ライフサイエンスコーパス: ectodomain

1 ing that dimerization occurs through CDCP1's ectodomain.

2 structure of the prefusion form of the HeV F ectodomain.

3 troduced at various locations throughout the ectodomain.

4 valently associated subunits, gp120 and gp41 ectodomain.

5 ids 504-505 of APP695, releasing a truncated ectodomain.

6 nd WR, which differ by two residues in the F ectodomain.

7 N-terminal domains I and II of the HSV-1 gH ectodomain.

8 complete 61 domains of the full-length LRP1 ectodomain.

9 acid inhibitory tract from the gamma-subunit ectodomain.

10 equires a more C-terminal portion of the APP ectodomain.

11 n causes an amino acid exchange in the CERK1 ectodomain.

12 finity similar to that of the wild-type DDR1 ectodomain.

13 sis at the cell surface to release a soluble ectodomain.

14 these structures span the entire gamma-Pcdh ectodomain.

15 r the Pd-enhancing function mediated by a Pd ectodomain.

16 how that IDA is sensed directly by the HAESA ectodomain.

17 tic release of the transmembrane TNF (tmTNF) ectodomain.

18 teins that contain varying numbers of TNFRSF ectodomains.

19 DAM family, leading to the shedding of their ectodomains.

20 homo- and heterotypic contact sites in their ectodomains.

21 SDC4 and HS are shed as intact proteoglycan ectodomains.

22 p governs dissociation of the nectin-4 and H ectodomains.

23 rry an agonistic sequence within their large ectodomains.

24 rface for proper assembly and display of the ectodomains.

25 s of PlxnA (PlxnA1, PlxnA2, and PlxnA4) full ectodomains.

26 Interestingly, the ectodomain, a region that carries the functional domain

27 er structural analyses suggest that all CNTN ectodomains adopt a bent conformation and might lie para

28 scopy, we show that the integrin alpha5beta1 ectodomain adopts extended-closed and extended-open conf

29 dy against PVRL3 or prebinding TcdB to PVRL3 ectodomain also inhibited cytotoxicity in cell culture.

30 RSV A2 recombinant unglycosylated G protein ectodomain (amino acids 67 to 298) expressed in Escheric

31 nducing proteolytic cleavage of the receptor ectodomain, an event that requires ligand to be endocyto

32 ike kinases, which comprise a ligand-binding ectodomain and an intracellular kinase domain, or recept

33 te metalloprotease access to the substrates' ectodomain and cleavage.

34 We inferred that the ectodomain and CTD have protein interfaces that have to

35 , we engineer a pre-fusion-stabilized hMPV F ectodomain and determine its crystal structure to 2.6 A

36 results also showed that purified syndecan-1 ectodomain and heparan compounds containing 2-O-sulfate

37 rthermore, we found that purified syndecan-1 ectodomain and heparan compounds containing 2-O-sulfate

38 Fabs from these MAbs bind a soluble EBOV GP ectodomain and that MAbs c2G4 and c4G7, but not c13C6, n

39 that block the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain.

40 rocess depends on the length of the extended ectodomain and the tethered agonist of the receptor, but

41 e substitutions at every residue of the gp41 ectodomain, and 362 space-filling residue substitutions

42 toplasmic domain, a transmembrane domain, an ectodomain, and a C-terminal membrane anchor.

43 methionine- and histidine-rich metal-binding ectodomain, and it exhibits reduced Cu(+) transport acti

44 t with receptors ANXUR1 and ANXUR2 via their ectodomains, and both sets of receptors bind RALF4 and R

45 Overall, ectodomain architecture influences the sequence and func

46 s ligand specificities are affected by their ectodomain architectures.

