ライフサイエンスコーパス: echinomycin

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1 sed to examine the conformational effects of echinomycin, a DNA bis-intercalating antibiotic, on line

2 Echinomycin, a ligand with a bisintercalative binding mo

3 Echinomycin, a member of the quinoxaline family of antib

4 mplexes containing different drugs including echinomycin, actinomycin-D, ethidium bromide, Hoechst 33

5 tranded DNA is not inhibited indicating that echinomycin acts by interacting with the DNA and not the

6 ts that direct molecular recognition between echinomycin and DNA, mediated by hydrogen bonding and va

7 respectively, L1210 cell line) comparable to echinomycin and one analogue, which bears the luzopeptin

8 Both inhibition of HIF-1 DNA binding by echinomycin and RNA interference of HIF-1alpha synthesis

9 mportantly, in mice with complete remission, echinomycin appeared to completely eliminate LICs becaus

10 portantly, in X.laevis embryos injected with echinomycin at the two-cell stage the drug specifically

11 which the 2-amino group that is crucial for echinomycin binding has been added or removed, respectiv

12 The structural perturbations induced when echinomycin binds to closed circular duplex pBR322 DNA w

13 available among the different DNA fragments; echinomycin binds to TpD sites much more tightly than to

14 high-affinity bisintercalation analogous to echinomycin, but with little or no perceptible sequence

15 poxia-inducible factor (HIF)1alpha inhibitor echinomycin can be used to treat relapsed AML without af

16 In the presence of increasing echinomycin concentration, the plasmid can be seen to pr

17 We show that echinomycin cured 40% to 60% of mice transplanted with r

18 The oxidation of echinomycin/DNA complexes containing duplexes with diffe

19 Evidence is presented that echinomycin interferes with chromatin decondensation, nu

20 About 66 echinomycin molecules are able to bind to each fragment,

21 One of the most potent compounds identified, echinomycin (NSC-13502), a small-molecule known to bind

22 In the case of echinomycin only one purine 2-amino group is required fo

23 t in a mouse model of relapsed AML, low-dose echinomycin selectively targets LICs and spares normal h

24 rcalating antibiotics (e.g., triostine A and echinomycin), the detailed interactions between those tw

25 ve examined the binding of actinomycin D and echinomycin to artificial DNA molecules asymmetrically s

26 Here we study the effect of echinomycin upon DNA replication using egg extracts and

27 For the association of echinomycin with DNA, we found DeltaG degrees = -7.6 kca

28 lative interaction of the peptide antibiotic echinomycin with DNA.

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