ライフサイエンスコーパス: early-stage

1 , particularly if detected and treated at an early stage.

2 ps33 are absent, Sec17 inhibits fusion at an early stage.

3 tumor that cannot be easily diagnosed at an early stage.

4 ight into rapid diagnoses of diseases in the early stage.

5 power at a local level to diagnose DR at an early stage.

6 in late differentiation stage but not in the early stage.

7 l when cancer is diagnosed and treated at an early stage.

8 can capture changes in brain activity at an early stage.

9 logy and function in mdx diaphragm muscle at early stages.

10 production by this system in the early stages.

11 gh the innovations are emerging and still in early stages.

12 order, which can lead to misdiagnosis in the early stages.

13 sual field (VF) defects in glaucoma, even in early stages.

14 .1%) patients met the primary outcome in the early (stage 2 AKI) and delayed (stage 3 AKI) initiation

15 cess should prove valuable for improving how early-stage academic biomedical concepts are cultivated,

16 and chain-shortening of polysulfide occur at early stage accompanied by the dissolution of long-chain

17 lay a role in B-cell lymphoma development at early stages across different subtypes.

18 individuals at risk of developing AD and/or early stage AD for which current therapies may be more b

19 nce in a new framework for understanding how early-stage AD-associated neurodegeneration affects auto

20 ently associated with rate of progression in early-stage ADPKD.

21 ing the initial generation of highly dynamic early stage aggregates or prefibrillar species.

22 in the CA1 hippocampal area of patients with early-stage Alzheimer's disease (AD).

23 are leaving the primary tumor mass at a very early stage and disseminate to peripheral organs.

24 cell show declined mating probability at an early stage and recover as the rejuvenated offsprings be

25 f anti-inflammatory mediators peaking during early-stage and midstage disease, and evidence of neutro

26 nteric AT (MeAT) was collected on d 0, 4, 7 (early stage), and 14 (cachexia stage) after tumor cell i

27 m mostly depends on host ATP synthesis at an early stage, and at later stages it can sustain its own

28 The study of DIET is in its early stages, and additional investigation is required t

29 volved in HIV that identified RNA-associated early-stage antiviral factor (REAF).

30 HCCs detected by surveillance programs at an early stage are candidates for potentially curative ther

31 iagnostic dilemma because retinal changes of early stages are often subtle.

32 vestigations to explore the role of miRNA in early stage BC in young women, including ethnic specific

33 In PM women with early-stage BC receiving AIs, treatment with a vaginal r

34 r an estradiol vaginal ring in patients with early-stage BC receiving an AI; secondary objectives inc

35 e been detected for a range of cancers at an early stage before the development of clinical symptoms.

36 cy of 3 and bridged the missing links in the early-stage biosynthesis of ambiguines.

37 aged 20 to 44 years who were diagnosed with early-stage breast cancer and received a CPM increased i

38 or older diagnosed with invasive unilateral early-stage breast cancer and treated with surgery from

39 ical approach of the axilla in patients with early-stage breast cancer has witnessed considerable evo

40 ration of normal ductal epithelial cells and early-stage breast cancer invasion and stemness.

41 ence to aromatase inhibitor (AI) therapy for early-stage breast cancer is limited by AI-associated mu

42 Participants included 5569 early-stage breast cancer patients, treated with breast-

43 ate the MammaPrint assay in 6,693 women with early-stage breast cancer provided a signal.

44 rial randomized 455 women with HER2-positive early-stage breast cancer to trastuzumab, lapatinib, or

45 Among the 1224947 women with early-stage breast cancer treated with surgery, the prop

46 aged 18 years or older with newly diagnosed, early-stage breast cancer who had a definite indication

47 ients with estrogen receptor (ER) -positive, early-stage breast cancer without overt lymph node metas

48 Early-stage breast cancer, age, cardiovascular disease,

49 uperior to those of placebo among women with early-stage breast cancer, although it resulted in more

50 inion use was low (<10%) among patients with early-stage breast cancer, and high decision satisfactio

51 nthracycline-based adjuvant chemotherapy for early-stage breast cancer, the use of scalp cooling vs n

52 ll beta-chain repertoire in 16 patients with early-stage breast cancer, we show that the clonal struc

53 sentinel node biopsy (SNB) for patients with early-stage breast cancer.

