ライフサイエンスコーパス: early-onset

1 entification and study of inherited forms of early-onset AD and genetic risk factors that provide ins

2 t the beta-secretase cleavage site linked to early-onset AD found in a Swedish pedigree enhances Abet

3 most familial mutations are associated with early-onset AD, recent studies report the AD-protective

4 is a significant cause of symptomatic, very early onset ADPKD.

5 viously unreported syndrome characterized by early-onset AF (age <35 years), conduction disease and s

6 ern and media debate over the possibility of early-onset age-related diseases in cloned animals.

7 Detailed ocular phenotyping identified early-onset (aged </=3 years) visual loss (mean [SD] bes

8 r protein (APP) gene have been implicated in early onset Alzheimer disease.

9 primary progressive aphasia (nfvPPA) or (5) early onset Alzheimer's disease (eoAD).

10 ils and a focal point of mutations linked to early onset Alzheimer's disease, is not detectable in th

11 Mutations in APP, PSEN1, and PSEN2 lead to early-onset Alzheimer disease (EOAD) but account for onl

12 associated with a greatly increased risk of early-onset Alzheimer's disease (AD).

13 t with the finding that Abeta42-A2V leads to early-onset Alzheimer's disease and enhances neurotoxici

14 Mutations in the ALS2 gene result in early-onset amyotrophic lateral sclerosis, infantile-ons

15 auses a familial form of PD characterized by early onset and a generally severe phenotype, including

16 Early onset and distinct phenotypic features of paediatr

17 sufficient for the HR (13R(+/+)) and develop early onset and more severe disease.

18 RATIONALE: Early onset and progression of lung disease in children

19 ed neuronal circuits, thereby pointing to an early onset and rapid impact of left hemispheric reentra

20 isease lag behind those in adults; given the early onset and therefore potential lifelong effect of m

21 of type 2 diabetes, and this occurs both in early-onset and in classical type 2 diabetes.

22 Early-onset and late-onset Alzheimer's disease exhibited

23 y is associated with protection against both early-onset and late-onset group B streptococcus disease

24 g of the AD immune map in both patients with early-onset and those with chronic disease.

25 he mitochondrial translation machinery cause early-onset and tissue-specific deficiency of one or mor

26 than the decline in asthma-COPD overlap with early-onset asthma (p=0.0001), the decline of 39.5 mL (2

27 decline in FEV1 in asthma-COPD overlap with early-onset asthma was 27.3 mL (standard error 5.0) per

28 n participants with asthma-COPD overlap with early-onset asthma, 12.8 years (11.1-14.6) shorter in th

29 with COPD, 68 with asthma-COPD overlap with early-onset asthma, and 202 with asthma-COPD overlap wit

30 c aberration in 4 related patients with CID, early-onset asthma, eczema, and food allergies, as well

31 ogressive neurological phenotypes, featuring early-onset ataxia and absence seizure without significa

32 iation has not been defined in patients with early-onset atopic dermatitis (AD).

33 ree in 222 infants in Northern Europe, where early-onset autoimmune diseases are common in Finland an

34 reg number and function, leading to a fatal, early-onset autoimmune disorder.

35 ve linked activating mutations in STAT3 with early-onset autoimmune disorders that include diabetes o

36 o consanguineous parents and with additional early-onset autoimmunity had recessive LRBA mutations.

37 of five private TCRbeta provoked spontaneous early-onset autoimmunity in mice.

38 conditions of immune dysregulation, such as early-onset autoimmunity.

39 tions, including DRPLA and Vici syndrome, an early-onset autolysosomal pathology, leads to the activa

40 The most important risk factor for early-onset (babies younger than 7 days) invasive group

41 l dementia face unique challenges due to its early onset, behavioral symptoms, and slow progression o

42 Most carriers had early onset bilateral advanced AMD and extramacular drus

43 n SNAP25, rs6039769, that is associated with early-onset bipolar disorder and a higher gene expressio

44 synaptic mechanism both in schizophrenia and early-onset bipolar disorder and confirm the shared gene

45 efore may increase the vulnerability to both early-onset bipolar disorder and schizophrenia.SIGNIFICA

46 9650 individuals with BPD (5167 thereof with early-onset BPD), and 21,363 typically developing contro

47 of 283 genes was performed in 240 women with early-onset breast cancer (</=40 years) or a family hist

48 sessed mutations in patients presenting with early-onset breast cancer, triple-negative breast cancer

49 , Nphp1, Nphp4 and Nphp5, exhibit relatively early onset (by 3 months of age) retinal degeneration an

50 y identified gene ALPK3 give rise to severe, early-onset cardiomyopathy in humans.

