ライフサイエンスコーパス: early protein

1 ated herpesvirus (KSHV) encodes an immediate-early protein.

2 activates expression of the other immediate-early protein.

3 nd in a bovine herpesvirus 4 major immediate-early protein.

4 r BRLF1 (in epithelial cells only) immediate-early protein.

5 1 inhibits expression of the major immediate-early protein.

6 prolonged expression of the viral immediate early proteins.

7 eleted for various combinations of immediate-early proteins.

8 ed prolonged synthesis of cellular and viral early proteins.

9 overcome by viral tegument and/or immediate-early proteins.

10 s at ND10 before the production of immediate-early proteins.

11 of virion input proteins or viral immediate early proteins.

12 and in the synthesis of immediate-early and early proteins.

13 of tumors as the result of the action of its early proteins.

14 onal activation by cytomegalovirus immediate-early proteins.

15 ease severity, and Th2-like responses to HPV early proteins.

16 dentified immunogenic peptides within HPV-11 early proteins.

17 ), phosphoprotein 150 (pp150), and immediate early protein 1 (IE1) immunodominant antigens into the v

18 The cytomegalovirus (CMV) immediate-early protein 1 (IE1) was previously shown to induce NF-

19 l responses to the pp65 (UL83) and immediate early protein 1 (IE1; UL123) gene products in 16 HCMV-in

20 was predicted to target the viral immediate-early protein 1 mRNA.

21 ized the CMV phosphoprotein 65 and immediate early protein 1, which have been considered major target

22 omegalovirus tegument proteins and immediate-early protein 1.

23 erized the mechanisms by which the immediate early protein 2 (IE2 or IE86), a master transcriptional

24 human cytomegalovirus (CMV) UL122 immediate early protein 2 (IE86).

25 Immediate-early protein 2 expression is modestly reduced with addi

26 A family members target the UL122 (immediate early protein 2) 3' untranslated region, resulting in re

27 ervical cancers and produce the oncoprotein, early protein 6 (E6), which binds to p53 and mediates it

28 require VZV replication; the viral immediate-early protein 62 (IE62) alone was sufficient to produce

29 VZV immediate early protein 62 (IE62) is recognized by cytotoxic T cel

30 er amino acid substitutions in the immediate-early protein 62.

31 by the abundant expression of the immediate early protein 63 (IE63), whereas other viral proteins ha

32 lish a new feedback mechanism between IE and early proteins, a new mechanism of promoter control via

33 f CaMKK has a negligible impact on immediate-early-protein accumulation yet severely attenuates produ

34 anscriptional activators, and each immediate-early protein activates expression of the other immediat

35 pUL96, although expressed as an early protein, acts late during virus maturation, simila

36 s accumulated representative viral immediate-early proteins and early proteins normally.

37 and initiation by isoleucine anticodon CAU; early proteins and nucleozymes were all membrane-attache

38 T) fused in frame to MmuPV1 E6 (mE6) and mE7 early proteins and residues 11 to 200 of the late protei

39 code the large T antigen and small T antigen early proteins and the VP1, VP2, and VP3 structural prot

40 igation and puncture to sham-operated mice ("early proteins") and 24-hr post-cecal ligation and punct

41 to quantify the transcription of E1A (first early protein) and hexon mRNA.

42 the initial accumulation of IE1 72 and viral early proteins, and viral DNA replication proceeds norma

43 totoxic T lymphocytes specific for immediate-early protein are present in seropositive individuals, a

44 We find that the HCMV immediate early proteins are mutagenic, and we propose that HCMV h

45 The early proteins are required to capture cargo and positio

46 egulate class I, indicating that one or more early proteins are responsible for the down-regulation o

47 ly demonstrated that ORF45, a KSHV immediate-early protein as well as a tegument protein of virions,

48 domain that included the Arabidopsis ALWAYS EARLY proteins AtALY2 and AtALY3, and two telomere bindi

49 eticulum membrane and are cleaved off during early protein biogenesis.

