ライフサイエンスコーパス: ectodomain shedding

1 hr(735), which is required for TACE-mediated ectodomain shedding.

2 novel trans-subunit mechanism for regulating ectodomain shedding.

3 sPmel17 is released by regulated proteolytic ectodomain shedding.

4 ntly down-regulated from the cell surface by ectodomain shedding.

5 ein interactions instead of membrane protein ectodomain shedding.

6 oject was to determine the mechanism of Sdc1 ectodomain shedding.

7 uster at an early stage and elicits nectin-1 ectodomain shedding.

8 ls with exogenous MMP-9 catalyzed E-cadherin ectodomain shedding.

9 lustering on proteinase-catalyzed E-cadherin ectodomain shedding.

10 of the receptor is rapidly down-regulated by ectodomain shedding.

11 ar regulation of Wnt signaling through VLDLR ectodomain shedding.

12 l surface can be cleaved in a process termed ectodomain shedding.

13 proteinase-mediated, phorbol ester-inducible ectodomain shedding.

14 can completely block PMA-induced syndecan-1 ectodomain shedding.

15 not capable of defining the requirements of ectodomain shedding.

16 induces EGFR transactivation through HB-EGF ectodomain shedding.

17 heart development, neurogenesis, and protein ectodomain shedding.

18 cell surface by autocatalytic processing and ectodomain shedding.

19 es that MT1-MMP is regulated by a process of ectodomain shedding.

20 from membrane-spanning receptor isoforms by ectodomain shedding.

21 plasma membrane in a process termed protein ectodomain shedding.

22 nderstood how PMA activates TACE and induces ectodomain shedding.

23 long been known as a potent agent to enhance ectodomain shedding.

24 at nitric oxide (NO) activates TACE-mediated ectodomain shedding.

25 state 13-acetate, a known inducer of protein ectodomain shedding.

26 ransmembrane domains are key determinants of ectodomain shedding.

27 beta-APP rendered betaglycan susceptible to ectodomain shedding.

28 tion) might represent a general principle in ectodomain shedding.

29 plasmic domain and did not require TbetaRIII ectodomain shedding.

30 der role of site-specific O-glycosylation in ectodomain shedding.

31 RTC2.2 itself is a target for P2X7-triggered ectodomain shedding.

32 omain in regulating ADAM10-dependent protein ectodomain shedding.

33 eogenin and allowing this protease to induce ectodomain shedding.

34 NFRI) from the surface of senescent cells by ectodomain shedding.

35 C-terminal fragments (Nrxn-CTF) generated by ectodomain shedding.

36 nly generated by ADAM10- and ADAM17-mediated ectodomain shedding.

37 unction of coiled coils in the regulation of ectodomain shedding.

38 xtracellular domain of Klotho is secreted by ectodomain shedding.

39 ed new light on the unexpected complexity of ectodomain shedding.

40 CERK1 undergoes ectodomain shedding, a well-known process in animal cell

41 phosphorylation and metalloprotease-mediated ectodomain shedding, activating phosphoinositide-3-kinas

42 identify a novel mechanism by which sortilin ectodomain shedding acts as a regulatory switch for deli

43 Surface ectodomain shedding affects numerous biological processe

44 embrane proteins are sequentially cleaved by ectodomain-shedding alpha-secretases and the gamma-secre

45 Sortilin is modified by ectodomain shedding, although the biological implication

46 hown to involve: 1) metalloprotease-mediated ectodomain shedding and gamma-secretase-mediated intrame

47 of different activities involved in protein ectodomain shedding and has implications for the functio

48 at ROS production is involved in PMA-induced ectodomain shedding and implicate a role for ROS in othe

49 dergoes sequential proteolytic processing by ectodomain shedding and intramembrane proteolysis.

