of the Ca transient with a fast early phase and a slow late phase.

21 r endothelium can be a target of GvHD in the early phase and circulating endothelial cells (CECs) rep

22 herein K5 is critical during the immediately early phase and K3 plays a significant role during later

23 colloids, and red blood cells (RBCs) in the early phase and plasma and platelets in the late phase.

24 yeloma progression with clonal sweeps in the early phase and regional evolution in advanced disease.

25 -free), netrin-1 expression is absent during early phases and detected concomitant with completion of

26 earch strategy yielded 11 studies (9 smaller early-phase and 2 larger outcome trials).

27 ease, inclusion of a separate cohort in both early-phase and later-phase trials is recommended, if CN

28 Early-phase and preclinical studies suggest that moxiflo

29 aging tasks at two time points; first in the early phase ( approximately 2 weeks) and then approximat

30 gs, could promote bacteremia by accelerating early phase bacterial growth prior to the induction of i

31 We propose that this early phase be called a high-replication, low-inflammati

32 ed during the innate lymphoid cell-dependent early phase, but significantly altered during the lympho

33 emerged as ideal noninvasive biomarkers for early-phase cancer detection.

34 Results from early-phase CAR T-cell-based clinical trials demonstrate

35 Although early phase clinical assessment indicated that treatment

36 sts are in various stages of preclinical and early phase clinical testing as potential anticancer dru

37 To improve this figure, several early phase clinical trials combining novel immunotherap

38 Accumulating data from preclinical and early phase clinical trials document their safety when d

39 seven such compounds have been advanced into early phase clinical trials for the treatment of human c

40 arget inhibition and therapeutic response in early phase clinical trials of PI3K inhibitors in childh

41 Early phase clinical trials suggest that intramyocardial

42 EZH2 small molecule inhibitors are entering early phase clinical trials.

43 e useful in monitoring treatment response in early phase clinical trials.

44 analyzed 67 heavily pretreated patients on 3 early phase clinical trials.

45 in active development, with several entering early phase clinical trials.

46 of preclinical evidence prior to initiating early-phase clinical studies has typically been performe

47 Preclinical and early-phase clinical studies have found specific pathway

48 Notably, the early-phase clinical symptoms in the conjunctiva after O

49 s manufacturers of investigational drugs for early-phase clinical trials engaged in industry partners

50 Early-phase clinical trials evaluating CD8(+) T cell-eli

51 in vitro, in xenograft model systems, and in early-phase clinical trials in humans.

52 hat are supported by preclinical studies and early-phase clinical trials suggesting that these approa

53 nst HER3 that has shown promising results in early-phase clinical trials, but an optimal target popul

54 approaches may resolve a major challenge for early-phase clinical trials, which is to recruit patient

55 pharmacodynamic biomarkers is increasing in early-phase clinical trials.

56 tential for targeting B cell malignancies in early-phase clinical trials.

57 ave been absent and only recently pursued in early-phase clinical trials.

58 matic, with limited single-agent activity in early-phase clinical trials.

59 applied to analyze tumor biopsy specimens in early-phase clinical trials.

60 nd point in pro-cognitive drug discovery and early-phase clinical trials.

61 ancer therapeutic in preclinical studies and early-phase clinical trials.

62 Our early-phase data showed that administration of ipilimuma

63 Our early-phase data suggested that children with neurofibro

64 kinetics, the latter of which could enhance early phase diastolic relaxation during beta-adrenergic

65 and molecular changes characteristic of the early phase disease.

66 lustrate how clinical imaging can facilitate early phase drug development and most effective medicine

67 will highlight the applications of q-NMR to early phase drug development testing and its efficient p

68 ton requires two phases of FGF signaling: an early phase during which FGFs drive pharyngeal pouch for

69 seems higher in tertiary centers both in the early phase, during the intensive care unit admission, a

70 sruption of this signaling axis impaired the early-phase expression of IRF3 target genes and the indu

71 Although increasingly used in the early phase following traumatic brain injury, the progno

72 n mean strength of gamma oscillations in the Early phase for snakes and the Late phase for monkey fac

73 The AMI group had higher unadjusted early phase hazard (hazard ratio [HR]: 1.24; p = 0.04) a

74 neurons, and was safe and well tolerated in early-phase human studies.

75 uch agent that showed significant promise in early phase I and II clinical trials.