50 ctor Oct-1 cooperates with the EBV immediate-early protein BRLF1 (R, Rta) to induce lytic viral react

51 The Epstein-Barr virus (EBV) immediate-early protein BRLF1 is a transcriptional activator that

52 The Epstein-Barr Virus (EBV) immediate-early protein BRLF1 is one of two transactivators which

53 tedly, expression of another viral immediate-early protein, BRLF1, can disrupt viral latency in an ep

54 An EBV early protein, BRRF1 (Na), is encoded by the opposite st

55 resulted in similar levels of VZV immediate-early proteins but reduced levels of glycoprotein E comp

56 and some expressed HSV-1 immediate early and early proteins, but did not produce HSV-1 late proteins

57 However, analysis of the viral early protein by Western blot and immunohistochemistry i

58 Expression of early proteins by the primary virus was necessary and su

59 The Epstein-Barr virus (EBV) immediate-early protein BZLF1 (Z) is a key regulator of the EBV la

60 The Epstein-Barr virus (EBV) immediate-early protein BZLF1 (Z) mediates the switch between late

61 of either Epstein-Barr virus (EBV) immediate-early protein BZLF1 (Z) or BRLF1 (R) is sufficient to co

62 arr virus (EBV) is mediated by the immediate early protein BZLF1 (Z).

63 The EBV immediate-early protein BZLF1 functions as a transcriptional activ

64 The Epstein-Barr virus (EBV) immediate-early protein BZLF1 is a transcriptional activator that

65 The Epstein-Barr virus immediate-early protein BZLF1 is a transcriptional activator that

66 The Epstein-Barr virus (EBV) immediate-early protein BZLF1 mediates the switch between the late

67 that the Epstein-Barr virus (EBV) immediate-early protein BZLF1 prevents TNF-alpha activation of tar

68 rs prevent expression of the viral immediate-early protein BZLF1.

69 le during lytic replication is the immediate-early protein BZLF1.

70 ction is mediated by the two viral immediate-early proteins BZLF1 (Z) and BRLF1 (R), which are not ex

71 The Epstein-Barr virus (EBV) immediate-early proteins BZLF1 and BRLF1 can both induce lytic EBV

72 ty of rAd vectors encoding the EBV immediate-early proteins BZLF1 and BRLF1 to induce the lytic form

73 ection, expression of either viral immediate-early protein (BZLF1 or BRLF1) is sufficient to convert

74 encing, yet the Epstein-Barr virus immediate-early protein, BZLF1 (Z), converts the virus from the la

75 The Epstein-Barr virus immediate-early protein, BZLF1 (Z), initiates the switch between l

76 We demonstrate that the EBV immediate-early protein, BZLF1, activates the DHRS9 promoter throu

77 that the Epstein-Barr virus (EBV) immediate-early protein, BZLF1, inhibits the IFN-gamma signaling p

78 that expression of a single viral immediate-early protein, BZLF1, is sufficient to initiate the swit

79 affect the ability of the two EBV immediate-early proteins, BZLF1 (Z) and BRLF1 (R), to induce the l

80 r, expression of either of the EBV immediate-early proteins, BZLF1 and BRLF1, is sufficient to induce

81 mmunohistochemical analysis of the immediate early protein c-Fos was performed as a marker for cellul

82 s from mammalian cells containing only viral early proteins, concordant with previous in vivo transfe

83 We detected IE3, an activator of early proteins, contemporaneously with gene products of

84 Vaccination against HPV early proteins could provide an effective means of treat

85 ulation can precede even the presentation of early protein-derived epitopes.

86 e Polyomaviridae express increased levels of early proteins during lytic infection.

87 d through the pro-inflammatory action of the early protein dUTPase that is produced even during incom

88 imilarity between MAGE-11 and the adenovirus early protein E1A, we determined whether MAGE-11 contrib

89 had suggested a potential role for the viral early protein E2, we found that E2 protein expression di

90 The adenovirus early protein E4 ORF3 is both necessary and sufficient t

91 The human adenovirus (Ad) early protein E4-ORF3 forms a unique scaffold throughout

92 Adenovirus early proteins E4 ORF3 and E4 ORF6 have complementary fu

93 HPV early proteins E6 and E7 deregulate cell cycle progressi

94 experiment, expression of a second immediate early protein, egr-1, was blocked as well, suggesting th

95 e of COX-2 inhibitors, but expression of the early protein EP0 was not affected by COX inhibition.