50 This is a process referred to as ectodomain shedding and is implicated in the process of

51 kinase C regulated, metalloprotease-mediated ectodomain shedding and is the substrate for gamma-secre

52 omal protein that is released by proteolytic ectodomain shedding and might be a useful and specific h

53 ared to inhibit tumor invasion by undergoing ectodomain shedding and producing soluble TbetaRIII, whi

54 n a membrane-proximal region that results in ectodomain shedding and retention of a 6-kDa transmembra

55 egulated intramembrane proteolysis, in which ectodomain shedding and subsequent intramembrane cleavag

56 ribe Tim-3 as novel target for ADAM-mediated ectodomain shedding and suggest a role of Tim-3 shedding

57 ous H2O2 mimicked PMA-induced enhancement of ectodomain shedding, and H2O2-induced shedding was block

58 dulates HGF/c-Met activity by inducing c-Met ectodomain shedding, and HGF/c-Met transactivates EGFR,

59 is a substrate for metalloprotease-dependent ectodomain shedding, and that the inhibitors block prote

60 sduction pathways to TPA-stimulated TNFalpha ectodomain shedding are mediated by TACE, a transmembran

61 Ectodomain shedding at the cell surface is a major mecha

62 s to demonstrate that sPmel17 is released by ectodomain shedding at the juxtamembrane and/or intramem

63 eavage site is utilized for basal syndecan-1 ectodomain shedding both in vitro from NMuMG and CHO cel

64 altered beta-amyloid precursor protein (APP) ectodomain shedding but was a result of an enhanced degr

65 invariant cytoplasmic Tyr residues abrogates ectodomain shedding, but not because it is Tyr phosphory

66 d murine IL-23R as novel targets for protein ectodomain shedding by ADAM10 and ADAM17.

67 Protein ectodomain shedding by ADAM17 (a disintegrin and metallo

68 ral signaling pathway molecules that undergo ectodomain shedding by ADAMs [e.g., ligands and receptor

69 Nectin-1 is known to undergo ectodomain shedding by alpha-secretase and subsequent pr

70 moting bacterial pathogenesis, activation of ectodomain shedding by alpha-toxin and beta-toxin may be

71 Blocking HB-EGF ectodomain shedding by inhibition of matrix metalloprote

72 and function in vivo, regulation of syndecan ectodomain shedding by physiological mediators indicates

73 ha signaling through this inability of TNFR1 ectodomain shedding contributes to chronic low-grade inf

74 unclear, we aimed to unravel how much TNFR1 ectodomain shedding controls the development of nonalcoh

75 activity, we sought to identify the cause of ectodomain shedding deficiencies in two mutated CHO subl

76 both the transient thrombocytopenia and GPVI ectodomain shedding depend on the Fc portion of the anti

77 , coiled coils can also act as regulators of ectodomain shedding depending on the biological context.

78 essing of various transmembrane proteins via ectodomain shedding followed by an intramembrane cleavag

79 ng of single pass transmembrane proteins via ectodomain shedding followed by intramembrane proteolysi

80 Here we found that beta2 undergoes ectodomain shedding followed by presenilin (PS)-dependen

81 a 55% decrease in constitutive collagen XVII ectodomain shedding from Adam9(-/-) keratinocytes, and (

82 sport to the cell surface but do not inhibit ectodomain shedding from the cell surface.

83 that a secreted form of GPNMB is released by ectodomain shedding from the largely Golgi-modified form

84 Ectodomain shedding has emerged as an important regulato

85 data demonstrate that CD93 is susceptible to ectodomain shedding, identify multiple stimuli that trig

86 rthermore, both PMA and H2O2 failed to cause ectodomain shedding in a cell line that lacks TACE activ

87 ptible to phorbol dibutyrate-induced protein ectodomain shedding in a time- and dose-dependent manner

88 xns with postsynaptic Nlgn1 or inhibition of ectodomain shedding in axonal Nrxn1-beta increases presy

89 ell death control and is the first report of ectodomain shedding in plants.

90 ic events and biological significance of the ectodomain shedding in the PTK7 function, we used highly

91 ent and emphasizes the importance of protein ectodomain shedding in vivo.

92 AGE splice variant 4), which is resistant to ectodomain shedding, inhibited RAGE ligand dependent cel

93 GF receptor activation through TACE-mediated ectodomain shedding intimately links inflammation and ca

94 ence of a common system for membrane protein ectodomain shedding involving one or several proteolytic

95 Protein ectodomain shedding is a critical regulator of many memb

96 Ectodomain shedding is a proteolytic mechanism by which

97 Although regulated ectodomain shedding is a well known process that affects

98 erminal fragment (CTF) of TREM2 generated by ectodomain shedding is cleaved by gamma-secretase.

99 Ectodomain shedding is crucial for receptor signaling an

100 One of the main proteases responsible for ectodomain shedding is disintegrin and metalloproteinase

101 s' roles by novel Col13a1tm/tm mice in which ectodomain shedding is impaired.