47 S, indicating that the effects of syndecan-1 ectodomain are structure-based.

48 oil helices, to a postfusion state where the ectodomains are arranged as a trimer of helical hairpins

49 In the postconfluent state, when CD31 ectodomains are homophilically engaged, NEU1 was recruit

50 ded tetherin model, in which the coiled-coil ectodomains are oriented perpendicular with respect to t

51 processed proforms on cell bodies, and their ectodomains are shed by metalloproteinases in response t

52 Thus these dimeric rsFcgammaR ectodomains are validated, defined probes that should pr

53 y yeast-surface display to engineer the PD-1 ectodomain as a high-affinity (110 pM) competitive antag

54 The shed ectodomain assembled ligand independently in a homotypic

55 ations suggested that more flexible cadherin ectodomains at lower Ca(2+) concentration alternated bet

56 affinity caused by perturbations outside the ectodomain binding site.

57 R spectroscopy that a water-soluble 6HB gp41 ectodomain binds to zwitterionic detergents that contain

58 Purified PVRL3 ectodomain bound to TcdB by pull-down.

59 we show the crystal structure of the HCMV gB ectodomain bound to the Fab fragment of 1G2, a neutraliz

60 ceded by shedding of most of the substrate's ectodomain by alpha- or beta-secretases.

61 DAR activity is required for shedding of its ectodomain by metalloproteinases.

62 As with the isolated ectodomain, c13C6 bound to the glycan cap, whereas c2G4

63 Expression of the Tmem2 ectodomain can rescue aspects of the MZtmem2 phenotype,

64 While loss of Tie2 ectodomain can suppress Angpt1 signalling locally in the

65 C-type lectin family 14, member A (CLEC14A) ectodomain, catalyzed by rhomboid-like 2 protein (RHBDL2

66 ion or TNF-alpha led to Tie1 inactivation by ectodomain cleavage and promoted the Tie2 antagonist act

67 Ectodomain cleavage by A-disintegrin and -metalloproteas

68 Ectodomain cleavage occurs, however, on the outside of t

69 metalloproteinase) proteases are involved in ectodomain cleavage of transmembrane proteins, and ADAM1

70 amphiregulin (AREG), epiregulin (EREG), and ectodomain cleavage protease MMP1, which is mediated by

71 This receptor can undergo regulated ectodomain cleavage that releases the ligand-binding dom

72 essential pre-condition for their regulated ectodomain cleavage.

73 a direct and rate-limiting step in the Ctr1 ectodomain cleavage.

74 We find that the MIC2-M2AP ectodomain complex is a highly elongated 1:1 monomer wit

75 beta1 legs, activate, and stabilize extended ectodomain conformations.

76 The HCV E2 ectodomain core features a globular architecture with an

77 We postulate that an excess of BAK1 or its ectodomain could trigger immune receptor activation in t

78 After shedding of this ectodomain, CTF-eta is further processed by ADAM10 and B

79 l structure of the human calcitonin receptor ectodomain (CTR ECD) in complex with a truncated analogu

80 by GP, VP40, and BST2 together requires the ectodomain cysteines needed for BST2 dimerization, the p

81 ariants, including the one lacking all three ectodomain cysteines, retained the ability to form non-c

82 he structure of a mouse coronavirus S trimer ectodomain determined at 4.0 A resolution by single part

83 Our model describes E1-E2 ectodomain dimerization interfaces, provides a structura

84 N211Q traffics to the cell surface, and its ectodomain displays collagen I binding with an affinity

85 The HIV gp41 ectodomain (e-gp41) is an attractive target for the deve

86 Recombinant EBOV-GP ectodomain (EBOV-GP1,2ecto) expressed in mammalian cells

87 We also observed that, overexpression of ectodomain (ECD) of Il-1Rrp2 or IL-1RAcP exhibited domin

88 P. aeruginosa flagellin engaged the MUC1 ectodomain (ED), increasing NEU1 association with MUC1.

89 The BST-2 ectodomain encodes three cysteine residues in its N-term

90 merization arm confirmed a critical role for ectodomain engagement in ligand-independent signaling.

