ライフサイエンスコーパス: ecdysteroid

1 ing before E75B, coincident with the rise of ecdysteroid.

2 nces in the sensitivity or responsiveness to ecdysteroids.

3 espectively, two tissues known to synthesize ecdysteroids.

4 ts is regulated by juvenile hormone (JH) and ecdysteroids.

5 important roles in cross-talk between JH and ecdysteroids.

6 compounds include organic acids, hematin, or ecdysteroids.

7 s in insects and plants that have endogenous ecdysteroids.

8 gered hormonally by the prepupal peak of the ecdysteroid, 20-hydroxyecdysone (20-HE).

9 cessfully obtained and used to identify four ecdysteroids: 20-hydroxyecdysone-3-O-beta-D-glycopyranos

10 Ecdysteroids acting through multiple isoforms of the ecd

11 in both JH (methoprene-tolerant protein) and ecdysteroid action (ecdysone receptor and ultraspiracle)

12 c morphogenesis and does so independently of ecdysteroid action.

13 orphosis reflect what would be predicted for ecdysteroid activation of the EcR/USP heterodimer.

14 field-use rates, a neurotoxic effect of the ecdysteroid agonist RH-5849 is observed that involves bl

15 Researchers have developed nonsteroidal ecdysteroid agonists for EcR that disrupt molting and ca

16 molting is known to be regulated largely by ecdysteroids and crustacean hyperglycemic hormone (CHH)

17 tasks, from the synthesis and degradation of ecdysteroids and juvenile hormones to the metabolism of

18 The EcR binds to ecdysteroids and regulates transcription of genes that c

19 horacic glands are the predominate source of ecdysteroids, and the rate of synthesis of these polyhyd

20 correlated with changes in the titers of the ecdysteroids, and these events could be prevented by app

21 Ecdysteroids are multifunctional hormones in male and fe

22 MF and the ecdysteroids are respectively synthesised under the nega

23 However, little is known about the action of ecdysteroids at the level of gene transcription and regu

24 evidence for negative feedback regulation of ecdysteroids at the site of moult-inhibiting hormone (MI

25 gland, which results in an increased rate of ecdysteroid biosynthesis (upregulation); (b) how the con

26 Ecdysteroid biosynthesis and its hormonal regulation are

27 This review summarizes the evidence for ecdysteroid biosynthesis by gonads and its metabolism in

28 25 hydroxylase and has an essential role in ecdysteroid biosynthesis during insect development.

29 , designated Cyp306a1, that is essential for ecdysteroid biosynthesis in the PGs of the silkworm Bomb

30 physiological properties of the enzymes for ecdysteroid biosynthesis, most of the molecular identiti

31 h npc2b in regulating sterol homeostasis and ecdysteroid biosynthesis, probably by controlling the av

32 ts that the embryonic epidermis is a site of ecdysteroid biosynthesis.

33 t the ring gland and regulates expression of ecdysteroid biosynthetic genes.

34 ifferentiative and maturational responses to ecdysteroids by requiring tonic exposure to the hormone

35 on and off repeatedly simply by shifting the ecdysteroid concentration to above or below this thresho

36 sis of a standard of 20-hydroxyecdysone- and ecdysteroid-containing plant extracts.

37 Ecdysteroid control of proliferation is distinguished fr

38 urs throughout such animals, suggesting that ecdysteroids control development of other tissues in a m

39 Subsequent ecdysteroid decline is required for peptide release, whi

40 In contrast to the ecdysteroid-deficient, larval-lethal phenotype of npc1a

41 ping Drosophila eye is an early metamorphic, ecdysteroid-dependent event.

42 ptic lobe development to be divided into two ecdysteroid-dependent phases.