102 iding at the injury site and that pro-HB-EGF ectodomain shedding is necessary for retina regeneration

103 TNFR1 ectodomain shedding is not an essential feedback mechani

104 TACE-mediated ectodomain shedding is regulated, and the cytoplasmic do

105 However, little is known about how syndecan ectodomain shedding is regulated.To elucidate the mechan

106 Although the physiological relevance of ectodomain shedding is well recognized, little is known

107 Ectodomain shedding may activate or inactivate a substra

108 ADAMs-mediated ectodomain shedding may have a role in gastric carcinoge

109 ignaling in Drosophila and C. elegans via an ectodomain shedding mechanism that depends on a metallop

110 ability through stimulation of the host cell ectodomain shedding mechanism.

111 ransferase (GalNAc-T) isoforms to coregulate ectodomain shedding mediated by the A Disintegrin And Me

112 different cancer entities released B7-H6 by ectodomain shedding mediated by the cell surface proteas

113 Because regulation of this ectodomain shedding might be critical in the generation

114 tion of L-selectin and better understand how ectodomain shedding might contribute to TEM.

115 Ectodomain shedding occurs in the immediate extracellula

116 lpha converting enzyme (TACE; ADAM17) in the ectodomain shedding of ACE and APP from human SH-SY5Y ce

117 r the involvement of ADAM17 in the regulated ectodomain shedding of ACE2.

118 Ectodomain shedding of both human and mouse RAGE was dep

119 e on epithelial cell surfaces is followed by ectodomain shedding of both matriptase and its Kunitz-ty

120 soluble leptin receptor may be derived from ectodomain shedding of both receptor isoforms in vivo.

121 We conclude that ADAM8 could contribute to ectodomain shedding of CD23 and may thus be a potential

122 ADAM15, and MDC-L, but not ADAM17, catalyzed ectodomain shedding of CD23, the low affinity IgE recept

123 Ectodomain shedding of cell surface membrane-anchoring p

124 Ectodomain shedding of cell surface proteins is an impor

125 cell and cell-matrix interactions as well as ectodomain shedding of cell surface receptors and ligand

126 i-inflammatory signaling events by promoting ectodomain shedding of cytokine precursors and cytokine

127 availability and signaling by inhibiting the ectodomain shedding of cytokines and their receptors.

128 at collagen binding induces ADAM10-dependent ectodomain shedding of DDR1.

129 0, a transmembrane metalloprotease mediating ectodomain shedding of diverse membrane proteins, was re

130 Inhibiting ectodomain shedding of Dsg2 with the matrix metalloprote

131 metalloproteinases, which are activators of ectodomain shedding of EGFR ligands, also blocked TPA-in

132 ys, the overexpression of ADAM9 enhanced the ectodomain shedding of EphB4, Tie-2, Flk-1, CD40, VCAM,

133 Ectodomain shedding of epidermal growth factor receptor

134 Our studies show that constitutive ectodomain shedding of full-length ErbB4 yields the appr

135 Ectodomain shedding of glycoprotein (GP) Ibalpha is thou

136 Ligand-induced ectodomain shedding of glycoprotein VI (GPVI) is a metal

137 ases ADAM10 and ADAM17 can produce sgp130 by ectodomain shedding of gp130, even though this mechanism

138 ng carcinoma showed decreased expression and ectodomain shedding of HB-EGF and reduced incidence of c

139 motes fetal type II cell differentiation via ectodomain shedding of HB-EGF and TGF-alpha.

140 cer conditioned medium on the expression and ectodomain shedding of HB-EGF by TNFalpha-converting enz

141 Constitutive and stimulated ectodomain shedding of HB-EGF is comparable in embryonic

142 ubsequent ERK1/2 phosphorylation result from ectodomain shedding of HBEGF through PKC-dependent activ

143 growth factor (EGF) receptor (EGFR) through ectodomain shedding of heparin-binding EGF-like growth f

144 a indicate that bacterial pathogens activate ectodomain shedding of host cell surface molecules to en

145 Several microbial pathogens stimulate the ectodomain shedding of host cell surface proteins to pro

146 Here, ectodomain shedding of human and murine IL-23R was ident

147 cytoplasmic domain of L-selectin to regulate ectodomain shedding of L-selectin on the other side of t

148 tin in the cell to modulate the function and ectodomain shedding of l-selectin.