96 sociated herpesvirus (KSHV) ORF57 is a viral early protein essential for KSHV multiplication.

97 protocell membranes played a crucial role in early protein evolution and show translation started wit

98 sly attempted to simulate domain creation in early protein evolution by recombining polypeptide segme

99 Models of early protein evolution posit the existence of short pep

100 suggest that this may have been a feature of early protein evolution.

101 ity of an HDAC inhibitor to activate IE1 and early protein expression during infection with a laborat

102 ring reactivation and enhances Rta-dependent early protein expression induced by multiple signals, as

103 ich results in accumulation of the immediate-early protein, failed to down-regulate class I, indicati

104 A simulation study shows that early protein folding events may be investigated by usin

105 Our results suggest differences in early protein folding of substrates for prokaryotic SRP-

106 with a virus that does not express immediate-early proteins, followed by superinfection with various

107 ired prior expression of the viral immediate early proteins for activation in fibroblasts.

108 n expression, this reduction does not affect early protein function.

109 Here we report that the phiC31 early protein, gp3 activated attL x attR recombination a

110 Early proteins had a second key role: coupling energy fl

111 ata suggest that the TTP and TIS11 immediate early proteins have similar but distinct effects on grow

112 minor capsid protein homolog), or ORF 57 (an early protein homolog), in association with increases in

113 pt K3 and K5 (bovine herpesvirus-4 immediate-early protein homologues), K7 (nut-1), and K12 (Kaposin)

114 ction between the C-USP7 and HSV-1 immediate-early protein ICP0 (infected cell protein 0), which is e

115 The immediate-early protein ICP0 (infected-cell polypeptide 0) of herp

116 e viral proteins gE and gD and the immediate-early protein ICP0 but did not have discernible effects

117 ssed in the infected cell, the HSV immediate-early protein ICP0 has E3 ubiquitin ligase activity and

118 nts that fail to express the viral immediate-early protein ICP0 have a pronounced defect in viral gen

119 Herpes simplex virus type 1 immediate early protein ICP0 influences virus infection by inducin

120 erpes simplex virus type 1 (HSV-1) immediate-early protein ICP0 interacts with several cellular prote

121 erpes simplex virus type 1 (HSV-1) immediate-early protein ICP0 is a general activator of viral gene

122 Herpes simplex virus type 1 immediate-early protein ICP0 is an E3 ubiquitin ligase of the RING

123 Herpes simplex virus 1 (HSV-1) immediate-early protein ICP0 is required for efficient lytic infec

124 Herpes simplex virus 1 (HSV-1) immediate-early protein ICP0 localizes to cellular structures know

125 The immediate early protein ICP0 of herpes simplex virus 1 (HSV-1) int

126 The immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1

127 Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1

128 The herpes simplex virus 1 (HSV-1) immediate early protein ICP0 performs many functions during infect

129 simplex virus type 1 (HSV-1), the immediate-early protein ICP0 serves as a counterdefense through de

130 nt viruses, we determined that the immediate-early protein ICP0 was necessary for the inhibition of I

131 nd in cells cotransfected with the immediate early protein ICP0, which degrades DNA-PKcs.

132 The immediate-early protein ICP0, which requires VP22 for packaging in

133 ith herpes simplex virus 1 (HSV-1) immediate early protein ICP0, which stimulates lytic HSV-1 infecti

134 in turn are destroyed by the HSV-1 immediate-early protein ICP0.

135 The alpha (immediate early) protein ICP0 of herpes simplex virus 1 enhances t

136 bsence of the "nonessential" viral immediate-early protein, ICP0, HSV-1 is severely impaired in its a

137 Another clone recognized an immediate early protein, ICP0.

138 d gC, and increased amounts of two immediate-early proteins, ICP0 and ICP4, as well as protein specie

139 erpes simplex virus type 1 (HSV-1) immediate-early protein ICP22 alters the phosphorylation of the ho

140 and other cells requires the HSV-1 immediate-early protein ICP22.