91 Here, we examined how syndecan-1 ectodomain enhances Staphylococcus aureus virulence in i

92 hereas administration of purified syndecan-1 ectodomain enhances virulence, suggesting that bacteria

93 the role in pH sensing of two regions of the ectodomain enriched in acidic residues: the acidic pocke

94 screened peptide libraries derived from the ectodomain for agonistic activity on the receptors.

95 he importance of cysteine positioning on the ectodomain for functional dimerization of BST-2.

96 The mean substitution rate of the G ectodomain for the Kilifi data set was estimated at 3.58

97 surface NgR1 by MT3-MMP generates a soluble ectodomain fragment that accelerates the formation of ex

98 s cleaved by proteases to generate a soluble ectodomain fragment, termed sEcad, which is elevated in

99 Here we report crystal structures of ectodomain fragments comprising cell-cell recognition re

100 evealing trans-homodimers, and of C-terminal ectodomain fragments from gamma-Pcdhs gammaA4 and gammaB

101 A small hydrophobic region in the TM ectodomain from amino acid residues 118 to 132, the hydr

102 the crystal structure of the Gn glycoprotein ectodomain from the Asiatic Hantaan virus (HTNV), the mo

103 The shedding of its ectodomain from the cell surface is physiologically regu

104 Crystal structures of ectodomains from Dsg2 and Dsg3 and from Dsc1 and Dsc2 sh

105 Biophysical studies showed that Pcdh ectodomains from gammaB-subfamily isoforms formed cis di

106 hemical binding studies with purified LjLYS6 ectodomains further showed that at least six GlcNAc moie

107 ins made of functional E-, N-, or P-cadherin ectodomains fused to the Fc fragment of immunoglobulin (

108 RSV) fusion protein (F) and glycoprotein (G) ectodomains fused to the transmembrane and cytoplasmic d

109 ble linker (FL20) between the gp120 and gp41 ectodomain (gp41ECTO) subunits to make the uncleaved 92U

110 Moreover, peptide P1 from the PEDF-R ectodomain had affinity for the 44-mer and a shorter fra

111 al structure of FSH bound to the entire FSHR ectodomain has been instrumental in more clearly definin

112 of three strongly conserved residues in the ectodomain has no effect on targeting or fusion, althoug

113 ides that interact with the insulin receptor ectodomain have been discovered by phage display and rep

114 , the pro-pathogenic functions of syndecan-1 ectodomain have yet to be clearly defined.

115 partial crystal structures of the E1 and E2 ectodomains have been determined.

116 while ignoring the same cysteine-containing ectodomains if not anchored at the ER membrane.

117 This work reveals a 2-fold role of the PlxnA ectodomains: imposing a pre-signaling autoinhibitory sep

118 lution structures of the trimeric MERS-CoV S ectodomain in complex with G4, a stem-directed neutraliz

119 , we report the crystal structure of the DR6 ectodomain in complex with the E2 domain of APP and show

120 m of inhibition, we crystallized alphaVbeta3 ectodomain in complex with the Fab fragment of 17E6.

121 llowed by the appearance of the soluble GPVI ectodomain in the plasma.

122 our findings unravel a new role for the BAK1 ectodomain in the tight regulation of Arabidopsis immune

123 O) and its receptor (EpoR), to dimerize EpoR ectodomains in non-native architectures.

124 ient cleavage of substrates retaining longer ectodomains, indicating that nicastrin actively excludes

125 uited for catalysis when its remaining short ectodomain interacts with the nicastrin component of gam

126 39, T140, S143, and T144) that reside in the ectodomain interface and the proline at position 148, wh

127 could be a driving force for stabilizing the ectodomain interface through formation of a hydrogen-bon

128 ial cells induces shedding of the P-selectin ectodomain into the circulation.

129 t of gamma-secretase, we find that substrate ectodomain is entirely dispensable for cleavage.

130 The receiver ectodomain is not required, but phosphorylation in trans

131 Our results indicate that extension of the ectodomain is possible without separating the legs or ex

132 The crystal structure of the OSCAR ectodomain is presented, both free and in complex with a

133 ogenesis in the absence of rhizobia, but its ectodomain is required for proper symbiont colonization.