76 avenue for new treatment development, where early phases (I, I/II) are designed to test safety and e

77 ALDI), (iii) MALDI-TOF MS identification and early phase implementation of TLA (TLA1), and (iv) MALDI

78 Notably, whereas during the early phase in both inflammatory conditions the inductio

79 nferred to fill gaps in our understanding of early phases in the breeding cycle of theropods.

80 The early phase includes induction of zinc and iron limitati

81 ents in functional islet mass and associated early-phase insulin secretion, which with decreased incr

82 sed pancreatic beta-cell function (27% lower early-phase insulin) and during circadian misalignment p

83 higher late-phase insulin) without change in early-phase insulin.

84 ious activation of Shh signaling during this early phase interferes with the Gli3-dependent specifica

85 al and physiological mechanisms to target in early phase intervention development.

86 dations for how the inclusion of children in early-phase investigational cancer drug trials might be

87 The early phase is characterized by a rapid acceleration in

88 MKII did not materialize after expression of early phase LTP suggesting impaired phosphorylation, whi

89 the combined treatments severely suppressed early phase LTP without affecting the late phase LTP of

90 tion, which may explain the severely blocked early phase LTP.

91 nd mechanistically classified into decaying (early-phase) LTP and nondecaying (late-phase) LTP.

92 Prostaglandin (PG) D2 is an early-phase mediator in inflammation, but its action and

93 obust and meaningful response end points for early-phase metastatic castration-resistant prostate can

94 oimmune encephalomyelitis (EAE), a model for early-phase MS.

95 In the early phase, Neurog1 and Neurog2 are also required for l

96 During the early phase, neutrophils infiltrated the epidermis, wher

97 TNFA genes consists of 2 distinct phases: an early phase, occurring rapidly and in a protein synthesi

98 otypic and functional differentiation in the early phase of a chronic LCMV infection without inheriti

99 e of the inverse-Compton emission during the early phase of a supernova.

100 hibition that may confer benefits during the early phase of acute coronary syndrome.

101 onset of ventricular arrhythmias during the early phase of acute myocardial ischemia after ligation

102 g model on transcriptional regulation in the early phase of adipogenesis and highlight the need of st

103 educing the inflammatory reaction during the early phase of AILI.

104 he role of infiltrating monocytes during the early phase of ALF is still ambiguous.

105 Variables associated with IF in the early phase of allogeneic HCT were receipt of antithymoc

106 therapy therefore should be initiated in an early phase of AMR.

107 h nonvalvular atrial fibrillation during the early phase of anticoagulant therapy.

108 TP1B protein expression was increased in the early phase of AP in mice and rats.

109 ation of retinal spike efficacy suggests the early phase of augmented suppression involves local thal

110 T/CT may be suggested before S-RT during the early phase of biochemical relapse, to select patients w

111 d for salvage radiation therapy (S-RT) in an early phase of biochemical relapse, to select which pati

112 te release from presynaptic terminals in the early phase of brain ischaemia.

113 te release from presynaptic terminals in the early phase of brain ischaemia.

114 derstanding of the mechanisms underlying the early phase of carcinogenesis.

115 ations reveal that the doses applied in this early phase of clinical application can be significantly

116 revealed heterogeneity in the timing of the early phase of CME, with transient recruitment of 2-4 mo

117 -1alpha-mediated Tox3 suppression during the early phase of CNS insult plays a crucial role in second

118 s derive from mature macrophages in the very early phase of CNS vascular development, which in turn a

119 t (cofactor) function of FV that targets the early phase of coagulation before prothrombinase assembl

120 ng that AMPAR diffusion is important for the early phase of contextual learning.

121 dence for remnant magnetism might suggest an early phase of crustal spreading.

122 e demonstrated that GBP1 acted mainly on the early phase of CSFV replication and inhibited the transl

123 During this early phase of development, cortical activity is far fro

124 Although these efforts are still in the early phase of development, there is great promise for f

125 -activated receptor gamma (PPARgamma) in the early phase of differentiation.

126 ression without affecting mRNA levels in the early phase of differentiation.

127 ing and triaging new hA3R antagonists in the early phase of drug discovery.

128 During an early phase of enhanced sensitivity called the critical

129 of functional mouse homologs of CXCL8 in the early phase of enterocolitis.

130 hondria Ca(2+) transfer increases during the early phase of ER stress induced by tunicamycin as an ad

131 shows that glucagon interactions during the early phase of fibrillation are mediated through C-termi

132 , how the cell replenishes energy during the early phase of glucose starvation is unknown.

