ライフサイエンスコーパス: ectopic expression

1 eases activities were unperturbed by LAMP-2C ectopic expression.

2 achieved through rescue of MRP RNA levels by ectopic expression.

3 Ectopic expression and functions of odorant receptors (O

4 chondrial targets is upregulated upon PLA2R1 ectopic expression, and this effect is mediated by JAK2.

5 RNA interference and ectopic expression assays found that Se-iap3 is responsi

6 and TAG accumulation in diverse plants, its ectopic expression can lead to undesired side effects de

7 srupts the shape of migrating neurons, while ectopic expression confers neuronal-like morphology to c

8 Although ectopic expression experiments have suggested an inhibit

9 Moreover miR-579-3p ectopic expression impairs the establishment of drug res

10 s isolated and functionally characterized by ectopic expression in a hybrid poplar (P. davidiana Dode

11 ion of the pluripotency marker Nanog and its ectopic expression in extra-embryonic lineages, whereas

12 Its ectopic expression in HEK293T cells localizes it to the

13 inhibiting TNF-alpha-induced apoptosis upon ectopic expression in HeLa cells, the percentage of infe

14 another bone fide AKI marker, Kim1 and noted ectopic expression in P7 non-dilated proximal tubules.

15 Upon ectopic expression in primary human articular chondrocyt

16 Conversely, ectopic expression in thymocytes induces DNA replication

17 In the cells negative for active p53, NPRL2 ectopic expression leads to activation of CHK1 or CHK2 k

18 This ectopic expression lowers FD mRNA levels, reducing respo

19 Loss of caspase-3 or ectopic expression of a caspase-3 non-cleavable lamin B

20 Ectopic expression of a catalytically inactive mutant di

21 Ectopic expression of a constitutively active DELLA prot

22 The discovery of high ectopic expression of a cyclin B1;1-based reporter of mi

23 Ectopic expression of a membrane-bound peroxidase allowe

24 Here, we show that the ectopic expression of a truncated RocA derivative, harbo

25 Ectopic expression of AcMFT in Arabidopsis promotes the

26 Ectopic expression of AINTEGUMENTA-LIKE6 at high levels

27 were transformed to cytokine independence by ectopic expression of an activated NPM-ALK fusion oncopr

28 Further, ectopic expression of an effector of autophagy (Atg3) or

29 Ectopic expression of an N-terminal fragment of NleE (Nl

30 Ectopic expression of AnxA8 in AnxA8-depleted cells led

31 Ectopic expression of APC, but not its familial adenomat

32 ve to ROS, and this phenotype was rescued by ectopic expression of Asp f3.

33 targeting of autophagosomes to FAs, whereas ectopic expression of autophagy-competent, but not autop

34 Although ectopic expression of AXL and TWIST2 individually in TAE

35 r B-cell numbers could be largely rescued by ectopic expression of B-cell lymphoma 2 (Bcl2), despite

36 Conversely, ectopic expression of beta1 integrin was sufficient to i

37 ther regulatory cell types simply by loss or ectopic expression of bHLH genes, and male-to-female and

38 We also demonstrate that ectopic expression of BigH1 similarly complements the de

39 Ectopic expression of both miRNA in drug-naive human mel

40 Ectopic expression of BRD7, but not its mutants defectiv

41 Ectopic expression of BTK was sufficient to induce apopt

42 Mutation of DFO1 causes the ectopic expression of C-class genes in the dfo1-1 mutant

43 ns, which is rescued via charge inversion by ectopic expression of CaM(R)(126E), as determined by ana

44 are enriched in full-length Bcl-xL, whereas ectopic expression of caspase-3 restores the cleavage of

45 Notably, ectopic expression of catalytically-inactive RICE1 not o

46 We further demonstrated that ectopic expression of CCHFV NSs induces apoptosis, as re

47 Ectopic expression of Cdh1 leads to premature differenti

48 On ectopic expression of CDX2, these transitional basal pro

49 Furthermore, ectopic expression of Cers2b protein itself reduces acti

50 rentiate, their plasticity is restricted and ectopic expression of CHE-1 no longer results in activat