43 ows two different developmental responses to ecdysteroids depending on the concentration to which it

44 Pulses of ecdysteroids direct Drosophila through its life cycle by

45 tor E74 is one of the early genes induced by ecdysteroids during metamorphosis of Drosophila melanoga

46 ithin the optic lobe anlagen is dependent on ecdysteroids during metamorphosis of the moth Manduca se

47 dysteroid receptor (EcR/USP) and products of ecdysteroid early responsive genes (E74, E75, and Broad)

48 t partially overlapping binding cavities for ecdysteroid (ECD) and diacylhydrazine (DAH) ligands, pro

49 ponasterone A), identified through screening ecdysteroids from local plants, demonstrated sustained r

50 The in vitro secretion of ecdysteroids from the prothoracic glands of last instar

51 amorphosis, a pulse of circulating steroids, ecdysteroids, governs the dramatic remodeling of larval

52 e fifth instar (after the commitment peak of ecdysteroids) had little effect on proliferation.

53 e gene regulation properties of one of these ecdysteroids have been examined in cell culture and in n

54 Fifty-eight ecdysteroids, herbal analogues of the insect molting hor

55 By removing the source of ecdysteroid hormone through ligation, and by subsequent

56 ods and considers the apparent uniqueness of ecdysteroid hormones in arthropods, given the predominan

57 The functional receptor for insect ecdysteroid hormones is a heterodimer consisting of two

58 od meal and stimulate the ovaries to secrete ecdysteroid hormones, which modulate yolk protein synthe

59 this complex responds to a distinct class of ecdysteroids in a manner that is independent of EcR.

60 integument of ticks are sources of secreted ecdysteroids in adults, as in earlier stages, but the ti

61 The role of ecdysteroids in modulating exoskeletal growth during the

62 nal) instar when the epidermis is exposed to ecdysteroids in the absence of juvenile hormone (JH) and

63 mplicating this tissue as a source of active ecdysteroids in the early embryo.

64 To better understand the role of ecdysteroids in the molt regulation, the full-length cDN

65 ttle is known about the relative activity of ecdysteroids in various arthropods.

66 o the changes in the levels of hemolymphatic ecdysteroids indicates that these tissues may have diffe

67 We propose that ecdysteroid-induced E75A expression defines a feed-forwa

68 The homolog of the ecdysteroid-induced transcription factor E75A in Drosoph

69 5A, E75B, and E75C, encoded by the E75 early ecdysteroid-inducible gene.

70 Ecdysteroids initiate molting and metamorphosis in insec

71 are elucidating the specificity of receptor-ecdysteroid interactions, the selectivity of some enviro

72 re viable and fertile with relatively normal ecdysteroid level.

73 Prior to behavioral onset, rising ecdysteroid levels induce expression of the ecdysone rec

74 proliferating and later degenerate with high ecdysteroids levels.

75 Ecdysteroids mediate a wide variety of developmental and

76 in regulating the cyclicity of vitellogenic ecdysteroid-mediated signaling through heterodimerizatio

77 Ecdysteroid metabolism occurs in several tissues of adul

78 eveloping epidermis when there is a surge of ecdysteroid midway through embryogenesis.

79 lateral cells of the ring gland that produce ecdysteroid molting hormone (EC).

80 eptor (EcR), functions as a receptor for the ecdysteroid molting hormones of insects.

81 urs at a characteristic concentration of the ecdysteroid molting hormones that regulate metamorphosis

82 Synthesis of ecdysteroids (molting hormones) by crustacean Y-organs i

83 The prepupal peak of ecdysteroids (molting hormones) triggers the regression

84 d by a combination of neuropeptide hormones, ecdysteroids (moulting hormones) and the isoprenoid, met

85 We use cultured tissues to show that ecdysteroids must be maintained above a sharp threshold

86 When exposed to low levels of ecdysteroid, NO production is stimulated and proliferati

87 ulture experiments indicate that the peak of ecdysteroids occurring at pupariation is required for th

88 Our results show the effect of ecdysteroids on MDR cancer cells for the first time.

89 signaling pathway, and the juvenile hormone/ecdysteroid pathway.