133 avoided by performing a secondary DMEK in an early phase of graft failure.

134 , apoptosis, and antigen presentation in the early phase of H5N1 virus infection leads to subsequent

135 alizing anti-receptor Abs are induced in the early phase of HCV infection, but not in control groups.

136 hils are the main leukocytes involved in the early phase of healing.

137 at neutrophils play an essential role in the early phase of hepatic ischemia-reperfusion injury and d

138 y which neutrophils are recruited during the early phase of histamine-induced inflammation involves t

139 se is likely to be more effective during the early phase of HIV-1 infection and diminishes at the lat

140 ved the presence of post-entry blocks to the early phase of HIV-1 infection in peripheral blood lymph

141 n vivo markers of platelet activation in the early phase of hospitalization of patients affected by c

142 striatum and specifically degenerate in the early phase of Huntington's disease.

143 elta cells, suggesting that Hir1 impacts the early phase of hyphal initiation.

144 of activation of the IFN response during the early phase of IBV infection, the signaling of nonself d

145 haplotypes and suggest that particularly the early phase of IgG-mediated neutrophil reactivity is inf

146 formation regarding perceived support in the early phase of illness.

147 +) T-cell activation was observed during the early phase of infection and decreased in untreated pati

148 ion and whether responses induced during the early phase of infection are preferentially depleted.

149 e role of resident sentinel cells during the early phase of infection is less clear.

150 pared with healthy subjects, patients in the early phase of infection presented with elevated Kyn/Trp

151 higher anti-CD81/CLDN1 Ab titers during the early phase of infection than controls.

152 , and antigen processing/presentation in the early phase of infection was limited in severe disease c

153 Forty patients in the early phase of infection were longitudinally followed fo

154 Whereas levels remained normal during the early phase of infection when the virus was actively rep

155 icient T cells are hyperactivated during the early phase of infection, exhibiting increased prolifera

156 transferred TCR-transgenic cells during the early phase of infection, suggesting that T cell priming

157 ba on human monocytes/macrophages during the early phase of infection.

158 ntrahepatic inflammatory response during the early phase of infection.

159 it a Foxp3(+) Treg cell response during this early phase of infection.

160 antiviral and cell-permeable to inhibit the early phase of infectious bronchitis virus and Dengue in

161 The early phase of injury causes loss of dendritic spines an

162 In the early phase of injury, the rate of myelin clearance was

163 al distribution of the microbiota during the early phase of its administration.

164 susceptible target cell, HIV-1 completes the early phase of its life cycle upon integration of revers

165 or cause of renal failure, especially at the early phase of kidney transplant when ischemia-reperfusi

166 In addition, early phase of learning was associated with increased ac

167 elia burgdorferi during tick feeding and the early phase of mammalian infection.

168 The heightened cytokine response during the early phase of MCMV infection in CD70(-/-) mice was para

169 peeds intracellular acidification during the early phase of metabolic acidosis (MAc), not just in neu

170 We found that c-Abl was activated during the early phase of mouse 3T3-L1 preadipocyte differentiation

171 edly reduced IFN-gamma production during the early phase of Mtb infection, bacterial growth was not i

172 Prefibrotic myelofibrosis represents an early phase of myelofibrosis, and is characterized by gr

173 , enhanced organelle fusion and promoted the early phase of neuronal differentiation.

174 ase gene is induced by Nod factor during the early phase of nodule initiation.

175 pensatory mechanisms are involved during the early phase of Parkinson's disease (PD) to delay the exp

176 During the early phase of petal initiation, RBE regulates a microRN

177 ory failure has the highest incidence in the early phase of postburn injury and decreases starting 5

178 provements in the clinical management of the early phase of psychosis.

179 smission in the pathophysiology of the acute early phase of psychotic illnesses.

180 Compared with the early phase of rejection, the cellular infiltrate is sig

181 plasma and platelet transfusions during the early phase of resuscitation.

182 how early flowering, which may arise from an early phase of rhythmic CO expression.

183 es an acute reduction of MPFC NAA during the early phase of schizophrenia, which may be a previously

184 ponsive and failed to proliferate during the early phase of secondary infection.