134 t of a novel tetramer of the E2 glycoprotein ectodomain (J6, genotype 2a strain), which allowed us to

135 mational change that consequently unfolds an ectodomain loop required for dimerization indirectly.

136 and 3 has been mapped to its three different ectodomains (loops 1, 3, and 6) exposed at the surface o

137 al and biophysical assays and find the IGF1R ectodomain maintains an autoinhibited state in which the

138 ad to the extracellular deposition of NOTCH3 ectodomain (Notch3(ECD) ) on the vessels.

139 20.6 gp140 trimer, the soluble and uncleaved ectodomain of (gp160)3, retains many antigenic propertie

140 nteraction and define the domains within the ectodomain of AAVR that facilitate this interaction.

141 se (PKD) repeat domain (PKD2) present in the ectodomain of AAVR.

142 s library possessing random mutations in the ectodomain of an H5 HA (altered to bind human-type recep

143 Soluble Klotho (sKlotho) is the shed ectodomain of antiaging membrane Klotho that contains 2

144 A recombinant soluble protein comprising the ectodomain of Apo2 ligand/TNF-related apoptosis-inducing

145 agonist, we found that it also binds to the ectodomain of APP.

146 r domain of Axl at the interface of the Ig-1 ectodomain of Axl and the Lg-1 of Gas6.

147 cture of antibody 17B1.3 in complex with the ectodomain of B7-H6 to 2.5A resolution.

148 e effects were mirrored by expression of the ectodomain of cancer-associated mucin MUC1.

149 to CD36, we characterized FA binding to the ectodomain of CD36 by the biophysical method surface pla

150 Regulated shedding of the ectodomain of cell membrane proteins by proteases is a c

151 Our data show that the ectodomain of CLEC14A regulates sprouting angiogenesis a

152 We present here the structure of the entire ectodomain of desmosomal cadherin desmoglein 2 (Dsg2), u

153 This structure reveals that the ectodomain of Dsg2 is flexible even in the calcium-bound

154 Novel alterations in the ectodomain of EGFR were identified in patients with acqu

155 Expression of GM-CSF and the ectodomain of FcgammaIIIA receptor led to approximately

156 in and metalloprotease (ADAM) 17 cleaved the ectodomain of FcgammaRIIIA/CD16A and a peptide for which

157 HPV PsV expressing a secreted ectodomain of gB (gBsec) or gD (gDsec), but not PsV expr

158 ted by lysines, in contrast to gp120 and the ectodomain of gp41.

159 The ectodomain of GPVI was shown to bind to immobilized mono

160 Thus, the ectodomain of HAP2 is essential for its surface expressi

161 ural homology modeling, we now show that the ectodomain of HAP2 orthologs from Tetrahymena thermophil

162 panel of monoclonal antibodies (MAbs) to the ectodomain of HKU1 spike protein.

163 The ectodomain of KIM-1 is shed into the lumen, and serves a

164 crystal structure of the trimeric, prefusion ectodomain of Lassa GP bound to a neutralizing antibody

165 vaccines targeting both HA and the conserved ectodomain of matrix protein 2 (M2e) would provide prote

166 ain of influenza virus hemagglutinin and the ectodomain of matrix protein.

167 nctional and translational evidence that the ectodomain of membrane-bound ephrin-B2 is shed from fibr

168 ss this discrepancy, we expressed the entire ectodomain of mouse P-selectin as a monomer (sP-selectin

169 Introduction of the shed ectodomain of NgR1 is sufficient to accelerate excitator

170 artially deglycosylated form of the 3-domain ectodomain of Pvr at a 4-A resolution, as determined by

171 valent complex between FVIIa and the soluble ectodomain of TF (sTF) was engineered by introduction of

172 Soluble klotho, the shed ectodomain of the antiaging membrane protein alpha-kloth

173 order to propose an in silico model for the ectodomain of the E1E2 heterodimer.