51 Early onset cases were able to maintain free walking sig

52 a-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight indepen

53 mutations are associated with congenital or early-onset cataract.

54 ls exhibiting congenital muscular dystrophy, early-onset cataracts, and mild intellectual disability

55 noncoding RNA RNU12 that was associated with early onset cerebellar ataxia.

56 l was conducted among adult outpatients with early-onset chronic depression who were not taking antid

57 than nonspecific therapy in outpatients with early-onset chronic depression who were not taking antid

58 entified the p.R252W mutation in 2 unrelated early onset CMT2 families and a second mutation p.E236G

59 Here, we demonstrate that Lcn2 protects from early-onset colitis and spontaneous emergence of right-s

60 se conditions among unselected patients with early-onset colorectal cancer (CRC) is largely undetermi

61 onally presented with a phenotype resembling early-onset common variable immunodeficiency, while extr

62 RPS20 were detected in a Finnish family with early-onset CRC (p.Val50SerfsTer23), a 39-year old indiv

63 te genes in 547 additional hereditary and/or early-onset CRC cases (502 additional families).

64 ion prevalence and spectrum in patients with early-onset CRC was determined.

65 Of 450 patients with early-onset CRC, 72 (16%) had gene mutations.

66 el could be considered for all patients with early-onset CRC.

67 y serve as the precursor for the majority of early-onset CRC.

68 ptibility gene mutations among patients with early-onset CRC.

69 with other patient characteristics, such as early onset, cuticular drusen on fluorescein angiography

70 f HNF-1beta in mouse kidney tubules leads to early-onset cyst formation and postnatal lethality.

71 toreceptors is followed shortly afterward by early-onset degeneration.

72 n was more strongly associated with HCV than early-onset depression.

73 ful for addressing severe congenital or very early-onset developmental disorders with high penetrance

74 Here, we identify two SNPs associated with early-onset DFS, rs715212 (P meta = 3.54 x 10(-5)) and r

75 Other signs include early onset diabetes, gout and hyperparathyroidism, elev

76 We describe a new syndrome characterized by early-onset diabetes associated with bone marrow failure

77 Patients with early-onset diabetes had a higher age-adjusted prevalenc

78 cells, but not Foxp3 deficiency, resulted in early-onset diabetes with complete penetrance.

79 h Mendelian inheritance typical for the rare early onset disease (before age 40) and complex inherita

80 SCO1 patients present with severe forms of early onset disease, and ultimately succumb from liver,

81 m HD individuals, particularly in those with early onset disease.

82 nd disease outcomes have not been studied in early-onset disease (EOD, </=7 days) or compared to late

83 inty range [UR], 101000-327000) infants with early-onset disease and 114000 (UR, 44000-326000) with l

84 ciated with FPIES to multiple foods included early-onset disease and FPIES to fruits, vegetables, or

85 o were LRRK2 Gly2019Ser carriers (seven with early-onset disease and seven elderly unaffected individ

86 nd 78% (45%-100%) the risk of GBS Ia and III early-onset disease in Europe.

87 Early-onset disease incidence was 0.41 (95% CI, .36-.47)

88 Although early-onset disease is typically more severe than infant

89 n primarily on liveborn children, especially early-onset disease.

90 up B streptococcus maternal colonisation and early-onset disease.

91 from a single multi-generational family with early onset diverticulitis in order to identify a geneti

92 ren with Canavan disease, neuroimaging shows early-onset dysmyelination and progressive brain atrophy

93 The most prevalent class was early-onset-early-resolving AD, which was associated wit

94 r LMP1 or LMP2A may be sufficient to promote early-onset EBV-induced tumors in this model.IMPORTANCE

95 Screening all infants with early onset eczema and/or egg allergy could require test

96 es identified known pathogenic variants with early-onset effects.

97 mutations as a pathophysiological cause for early-onset encephalopathies due to abnormal protein ufm

98 ariants in YWHAG, establishing their role in early-onset epilepsy, and we provide additional support

99 ividuals with a similar phenotype, including early-onset epilepsy, severe intellectual disability, po

100 We sought to identify genetic causes of early onset epileptic encephalopathies with burst suppre

101 dly expanding group of genes associated with early-onset epileptic encephalopathies.

