ライフサイエンスコーパス: ecdysone

1 competent to respond to the systemic hormone ecdysone.

2 generation controlled by the steroid hormone ecdysone.

3 ocalized growth-perturbation are mediated by ecdysone.

4 nce or absence, respectively, of the hormone ecdysone.

5 duration of secretion of the steroid hormone ecdysone.

6 promotes the release of the steroid hormone ecdysone.

7 al that are regulated by the steroid hormone ecdysone.

8 architectural proteins upon stimulation with ecdysone.

9 pathways that are regulated in MB neurons by ecdysone.

10 premature amplification when incubated with ecdysone.

11 ormal muscle and gut function and respond to ecdysone.

12 gitudinal vein are born prior to the rise in ecdysone.

13 -autonomous reception of the nuclear hormone ecdysone.

14 nitiate metamorphosis through the release of ecdysone.

15 d developmental defects due to deficiency of ecdysone.

16 roduction and release of the molting steroid ecdysone.

17 iation when treated with the steroid hormone ecdysone.

18 ying the distinct response of early genes to ecdysone.

19 ction between the steroid hormone 20-hydroxy-ecdysone (20E) transferred by males during copulation an

20 regulated by sexually transferred 20-hydroxy-ecdysone (20E), a steroid hormone that is produced by th

21 d ETH receptor genes is in turn dependent on ecdysone (20E).

22 The physiological substrate ecdysone 22-phosphate was modeled in a hydrophobic cavit

23 s) often associated with decreased levels of ecdysone - a steroid hormone that regulates developmenta

24 regulating the production and/or release of ecdysone, a steroid hormone that stimulates molting and

25 neration is initiated by the steroid hormone ecdysone, acting through a nuclear receptor complex comp

26 Recent new advances in our understanding of ecdysone action have relied heavily on the application o

27 The steroid hormone 20-hydroxyecdysone (ecdysone) activates a relatively small number of immedia

28 romoters and multiple distant EcREs prior to ecdysone activation.

29 Ecdysone also induces transcription of the II/9A genes.

30 Treatment with the ecdysone analog ponasterone-A induced tightly regulated

31 or DHR78 is regulated by the steroid hormone ecdysone and is required for growth and viability during

32 The steroid hormone ecdysone and its receptor (EcR) play critical roles in o

33 he interaction with insect hormones, such as ecdysone and juvenile hormone.

34 lear receptors and their effector molecules, ecdysone and NO.

35 duct whose mutations impair the synthesis of Ecdysone and produce cell-autonomous survival defects, b

36 rent dendrite degradation, despite activated ecdysone and UPS pathways.

37 The surge of 20-OH ecdysone and/or ponasterone A initiates the molting proc

38 gulated by two hormones, 20-hydroxyecdysone (ecdysone) and juvenile hormone.

39 s of stage- and tissue-specific responses to ecdysone, and (c) feedback regulation and coordination o

40 nd results in the accumulation of unreleased ecdysone, and the knockdown of calcium-mediated vesicle

41 e with juvenoids resulted in deregulation of ecdysone- and farnesoid-regulated genes, accordingly wit

42 role of JH in regulating growth rate via the ecdysone- and insulin-signaling pathways.

43 Instead, ecdysone appears to regulate the growth of imaginal disc

44 ic cascades triggered by the steroid hormone ecdysone at the onset of metamorphosis, acting as both a

45 on These results indicate the requirement of ecdysone binding to the EcR:RXR:MfR complex to regulate

46 e focus on three major aspects of Drosophila ecdysone biology: (a) factors that regulate the timing o

47 While overexpressing FoxO in the PGs delays ecdysone biosynthesis and critical weight, disrupting Fo

48 ng in the prothoracic glands (PGs) regulates ecdysone biosynthesis and critical weight.

49 Thus, nutrition controls ecdysone biosynthesis partially via FoxO-Usp prior to cr

50 one 20-hydroxyecdysone, or the precursors of ecdysone biosynthesis, cholesterol and 7-dehydrocholeste

51 scriptional levels, respectively, to control ecdysone biosynthetic enzyme expression.

52 ay involve the transcriptional regulation of ecdysone biosynthetic genes.

53 ticipate as stage-specific components of the ecdysone biosynthetic machinery.