174 codons represented at most positions in the ectodomain of the E2 gene.

175 The uncleaved ectodomain of the envelope protein, called gp140, has al

176 The ectodomain of the P2X receptor is formed mainly from two

177 tinic receptors in vitro, as did full length ectodomain of the rabies virus glycoprotein.

178 ar domain modification communicates with the ectodomain of the substrate to allow for cleavage to occ

179 s, a single-amino-acid change (T568I) in the ectodomain of the TM subunit was sufficient to confer Vp

180 e that inflammation promotes cleavage of the ectodomain of Tie1 and that this cleavage event correspo

181 n extracellular protein, associated with the ectodomain of TLR4, that plays a critical role in the re

182 lipid nucleic acid complexes (CLNCs) and the ectodomain of WEEV E1 protein (E1ecto).

183 HIV-1 gp140 trimers-the uncleaved ectodomains of (gp160)3-from a few selected viral isolat

184 Furthermore, we showed that soluble ectodomains of both type I and type III NRG1 significant

185 The ectodomains of the three proteins bind cooperatively.

186 An essential activity of the ectodomains of these proteins is the specific recognitio

187 as of a yet undefined region with a distinct ectodomain on the PEDF receptor (PEDF-R).

188 However, in non-Pd GPI-APs, the ectodomain overrides the Pd targeting function of the GP

189 wever, the function of the diffusible p75NTR ectodomain (p75ECD) after shedding remains largely not k

190 at the gH cytotail, in addition to the gH/gL ectodomain, plays an essential role in gB activation, po

191 8 types of vertebrate TLRs showed that their ectodomains possessed three types of architectures: a si

192 Although the structure of the gB ectodomain postfusion conformation has been determined,

193 of recombinant unglycosylated RSV G protein ectodomain produced in E. coli (in presence and absence

194 RSV A2 recombinant unglycosylated G protein ectodomain produced in E. coli (REG) and those of glycos

195 a) and the corresponding N-terminal-secreted ectodomain product sAPPalpha.

196 We found that syndecan-1 ectodomain promotes S. aureus corneal infection in an HS

197 Accordingly, administration of the HVEM ectodomain protein (solHVEM((P37-V202))) binds BTLA and

198 production of isolated domains of multimeric ectodomain proteins has proven difficult, we report a me

199 s a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectivel

200 e report crystal structures of Sdk1 and Sdk2 ectodomain regions, revealing similar homodimers mediate

201 and specifically the orientation of the EGFR ectodomain relative to the membrane.

202 suggesting that bacteria subvert syndecan-1 ectodomains released by shedding for their pathogenesis.

203 in the C-terminal Ig-like domain (D5) of the ectodomain, rendering KIT tyrosine kinase activity const

204 ists in stabilizing the overall shape of TLR ectodomains responsible for ligand recognition.

205 RHBDL4 cleaves APP multiple times in the ectodomain, resulting in several N- and C-terminal fragm

206 The crystal structure of the CD300lf ectodomain reveals a potential ligand-binding cleft comp

207 The 2.3-A crystal structure of the LjLYS6 ectodomain reveals three LysM betaalphaalphabeta motifs

208 Ca(2+) ions are critical to cadherin ectodomain rigidity, which is required for the activatio

209 ecombinant soluble (rs) dimeric low-affinity ectodomains (rsFcgammaR) that have an absolute binding r

210 cleaved, resulting in secretion of its large ectodomain (sec49K).

211 osa, where proteolytic cleavage releases the ectodomain (secretory component [SC]) as an integral com

212 lia to mucosal secretions, where the cleaved ectodomain (secretory component; SC) becomes a component

213 se structural substrate changes that enhance ectodomain sensitivity of neuregulin-1 (NRG1; epidermal-

214 etermined structure suggests that the HCV E2 ectodomain shares structural and functional similarities

215 ecretase selectively recognizes and recruits ectodomain-shed substrates for catalysis remains unclear

216 gulate the maturation of the multi-substrate ectodomain sheddase enzyme ADAM17 (TACE) in macrophages.

