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5 e 2beta-alkyl derivatives were obtained from ecgonine methyl ester (17) through a series of reactions
8 es hydrolysis of cocaine to benzoic acid and ecgonine methyl ester acutely blocked cocaine seeking in
9 and LC/APCI-MS/MS was selected to determine ecgonine methyl ester and norcocaine in plasma collected
11 ct cocaine, benzoylecgonine, norcocaine, and ecgonine methyl ester to quantify the effect of DM-CocE
12 ccelerated catalysis, the hydrolysis product ecgonine methyl ester was increased >10-fold in plasma o
13 he first evidence that a compound (3-acetoxy ecgonine methyl ester) exists that prevents inhibition o
15 ed on the transitions of m/z 200 to m/z 182 (ecgonine methyl ester), m/z 290 to m/z 168 (benzoylecgon
17 tation of cocaine and its major metabolites (ecgonine methyl ester, benzoylecgonine, and norcocaine)
19 cocaine, and norcocaine was 2 ng/mL, and for ecgonine methyl ester, the LLQ was 5 ng/mL for plasma.
20 at the potencies of these 3 beta-substituted ecgonine methyl esters were dominated by steric effects
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