ライフサイエンスコーパス: ectoenzyme

1 t not ART2.2, as a GPI-anchored cell surface ectoenzyme.

2 f 1321N1 cells, suggesting involvement of an ectoenzyme.

3 glycosylphosphatidylinositol (GPI)-anchored ectoenzymes.

4 also tested the hypothesis that endothelial ectoenzyme activity is an earlier indicator of lung inju

5 These findings indicate that BP-1 ectoenzyme activity is not essential for normal B and T

6 mbrane protein ANK and generation of ePPi by ectoenzyme activity, continue to be supported and better

7 ffects of monocytes on endothelial cell (EC) ectoenzyme activity.

8 ors, 1,25(OH)2D3 rapidly induced CD38 Ag and ectoenzyme activity.

9 ADP-ribose (cADPR), which is generated by an ectoenzyme ADP-ribosyl cyclase, CD38.

10 zation process include the integral membrane ectoenzymes alkaline phosphatase (ALPase) and nucleotide

11 Inhibition of the multifunction ectoenzyme/amino acid transporter gamma-glutamyltranspep

12 f total cysteine transport), multifunctional ectoenzyme/amino acid transporter gamma-glutamyltranspep

13 DP-ribosyl cyclase family and possesses both ectoenzyme and receptor functions.

14 CD38 is an ectoenzyme and receptor with key physiological roles.

15 CD157/BST-1 behaves both as an ectoenzyme and signaling receptor and is an important re

16 Newly synthesized canalicular ectoenzymes and a cell adhesion molecule (cCAM105) have

17 In this review, we focus on CD39 and CD73 ectoenzymes and encompass aspects of the biochemistry of

18 e of ATP, which is converted to adenosine by ectoenzymes and subsequently activates neuronal adenosin

19 ellular pyrophosphate is likely generated by ectoenzymes and/or is a consequence of transport of intr

20 complement regulatory proteins, cell surface ectoenzymes, and growth factor receptors.

21 s indicate that, whereas the Ap(n)A-cleaving ectoenzyme appears to be located mainly in the oocyte, e

22 Ectoenzymes are differentially localized in cartilage an

23 Quiescent EC express the ectoenzyme ATP-diphosphohydrolase (ATPDase; an apyrase),

24 eral step in the homing cascade in which the ectoenzyme ATX facilitates the entry of lymphocytes into

25 membrane protein that acts as a bifunctional ectoenzyme, catalyzing the synthesis of cyclic ADP-ribos

26 The ectoenzyme CD38 catalyzes the production of cyclic ADP-r

27 mAbs directed against the ectoenzyme CD38 will induce B cell proliferation in norm

28 NMN is a substrate of both ectoenzymes CD38 and CD73, with generation of NAM and NR

29 The ectoenzyme CD39 on the plasmalemma of endothelial cells

30 The ectoenzyme CD39 suppresses thrombosis and inflammation b

31 rgistic effect through downmodulation of the ectoenzyme CD39, which converts ATP to ADP/AMP, and an i

32 the immunosuppressive factor adenosine, the ectoenzymes CD39 and CD73 are important contributors to

33 viously, we found that mice deficient in the ectoenzyme CD73, which generates adenosine in the extrac

34 xpressed ADP-ribosyltransferase 2 (ART2) are ectoenzymes competing for NAD substrate.

35 Ectoenzymes detected on these cells were recently shown

36 l membrane gelatinase that is related to the ectoenzyme dipeptidyl peptidase IV.

37 tigated the role of the adenosine-generating ectoenzyme, ecto-5'-nucleotidase (CD73), in regulating i

38 asis, including the pyrophosphate-generating ectoenzyme Enpp1.

39 Ectoenzymes expressed on the surface of vascular cells a

40 Expression of the ectoenzyme gamma-glutamyl transpeptidase (GGT) is regula

41 The ectoenzyme, gamma-glutamyl transpeptidase (GGT, EC ) cle

42 sine 5'-diphosphate (ADP)-ribosyltransferase ectoenzyme gene family.

43 These ectoenzymes generate pericellular adenosine from extrace

44 To study the structure of this ectoenzyme, human CD39 was modified by directed mutation

45 odon and encodes an active GGT heterodimeric ectoenzyme identical to constitutive GGT cDNA but transl

46 nowledge of the functions of nucleotides and ectoenzymes in the cartilage extracellular matrix.