54 n CT decisions in patients with ER-positive, early-stage breast cancer.

55 ncer recurrence in hormone receptor-positive early-stage breast cancer.

56 mportant competing risk for older women with early-stage breast cancer.

57 epidermal growth factor receptor 2-positive early-stage breast cancer.

58 ab in neoadjuvant treatment of HER2-positive early-stage breast cancer.

59 The technology is still at early stage but rapidly growing and will earn great atte

60 ective breast cancer screening should detect early-stage cancer and prevent advanced disease.

61 ssociated RNAs with low expression levels in early-stage cancer remains a challenge and is highly val

62 In patients diagnosed with early-stage cancers, SMARCE1 expression is a strong pred

63 ly difficult to obtain for the most reactive early stage candidate intermediates (e.g., Fe-N horizont

64 This study aimed to evaluate early stage cardiac autonomic dysfunction with electroca

65 k populations and may prevent progression of early-stage cataracts.

66 During the early stage, cells transition from growth-arrested to gr

67 eurocognitive outcomes of boys with cALD and early-stage cerebral disease who were treated with an al

68 tem cell types that have been used in recent early-stage clinical trials.

69 Solid-state surfactant esters accelerated early-stage cocoa butter solidification while suppressin

70 retrospective cohort study of patients with early-stage colon cancer from the province of Ontario, C

71 derived exosomal miRNA was isolated from 50 early-stage colon cancer patients and 50 matched healthy

72 eadily accessible as diagnosis biomarker for early-stage colon cancer.

73 r molecular and prognostic classification of early-stage colorectal cancer.

74 However, changes in early stages could be important because they would affec

75 Unexpectedly, in vivo examination of early-stage developing nephron tubules reveals that cell

76 agliptin would be more effective in treating early-stage diabetic patients before they develop severe

77 od is motivated by increasing demand for the early stage diagnosis of genetic diseases.

78 examine change in the percent uninsured and early-stage diagnosis among nonelderly patients with new

79 A trend toward early-stage diagnosis for select cancers in expansion st

80 s can identify those who are at risk or with early stage disease, offering the opportunity for early

81 delay were more likely to be diagnosed with early-stage disease (AJCC stage 0, I, or II) than those

82 s documented, 45 (48.4%) were diagnosed with early-stage disease (American Joint Committee on Cancer

83 Patients were required to have early-stage disease and gadolinium enhancement on magnet

84 s highly desirable in various fields such as early-stage disease diagnosis, environmental monitoring

85 In early-stage disease, lesions are limited to the skin, bu

86 e or death for many years after treatment of early-stage disease.

87 rowing need to develop efficient methods for early-stage drug discovery, continuous manufacturing of

88 as a widespread technique has stalled at the early stages due to numerous limitations which include s

89 and analysed global transcriptome changes at early stages during the reprogramming of mouse fibroblas

90 ained from this study are highly relevant to early stage embryogenesis.

91 arget profile of 1, an inhibitor of TarO, an early stage enzyme in the biosynthetic pathway for wall

92 tes during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast canc

93 Finally, we find that, at early stages, fast growing clones exhibit greater cell g

94 -adapted treatment strategies, especially in early-stage favorable HL, regular clinical follow-up is

95 t RBV was used for 12 weeks in patients with early-stage fibrosis (F0-F2) or for 24 weeks in those wi

96 JAZ gene, NaJAZi, specifically expressed in early-stage floral tissues.

97 a manganese oxidizing complex, and describe early stage formation of its mineral products.

98 the task was to distinguish the disease-free/early stages from the referable intermediate/advanced st

99 ed long-term survival data for patients with early-stage HCC who undergo RFA.

100 sess the long-term outcomes of patients with early-stage hepatocellular carcinoma (HCC) after radiofr

101 rrent risk-adapted therapeutic strategies in early-stage HL.