90 gulated CYP307A1 in the juvenile hormone and ecdysteroid pathways, respectively, were linked to accel

91 result from some cells 'misinterpreting' the ecdysteroid peaks that drive metamorphosis.

92 The results suggest that both neurons and ecdysteroids play an important regulatory role in adult

93 100-400 microg on column) but also the major ecdysteroids present in crude extracts of Silene otites,

94 ease in intracellular free Ca(2+) stimulates ecdysteroid production by crustacean molting glands (Y-o

95 dently stimulated yolk uptake by oocytes and ecdysteroid production by the ovaries at lower concentra

96 Ecdysteroid pulses trigger the major developmental trans

97 responses are thought to be mediated by the ecdysteroid receptor (EcR) and its heterodimeric partner

98 consisting of two nuclear hormone receptors, ecdysteroid receptor (EcR) and the retinoid X receptor h

99 traspiracle (USP), the obligatory functional ecdysteroid receptor (EcR) partner.

100 erived from the Drosophila melanogaster (Dm) ecdysteroid receptor (EcR)- and retinoid X receptor (RXR

101 s an obligatory dimerization partner for the ecdysteroid receptor (EcR).

102 yecdysone (20E) are dually controlled by the ecdysteroid receptor (EcR/USP) and products of ecdystero

103 ow that a transcriptional coactivator of the ecdysteroid receptor complex, FISC, acts as a functional

104 operative interaction between AaE74B and the ecdysteroid receptor is required for high-level expressi

105 secticidal activity via interaction with the ecdysteroid receptor proteins.

106 AaE74B and the ecdysteroid receptor synergistically enhanced 20E-induce

107 AHR38 also disrupts binding of ecdysteroid receptor to ecdysone response elements.

108 h is an obligatory partner in the functional ecdysteroid receptor, exists at the state-of-arrest as a

109 DHR78, which encodes another candidate ecdysteroid receptor, is also not required.

110 pendent activation of a reporter gene by the ecdysteroid receptor.

111 nuclear receptor isoforms are the only known ecdysteroid receptors, we show that the Ecdysone recepto

112 Ecdysteroids regulate a wide variety of cellular process

113 Ecdysteroids regulate many key developmental events in a

114 n the ecdysone biosynthetic pathway and that ecdysteroids regulate many late embryonic morphogenetic

115 Ecdysteroids regulate the remodeling of the dorsal exter

116 DHR78 protein is bound to many ecdysteroid-regulated puff loci, suggesting that DHR78 d

117 receptor, DHR78, functions at the top of the ecdysteroid regulatory hierarchies.

118 n rather than binding competition for the Vg ecdysteroid response element accounts for the inhibition

119 idermal growth factor signaling pathways, an ecdysteroid-response gene, cabut, and an ubiquitin-speci

120 Our results provide novel evidence for an ecdysteroid responsive gene in a crustacean that has man

121 This paper reports the cloning of an ecdysteroid responsive gene, HHR3, a potential Manduca s

122 the question of whether a similar cascade of ecdysteroid responsive genes exist in other members of A

123 Although EcR.USP-A recognizes the same ecdysteroid-responsive elements, EcR.USP-B binds them wi

124 lude that EcR/USP activation by the systemic ecdysteroid signal may be spatially restricted in vivo.

125 Ecdysteroid signaling in insects is transduced by a hete

126 monitor the temporal and spatial patterns of ecdysteroid signaling in vivo we established transgenic

127 Furthermore, we showed that ecdysteroid signaling is essential for the proper activa

128 In this study, we demonstrated that ecdysteroid signaling is operating in mature follicle ce

129 We provide evidence for a second ecdysteroid signaling pathway mediated by DHR38, the Dro

130 sis, providing a new tool for characterizing ecdysteroid signaling pathways during development.

131 Although ecdysteroid signaling regulates multiple steps in oogene

132 Initially, moderate levels of ecdysteroid stimulate proliferation.

133 f NO repression though, but also requires an ecdysteroid stimulatory pathway.