185 etween mast cells and macrophages during the early phase of sepsis development that aggravates the ou

186 Although the early phase of sepsis features impaired thirst and enhan

187 High blood lactate levels in the early phase of sepsis have classically been thought to b

188 However, recent studies have shown that the early phase of sepsis is associated with increased AVP l

189 At the early phase of STEMI, the risk of prehospital SCA can be

190 cts of BDNF and proteasome inhibition on the early phase of synaptic potentiation (E-LTP) induced by

191 phic evidence of demineralization during the early phase of syndrome, as a result advanced imaging is

192 rowth factor delivery (CTGF delivery) in the early phase of tendon healing, followed by tenogenic dif

193 ruli isolated from wild-type mice during the early phase of the disease was higher than outgrowth fro

194 Further studies focused on the early phase of the disease will be required to identify

195 omerulosclerosis in alpha7(-/-) mice in this early phase of the disease.

196 ays a role in the autoimmune response in the early phase of the disease.

197 brain serotonin transporter function at the early phase of the disease.

198 ture) caused demographic recovery during the early phase of the experiment, but ultimately reduced th

199 oreover, phage DNA motion is the same in the early phase of the infection cycle, irrespective of whet

200 onstrates considerable complexity during the early phase of the infection that can influence the abil

201 We found at early phase of the infection, PFOS inhibited the expansi

202 e to different parasite numbers occurs in an early phase of the infection, which could dictate the es

203 establishes infection in the CNS during the early phase of the infection, which was not observed in

204 way members that were upregulated during the early phase of the infection.

205 North Atlantic freshwater forcing during the early phase of the last deglaciation, NADW nearly collap

206 by high intrahepatic antigen load during the early phase of the response; cytolytic function was rest

207 vidence of disk fragmentation as it is in an early phase of the star formation process, it is likely

208 Depressive symptoms in the early phase of the study corresponding to midlife, even

209 urated after three stimuli and dominated the early phase of the train EPSC; and the other, with small

210 sential roles at virtually every step in the early phase of the viral life cycle.

211 Here, we monitor the early phase of this cascade at high spatiotemporal resol

212 The early phase of this decline in coronary heart disease an

213 The early phase of TLR signaling and the TLR-dependent secre

214 ion of acute upregulation of miR-200c at the early phase of wound healing in aged skin.

215 During the early phase of wound healing, first plasma fibronectin (

216 PNPLA3 gene and protein increases during the early phases of activation and remains elevated in fully

217 e stem cell population that orchestrates the early phases of adult flight muscle development.

218 the heterochromatic ribosomal DNA during the early phases of aging, followed by sustained loss of sil

219 mulated per-capita CO2 emissions from LUC in early phases of agricultural development, humans emerge

220 ct for causing cognitive deficits during the early phases of Alzheimer's disease (AD).

221 ing of females was largely absent during the early phases of animal domestication.

222 es with HIV-1 RNA and degrades it during the early phases of cell infection.

223 may affect the dentin caries process at the early phases of demineralization.

224 We document a similar pattern in the early phases of diet-induced insulin resistance, and pro

225 of streptomycin were not observed during the early phases of disease and were abrogated in recombinat

226 t children can be included in studies at the early phases of drug development and should be an integr

227 Recent advances in the early phases of drug discovery including hit finding, ta

228 lecting new hCB1 receptor antagonists in the early phases of drug discovery.

229 gene expression plays a key role during the early phases of embryonic development.

230 ant does not synthesize detectable SB during early phases of growth.

231 ore fails to secrete normal levels of Hla at early phases of growth.

232 nt ligand upregulation, thus indicating that early phases of HCMV infection are involved in ligand in

233 ival, they control Tcon proliferation in the early phases of HCT.

234 tion of effector cells and contribute to the early phases of immune response, orchestrating the funct

235 y accumulates around the bacteria during the early phases of infection and is required for both optim

236 These early phases of infection are notably vulnerable to supp

237 vitro studies revealed that during the very early phases of infection, GSH depletion and the downreg

238 known about the function of TGF-beta in the early phases of intestinal tumorigenesis.

239 ocampal and neocortical contributions to the early phases of memory formation, we closely followed ch

240 (EMT) and therefore presumably suppress the early phases of metastasis.

241 d to mitotic spindle poles (MSPs) during the early phases of mitosis where it colocalizes with its pa

242 es of results that should be reported in the early phases of molecular biomarker development, discuss

243 for improving cognitive function during the early phases of neurodegenerative diseases.