54 t between Diptera and Lepidoptera in how the ecdysone biosynthetic pathway is regulated during develo

55 In the absense of ecdysone, both ecdysone receptor subunits localize to th

56 omplex (BRC), a primary response gene in the ecdysone cascade, encodes a family of transcription fact

57 ession by E75A is triggered by a decrease in ecdysone concentration and by direct repression of the E

58 In Drosophila, the steroid hormone ecdysone controls developmental transitions, thereby reg

59 Here, we show that the steroid hormone ecdysone controls the expression of the pattern recognit

60 e show that hypomorphic gt mutations lead to ecdysone deficiency and developmental delay by affecting

61 Mef2 transcription in larval myoblasts is an ecdysone-dependent event which acts upon an identified M

62 To identify ecdysone-dependent gene expression changes in MB gamma n

63 e production in the beetle and up-regulating ecdysone-dependent gene expression.

64 Moreover, purified NURF binds EcR in an ecdysone-dependent manner, suggesting it is a direct eff

65 eurons degenerate during metamorphosis in an ecdysone-dependent manner.

66 While the general mechanism of ecdysone-dependent transcription is well characterized,

67 hanism at work in salivary glands during the ecdysone-dependent transition from larvae to pupae.

68 regulate lipid storage and that an excess of ecdysone disrupts the whole process, probably by trigger

69 ects, in which pulses of the steroid hormone ecdysone drive the wholesale transformation of the larva

70 icides to Drosophila melanogaster during the ecdysone-driven onset of metamorphosis results in lethal

71 o the rapid and powerful response of E75A to ecdysone during Drosophila development.

72 r protein that is required for production of ecdysone during Drosophila larval development.

73 d), encoding the monooxygenase that converts ecdysone (E) to the more active 20-hydroxyecdysone (20E)

74 The 20E precursor ecdysone (E) was also able to induce differentiation at

75 In the presence of ecdysone, early genes exhibit a highly characteristic ra

76 ow that components of the steroid-responsive ecdysone (Ec) pathway modulate Hippo transcriptional eff

77 ggered by release of steroid molting hormone ecdysone from the prothoracic gland (PG).

78 Thus, ecdysone functions at two levels to support reproduction

79 We show that the steroid hormone ecdysone functions in Drosophila to control lipid metabo

80 Ecdysone has two distinct functions: At low concentratio

81 identify the bithorax-complex genes and the ecdysone hormone as critical factors in these difference

82 ng regulation and chromatin accessibility of ecdysone hormone regulated genes, revealing that SNR1 fu

83 coordinating gene expression in response to ecdysone hormone signaling at critical points during dev

84 Cmi is required for the activation of ecdysone hormone targets and plays a critical role in de

85 demonstrate that the molting steroid hormone ecdysone in adult Drosophila is critical to the evolutio

86 However, the functions of ecdysone in adult physiology remain largely elusive.

87 boule expression is downregulated by ecdysone in MB neurons at the onset of pruning, and forc

88 cdysone pathway, we investigated the role of ecdysone in the development of the adult-specific neuron

89 nt to adulthood, suggesting that the lack of ecdysone in the mutants is the cause of death.

90 These results implicate ecdysone in the regulation of DNA amplification in Sciar

91 or dn-Raf in the PG greatly attenuates the [ecdysone] increase that causes growth cessation and pupa

92 We also present evidence that the ecdysone-induced Broad Complex of zinc finger transcript

93 s present at both enhancers and promoters of ecdysone-induced Drosophila genes, where it phosphorylat

94 We found the hormone-responsive Ecdysone-induced genes (Eig) were strongly misregulated

95 these proteins at enhancers and promoters of ecdysone-induced genes results in the establishment of t

96 r supported that hypoxia leads to growth and ecdysone-induced molting.

97 In addition, ecdysone-induced overexpression of HO-1 in cells led to

98 a circadian function for a nuclear receptor, ecdysone-induced protein 75 (Eip75/E75), which we identi

99 blocking cell death, allowing for subsequent ecdysone-induced reaper and head involution defective de

100 sis, acting as both a repressor of the early ecdysone-induced regulatory genes and an inducer of the

101 Finally, we show that the ecdysone-induced transcription factor E93 controls tempo

102 that this shift is controlled in part by the ecdysone-induced transcription factor E93.