149 The ectodomain shedding of ligand can be stimulated by Notch

150 suggesting that sup-17 and adm-4 may mediate ectodomain shedding of LIN-12 and/or GLP-1.

151 ginine 4442 as key amino acids important for ectodomain shedding of LRP1B.

152 ly, IL-3 decreases soluble RANKL by reducing ectodomain shedding of membrane RANKL through downregula

153 rin alpha) is a key enzyme implicated in the ectodomain shedding of membrane-anchored heparin-binding

154 eolytically active ADAMs are responsible for ectodomain shedding of membrane-associated proteins.

155 gh initiation of an autocrine loop requiring ectodomain shedding of membrane-bound RANKL in prostate

156 yristate 13-acetate and ionomycin stimulated ectodomain shedding of meprin beta and meprin A.

157 This induces ectodomain shedding of metalloprotease-sensitive cell su

158 Furthermore we demonstrate that the ectodomain shedding of MT1-MMP can serve as a mechanism

159 vation of the MMP2 proenzyme (pro-MMP2), the ectodomain shedding of MT1-MMP, and the collagenolysis a

160 ated a first proteolytic event, resulting in ectodomain shedding of nectin-1alpha.

161 ntramembraneous proteolysis of p75(NTR), and ectodomain shedding of Nogo receptor, correlated with a

162 M10/Kuzbanian catalyzes the ligand-dependent ectodomain shedding of Notch receptors and activates Not

163 Because ectodomain shedding of p75NTR releases a soluble ectodom

164 udy, we evaluated the activities involved in ectodomain shedding of p75NTR, a neurotrophin receptor w

165 e-bound metalloproteinase is responsible for ectodomain shedding of pathologically significant substr

166 Here we observed that ectodomain shedding of RAGE is critical for its role in

167 se (ADAM) 17, a metalloenzyme that catalyzes ectodomain shedding of receptor tyrosine kinase ligands.

168 metalloprotease-disintegrin involved in the ectodomain shedding of several proteins and is critical

169 Here we show that activity-dependent ectodomain shedding of signal regulatory protein-alpha (

170 Thus, ectodomain shedding of SIRPalpha is an activity-dependen

171 talloproteinase (MT1-MMP) expression and the ectodomain shedding of soluble (s)CD44.

172 ne of the main proteases responsible for the ectodomain shedding of surface proteins.

173 inosa and Staphylococcus aureus activate the ectodomain shedding of syndecan-1 and that syndecan-1 sh

174 The ectodomain shedding of syndecan-1, a major cell surface

175 with the ability of beta-toxin to stimulate ectodomain shedding of syndecan-1, a major heparan sulfa

176 t several major bacterial pathogens activate ectodomain shedding of syndecan-1, the major heparan sul

177 ta-toxin, but not alpha-toxin, also enhanced ectodomain shedding of syndecan-4 and heparin-binding ep

178 Inhibiting ectodomain shedding of TbetaRIII increased TGF-beta resp

179 In this study, we investigated the ectodomain shedding of the betacellulin precursor (pro-B

180 Pseudomonas virulence, including stimulating ectodomain shedding of the cell surface heparan sulphate

181 , we offer evidence of a mechanism involving ectodomain shedding of the EGFR ligands amphiregulin (AR

182 aling-dependent manner, leading to increased ectodomain shedding of the epidermal growth factor (EGF)

183 ivation either by increasing ADAM17-mediated ectodomain shedding of the Notch receptor or by modifica

184 lin regulates in an "inside-out" fashion the ectodomain shedding of the receptor.

185 This catalytic activity requires prior ectodomain shedding of the substrate and can cleave liga

186 acterized the activities involved in protein ectodomain shedding of the tumor necrosis factor family

187 suggested susceptibility gene for ccRCC and ectodomain shedding of this molecule may be a predictive

188 ha to its mature form and is involved in the ectodomain shedding of TNF receptors.

189 hat following TNF-converting enzyme-mediated ectodomain shedding of TNF type I receptor (TNFR1), the

190 on vectors for human and mouse TACE restored ectodomain shedding of TNF-alpha and TGF-alpha, suggesti

191 Inflammatory stimuli activate ectodomain shedding of TNF-alpha, L-selectin, and other

192 ; ADAM17) is known to have a key role in the ectodomain shedding of TNFalpha in several cell types.