102 is widely considered the standard of care in early-stage Hodgkin lymphoma (HL), and treatment intensi

103 erall survival (PFS and OS, respectively) in early-stage I and II non-small cell lung cancer (NSCLC)

104 Patients and Methods Early-stage (I-III) AABCS were randomly assigned to a 6-

105 with involved-field radiotherapy (25 Gy) for early stage (IA, IB, and IIA) and advanced stage (IIB-IV

106 anscriptional regulatory networks underlying early stages (ie, from mesoderm to cardiac mesoderm) of

107 Endocytosis is entirely blocked at an early stage in Flower-deficient CTLs and is rescued to w

108 tes a spatial pattern of prebranch sites, an early stage in lateral root formation characterized by a

109 ores a potential therapy for MPS-I at a very early stage in life and represents a novel model to test

110 field (FEF; N = 51) and as a comparison, an early stage in the primary visual cortex (V1; N = 15) of

111 tal eye field (FEF)] and as a comparison, an early stage in V1.

112 ice culture models provide an alternative to early stage in vivo studies as an integrated tissue syst

113 nd nitric oxide pathways are dysregulated at early stages in HD.

114 e the near absence of tissue inflammation in early-stage infection, parasite replication could be con

115 preferred treatment for women diagnosed with early stage invasive breast cancer.

116 e to which these pathways are established at early stages is not well explored.

117 vealed that the TF genes up-regulated at the early stages likely initiated the cascading regulation a

118 or decrease disease recurrence in women with early-stage, low-grade endometrial carcinoma.

119 from biopsies of 27 patients with suspected early-stage lung malignancy (control subjects).

120 hieved moderate consensus for factoring into early-stage management discussion, with stronger consens

121 tor abnormalities, in the pathophysiology of early-stage MDD.

122 mbranes to unravel the mechanisms underlying early stage membrane biofouling.

123 ctive tool to predict disease progression of early-stage MF at the time of diagnosis.

124 skin biopsies from 154 Danish patients with early-stage MF.

125 integrity in the cortex and white matter in early stage multiple sclerosis, their distribution in le

126 Identification of patients with early stage non-small cell lung cancer (NSCLC) with high

127 tigates tumor heterogeneity and evolution in early-stage non-small cell lung cancer.

128 rationale for administering immunotherapy in early-stage non-small cell lung cancer.

129 Adjuvant chemotherapy for resected early-stage non-small-cell lung cancer (NSCLC) provides

130 c body radiotherapy (SBRT) for patients with early-stage non-small-cell lung cancer.

131 rchitecture to predict disease recurrence in early stage NSCLC from digitized H&E tissue microarray (

132 Using a retrospective cohort of early stage NSCLC patients (Cohort #1, n = 70), we const

133 gene linked with decreased risk of death in early stage NSCLC patients.

134 ed multiregion whole-exome sequencing on 100 early-stage NSCLC tumors that had been resected before s

135 adjuvant therapy for patients with resected early-stage NSCLC.

136 driver events and evolutionary processes in early-stage NSCLC.

137 In this work, 3xTg-AD mice in the early stage of AD were treated with SLAB51 probiotic for

138 detachment efficiencies of up to 80% at the early stage of bacterial adhesion.

139 -23b - whose expression was increased in the early stage of C2C12 differentiation - are involved in t

140 This might indicate an early stage of chronic obstructive pulmonary disease.

141 CAR-T therapies for MM are at an early stage of development but have great promise to imp

142 k-old Zucker diabetic fatty (ZDF) rats at an early stage of diabetes embody metabolic characteristics

143 accompanied by loss of CD19 expression at an early stage of differentiation and that aging is not an

144 ive for significant feature detection during early stage of disease development.

145 the glomerular gene expression profile at an early stage of disease progression in FVB/N Cd151 (-/-)

146 he past decade, researchers are still in the early stage of exploring the world of complex proteoform

147 lengths were measured repeatedly during the early stage of growth.