102 it gene (GABRB3) identified in patients with early-onset epileptic encephalopathy (EOEE) and profound

103 Early-onset epileptic encephalopathy (EOEE) represents a

104 Responding to a need for early-onset evidence predicting disease development, hig

105 tions in PS1 lead to dominant-inheritance of early-onset familial Alzheimer's disease (FAD).

106 high-coverage exome sequencing data on 1,006 early-onset familial CRC cases and 1,609 healthy control

107 Insight may be gained from study of early-onset familial idiopathic noncirrhotic portal hype

108 ngs displaying multiple clinical symptoms of early-onset fatal mitochondrial encephalopathy with live

109 he identification of a recessively inherited early-onset feline PRA.

110 ancy or improve pregnancy outcomes in severe early-onset fetal growth restriction and therefore it sh

111 Severe early-onset fetal growth restriction can lead to a range

112 nd 29 weeks and 6 days' gestation and severe early-onset fetal growth restriction to receive either s

113 ythroblastic subtype, and 1 family displayed early-onset follicular lymphoma.

114 The degeneration of rod cells is early onset, followed by the death of cone cells.

115 cases, 4,001 controls), the most severe and early onset form of periodontitis.

116 identified as a modifier associated with the early onset form.

117 The early-onset form of Myasthenia Gravis (MG) is prevalent

118 Several rare mutations in TREM2 cause an early-onset form of neurodegeneration when inherited hom

119 ,104 controls), a rare but highly severe and early-onset form of periodontitis, validated the associa

120 A subset of patients with early onset formed hallucinations (n=21) had reduced hig

121 etabolomics from subjects with classical and early-onset forms of type 2 diabetes (T2D).

122 in three unrelated subjects presenting with early-onset generalized hypotonia, psychomotor delay, re

123 e therapeutic targets for some patients with early-onset glaucoma based on the molecular and cellular

124 Diagnostic genetic tests using early-onset glaucoma genes are also proving useful for p

125 Other early-onset glaucomas may arise secondary to development

126 ibiotic chemoprophylaxis (IAP) prevents most early-onset group B streptococcal (GBS) disease.

127 Early-onset group B streptococcal disease (EOGBS) occurs

128 roup had similar parietal involvement to the early-onset group with localised volume loss in the thal

129 extensive temporoparietal involvement in the early-onset group, and more focal medial temporal lobe l

130 cts with an atypical association of LCA with early-onset hearing loss, we identified two heterozygous

131 This early onset hemolysis correlated with an increased lesio

132 cterized by genome instability, progeria and early onset hepatocellular carcinoma.

133 fraction, but was higher for delayed- versus early-onset HF (P for heterogeneity =0.002).

134 cle disorders characterized by congenital or early-onset hypotonia and muscle weakness, and specific

135 analysis of DNA from 150 patients with very-early-onset IBD not associated with known genetic factor

136 The findings suggest early onset illusions and formed hallucinations are link

137 the current mainstay of prevention, reducing early-onset infant disease in high-income contexts.

138 interleukin 10 receptor (IL10R) develop very early onset inflammatory bowel disease.

139 phoproliferative syndrome 2 (XLP-2) and very-early-onset inflammatory bowel disease (VEO-IBD).

140 O2 in the intestine has been associated with early-onset inflammatory bowel disease and colon cancer.

141 ammatory bowel disease, treatment effects in early-onset inflammatory bowel disease are less certain.

142 Heritability of early-onset inflammatory bowel disease is hypothesised t

143 usal variants; 50 genes associated with very-early-onset inflammatory disease have been identified.

144 completely explain geographical variation in early-onset invasive disease incidence.

145 isorder of connective tissue, manifesting as early-onset joint hypermobility, joint contractures, mus

146 were identified (early-onset-persistent and early-onset-late-resolving); these were most strongly as

147 clein, which shows robust neurodegeneration, early-onset locomotor deficits, and abundant alpha-synuc

148 chain reaction, we confirmed this finding in early-onset (<34 gestational week, n=26) and late-onset

149 t that LMP1 and LMP2A collaborate to promote early-onset lymphomas in this model, but neither protein

150 cluding achromatopsia, cone dystrophies, and early onset macular degeneration.

151 th arRP, among whom 3 patients had bilateral early-onset macular pseudocoloboma.