47 ked by a VIP antagonist and augmented by the ectoenzyme inhibitor, phosphoramidon.

48 idylpeptidase IV (CD26) is a multifunctional ectoenzyme involved in T cell activation that has been i

49 appears to be located mainly in the oocyte, ectoenzymes involved in the dephosphorylation of mononuc

50 The ectoenzyme is activated by Ca(2+) and Mg(2+), reaches ma

51 regulatory cells" through ADO produced by an ectoenzymes network, with a pivotal role of CD38.

52 Deficient generation of ePPi by the ectoenzyme nucleoside triphosphate pyrophosphohydrolase

53 e nucleotide polymorphism (SNP) K121Q in the ectoenzyme nucleotide pyrophosphate phosphodiesterase (E

54 the nonsynonymous K121Q polymorphism in the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1

55 Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1

56 We have reported previously that the ectoenzyme of membrane type matrix metalloproteinase 5 (

57 These data show that GGT, a regulated ectoenzyme on T cells, controls the rate of nitric oxide

58 ters of the enzyme reaction catalyzed by the ectoenzyme pantetheinase are KM,C/alpha = 4.4 +/- 1.1 mM

59 components include alkaline phosphatase, the ectoenzyme PC-1, and osteopontin.

60 more complex understanding of the ank gene, ectoenzyme PC-1, and the transglutaminase enzyme family

61 ch as the inorganic pyrophosphate-generating ectoenzyme PC-1/nucleotide pyrophosphatase phosphodieste

62 The two ectoenzymes presented opposite airway distributions, ect

63 nucleotides are metabolized by a variety of ectoenzymes, producing free phosphate (Pi) or pyrophosph

64 Human CD38 is a multifunctional ectoenzyme responsible for catalyzing the conversions fr

65 with a specific monoclonal antibody to this ectoenzyme revealed high expression in liver with lesser

66 veloped to integrate nucleotide release, the ectoenzymes supporting the dephosphorylation of ATP into

67 Human CD38 is an ectoenzyme that can use NAD(+) to synthesize two calcium

68 Autotaxin (ATX) is an ectoenzyme that catalyzes the conversion of lysophosphat

69 gamma-Glutamyl transpeptidase (GGT) is an ectoenzyme that catalyzes the first step in the cleavage

70 entified BP-1 as glutamyl aminopeptidase, an ectoenzyme that catalyzes the hydrolysis of acidic amino

71 It can serve as an ectoenzyme that catalyzes the synthesis and hydrolysis o

72 sphate diphosphohydrolase 2 (E-NTPDase2), an ectoenzyme that converts ATP to ADP, caused ectopic eye-

73 Recent evidence suggests that CD38, an ectoenzyme that converts NAD(+) to cyclic ADP-ribose (cA

74 ooth muscle and the upregulation of NEP, the ectoenzyme that degrades BNP, in the vascular wall in at

75 Mice lacking CD38, an ectoenzyme that generates the calcium-mobilizing metabol

76 phohydrolase (NTPDase or CD39) is a vascular ectoenzyme that hydrolyses ATP and ADP; however, this ac

77 PD1 is the dominant vascular and immune cell ectoenzyme that hydrolyzes extracellular nucleotides to

78 CD38 is an ectoenzyme that mediates the release of brain OT.

79 ransmembrane glycoprotein, is a bifunctional ectoenzyme that participates in signal transduction path

80 stromal antigen 1 (Bst1) in Paneth cells-an ectoenzyme that produces the paracrine factor cyclic ADP

81 nment plays an important role, including the ectoenzyme that triggers blood clotting, the plasma seri

82 Although the existence of ectoenzymes that metabolize extracellular nucleotides is

83 lls that expresses CD73 as well as CD39, two ectoenzymes that together catalyze the extracellular dep

84 iological function(s) of this novel class of ectoenzyme we generated mice carrying a null mutation in

85 The basic properties of this ectoenzyme were investigated using as substrates di-(1,N

86 This ectoenzyme, which is also present on bone marrow-derived

87 alpha protein suggests a transmembrane-bound ectoenzyme, which, in addition to the phosphodiesterase-