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1                                   Ten 3 beta-ecgonine analogues were synthesized and characterized by
2                                              Ecgonine appears to hold the most promise as a diagnosti
3                     The SN2 reaction between ecgonine methyl ester (13) or appropriately substituted
4 ized from acetylsalicyloyl chloride (23) and ecgonine methyl ester (13).
5 e 2beta-alkyl derivatives were obtained from ecgonine methyl ester (17) through a series of reactions
6  from COC such as benzoylecgonine (BZE), and ecgonine methyl ester (EME).
7 abolites from COC [benzoylecgonine (BZE) and ecgonine methyl ester (EME)] are present.
8 es hydrolysis of cocaine to benzoic acid and ecgonine methyl ester acutely blocked cocaine seeking in
9  and LC/APCI-MS/MS was selected to determine ecgonine methyl ester and norcocaine in plasma collected
10 s of cocaine and norcocaine while increasing ecgonine methyl ester formation.
11 ct cocaine, benzoylecgonine, norcocaine, and ecgonine methyl ester to quantify the effect of DM-CocE
12 ccelerated catalysis, the hydrolysis product ecgonine methyl ester was increased >10-fold in plasma o
13 he first evidence that a compound (3-acetoxy ecgonine methyl ester) exists that prevents inhibition o
14 gonine, cocaine, and norcocaine) or 5 ng/mL (ecgonine methyl ester) to 1000 ng/mL in rat plasma.
15 ed on the transitions of m/z 200 to m/z 182 (ecgonine methyl ester), m/z 290 to m/z 168 (benzoylecgon
16 elevant cocaine metabolites benzoylecgonine, ecgonine methyl ester, and ecgonine, respectively.
17 tation of cocaine and its major metabolites (ecgonine methyl ester, benzoylecgonine, and norcocaine)
18                                     Cocaine, ecgonine methyl ester, norcocaine, cocaethylene, and mep
19 cocaine, and norcocaine was 2 ng/mL, and for ecgonine methyl ester, the LLQ was 5 ng/mL for plasma.
20 at the potencies of these 3 beta-substituted ecgonine methyl esters were dominated by steric effects
21 nonpsychoactive metabolites benzoic acid and ecgonine methylester.
22  benzoylecgonine, ecgonine methyl ester, and ecgonine, respectively.

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