152 Early-onset major depressive disorder (MDD) is common in

153 cluster of five mutations with particularly early onset (mean age at onset <40 years) involving PSEN

154 ause mortality associated with premature and early-onset menopause could be an important factor affec

155 rtality in women who experience premature or early-onset menopause.

156 current atypical mycobacterial infection and early-onset metastatic bladder carcinoma.

157 clusters as: "Difficult asthma" (n = 132); "Early-onset mild atopic" (n = 210); "Early-onset mild no

158 a was a significant feature of "Difficult," "Early-onset mild atopic," and "Late-onset asthma." Child

159 132); "Early-onset mild atopic" (n = 210); "Early-onset mild non-atopic: (n = 153); "Late-onset" (n

160 mutation of this gene and demonstrates that early-onset mitochondrial disease can be caused by recur

161 evated rGMP incorporation is associated with early-onset mtDNA depletion in liver and late-onset mult

162 tations as inborn de novo mutations cause an early onset multisystem disorder with failure to thrive,

163 ents, respiratory dysfunction was part of an early-onset multisystemic neuromuscular phenotype with m

164 Centronuclear myopathies are early-onset muscle diseases caused by mutations in sever

165 (rs11206510), which has been identified for early onset myocardial infarction (MI), modified the ass

166 based analysis of whole exome sequencing for early onset myocardial infarction.

167 e case-control cohorts for the evaluation of early-onset myocardial infarction, participants with CHI

168 Mutations in MEGF10 cause early onset myopathy, areflexia, respiratory distress, a

169 and recessive mutations in humans result in early-onset myopathy, areflexia, respiratory distress, a

170 -dependent achlorhydria is a major factor in early-onset NAFLD in Kcne2( horizontal line / horizontal

171 -exon boundaries either in 142 patients with early-onset NAFLD nor in 100 healthy individuals with al

172 unction PNPLA3 variants were not detected in early-onset NAFLD.

173 ation as a phenotypic characteristic of this early-onset NCD.

174 h incidence of GBS-associated stillbirth and early onset neonatal disease (EOD) in hospital (0.91 (0.

175 osed neonates were not at increased risk for early-onset neonatal disease, but were 4.43 times more l

176 and delivery has decreased the incidence of early-onset neonatal infection, these measures do not pr

177 tive organisms were the predominant cause of early-onset neonatal sepsis, with a high prevalence of e

178 our of the six affected individuals also had early-onset nephropathy with features of tubulo-intersti

179 disease characterized by the combination of early-onset nephrotic syndrome (SRNS) and microcephaly w

180 years), as well as 9 individuals affected by early-onset neurodegeneration due to genetic disorders o

181 Affected members were diagnosed with early onset non-syndromic progressive retinal degenerati

182 ster 1 was composed of younger patients with early-onset nonsevere asthma and reversible airflow obst

183 a clinical presentation that often includes early-onset nystagmus, ataxia and spasticity and a wide

184 he original concerns that cloning had caused early-onset OA in Dolly were unfounded.

185 levels and pleiotropic phenotypes, including early-onset obesity, growth defects, and metabolic dysre

186 ding proopiomelanocortin (POMC) have extreme early-onset obesity, hyperphagia, hypopigmentation, and

187 This mutation is associated with the early onset of AD-type dementia in homozygous individual

188 antiretroviral therapy (ART) are at risk for early onset of age-related diseases.

189 ed as early as after 2 months to monitor the early onset of AIT efficacy.

190 rils of D23N Iowa mutant, associated with an early onset of Alzheimer disease.

191 e Dutch and Arctic mutations associated with early onset of Alzheimer's disease.

192 nile social interaction, coinciding with the early onset of ASD symptoms.

193 tation was found to be a risk factor for the early onset of cardiac conduction disturbance and the oc

194 is an important technology for detecting the early onset of cardiovascular disease and assessing pers

195 study, transcriptomic analyses revealed the early onset of cholecystitis in Sox17(+/-) embryos, toge

196 Age-stratified HIV prevalence showed early onset of infection with 11.8% (95% CI 7.3-18.4) of

197 , obstructions in the peripheral airways and early onset of lung stiffening are often difficult to de

198 The early onset of major depression seen in the offspring of

199 an ZIP14 have been linked to symptoms of the early onset of Parkinsonism and Dystonia.

200 rocytes is potentially neuroprotective at an early onset of reactive astrogliosis.

201 sory tracts and dental problems (hypodontia, early onset of severe and aggressive periodontal disease

202 nnose-specific EII also acted to prevent the early onset of SLS-mediated hemolysis.