244 Metoprolol acts during early phases of neutrophil recruitment by impairing stru

245 pothesize that inflammation that accompanies early phases of pancreatic ductal adenocarcinoma (PDAC)

246 vel, an upregulation of ERK signaling during early phases of postnatal development, but not in the ad

247 d the stabilization of either protein during early phases of reprogramming is sufficient to induce th

248 -promoting activity of activated NRF2 during early phases of skin tumorigenesis.

249 lators, cytokinin also is accumulated during early phases of symbiotic interaction, but the pathways

250 Our observations suggest that early phases of T2DM characterized by high levels of glu

251 greatest improvement potential occurs at the early phases of technology development; therefore, prosp

252 fragments, including known genes involved in early phases of the adenoma-carcinoma sequence (such as,

253 the TCR-pMHC interaction in isolation in the early phases of the decision process.

254 systems for defining cellular changes in the early phases of the disease process provide both mechani

255 when distinguishing between the late and the early phases of the experiment.

256 risk pathway may be of greatest value during early phases of the lifespan.

257 nal transduction pathways present during the early phases of the seed-to-seedling transition anticipa

258 cognitive-behavioral analyses, we are in the early phases of understanding how parental brain circuit

259 For the early phase, one single-nucleotide polymorphism (rs76424

260 ing Ab at 3, 6, and 9 d postinfection (dpi) (early phase) or at 15, 18, and 21 dpi (late phase).

261 Some are making the transition into early-phase patient trials, but the lack of validated bi

262 prescription choice in a national cohort of early-phase patients.

263 hanisms that support cardiac function in the early phase post MI and identifying the processes that i

264 prevent or limit reparative processes in the early-phase postinjury.

265 ir use as (1) initial short-term readouts in early phase/proof-of-concept studies over 6 or 9 months,

266 ship was observed for activation in both the early phase (r = 0.363, P = 0.03 one-tailed) and the lat

267 ography immediately after the 4th challenge (early-phase response, EPR) and 24 h after the 6th challe

268 AQX-1125 had no effect on the early-phase response.

269 We previously described and characterized an early-phase restriction of HIV-1 and -2 replication in h

270 The early phase (sampled at embryonic day [E]27-E35 followin

271 We included 83 patients with early phase schizophrenia and minimal exposure to antips

272 d mid- and late-phase but not VAMP2-mediated early-phase secretion.

273 In the early phase, stathmin is dephosphorylated, enhancing its

274 the difference in safety between the smaller early-phase studies and the larger outcome studies.

275 However, early-phase studies show unique challenges associated wi

276 inhibitor without adverse safety signals in early-phase studies that demonstrated preliminary activi

277 In early-phase studies, ibrutinib demonstrated high respons

278 As an early phase study, limitations include small patient num

279 shows potential as a treatment for MDD in an early phase study.

280 lly distinct phases of protein synthesis: an early phase that appears to prime LTM; and a later phase

281 epidemic among PWID in overall a relatively early phase, there is a window of opportunity for preven

282 In the early phase, there was also upward displacement of the e

283 Although some early-phase trial data are promising, reports of blindin

284 Furthermore, results of this early-phase trial may aid in design of future studies ai

285 ombination with chemotherapy is currently in early phase trials for the treatment of cancer.

286 on of more potent gene transfer vectors into early phase trials.

287 chimeric antigen receptor (CAR) T cells from early-phase trials in relapsed patients to a viable ther

288 come in multiple experimental models and two early-phase trials involving patients with TBI.

289 Efforts are underway for early-phase trials of candidate treatments for cerebral

290 Some early-phase trials of cell therapies suggest acceptable

291 rugs proceed through preclinical testing and early-phase trials only to fail in late-stage clinical t

292 sion of pediatric patients is appropriate in early-phase trials that assess dose, safety, and pharmac

293 Early-phase trials with monoclonal antibodies targeting

294 In early-phase trials, dupilumab, a fully human mAb targeti

295 y beneficial activity in patients with MF in early-phase trials.

296 d IL-13 (P = 0.07, area under the curve) and early-phase tryptase levels (P = 0.06).

297 H2O2 is critical at the early phase, whereas CXCL8 plays a key role in the late

298 In an early phase, with peak expression at about 15 h post-fer

299 e transcriptome of regenerating cells in the early phase within 24 h after wounding.

300 ivation in human keratinocyte HaCaT cells in early phase (within 6 h) post-UVB.