51 In undifferentiated cells, ectopic expression of CHE-1 results in activation of ASE

52 Here we find that ectopic expression of chinmo is sufficient to induce a m

53 Defects upon RetSat depletion are rescued by ectopic expression of ChREBP but not by its putative enz

54 Ectopic expression of cmo-miR156, using a virus-based mi

55 Ectopic expression of COUP-TFII in murine SCs led to Duc

56 Ectopic expression of CRK4 induced STT3a/N-glycosylation

57 Conversely, ectopic expression of CSDE1 impairs neural differentiati

58 Ectopic expression of CsMYBF1 in tomato led to an up-reg

59 Ectopic expression of CtHsfA2b improved heat tolerance i

60 Most importantly, the ectopic expression of CX45 significantly enhanced the re

61 We demonstrated that ectopic expression of cytoplasmic p27 promoted migration

62 Conversely, ectopic expression of DA1 or BB restricted growth and pr

63 rogrammed into pluripotent stem cells by the ectopic expression of defined transcriptional factors.

64 lation and gene expression levels, featuring ectopic expression of developmental transcription factor

65 the major Glut4 PAT, based on evidence that ectopic expression of DHHC7 increased Glut4 palmitoylati

66 Ectopic expression of DHHC7, but not a DHHC7 catalytic m

67 Ectopic expression of different members of the RAS super

68 Conversely, ectopic expression of Dmrt1 led to largely masculinized

69 hd-knockdown defects, which were reversed by ectopic expression of EcR.B2 but not by EcR.A or EcR.B1

70 Ectopic expression of EgWRI1-1 in plant produced dramati

71 Ectopic expression of either IRF4 or MYC antagonizes the

72 ginosa, which can be almost fully rescued by ectopic expression of either Rac2 or Rac1 specifically i

73 Ectopic expression of either RPC32 or TERT restored tRNA

74 In H1-depleted animals, ectopic expression of Elba2 rescues the increased lethal

75 Ectopic expression of EP300-ZNF384 and CREBBP-ZNF384 fus

76 In a new mouse model, ectopic expression of ephrin-A3 (Efna3) in a subset of r

77 uirement for the COP9 signalosome to prevent ectopic expression of Epidermal growth factor receptor (

78 Bacterial infection and/or ectopic expression of EspL leads to rapid inactivation o

79 Ectopic expression of EspW results in formation of uniqu

80 inhibited by EZH2 depletion, was rescued by ectopic expression of EZH2 but not by TRIM28 expression

81 Ectopic expression of FBXO11 attenuated increased apopto

82 Consistent with this finding, ectopic expression of female sex determinants in the adu

83 Furthermore, ectopic expression of FGF2 in mouse joints potentiated I

84 ollagen-induced arthritis (CIA) model, while ectopic expression of FGF2 in vivo exacerbated tissue in

85 Here, we show that ectopic expression of functionally active PAR1 in MCF-7

86 cl11ba-deficient zebrafish, were reversed by ectopic expression of functionally intact human BCL11B b

87 Furthermore, ectopic expression of GADD45B in KSHV-infected cells pro

88 Correspondingly, ectopic expression of GATA4 in cultured continuous ECs m

89 iation of Gene 33 with histone H2AX and that ectopic expression of Gene 33 promotes the interaction b

90 Here we show that ectopic expression of Gene 33 triggers DDR in an ATM ser

91 Ectopic expression of GhCHR in Arabidopsis conferred sal

92 Here, we show that ectopic expression of GPR124 promotes cell adhesion, add

93 Ectopic expression of hCDC14A induced stress fiber forma

94 x2 proteins are enhanced during infection or ectopic expression of HCV core protein.IMPORTANCE Endogl