203 The early onset of symptoms may predict a more severe subseq

204 -R258C, a recurrent mutation associated with early onset of TAAD and occlusive moyamoya-like cerebrov

205 -SYN encoding gene (SNCA) is correlated with early onset of the disease underlining the significance

206 The progressive and early onset of these defects suggest a primary myopathy

207 t low dose and a tumor-inducing level led to early onset of vaginal opening and to obesity in female

208 CASE PRESENTATION: We report the atypical early onset of XLRS in 3-month-old monozygotic twins.

209 e neurodegenerative disease characterized by early-onset optic atrophy and diabetes mellitus, which c

210 ociations of heterozygous LoF mutations with early-onset or triple-negative BC, FANCM should be inclu

211 WNT1 cause osteogenesis imperfecta (OI) and early-onset osteoporosis, identifying it as a key Wnt li

212 The incidence of early-onset paediatric inflammatory bowel disease is inc

213 p.Arg222His, was identified in patients with early-onset pain in distal extremities including joints

214 Patients from a large family with early-onset pain symptoms were evaluated by clinical exa

215 ted induced Pluripotent Stem Cell lines from early onset Parkinson's Disease patients with SNCA A53T

216 loss of function mutations of PINK1 lead to early onset Parkinson's disease, there has been growing

217 NK1) are associated with autosomal recessive early-onset Parkinson's disease (PD).

218 e sequencing in 62 isolated individuals with early-onset parkinsonism and confirmed consanguinity fol

219 tions are associated with a distinct form of early-onset parkinsonism characterized by rapid and seve

220 Autosomal-recessive early-onset parkinsonism is clinically and genetically h

221 mutation in its Sac domain was identified in early-onset parkinsonism patients.

222 ATP13A2, which is mutated in some types of early-onset Parkinsonism, has been suggested as a regula

223 d double-blind, placebo controlled trial, 22 early onset PD patients, were administered deferiprone,

224 sorder symptoms compared to patients without early onset PD psychosis but no differences in cognitive

225 arkin is associated with autosomal recessive early-onset PD, and controls the transcription of PGC-1a

226 e polyadenylation signatures associated with early-onset PE (EO-PE; symptom onset < 34 weeks) and lat

227 ts: 14 with uncomplicated pregnancy; 13 with early-onset PE (eoPE); and 11 with late-onset PE (loPE).

228 autosomal-dominant disorder characterized by early-onset periodontitis leading to premature loss of t

229 al uncontrolled asthma increases the risk of early-onset persistent and transient asthma.

230 Higher prevalence of early-onset persistent asthma was observed among childre

231 tcomes were offspring early-onset transient, early-onset persistent, and late-onset asthma.

232 asses of persistent disease were identified (early-onset-persistent and early-onset-late-resolving);

233 of-function mutations; and (iii) most severe early-onset phenotypes, occasionally with neonatal onset

234 hotoelectrolysis performance, even at a very early onset potential of 1.1 V vs RHE.

235 atic decrease in Tafel slope of over 20% and early onset potential of 1.344 V vs. reversible hydrogen

236 lar remodeling are most marked in severe and early-onset preeclampsia, but are also markers of preecl

237 The most common cause of early onset primary dystonia, a neuromuscular disease, i

238 Early onset profound hearing loss in KO mice and lack of

239 l degradation programs: a maternally encoded early-onset program and a late-onset program that accele

240 that heterozygous Gfi1(Cre) mice exhibit an early onset progressive hearing loss as compared with th

241 ion (stonedeaf, stdf ) leading to recessive, early-onset progressive hearing loss was detected and ex

242 The diagnosis of early-onset progressive retinal atrophy (PRA) was suppor

243 ramidase deficiency that usually presents as early-onset progressive visceral and neurologic disease.