148 ogen interactions in the decidua during this early stage of infection remain poorly understood.

149 higher expression in HdT than in Caturra at early stage of infection.

150 For detecting AIS at an early stage of invasion when the species is rare, accura

151 ne frontal cortex, becomes active during the early stage of learning a novel vocabulary.

152 ration and recruitment are often seen at the early stage of lung inflammatory responses to noxious st

153 ting local high-order visual patterns in the early stage of object recognition hierarchy.

154 , disassembly of MFs with cytochalasin D, at early stage of PIXV replication cycle, significantly inc

155 abel-free tool to detect abnormalities at an early stage of pregnancy, a GO-peptide-based surface pla

156 nscription in vitro We found that, during an early stage of reverse transcription the pressure inside

157 n SSc and likely play a critical role in the early stage of SSc skin disease.

158 waste via chain elongation at this current, early stage of technological development.

159 ism is significantly disrupted in HD even at early stage of the disease and importantly, we revealed

160 ident in the skin lesions of patients in the early stage of the disease, exhibit an effector memory p

161 ainting were observed and interpreted as the early stage of the formation of internal protrusions.

162 omains, into dimers that play a role at some early stage of the fusion process.

163 n fructose and fructofuranosyl cation to the early stage of the Maillard reaction.

164 nase effectively block HRV replication at an early stage of the viral life cycle.

165 copy in solution, shows a transition from an early stage of uniform Ag(0) incorporation exclusively i

166 at tumor sites will enable investigations of early stages of adaptive antitumor immunity, as well as

167 In a pilot study on differentiating early stages of Alzheimer's disease (AD) from Dementia w

168 rom trimers have special significance in the early stages of Alzheimer's disease.

169 miting parasite population growth during the early stages of an acute blood-stage Plasmodium infectio

170 sion seem to be more frequent in patients at early stages of anti-VEGF treatment.

171 At early stages of Arabidopsis (Arabidopsis thaliana) flowe

172 ll cycle progression and division during the early stages of B cell development.

173 is more important or more exposed during the early stages of biofilm formation.

174 d to generate overnight biofilms, reflecting early stages of biofilm maturation.

175 KEY MESSAGE: RNA-seq of Vitis during early stages of bud development, in male, female and her

176 f previously unannotated genomic loci during early stages of bud development.

177 ection of mutations difficult, especially at early stages of cancer.

178 was found in 7 (4.4%) patients, 2 of them in early stages of Chagas disease.

179 of hepatic inflammation and fibrosis in the early stages of chronic liver diseases.

180 Many promising new drugs fail in the early stages of clinical trials.

181 ative live-cell analyses to measure discrete early stages of CME and show how sequential, allosterica

182 erative disorders, critically modulating the early stages of cognitive decline.

183 ommended in symptomatic smokers, even though early stages of COPD can be asymptomatic.

184 te the presence of oligo-chain aggregates in early stages of copolyelectrolyte assembly, at experimen

185 ven LS genes in Vd991 were higher during the early stages of cotton infection, as compared with other

186 olved in many physiological functions during early stages of development and in cancer and is require

187 ct that roots were more proliferative during early stages of development in the T-DNA insertional mut

188 of the brain can occur not only during very early stages of development, but also in later fetal/ear

189 We also found that during early stages of development, leaves of da1-1 and bb/eod1

190 ss the potential of a protein to be toxic at early stages of development.

191 ignaling factors, Nodal and Gdf3, during the early stages of development.

192 to distinguish inflammation from fibrosis at early stages of disease, even before the development of

193 cardiovascular disease (CVD) focused on the early stages of DR.

194 alleles revealed that Copb2 is essential for early stages of embryogenesis.

195 In the early stages of endocytosis, fPlas-gold nanoparticles ap

196 aches to identify Hoxa1-bound regions during early stages of ES cell differentiation into the neuro-e

197 The early stages of fibril formation are difficult to captur

198 ounds present on the host cuticle during the early stages of fungal infection.