103 s that stress response genes are induced and ecdysone-induced transcription factors are severely repr

104 n and contain sequences sufficient to confer ecdysone inducibility to a reporter gene.

105 Using an ecdysone-inducible expression system in mammalian dopami

106 98 in mediating enhancer-promoter looping at ecdysone-inducible genes.

107 Induction of SYK in an ecdysone-inducible mammalian expression system results i

108 Injection of ecdysone into pre-amplification stage larvae induces amp

109 hosis, suggesting that specific responses to ecdysone involve distinct EcR isoforms.

110 We propose that ecdysone is able to consolidate memories possibly by rec

111 The regulation of organ growth by ecdysone is evolutionarily conserved in hemimetabolous i

112 played little sleep rebound, suggesting that ecdysone is involved in homeostatic sleep regulation.

113 of other organs in the body, indicating that ecdysone is limiting for their growth, and disrupts the

114 la, endocrine release of the steroid hormone ecdysone is mediated through a regulated vesicular traff

115 Although ecdysone is present throughout life in both males and fe

116 EcR is involved in gene activation when ecdysone is present, and gene repression in its absence.

117 Here we show that the hormone ecdysone is required to down-regulate Chinmo/Imp and act

118 The steroid hormone ecdysone is the central regulator of insect developmenta

119 Ecdysone is the major steroid hormone in insects and pla

120 In insects, ecdysone is the major steroid hormone, and it is well ch

121 Finally, endogenous ecdysone levels increased after sleep deprivation, and m

122 ble for these phenotypes, we measured larval ecdysone levels indirectly, via the transcriptional acti

123 cell death triggered by the steroid hormone ecdysone, making room for their developing adult counter

124 research suggested that the steroid hormone ecdysone may play a role in this polyphenism.

125 ry in cells that have previously experienced ecdysone, mediated by Nup98-dependent enhancer-promoter

126 In this study we demonstrate that ecdysone-mediated signaling in the adult is intimately i

127 lianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodel

128 h genes known to be regulated in response to ecdysone or EcR.

129 Experimental injections of ecdysone or its analog resulted in a decreased productio

130 racellular and extracellular mechanisms: The ecdysone pathway and ubiquitin-proteasome system (UPS) a

131 ere consistent with a down-regulation of the ecdysone pathway being involved in the production of win

132 eurons in the CNS is highly dependent on the ecdysone pathway, we investigated the role of ecdysone i

133 Broad Complex (BRC) is a highly conserved, ecdysone-pathway gene essential for metamorphosis in Dro

134 mponents of the insulin/insulin-like/Tor and ecdysone pathways in the control of organ growth.

135 neurite remodeling following the late-larval ecdysone peak.

136 In response to ecdysone, ph mutant neurons are transformed into cells w

137 ere, we present the crystal structure of the ecdysone phosphate phosphatase (EPPase) phosphoglycerate

138 are therefore consistent with the idea that ecdysone plays a causative role in the regulation of the

139 dnpc1a is normally highly expressed in the ecdysone-producing ring gland.

140 However, the mechanism by which gt regulates ecdysone production has remained elusive.

141 I larvae promote beetle pupation by inducing ecdysone production in the beetle and up-regulating ecdy

142 g gland, we conclude that gt likely controls ecdysone production indirectly by contributing the pepti

143 Null mutants rescued to adults by restoring ecdysone production mimic human NPC patients with progre

144 Here we show that ecdysone promotes the growth of imaginal discs in mid-th

145 transcriptional responses to the late larval ecdysone pulse delays the onset of the subsequent prepup

146 delays the onset of the subsequent prepupal ecdysone pulse, resulting in a significantly longer prep

147 s in apparent response to a mid-third instar ecdysone pulse, when CBP is necessary and sufficient for

148 is determined by the length of time between ecdysone pulses.

149 tain an ABC transporter that functions as an ecdysone pump to fill vesicles.