244 s with abdominal pain and diarrhea caused by early-onset protein-losing enteropathy with primary inte

245 ted with glomerular disease characterised by early onset proteinuria and ultrastructural thickening a

246 vides novel information for the treatment of early-onset psychosis and highlights the importance of a

247 ison of quetiapine-ER versus aripiprazole in early-onset psychosis showed no significant group differ

248 We found a paucity of early onset PTLD in our cohort with no cases in the firs

249 Three signals regulated early-onset rates: stabilizing poly-U and UUAG sequences

250 Mild-to-moderate early-onset reactogenicity was frequent but transient (m

251 ic mutations in ARSs typically cause severe, early-onset, recessive diseases that affect a wide range

252 se findings, we securely implicate PPP3CA in early-onset refractory epilepsy and further support the

253 mor types, as </= 10% of pheochromocytoma or early-onset renal cell carcinoma and </= 40% of CNS hema

254 y the molecular cause of autosomal recessive early onset retinal degeneration in a consanguineous ped

255 LCA is a severe early onset retinal dystrophy.

256 d individuals from 4 unrelated families with early-onset retinal dystrophy as a primary manifestation

257 itreoretinochoroidopathy (ADVIRC) is a rare, early-onset retinal dystrophy characterised by distinct

258 Trp19Ter) variant as the underlying cause of early-onset retinal dystrophy in each family.

259 Mutations in the SRD5A3 gene may cause early-onset retinal dystrophy, a previously underdescrib

260 Mutations in the Tulp1 gene cause severe, early-onset retinitis pigmentosa (RP14) in humans.

261 Two early-onset seasons associated with antigenic novelty ha

262 brain ganglioside biosynthesis, result in an early-onset seizure disorder with profound motor and cog

263 motor apraxia 4 (AOA4) and microcephaly with early-onset seizures and developmental delay (MCSZ).

264 with global developmental delay, hypotonia, early-onset seizures, cerebellar atrophy, and osteopenia

265 me is a catastrophic childhood epilepsy with early-onset seizures, delayed language and motor develop

266 ssive neurological disorder characterized by early-onset sensorineural deafness and brain anomalies.

267 Patients presented with early-onset sensorineural deafness and distal renal tubu

268 urrent algorithms for management of neonatal early-onset sepsis (EOS) result in medical intervention

269 Among the remaining 8824 infants without early-onset sepsis, late-onset sepsis, or NEC, a 10% inc

270 monosomy 7, whereas MECOM patients presented early-onset severe aplastic anemia, and ERCC6L2 patients

271 creening a large cohort of 132 patients with early-onset severe sensory, motor and cranial nerve neur

272 The early onset, severity, and distinctive findings suggeste

273 We report seven individuals with an early-onset spastic-ataxia phenotype.

274 We demonstrate early-onset suppression of GH release in rapidly growing

275 protein A20, in six unrelated families with early-onset systemic inflammation.

276 eral blood mononuclear cells (PBMCs) from 18 early-onset SZ cases and 12 controls.

277 e show that MEK inhibition adversely affects early onset T-cell effector function.

278 ology by highlighting patients with probable early-onset T1D (GRS >50th T1D centile) who were diagnos

279 ean (SD) ages were 33.5 (7.5) for those with early-onset T2DM and 50.6 (6.5) with late onset T2DM.

280 Those with early-onset T2DM had higher mean (SD) preoperative BMI a

281 ctiveness and durability in the remission of early-onset T2DM has not yet been explored.

282 At 5 years, patients with early-onset T2DM still maintained a higher rate of weigh

283 ing glycemic control in select patients with early-onset T2DM than in those with late-onset T2DM.

284 xamining bariatric surgery for patients with early-onset T2DM.

285 e higher rate of remission in the group with early-onset T2DM.

286 luation of an SCN1A mutation in a child with early-onset temperature-sensitive seizures.

287 A borderline increased prevalence of early-onset transient asthma was observed among children

288 The outcomes were offspring early-onset transient, early-onset persistent, and late-

289 ere neurological condition that mimicked the early-onset twisting, stiff limbs and tremor that is obs

290 Because non-Chinese patients with early-onset type 2 diabetes (defined here as diagnosis a

291 Chinese patients with early-onset type 2 diabetes are at increased risk of non

292 er adjustment for age and sex, patients with early-onset type 2 diabetes had higher risk of non-fatal

293 The prevalence of early-onset type 2 diabetes mellitus (T2DM), which respo

294 Early-onset type 2 diabetes remained associated with inc

295 essive condition characterized by severe and early-onset vascular disease similar to FMD and variable

296 ar complications, we investigated effects of early-onset versus late-onset type 2 diabetes on risk of

297 k of cardiovascular disease in patients with early-onset versus late-onset type 2 diabetes.

298 Early onset XLRS is associated with a more progressive f

299 which is characterized by bilateral multiple early-onset yellow dots at the macula.

300 estricting the analyses to BPD cases with an early onset yielded one genome-wide significant associat