134 ervous systems (CNS) cultured with low or no ecdysteroids survive and continue to divide, whereas the

135 mol and testosterone (reported inhibitors of ecdysteroid synthesis and an EcR antagonist, respectivel

136 th decreased expression of genes involved in ecdysteroid synthesis and signaling.

137 mic hormone (CHH), which not only influences ecdysteroid synthesis but also water uptake during moult

138 ined hyperglycemia in vivo and repression of ecdysteroid synthesis in vitro.

139 stacean hyperglycaemic hormone (CHH) repress ecdysteroid synthesis of the target tissue (Y-organ) onl

140 nd cellular level by bioassay (inhibition of ecdysteroid synthesis), radioligand (receptor) binding a

141 lt-inhibiting hormone (MIH), which represses ecdysteroid synthesis; crustacean hyperglycaemic hormone

142 Molting is elicited by a critical titer of ecdysteroids that includes the principal molting hormone

143 lowed by betaFTZ-F1 mRNA expression when the ecdysteroid titer becomes low.

144 tly during the larval and pupal molts as the ecdysteroid titer begins to decline and again just befor

145 low levels and in the adult molt just as the ecdysteroid titer begins to decline.

146 sion patterns are correlated with changes in ecdysteroid titer during development.

147 ward pathway that amplifies or maintains the ecdysteroid titer during larval development, ensuring pr

148 In contrast, E75A mutants have a reduced ecdysteroid titer during larval development, resulting i

149 s transiently at the onset of the decline of ecdysteroid titer followed by betaFTZ-F1 mRNA expression

150 e in the larval and the pupal molts when the ecdysteroid titer has declined to low levels and in the

151 A and MHR3, whose mRNAs are induced when the ecdysteroid titer increases, the expression of MHR4 mRNA

152 s observed at the end of the instar when the ecdysteroid titer is high.

153 is seen in mid-third instar larvae when the ecdysteroid titer is low, and strong widespread activati

154 ng the development of the adult wings as the ecdysteroid titer is rising, and this increase was preve

155 s from a failure to induce the large rise in ecdysteroid titer that triggers metamorphosis.

156 were not well correlated with the hemolymph ecdysteroid titer, developmental expression and phosphor

157 nic stages, corresponding to a period of low ecdysteroid titer, while USP-B mRNA exhibits its highest

158 vitellogenic period, correlating with a high ecdysteroid titer.

159 rrelated with PTTH release and the hemolymph ecdysteroid titer.

160 , about the time of the premolt peaks in the ecdysteroid titer.

161 nearly disappears in mid-vitellogenesis when ecdysteroid titers are high.

162 uring pre- and postvitellogenic periods when ecdysteroid titers are low.

163 he spook (spo) locus result in low embryonic ecdysteroid titers, severe late embryonic morphological

164 d by interactions between rising and falling ecdysteroid titers, the pattern of expression of EcR iso

165 s the overgrowth and is a consequence of low ecdysteroid titers.

166 ds to the period of the moult cycle when the ecdysteroid titre is high.

167 reach a peak prior to that of the haemolymph ecdysteroid titre, supporting a role for the enzyme in d

168 ured primordia simply by adjusting levels of ecdysteroid to be above or below a critical threshold co

169 nile hormone, which acts in conjunction with ecdysteroids to control gene expression in insects.

170 n that it does not involve direct binding of ecdysteroids to either DHR38 or USP.

171 ring the third larval instar with defects in ecdysteroid-triggered developmental responses.

172 The ecdysteroids unequivocally identified in these extracts

173 , we have analyzed the activities of various ecdysteroids using gel mobility shift assays and transfe

174 nvolvement of hormone signaling by measuring ecdysteroids, which increase following cocaine exposure,

175 The observed bioactivity and composition of ecdysteroids will contribute to the future development o

176 gism or antagonism was observed by combining ecdysteroids with doxorubicin, and specific structure-ac

177 l-derived animal steroid hormones and insect ecdysteroids, with no known function in mammals.