150 We have developed a Choristoneura fumiferana ecdysone receptor (CfEcR)-based two-hybrid gene switch t

151 ts conserved heterodimeric nuclear receptor: Ecdysone Receptor (EcR) and Ultraspiracle (USP)/Retinoid

152 ulation of Notch signaling and activation of ecdysone receptor (EcR) are required for the E/A switch

153 On hormone activation, the ecdysone receptor (EcR) binds to the SET domain-containi

154 Finally, we show that Ecdysone receptor (EcR) functions autonomously both for

155 ogous to the acetylcholinesterase (AChE) and ecdysone receptor (EcR) genes of B. tabaci, resulted in

156 The ecdysone receptor (EcR) has been used to develop gene sw

157 In addition, disruption of the Ecdysone receptor (EcR) in mature follicle cells mimicke

158 erexpressing a dominant negative form of the Ecdysone receptor (EcR) or its heterodimeric partner ult

159 receptor coactivator (SRC) and GATAa but not ecdysone receptor (EcR) or its partner, ultraspiracle (U

160 Loss of function of either the ecdysone receptor (EcR) or Ultraspiracle (USP), the two

161 In addition, knocking down the Ecdysone receptor (EcR) selectively in the discs also pr

162 n Orthodenticle (Otd) acts together with the ecdysone receptor (EcR) to directly repress the expressi

163 ng this tool, we show that signaling via the Ecdysone Receptor (EcR), a known regulator of developmen

164 One insect NR, ecdysone receptor (EcR), functions as a receptor for the

165 B) defects and Df(4)dCORL larvae are lacking Ecdysone Receptor (EcR-B1) expression in MB neurons.

166 we identify a role for the B1 isoform of the ecdysone receptor (EcR-B1) in this process.

167 s using a dominant-negative construct of the ecdysone receptor (EcR-DN).

168 The Drosophila ecdysone receptor (EcR/Usp) is thought to activate or re

169 ents represent in vivo binding sites for the ecdysone receptor and are necessary for hormone-mediated

170 ushroom body (MB), are decommissioned by the ecdysone receptor and mediator complex, causing them to

171 ne-tolerant protein) and ecdysteroid action (ecdysone receptor and ultraspiracle) suggest that these

172 interfering with ecdysone signaling using an ecdysone receptor antagonist or knocking down the ecdyso

173 They showed premature ecdysone receptor B1 (EcR-B1) in the photoreceptors and

174 x composed of USP (ultraspiracle) and EcRB1 (ecdysone receptor B1) to regulate gene expression in MB

175 that Ash2 functions together with Trr as an ecdysone receptor coactivator.

176 These results indicate that the ecdysone receptor complex influences the fine-tuning of

177 cohesin cleavage, long before any decline in ecdysone receptor could be detected at this locus.

178 C1(-/-) clones exhibit reduced levels of the ecdysone receptor EcR-B1, a key regulator of axon prunin

179 one receptor antagonist or knocking down the ecdysone receptor gene with RNAi resulted in an increase

180 reases recruitment of FISC to the functional ecdysone receptor in a 20E-dependent manner.

181 hemical evidence for the central role of the ecdysone receptor in his model.

182 E93 transition by inducing expression of the Ecdysone receptor in mid-larval neuroblasts, rendering t

183 The ecdysone receptor is also expressed in central clock cel

184 ronal remodeling and suggest that functional ecdysone receptor is necessary for some, but not all, re

185 We find that ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomous

186 DNA amplification in Sciara and suggest the ecdysone receptor may be the elusive amplification facto

187 taFtz-F1 facilitates loading of FISC and the ecdysone receptor on the target promoters, leading to en

188 med human hepatocyte line cell HH4 using the ecdysone receptor regulatory system.

189 In the absense of ecdysone, both ecdysone receptor subunits localize to the cytoplasm, an

190 ild-type and mutant MB neurons in which EcR (ecdysone receptor) activity is genetically blocked, and

191 ne 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer of the nuclear receptor

192 traspiracle (USP), the two components of the ecdysone receptor, causes precocious differentiation of

193 ssion after mating is induced by 20E via the Ecdysone Receptor, demonstrating a close cooperation bet

194 ke 20-hydroxyecdysone (natural ligand of the ecdysone receptor, EcR), methyl farnesoate, pyrirproxyfe

195 Second, global signaling via the ecdysone receptor, EcR, establishes a female metabolic s

196 betaFtz-F1 and a p160/SRC coactivator of the ecdysone receptor, FISC, is crucial for the stage-specif

197 ins interact with each other as well as with ecdysone receptor, ultraspiracle, and methoprene-toleran

198 ns of ecdysone signal transduction involving ecdysone receptor-B (EcR-B) isoforms suppressed vCrz dea

199 Myoglianin, Baboon, and Ecdysone Receptor-B1 are also required for neuromuscular

200 axon pruning by regulating the expression of Ecdysone Receptor-B1, a key initiator of axon pruning.