95 Finally, the ectopic expression of HD5 in tumor cells diminished the

96 Furthermore, we show that ectopic expression of histone H3.3 lysine 4-to-methionin

97 Ectopic expression of HLH-2 and HLH-3 together promoted

98 Using shRNA silencing and ectopic expression of HLJ1, we found that HLJ1 not only

99 We demonstrate that ectopic expression of HOTAIR induces NF-kappaB activatio

100 Conversely, ectopic expression of HOXA5 in aggressive SUM149 or SUM1

101 Although ectopic expression of HRAS increased statin sensitivity,

102 rant receptors (HsOrs) responds to CHCs, and ectopic expression of HsOrs in Drosophila neurons impart

103 n cells that had escaped senescence, whereas ectopic expression of hTERT facilitated OIS escape.

104 These data reveal that virally mediated ectopic expression of human rod opsin can restore vision

105 Likewise, ectopic expression of human THOR in zebrafish accelerate

106 Ectopic expression of ICP0 from a transfected plasmid wa

107 replication or infection, and reciprocally, ectopic expression of IFIT1 in HEK293T cells did not inh

108 Third, ectopic expression of IFITMs, known to potently block in

109 Moreover, ectopic expression of IkappaBzeta was sufficient to stim

110 Ectopic expression of IL-15DeltaE7 in WT skin prevented

111 CSC marker expression and behavior, whereas ectopic expression of ILK stimulated CSC development und

112 The ectopic expression of ILT3 in CLL was a distinctive feat

113 UB aggregates, which are resolved following ectopic expression of individual GABARAPs.

114 In this study, we demonstrate that ectopic expression of insulin epitope B:9-23 (InsB9-23)

115 Furthermore, we find that ectopic expression of IR21a can confer cool-responsivene

116 JJ2, which facilitates Orb2 aggregation, and ectopic expression of JJJ2 enhances the animal's capacit

117 xpression and mouse HL-1 cardiomyocytes with ectopic expression of K2P1 channels recapitulate two lev

118 ptosis following detachment and, conversely, ectopic expression of KDM3A induces cell death in attach

119 the entire sub-bulge follicle and cyst, and ectopic expression of keratin 10, a marker of interfolli

120 tly, bone morphogenetic protein 4 (BMP4), or ectopic expression of key germline transcription factors

121 ellular injuries induce KLF4 expression, and ectopic expression of KLF4 in acinar cells reduces acina

122 Finally, as an in vivo example of ectopic expression of KRT9 independent of volar fibrobla

123 ls from a mouse model of SCLC and found that ectopic expression of L-Myc, c-Myc, or N-Myc conferred t

124 ced in Lck/Hck/Fgr triple knockout cells and ectopic expression of Lck/Hck/Fgr dampened the antiviral

125 Ectopic expression of LECT-2 from seam cells is sufficie

126 g defects in lefty mutants can be rescued by ectopic expression of lefty far from its normal expressi

127 7 downregulates chinmo in many contexts, and ectopic expression of let-7 in the adult testis is suffi

128 ch in mesenchymal nephron progenitors causes ectopic expression of Lhx1 and Hnf1b and that these cell

