ライフサイエンスコーパス: ecto-apyrase

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1 ted ecto-apyrase and the tunicamycin-treated ecto-apyrase.

2 ne encodes the first reported human secreted ecto-apyrase.

3 ut not in the glandular cells containing the ecto-apyrase.

4 on immune cells suggests that CD39 may be an ecto-apyrase.

5 as HB6 and CD39L3) is a membrane-associated ecto-apyrase.

6 Finally, we show that CD39 indeed has ecto-apyrase activity by expression in COS-7 cells.

7 The coincidence between CD39 expression and ecto-apyrase activity on immune cells suggests that CD39

8 sion chromatography of detergent-solubilized ecto-apyrase and cross-linking of membrane-bound ecto-ap

9 at the stomach 80-kDa protein isolated is an ecto-apyrase and is related to both the chicken liver an

10 contrast to the enzymatically deglycosylated ecto-apyrase and the tunicamycin-treated ecto-apyrase.

11 Anti-ecto-apyrase antibody detected a single 80-kDa band (put

12 he results suggest that the ecto-ATPases and ecto-apyrases are part of, or closely related to, the ac

13 ocalization of extracellular ecto-ATPase and ecto-apyrase (ATPDase) in adult chicken gizzard and stom

14 he N-terminal sequence of the 80-kDa stomach ecto-apyrase band (which reacted with anti-ecto-ATPDase

15 These results clearly suggest that GS52 ecto-apyrase catalytic activity is critical for the earl

16 NA analysis revealed an increase in CD73 and ecto-apyrase CD39 in hypoxic epithelial cells.

17 lar results were obtained with another human ecto-apyrase, CD39, suggesting that the importance of gl

18 an 187 to alanine yielded a poorly expressed ecto-apyrase completely devoid of nucleotidase activity.

19 se data suggest a critical role for the GS52 ecto-apyrase during nodulation.

20 The glycosylated ecto-apyrase exists as a homodimer in situ as assessed b

21 The human ecto-apyrase gene family consists of five reported membe

22 important role for the soybean (Glycine max) ecto-apyrase GS52 in rhizobial root hair infection and r

23 The cDNA encoding a human ecto-apyrase (HB6), predicted to have seven N-linked gly

24 e fractions, but the antibody did not detect ecto-apyrase in immunolabeled gizzard cryosections.

25 Overexpression of the GS52 ecto-apyrase in Lotus japonicus increased the level of r

26 -apyrase and cross-linking of membrane-bound ecto-apyrase, in contrast to the enzymatically deglycosy

27 strated homology with other ecto-ATPases and ecto-apyrases, including those from the parasitic protoz

28 Ecto-apyrase is enriched in brain postsynaptic density m

29 re present throughout the brain suggest that ecto-apyrase is involved in regulating synaptic transmis

30 We also partially purified the ecto-apyrase of chicken stomach, an 80-kDa membrane glyc

31 We have shown that ecto-apyrase protein is expressed in primary neurons and

32 ent immunohistochemical studies showing that ecto-apyrase protein is widely distributed in rat brain,

33 The two transmembrane domains of CD39 ecto-apyrase regulate the formation of fully active homo

34 Immunolocalization of this active mutant ecto-apyrase revealed a cellular pattern similar to that

35 ibition by azide, a more potent inhibitor of ecto-apyrases than ecto-ATPases.

36 (R146P) essentially converted the eNTPDase-3 ecto-apyrase to an ecto-ATPase (eNTPDase-2), mainly by d

37 of an E-type ATPase essentially converts an ecto-apyrase to an ecto-NTPase.

38 se specific activity of the purified stomach ecto-apyrase was 75,000 micromol of Pi/mg of protein/h,

39 The ecto-apyrase was also expressed in the presence of tunic

40 protein 70/sugar kinase superfamily, a human ecto-apyrase was analyzed by site-directed mutagenesis o

41 In adult chicken stomach, the ecto-apyrase was observed at the apical membrane of the

42 A human brain E-type ATPase (HB6 ecto-apyrase) was subjected to site-directed mutagenesis

43 GS52, a soybean (Glycine soja) ecto-apyrase, was previously shown to be induced very ea

44 of tryptophan 459 to alanine resulted in an ecto-apyrase with enhanced NTPase activity, but diminish

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