201 f these neurons, however, are independent of ecdysone receptor-B2 regulation.

202 ific isoform of the steroid hormone receptor ecdysone receptor-B2, for which functions have thus far

203 abscisic acid (ABA) biosynthesis, using the ecdysone receptor-based plant gene switch system and the

204 the EcR subunit of the heterodimeric EcR-USP ecdysone receptor.

205 e that it is efficiently bound by the Sciara ecdysone receptor.

206 also enhance dominant-negative mutations in ecdysone receptor.

207 eracts with Ultraspiracle (Usp), part of the ecdysone receptor.

208 the physical locations of the heterodimeric Ecdysone receptor/Ultraspiracle (ECR/USP) nuclear hormon

209 inds to the nuclear hormone receptor complex Ecdysone Receptor/Ultraspiracle, and is recruited to the

210 r analysis implicated ecdysone signaling via ecdysone receptors A/B1 and the nuclear receptor ftz-f1

211 and conditional overexpression of wild-type ecdysone receptors in the adult mushroom bodies resulted

212 Third, mutants for nuclear ecdysone receptors showed reduced sleep, and conditional

213 Sequential pulses of the steroid hormone ecdysone regulate the major developmental transitions in

214 me of which resemble those in mutants of the ecdysone-regulated Broad-Complex (BR-C).

215 Four of these are ecdysone-regulated enhancers, which possess hormone-resp

216 orphosis possibly caused by misregulation of ecdysone-regulated expression.

217 80 facilitates transcriptional repression of ecdysone-regulated genes during prepupal development.

218 Notch-regulated Hey1 gene and at Drosophila ecdysone-regulated genes.

219 tion of apoptosis and autophagy genes during ecdysone-regulated programmed cell death of Drosophila s

220 Ecdysone regulates biological responses by directly init

221 Ecdysone regulation allows females to assess the demands

222 nes from the carbohydrate metabolism and the ecdysone regulatory pathway.

223 Here, we analyzed ecdysone-related gene expression patterns and found that

224 he prothoracic gland of Drosophila modulates ecdysone release and thereby influences both the duratio

225 We also suggest that ecdysone release is regulated in two ways: a PI3K-depend

226 To test the possibility that altered ecdysone release is responsible for these phenotypes, we

227 ogy: (a) factors that regulate the timing of ecdysone release, (b) molecular basis of stage- and tiss

228 tion of Ras within the PG induces precocious ecdysone release, whereas expression of either dn-PI3K o

229 duration of each larval stage by regulating ecdysone release.

230 in turn might be regulated by the timing of ecdysone release.

231 We report the presence of a putative ecdysone response element directly adjacent to the origi

232 tabase, we then identified a set of putative ecdysone response elements (EcREs).

233 arly genes, E75, harbors multiple functional ecdysone response elements (EcREs).

234 ction required the E74-binding sites and the ecdysone response elements in the Vg 5' regulatory regio

235 the immature stage by suppressing E93 (early ecdysone response gene) in N4.

236 protein recruitment are regulated during the ecdysone response.

237 set of genes, including those mediating the ecdysone response.

238 kr-h1, and SRC is required for expression of ecdysone-response genes.

239 insulator proteins during the heat-shock and ecdysone responses.

240 s and is required for activation of the E75A ecdysone-responsive and hsp70 heat-shock genes.

241 ng discs caused precocious expression of the ecdysone-responsive gene broad.

242 l visualization of transcription at selected ecdysone-responsive genes reveals that puffing at Eip74E

243 metamorphosis due to a lack of activation of ecdysone-responsive genes.

244 Strikingly, a large set of ecdysone-responsive targets is included among several hu

245 e species, which stimulate the high level of ecdysone secretion that induces a molt.

246 der low-nutrition conditions, TOR suppresses ecdysone secretion--which otherwise terminates larval de

247 variation in both the duration and level of ecdysone secretion.