199 riments can hardly detect the nucleation and early stages of growth because of the short time scale i

200 Direct observation of nanoparticles in the early stages of growth with unobtrusive laser probes sho

201 le is known about its genetic changes during early stages of human infection, as the bacteria adapt t

202 Plasmodium has been challenging because the early stages of infection are clinically silent.

203 P) have poor sensitivities and cannot detect early stages of infection, therefore, there is need to f

204 growth factor 23 (FGF23) increase during the early stages of kidney disease, but the underlying mecha

205 sed at high levels by macrophages during the early stages of kidney repair and promotes tubular cell

206 hat ROS induced via NADPH oxidase during the early stages of L. amazonensis infection is critical for

207 predicted firing rates most strongly during early stages of learning, and shell but not core neurons

208 However, there is evidence that in the early stages of learning, networks within multiple-deman

209 Thus, CTCs isolated from early stages of lung cancer are predictive of poor progn

210 of acute expression of mutant PIK3CA during early stages of malignancy is unknown.

211 eins are coexpressed in spermatocytes at the early stages of meiotic prophase I, the limited period w

212 t anti-tumor immune response only during the early stages of melanoma, poor tumor growth inhibition h

213 r industrial processes however, tracking the early stages of metallic phase nucleation is challenging

214 gro-vagal pathway was compromised during the early stages of motor deficit development.

215 bral cortex of a large cohort of patients in early stages of multiple sclerosis.

216 blishes a new system with potential to study early stages of NBL oncogenesis, to functionally assess

217 that delayed expression of UGT1A1 during the early stages of neonatal development is a tightly contro

218 bidopsis thaliana) AUX1, as being induced at early stages of nodule development.

219 The early stages of nonalcoholic fatty liver disease (NAFLD)

220 visual system alterations can be detected in early stages of Parkinson disease and that the entire in

221 Our combined results indicated that early stages of phagocytosis in the RPE are mainly chara

222 tes that wAnga-Mali infection does not limit early stages of Plasmodium infection in the mosquito, bu

223 formation, we studied folding events at the early stages of polypeptide chain translocation into the

224 and amacrine cells (ACs), beginning with the early stages of postmitotic development.

225 e of vertebrates particularly at the crucial early stages of product development.

226 r power plant and play a central role in the early stages of programmed cell death (apoptosis).

227 Early stages of proliferation may be difficult to distin

228 that Vitamin E promotes tumorigenesis in the early stages of prostate cancer evolution.

229 Especially poorly understood are the very early stages of protein folding, which are likely define

230 The early stages of protein misfolding remain incompletely u

231 hat governs their recruitment to SpAs in the early stages of remodeling and has identified potential

232 e hippocampus, is selectively reduced in the early stages of schizophrenia.

233 oplasmic reticulum (ER) stress occurs in the early stages of SCI and affects prognosis and cell survi

234 of association cortices downstream from the early stages of sensory processing.

235 on for why sexual selection appears to drive early stages of speciation while playing a seemingly lim

236 ough EDTA had some inhibitory effects in the early stages of storage.

237 alterations in transcription rate during the early stages of stress response, indicating orthogonal t

238 anges that these bacteria undergo during the early stages of symbiotic colonization.

239 he electrostatics of the protein scaffold in early stages of the computational design, utilizing elec

240 strategies are only effective if started at early stages of the disease process in a primary prevent

241 is difficult to interpret the results at the early stages of the disease.

242 ess fracture risk among T2DM patients in the early stages of the disease.

243 shift in their expression scores towards the early stages of the disease.

244 ly greater extracellular water volume in the early stages of the disorder; however, its clinical and

245 ations in South Africa, deposited during the early stages of the first rise in atmospheric oxygen on

246 Our data also show that ES7c is cleaved at early stages of the gene expression program that enables

247 Middle Stone Age hominin site that documents early stages of the H. sapiens clade in which key featur

248 genome plasticity and epidemic risk, but the early stages of the infection have not been thoroughly s

249 We show that Zonda operates at early stages of the process, specifically for Vps34-medi

250 nd we map the requirement of PLK activity to early stages of the viral replication cycle.