217 ADAM17 is an ectodomain sheddase that can modulate the signaling acti

218 h impaired (DeltaShed-TbetaRIII) or enhanced ectodomain shedding (SS-TbetaRIII).

219 Surface ectodomain shedding affects numerous biological processe

220 egulated intramembrane proteolysis, in which ectodomain shedding and subsequent intramembrane cleavag

221 d murine IL-23R as novel targets for protein ectodomain shedding by ADAM10 and ADAM17.

222 ral signaling pathway molecules that undergo ectodomain shedding by ADAMs [e.g., ligands and receptor

223 both the transient thrombocytopenia and GPVI ectodomain shedding depend on the Fc portion of the anti

224 xns with postsynaptic Nlgn1 or inhibition of ectodomain shedding in axonal Nrxn1-beta increases presy

225 Ectodomain shedding is crucial for receptor signaling an

226 One of the main proteases responsible for ectodomain shedding is disintegrin and metalloproteinase

227 s' roles by novel Col13a1tm/tm mice in which ectodomain shedding is impaired.

228 ransferase (GalNAc-T) isoforms to coregulate ectodomain shedding mediated by the A Disintegrin And Me

229 different cancer entities released B7-H6 by ectodomain shedding mediated by the cell surface proteas

230 tion of L-selectin and better understand how ectodomain shedding might contribute to TEM.

231 Ectodomain shedding occurs in the immediate extracellula

232 Ectodomain shedding of both human and mouse RAGE was dep

233 at collagen binding induces ADAM10-dependent ectodomain shedding of DDR1.

234 Inhibiting ectodomain shedding of Dsg2 with the matrix metalloprote

235 Ectodomain shedding of glycoprotein (GP) Ibalpha is thou

236 ases ADAM10 and ADAM17 can produce sgp130 by ectodomain shedding of gp130, even though this mechanism

237 Here, ectodomain shedding of human and murine IL-23R was ident

238 ly, IL-3 decreases soluble RANKL by reducing ectodomain shedding of membrane RANKL through downregula

239 eolytically active ADAMs are responsible for ectodomain shedding of membrane-associated proteins.

240 This induces ectodomain shedding of metalloprotease-sensitive cell su

241 Here we observed that ectodomain shedding of RAGE is critical for its role in

242 hat following TNF-converting enzyme-mediated ectodomain shedding of TNF type I receptor (TNFR1), the

243 Ectodomain shedding of transmembrane precursor proteins

244 or matrix, and mouse plasma, indicating that ectodomain shedding of VLDLR occurs endogenously.

245 share the same subcellular distribution and ectodomain shedding properties.

246 VLDLRII displayed a higher ectodomain shedding rate and a more potent inhibitory ef

247 but not VLDLRII, determined the differential ectodomain shedding rates.

248 nd transmembrane molecule, it also undergoes ectodomain shedding to become a synaptic basal lamina co

249 nges, we identified critical determinants of ectodomain shedding within the stalk region of the IL-23

250 y cleaved from the plasma membrane (known as ectodomain shedding), with little knowledge of the timin

251 AGE splice variant 4), which is resistant to ectodomain shedding, inhibited RAGE ligand dependent cel

252 immunodepletion predominantly occurs through ectodomain shedding, which is accompanied by a transient

253 ar regulation of Wnt signaling through VLDLR ectodomain shedding.

254 tion) might represent a general principle in ectodomain shedding.

255 plasmic domain and did not require TbetaRIII ectodomain shedding.

256 der role of site-specific O-glycosylation in ectodomain shedding.

257 RTC2.2 itself is a target for P2X7-triggered ectodomain shedding.

258 omain in regulating ADAM10-dependent protein ectodomain shedding.

259 eogenin and allowing this protease to induce ectodomain shedding.