248 In this way, the ecdysone signal can function as a developmental timer co

249 ess each other's expression and that a local Ecdysone signal is required to shift the balance in favo

250 ther Ecdysone synthesis or the expression of Ecdysone signal transducers or targets in the cyst cells

251 Genetic and transgenic disruptions of ecdysone signal transduction involving ecdysone receptor

252 tion, is attributed to Notch downregulation, ecdysone signaling activation and upregulation of the zi

253 20E levels are lower in males than females, ecdysone signaling acts through distinct cell types and

254 These results suggest that activated ecdysone signaling determines precise developmental timi

255 sleep deprivation, and mutants defective for ecdysone signaling displayed little sleep rebound, sugge

256 Ecdysone signaling downregulates miR-965 at the onset of

257 e, the genetic interaction between Notch and ecdysone signaling in regulation of cell cycle programs

258 We also found that mutants in which ecdysone signaling is reduced were defective in LTM, and

259 EcR-B2 in the CySC lineage, indicating that ecdysone signaling supports stem cell viability primaril

260 lting hormone ecdysone, we hypothesized that ecdysone signaling switches the larva to a nutrition-ind

261 We find that ecdysone signaling through Ecdysone receptor isoform B1

262 Conversely, interfering with ecdysone signaling using an ecdysone receptor antagonist

263 Further analysis implicated ecdysone signaling via ecdysone receptors A/B1 and the n

264 We therefore predicted that reduced ecdysone signaling would result in more winged offspring

265 (c) feedback regulation and coordination of ecdysone signaling.

266 unding member of a new pathway downstream of ecdysone signaling.

267 In contrast, GSCs non-autonomously require ecdysone signaling.

268 ttributable to loss of cholesterol-dependent ecdysone steroid hormone production.

269 ors following a pulse of the steroid hormone ecdysone such that different times in wing development c

270 maginal discs from larvae with reduced or no ecdysone synthesis are smaller than wild type due to sma

271 Second, mutants for ecdysone synthesis displayed the "short-sleep phenotype,

272 Discs from larvae with reduced ecdysone synthesis have elevated levels of Thor, while m

273 s) and for proper storage of cholesterol and ecdysone synthesis in ring glands.

274 ppears to be mediated, at least in part, via ecdysone synthesis in the prothoracic gland.

275 In spi mutant animals, reducing either Ecdysone synthesis or the expression of Ecdysone signal

276 and secreted normally in larvae with reduced ecdysone synthesis, and upstream components of insulin/i

277 g gland cells, and, consequently, inadequate ecdysone synthesis.

278 where sterols must be delivered to sites of ecdysone synthesis.

279 The early genes are a key group of ecdysone targets that function at the top of the signali

280 y, via the transcriptional activation of two ecdysone targets, E74A and E74B.

281 in response to a peak of the molting hormone ecdysone that coincides with a nutrition-dependent check

282 Growth is stopped by the pulse of ecdysone that initiates the metamorphic molt.

283 roxyecdysone (20E), the active metabolite of ecdysone that is induced by environmental stimuli in adu

284 h is controlled by two hormones, insulin and ecdysone, that act synergistically by controlling cell g

285 s locus is controlled by the steroid hormone ecdysone, the master regulator of insect development.

286 d by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor, a heterodimer o

287 ell-autonomous manner by the steroid hormone ecdysone, through changes in expression of critical pro-

288 ne giant (gt) have long been known to affect ecdysone titers resulting in developmental delay and the

289 Further, feeding ecdysone to larvae eliminates the effects of critical we

290 Application of ecdysone to larvae with growth-perturbed wing discs resc

291 poral requirement for nos correlates with an ecdysone-triggered switch in sensitivity to apoptotic st

292 he onset of metamorphosis have identified an ecdysone-triggered transcriptional cascade that consists

293 The molting hormone ecdysone triggers chromatin changes via histone modifica

294 A pulse of the steroid hormone ecdysone triggers the destruction of larval salivary gla

295 The steroid hormone ecdysone triggers the rapid and massive destruction of l

296 The steroid hormone ecdysone triggers transitions between developmental stag

297 ulates the production of the molting hormone ecdysone via an incompletely defined signaling pathway.

298 Because the PGs produce the molting hormone ecdysone, we hypothesized that ecdysone signaling switch

299 f mixtures with fenarimol, testosterone, and ecdysone were antagonistic, mixtures of juvenoids showed

300 Co-exposures of ecdysone with juvenoids resulted in deregulation of ecdy