129 Remarkably, ectopic expression of Lin28b enables adult progenitors t

130 Ectopic expression of lineage master regulators induces

131 Knockdown of LKB1 increased and ectopic expression of LKB1 decreased glycolysis, anchora

132 Finally, we observed that ectopic expression of LmPRL-1 in L. major led to an incr

133 Ectopic expression of LRRC25 impaired NF-kappaB activati

134 Ectopic expression of LT-resistant MKK2 and MKK4 variant

135 Conversely, ectopic expression of MAGE-A4 (in cell lines lacking end

136 Impaired CSR can be rescued by ectopic expression of Mbd4 Mbd4 deficiency yields a defi

137 Ectopic expression of MDA-5 has been shown to induce can

138 Here, we demonstrate that ectopic expression of MDA-5 via replication-incompetent

139 Either ectopic expression of mda-7/IL-24 or treatment with reco

140 Ectopic expression of Medicago NB-LRR-targeting miRNAs i

141 Ectopic expression of melanoma differentiation-associate

142 Intriguingly, ectopic expression of members of a clade of RWP-RK domai

143 Ectopic expression of membrane-anchored Pak1 overrides t

144 Conversely, ectopic expression of Mex3b ubiquitinated SUZ12, displac

145 Ectopic expression of miR-1180 has an anti-apoptotic eff

146 Ectopic expression of miR-139-3p strongly inhibited prol

147 Ectopic expression of miR-17 imparted effector-T-cell-li

148 Conversely, ectopic expression of miR-200 inhibited this sprouting b

149 Ectopic expression of miR-21 and miR-29a promotes angiog

150 Ectopic expression of miR-211 reduced hypoxia-inducible

151 moxifen (TAM)-resistant breast cancer cells, ectopic expression of miR-29b-1/a did not drive TAM-resi

152 ession following vascular injury and whether ectopic expression of miR-30 can inhibit CaMKIIdelta-dep

153 Ectopic expression of miR-383 inhibited tumor-initiating

154 Ectopic expression of miR-6883-5p or miR-149* downregula

155 Ectopic expression of miR-K6-5p specifically inhibited t

156 Strong, ectopic expression of miR393j-3p, as well as RNAi silenc

157 d temperatures, amino acid analogues, or the ectopic expression of misfolded proteins, induce protein

158 tochord to somite fate after gastrulation by ectopic expression of msgn1, a master regulator of parax

159 The above phenotypes can be rescued by ectopic expression of MSH2.

160 Ectopic expression of MtTT8 restores anthocyanins and PA

161 Ectopic expression of murine SH3BGRL (mSH3BGRL) strongly

162 Modulation of AKT or HSF1 activity via the ectopic expression of mutant alleles support the ability

163 sites on target proteins typically requires ectopic expression of mutant SUMOs with introduced trypt

164 found reduction of ERalpha expression, while ectopic expression of MYST3 had the reversed effect.

165 The ectopic expression of NANOG inhibits GLI1-mediated trans

166 The ectopic expression of Nanog is not sufficient to induce

167 Consistent with this, loss of sydn-1 blocks ectopic expression of neuronal ankyrin and suppresses ep

168 ultipolar stage and accompanied by premature ectopic expression of neuronal differentiation markers.

169 t loss of Foxp1 and Foxp4 expression induces ectopic expression of neuropeptide Y (Npy), which has be

170 life of cyclin E1 mRNA, which was rescued by ectopic expression of NF90.

171 In contrast, ectopic expression of NFI-A in myeloid progenitors from

172 Ectopic expression of NHE9 in hBMVECs without external c

173 Ectopic expression of Nix resulted in genetic females wi

174 bal profile of arginine GlcNAcylation during ectopic expression of NleB1, EPEC infection in vitro, or

175 l muscle of Zfp106 knockout mice resulted in ectopic expression of NOGO-A, the neurite outgrowth fact

176 Ectopic expression of non-phosphorylated SNAP-23 mutant

177 onstrate that, in the cells with active p53, ectopic expression of NPRL2 induces NOX2-dependent produ

178 Ectopic expression of NS1 alone did not reduce cyclin B1

179 Consistent with this, we found that ectopic expression of oncogenic KRas and HRas in cells r

180 Ectopic expression of OPN4 using a ubiquitous promoter r

181 Mechanistically, we demonstrated that ectopic expression of OSBPL3 facilitates SREBP-1 process

182 involve dedifferentiation of beta-cells and ectopic expression of other islet hormones, including so

183 Ectopic expression of p205 induced expression of an Asc

184 While ectopic expression of p54/nrb increases, suppression of

185 In MECs, ectopic expression of PAF induces anchorage-independent

186 In contrast to PARG, ectopic expression of PARP1 suppresses BMP signaling, wh

187 We demonstrate that the ectopic expression of Pax4 in delta cells is sufficient

188 ated and converted into beta-like cells upon ectopic expression of Pax4 opened new avenues of researc

189 kdown or knock-out of PCBP2 reduces, whereas ectopic expression of PCBP2 increases, TAp73 expression.