193 TNFalpha and more than a 6-fold increase in ectodomain shedding of TNFalpha into the serum of PKCeps

194 Ectodomain shedding of transmembrane precursor proteins

195 Ectodomain shedding of transmembrane proteins may be reg

196 bilayer and that anionic lipids may modulate ectodomain shedding of transmembrane receptors.

197 lization, myoblast fusion, neurogenesis, and ectodomain shedding of tumor necrosis factor (TNF)-alpha

198 Ectodomain shedding of tumor necrosis factor receptor 1

199 e amino-terminal stubs that are generated by ectodomain shedding of type I transmembrane proteins.

200 or matrix, and mouse plasma, indicating that ectodomain shedding of VLDLR occurs endogenously.

201 loprotease, activity, distinguishing it from ectodomain "shedding" of other membrane receptors, which

202 for further studies examining the impact of ectodomain shedding on platelet function.

203 We propose that sVEGFR-1 produced via ectodomain shedding plays a prominent role in the VEGF r

204 gest that TACE-mediated cell surface protein ectodomain shedding plays an essential and a novel regul

205 orylated c-Met expression and elevated c-Met ectodomain shedding postliver IRI.

206 n molecules, and NO may be involved in other ectodomain shedding processes.

207 share the same subcellular distribution and ectodomain shedding properties.

208 VLDLRII displayed a higher ectodomain shedding rate and a more potent inhibitory ef

209 but not VLDLRII, determined the differential ectodomain shedding rates.

210 These studies suggest that ectodomain shedding regulates the pericellular and extra

211 However, TbetaRIII can also undergo ectodomain shedding, releasing soluble TbetaRIII, which

212 er of PM proteins, delivery to lysosomes and ectodomain shedding represent distinct parallel mechanis

213 t the level of expression, protease-mediated ectodomain shedding represents an alternative means of r

214 ed form of LIN-12 that mimics the product of ectodomain shedding rescues this fertility defect, sugge

215 Interestingly, abrogating ectodomain shedding resulted in a loss of the ability of

216 integrin and metalloprotease (ADAM)-mediated ectodomain shedding resulting in a soluble form of Tim-3

217 tion of VEGFR-1 and render it susceptible to ectodomain shedding, resulting in the generation of sVEG

218 h impaired (DeltaShed-TbetaRIII) or enhanced ectodomain shedding (SS-TbetaRIII).

219 The calmodulin (CaM) hypothesis of ectodomain shedding stipulates that CaM, an intracellula

220 d that Cys(600) was absolutely essential for ectodomain shedding, suggesting that Cys(600), similar t

221 ic epitope harbors the cleavage site for its ectodomain shedding, suggesting that proteolysis has an

222 Induction of HB-EGF expression and ectodomain shedding synergistically led to robust epider

223 that bre-5 functions prior to ligand-induced ectodomain shedding that activates LIN-12 for signal tra

224 ases have also been implicated in E-cadherin ectodomain shedding, the current study was undertaken to

225 Protein ectodomain shedding, the proteolytic release of the extr

226 y accepted model of calmodulin regulation of ectodomain shedding, the R152E/L153E mutation in the GPI

227 n metalloproteases plays important roles in "ectodomain shedding," the process by which biologically

228 nd transmembrane molecule, it also undergoes ectodomain shedding to become a synaptic basal lamina co

229 smembrane precursors and undergo proteolytic ectodomain shedding to release a soluble mature growth f

230 the prognostic value of ALCAM by visualizing ectodomain shedding using a dual stain that detects both

231 stablish that S. aureus activates syndecan-1 ectodomain shedding via its two virulence factors, alpha

232 d by integrin aggregation, integrin-mediated ectodomain shedding was inhibited by a MMP-9 function bl

233 R-CTF accumulation, demonstrating that prior ectodomain shedding was prerequisite for PS/gamma-secret

234 immunodepletion predominantly occurs through ectodomain shedding, which is accompanied by a transient

235 This resulted in a substantial increase of ectodomain shedding, which was not mediated by disintegr

236 knockdown of ROCK2 with siRNA decreased LR11 ectodomain shedding while simultaneously increasing intr

237 avage in the extracellular domain results in ectodomain shedding while the cytoplasmic domain remains

238 s revealed non-redundant roles of BACE1/2 in ectodomain shedding with BACE1 regulating a broader and

239 y cleaved from the plasma membrane (known as ectodomain shedding), with little knowledge of the timin

240 nges, we identified critical determinants of ectodomain shedding within the stalk region of the IL-23