141 nd that certain mutations in viral immediate early protein ICP27 can confer LMB resistance.

142 In addition, synthesis of the immediate early protein ICP27 causes partial inhibition of pre-mRN

143 erpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is an RNA-binding protein that perfo

144 erpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is required posttranscriptionally fo

145 V genome, we provide evidence that immediate-early protein ICP4 is involved in the process of convert

146 ith DeltaU(L)31, expression of the immediate-early protein ICP4, early protein ICP8, and late protein

147 DNA sequence, OriS, and the viral immediate-early proteins ICP4 and ICP27 are sufficient for a repor

148 ble effects on accumulation of the immediate-early proteins ICP4 or ICP27.

149 nt, granzyme B, degrades the HSV-1 immediate early protein, ICP4, which is essential for further vira

150 The herpes simplex virus (HSV) immediate early protein ICP47 inhibits the transporter associated

151 The immediate early protein ICP47 of herpes simplex virus (HSV) inhibi

152 us serotype 1 (HSV-1) expresses an immediate-early protein, ICP47, that effectively blocks the major

153 and 2 (HSV-1 and HSV-2) express an immediate-early protein, ICP47, that effectively inhibits the huma

154 ression of the immediate-early protein ICP4, early protein ICP8, and late protein glycoprotein C (gC)

155 Human cytomegalovirus (HCMV) immediate early protein IE1 and the tegument protein pp71 are requ

156 Immediate-early protein IE1 is a principal regulator of viral tran

157 Human cytomegalovirus (HCMV) major immediate-early protein IE1 is an abundant 72-kDa nuclear phosphop

158 The immediate-early protein IE1 is the principal transcriptional regul

159 alteration of the pre-RC, and the immediate-early protein IE1 was not required.

160 We also demonstrate that the HCMV immediate-early protein IE1-72 complexes in vivo with the p107 pro

161 individual expression of the viral immediate-early protein IE1-72, mimicking full virus infection.

162 Human cytomegalovirus (HCMV) immediate-early protein IE1/IE72 is involved in undermining many c

163 o express high levels of the major immediate-early proteins IE1 and IE2.

164 However, the viral immediate-early proteins IE1-72 and IE2-86, either alone or in com

165 nsactivator plasmid expressing the immediate early protein (IE1) from the Bombyx mori nuclear polyhed

166 icapsid nuclear polyhedrosis virus immediate-early protein, IE1, is a 582-amino-acid phosphoprotein t

167 Immediate-early protein IE180, major capsid protein VP5, and glyco

168 replication and interacts with the immediate-early protein IE2 in lytically infected cells.

169 human cytomegalovirus (HCMV) major immediate-early protein IE2 is a nuclear phosphoprotein that is be

170 ified as a binding element for the immediate-early protein IE2, was essential for oriLyt(PM) activity

171 The 86-kDa major immediate-early protein (IE2/IEP86) of human cytomegalovirus (HCMV

172 s corresponding to residues of the immediate early protein, IE62, of varicella-zoster virus (VZV) wer

173 tibody (rec-MAb 63P4) that detects immediate-early protein IE63 encoded by varicella-zoster virus (VZ

174 r immediate promoter (MIEP) by its immediate-early protein IE72 (determined by cotransfection of an I

175 ther HCMV tegument protein pp65 or immediate-early protein IE72 are found in both CD45RO(high) cells

176 mechanism involving the HCMV major immediate-early protein IE72.

177 ttenuation is mediated by the HCMV immediate-early protein IE86.

178 ion of this promoter by the 86-kDa immediate-early protein (IE86) is controlled by sequences between

179 (IR2P) is a truncated form of the immediate-early protein (IEP) lacking the essential acidic transcr

180 DNA-binding activity of the EHV-1 immediate-early protein (IEP).

181 The 86-kDa major immediate-early protein, IEP86 (IE2, IE2(579aa), or ppUL122a), fro

182 mors induced by the human polyomavirus, JCV, early protein in a whole animal system.