260 NFRI) from the surface of senescent cells by ectodomain shedding.

261 C-terminal fragments (Nrxn-CTF) generated by ectodomain shedding.

262 embrane proteins are sequentially cleaved by ectodomain-shedding alpha-secretases and the gamma-secre

263 ary, this investigation of the complete LRP1 ectodomain significantly advances our understanding of t

264 constructed to contain mutant RSV F protein ectodomains stabilized in prefusion (pre-F/F) or postfus

265 6 cleavage takes place in the juxta-membrane ectodomain stretch of twelve amino acids that generates

266 vealed that the L858R kinase mutation alters ectodomain structure such that unliganded mutant EGFR ad

267 All our PlxnA ectodomain structures show autoinhibitory, intermolecula

268 cis-dimerization mutations to the C-terminal ectodomain structures.

269 tor protein tyrosine phosphatases with large ectodomains, such as CD45.

270 rs, or mainly via shedding of their secreted ectodomains, such as neurotrophic APPsalpha.

271 , regulation could be conferred to a foreign ectodomain, suggesting a common higher-order structure.

272 A number of endoglin ectodomain-targeting antibodies (Abs) can effectively su

273 racking to measure the diffusion of cadherin ectodomains tethered to supported lipid bilayers at vary

274 ctions are mediated by both the secreted APP ectodomain that acts as a neurotrophic factor and full-l

275 age event in the juxtamembrane region of the ectodomain that generated a dominant-negative form of TL

276 eavage sites, we isolated an uncleaved RSV F ectodomain that is predominantly monomeric and requires

277 However, in acute endotoxemia, the Tie1 ectodomain that is responsible for interaction with Tie2

278 s Golgi transport of a chimera with a native ectodomain that passes the luminal quality control scrut

279 e we report the crystal structure of the m04 ectodomain, thereby providing insight into this large im

280 gression, and c-Met is released as a soluble ectodomain through ADAM10- and ADAM17-mediated cleavage,

281 have hindered structural studies of the full ectodomain, thus preventing a molecular understanding of

282 cumsporozoite protein (CSP) exposed the SSP3 ectodomain to antibodies in some sporozoites.

283 on chromatography analysis of recombinant HA ectodomain to compare the differences among recombinant

284 e, and crystallography of the ligand-binding ectodomain to establish receptor homology models.

285 ere, we show that postsynaptic SDC2 uses its ectodomain to interact with and facilitate dendritic fil

286 FcgammaRs, the binding of dimeric rsFcgammaR ectodomains to Ab immune complexes was affected by Ab su

287 the overall charge of HS, permits syndecan-1 ectodomains to promote S. aureus corneal infection by in

288 oned M protein at the boundaries between the ectodomain, transmembrane domains, or endodomain.

289 Ligand binding to the receptor ectodomain triggers tyrosine autophosphorylation of the

290 r-packaging signal, and (iii) secreted pre-F ectodomain trimer.

291 Whether beta1 integrin ectodomains visit conformational states similarly to bet

292 bstitution (D122N) in the IgV-core of the gD ectodomain was impaired on nectin-1-bearing cells.

293 led that the plasma membrane-associated BAK1 ectodomain was sufficient to induce autoimmunity, indica

294 tic drug cisplatin via direct binding to the ectodomain, we demonstrate that the combination of cispl

295 ght ligands, whose binding sites in the HARE ectodomain were mapped by competition studies.

296 protease that cleaves the Ctr1 metal-binding ectodomain, which functions to regulate cellular Cu(+) a

297 ion is mediated by a soluble form of NRX-1's ectodomain, which is released from the post-synaptic mem

298 cture of the N-terminal domain of the HCV E1 ectodomain, which reveals a complex network of covalentl

299 re the X-ray crystal structure of the ADAM10 ectodomain, which, together with biochemical and cellula

300 Chimeric molecules of human CD4 ectodomain with WC1 endodomains transfected into Jurkat