251 rected by male baboons at females during the early stages of their breeding cycle increases chances t

252 d in the dental epithelium and mesenchyme at early stages of tooth development and later during cell

253 hymal cells that surrounds the tooth germ in early stages of tooth development.

254 ephrinB1 axis plays significant roles in the early stages of tooth injury.

255 situ and invasive cancers and may influence early stages of tumorigenesis.

256 dentified that are thought to be involved in early stages of tumorigenesis.

257 e reactive oxygen species (ROS) burst in the early stages of various stresses, as a result of the low

258 sease type C protein 1 (NPC1) arising during early stages of viral infection.

259 appear to be in complex with VPS4 during the early stages of virus infection.

260 basis, we show here that a difference in the early stages of visual processing between mammals and in

261 At the early stages of zebrafish heart valve formation, we show

262 identification of at-risk individuals at an early stage or even before signs of glaucoma are present

263 s, the study of the cortical distribution of early-stage pathologic alterations is critical in unders

264 arious methods and that hPGCLCs resemble the early-stage PGCs randomly migrating in the midline regio

265 Thus, analyzing early-stage primary tumors may reveal the presence of T

266 cruitment to the MMP13 promoter occurs at an early stage prior to gene transcription and that recruit

267 om treating aggressive (Gleason score, >/=7) early-stage prostate cancer are undermined by harms from

268 sight into the facile reactivity profiles of early stage protonated Fe-N2 and Fe-CN species.

269 rectly on brain function and/or treatment in early-stage psychosis populations are needed.

270 is review, we describe speculative ideas and early stage research concerning the flow of genetic info

271 ients who also received adjuvant therapy-for early-stage resectable pancreatic adenocarcinoma.

272 In this population-based cohort of early-stage resected colon cancer, disease laterality wa

273 n of bevacizumab to adjuvant chemotherapy in early-stage resected NSCLC.

274 altered function of immune cells in brain in early-stage schizophrenia.

275 energic mechanisms, can substantially affect early-stage sensory signal processing and subsequent beh

276 Derisking this process, particularly in the early stages, should increase translational efficiency a

277 ies in contrast to a uniform distribution in early stage, small colonies.

278 ituitary adenomas should be identified at an early stage so that effective treatment can be implement

279 Imbalanced early-stage sound level processing could partially expla

280 ne with topical carmustine for patients with early stage (stage IA through stage IIA) cutaneous T-cel

281 liorated arthritis severity and incidence at early stage STIA and reduced the levels of major cytokin

282 that the approach allowed detection of very early stage surface crystallization.

283 s with HCM and can be detected at relatively early stages, the abrupt onset of congestive heart failu

284 in African ancestry populations is still in early stages, there are already many examples of novel a

285 In early stages, this region appears crescent-shaped, while

286 m and allows disease to progress from a very early stage to a lethal state.

287 ecies (ROS) influence tumor development from early stages to the metastasis phase.

288 rentially methylated gene regions (DMGRs) in early stage tumors across eleven genes (AGRN, C1orf170,

289 ed DNAm alterations across tumor subtypes in early stage tumors advances our understanding of common

290 heir perception as locally advanced (cT3) or early-stage tumors (stage II).

291 tocyte nuclear factor 4A knockout mice; were early-stage tumors by Barcelona Clinic Liver Cancer, Can

292 1 as a key driver of invasive progression in early-stage tumors.

293 reatment can prevent or delay progression of early-stage type 2 diabetes and prediabetes.

294 d in the proportion of CPMs among women with early-stage unilateral breast cancer treated with surger

295 s in the proportion of CPMs among women with early-stage unilateral breast cancer treated with surger

296 Cytotoxicity at the early stage was investigated on twenty types of polymers

297 At early stages, we find that clones derived from a small p

298 In the early stages, we show that nucleation requires a structu

299 olar collapse might already be present in an early stage when there is only little pulmonary fibrosis

300 roach to detect impending range shifts at an early stage will allow resource managers and researchers