183 istry indicated high level production of JCV early protein in the tumor tissue, but not in any other

184 vestigate the oncogenic potential of the JCV early protein in vivo, transgenic mice expressing JCV T-

185 d thereby define in vivo activities of these early proteins, including gene-specific regulation and i

186 Early protein increases at 6 h were not preceded by incr

187 We demonstrate that an immediate-early protein, infected cell protein 0 (ICP0), is requir

188 The herpes simplex virus 1 (HSV-1) immediate-early protein, infected cell protein 22 (ICP22), is requ

189 ned, enabling topological arbitration during early protein insertion.

190 There is also evidence suggesting that early protein intake may improve growth in these very lo

191 provide a more complete understanding of how early protein interactions involving virus-encoded tegum

192 We also identified two HSV-1 early proteins involved in nucleotide metabolism, UL39 a

193 Thus, degradation of Tip60 by the adenoviral early proteins is important for efficient viral early ge

194 Thus, degradation of Tip60 by the adenoviral early proteins is important for efficient viral early ge

195 translation, the presence of viral immediate-early proteins is sufficient to establish a state permis

196 cription factor, the 72K principal immediate-early protein, is abundantly expressed before this block

197 ICP0, a herpes simplex virus (HSV) immediate-early protein, is necessary and sufficient to dissociate

198 eted to sequences encoding Rta, an immediate-early protein known as an initiator of the lytic viral g

199 -gamma inhibited the expression of the viral early protein large tumor antigen (TAg) and the late pro

200 using a recombinant Listeria expressing MCMV early protein (Lm-MCMV).

201 A phage-encoded early protein, Lpa (late promoter activator protein, for

202 rminant of myofibroblast differentiation and early protein marker for stromal cell response to tissue

203 These data suggest that the R immediate-early protein may activate a key early EBV promoter (pol

204 human cytomegalovirus (HCMV) major immediate-early proteins (MIEPs) can rescue the transcription defe

205 sed, production of HSV-1 immediate early and early proteins might activate CD8(+) T cells aborting vi

206 We found that a viral immediate-early protein, namely ORF45, interacts with cellular int

207 Translocation of a Gag epitope into the early protein Nef markedly increased the activity of CTL

208 sentative viral immediate-early proteins and early proteins normally.

209 ICP22, an immediate-early protein of herpes simplex virus type 1 (HSV-1), is

210 dent on the expression of ICP0, an immediate early protein of HSV-1.

211 The early protein of JCV, T antigen, which is produced at th

212 The immediate early protein of the virus ICP0 plays major role in this

213 The immediately early protein of the virus, infected cell protein 0 (ICP

214 Although the immediate-early proteins of both herpes simplex virus (HSV) and cy

215 lation has come from studies using immediate-early proteins of DNA tumor viruses.

216 2 transcripts encoding IE1 and IE2 immediate-early proteins of HCMV.

217 ctions between ICP4 and ICP27, two immediate-early proteins of HSV-1 that are essential for virus rep

218 ICP0, an alpha (immediate-early) protein of herpes simplex virus 1, performs at le

219 es indicated that Rosco caused the immediate-early proteins ORF4 and IE62 to abnormally localize in i

220 ion was also mediated by the viral immediate-early protein Orf50/Rta, suggesting that the K15 gene is

221 eactivate latent VZV or target the immediate-early protein ORF62p to the nucleus in cultured guinea p

222 We identified early protein oxidation and impaired endothelial NOS hom

223 n the redox imbalance in post-mortem muscle, early protein oxidation and the onset of pale, soft and

224 8]) open reading frame 57 (ORF57) is a viral early protein participating in posttranscriptional regul

225 e herpes simplex virus (HSV) ICP27 immediate-early protein plays an essential role in the expression

226 Human cytomegalovirus immediate-early protein pUL37 x 1 induces Bax mitochondrial transl

227 The human cytomegalovirus immediate-early protein pUL37x1 induces the release of Ca(2+) stor

228 CTL-targeting epitopes in early proteins remained susceptible to the effects of Ne

229 ORF59 binds to oriLyt through an immediate early protein, replication and transcription activator (

230 including repression of the viral immediate-early protein Rta and a cellular factor, Rbl2, that regu

231 We postulated that the EBV early proteins SM and M, which appear to act posttranscr

232 of an RNA framework, perhaps reflecting how early protein structures evolved in an "RNA world."

233 rease in OBP phosphorylation is dependent on early protein synthesis and is independent of viral DNA

234 had no effect on viral early mRNA synthesis, early protein synthesis, or viral DNA replication.

235 from the principal cell bodies also required early protein synthesis.

236 ells requires the participation of the viral early protein T antigen, cellular replication factors, a

237 Expression of the JCV early protein T-antigen in transgenic mice leads to the

238 lly and functionally interact with the viral early protein, T antigen, and downregulate viral gene ex

239 JCV and the transforming ability of the JCV early protein, T antigen, we investigated the associatio

240 Expression of the viral oncogenic early protein, T-antigen, and the late auxiliary protein

241 The JCV early protein, T-antigen, has greater than 70% homology

242 of JCV late gene transcription by the viral early protein, T-antigen.

243 The early proteins Tat, Rev, and Nef may be better CD8(+) T

244 CTL against the early proteins (Tat, Rev, and Nef) and against regulator

245 CP22P) of Equine herpesvirus 1 (EHV-1) is an early protein that functions synergistically with other

246 One of the genes, ORF4, encodes an immediate-early protein that is present in the virion tegument.

247 escribed here, we conclude that EBV PK is an early protein that requires viral-DNA replication for ma

248 erpes simplex virus type 1 (HSV-1) immediate-early protein that stimulates viral mRNA expression from

249 (80 kDa) are expressed as several species of early proteins that are first detected at 3 to 4 h posti

250 0, and M141 gene products were identified as early proteins that localize to both the nucleus and cyt

251 ne of two Epstein-Barr virus (EBV) immediate-early proteins that mediate the switch from the latent t

252 Expression of the immediate early protein tristetraprolin (TTP) is induced by numero

253 The immediate early protein tristetraprolin (TTP) is required to preve

254 vents in the conventional pathway, including early protein tyrosine phosphorylation, were unimpeded b

255 ociated with a diminished capacity to induce early protein tyrosine phosphorylation.

256 infection revealed that the viral immediate-early protein Vmw110 (also known as ICP0) formed discret

257 Herpes simplex virus type 1 immediate-early protein Vmw110 is a non-specific activator of gene

258 erpes simplex virus type 1 (HSV-1) immediate-early protein Vmw110 stimulates the onset of virus infec

259 Herpes simplex virus type 1 immediate-early protein Vmw110 stimulates the onset of virus infec

260 ant on the expression of the HSV-1 immediate-early protein Vmw110.

261 iral genome prior to the expression of these early proteins was previously unknown.

262 interact with the mammalian TIS21 immediate-early protein, was then shown to have protein arginine m

263 ilar patterns of metabolically labeled viral early proteins were detected at permissive and nonpermis

264 While the 86- and 72-kDa immediate-early proteins were not detected in HPCs infected with H

265 70% homology to the well characterized SV40 early protein which has established oncogenic properties

266 In PML patients, the viral early protein, which is produced exclusively in glial ce

267 nd TRS1 open reading frames encode immediate-early proteins with identical N-terminal domains and div

268 cation function of the EBV-encoded immediate-early protein Zta (also referred to as ZEBRA, EB1, and B

269 Epstein-Barr virus (EBV) immediate-early protein Zta is a member of the basic-leucine zippe

270 The immediate-early protein Zta is a member of the basic-leucine zippe

271 l activation function of the viral immediate-early protein Zta.

272 ic replication is initiated by the immediate-early protein Zta.

273 The Epstein-Barr virus immediate-early protein (Zta) plays an essential role in viral lyt

274 ted by overexpression of the viral immediate-early protein, Zta.