190 2-regulated TAp73 expression, we showed that ectopic expression of PCBP2 inhibits, whereas knockdown

191 Conversely, ectopic expression of PDE10 in normal and precancerous c

192 Ectopic expression of pdgfaa interferes with cardiac fus

193 Ectopic expression of PGBD5 in primary immortalized huma

194 CYP2C8 promoter activity was increased by ectopic expression of PPARalpha in HepG2 cells, with a f

195 Ectopic expression of PPP1R11 in CRC cells induced EMT,

196 the EKLF/KLF1 transcription factor leads to ectopic expression of proteins that are not normally exp

197 We also found that ectopic expression of PS improves Arabidopsis resistance

198 Furthermore, ectopic expression of Pt-Ets4 is sufficient to induce ce

199 alisation of RABEP2 and Rab5 in cells, while ectopic expression of RABEP2 had no effect on endosomal

200 eclinical models of experimental metastasis, ectopic expression of RAGE on human prostate cancer cell

201 function in neurons impaired flight, whereas ectopic expression of Ral in SOCE-compromised neurons re

202 s arrested in L. japonicus ram1 mutants, and ectopic expression of RAM1 activates genes critical for

203 nstream of CCaMK, CYCLOPS, and DELLA because ectopic expression of RAM1 restores arbuscule formation

204 Previous research has demonstrated that ectopic expression of Ran-binding protein (RanBP) in Ara

205 Importantly, we showed that ectopic expression of rat C/EBPalpha restores osteoclast

206 Ectopic expression of RCP induced Slug expression.

207 Strikingly, ectopic expression of RCP was sufficient to enhance meta

208 Importantly, ectopic expression of RPL10L prevents the death of cultu

209 However, ectopic expression of Runx3 enhances cytokine-driven ES-

210 ts tumor growth and lung metastasis, whereas ectopic expression of S1PR3 promotes the growth of human

211 In a breast cancer animal model, ectopic expression of SAA1 or SAA3 in tumor cells potent

212 Conversely, ectopic expression of SATB1 accelerated DNA repair and r

213 Blocking of FGF8 caused ectopic expression of SEMA3C and a migration defect of c

214 ey SHF transcription factor, resulted in the ectopic expression of Sema3c in the pharyngeal arch regi

215 homologues ADP-ribosylate Src E310 in vitro Ectopic expression of SeoC/SboC inhibited phagocytosis o

216 t in Caenorhabditis elegans, axotomy induces ectopic expression of serotonin (5-HT) in axotomized non

217 ocked follicle rupture, which was rescued by ectopic expression of shd or exogenous 20E.

218 pregulation of the transcription factor GLI1 Ectopic expression of SHH or IHH in mouse T cells in viv

219 Ectopic expression of Slit2 not only increased the numbe

220 and SinR antagonist slrR Deletion of sinR or ectopic expression of slrR in the spermidine-deficient D

221 of fibrosis was significantly alleviated by ectopic expression of Smad3.

222 Ectopic expression of Snail in cancer cell lines lacking

223 Ectopic expression of SNHG6-003 in HCC cells promoted ce

224 population from SOX2-positive cells, whereas ectopic expression of SOX2 inhibited SOX9 with increased

225 Ectopic expression of SOX30 induces cancer cell apoptosi

226 pre-B cells into macrophages induced by the ectopic expression of specific transcription factors.

227 keratin 5-positive (Krt5(+)) basal cells and ectopic expression of squamous-like differentiation mark

228 Ectopic expression of superoxide dismutase 2 (SOD2) redu

229 Ectopic expression of TAC1 in nontumorigenic breast cell

230 Finally, ectopic expression of TAK1 in a HBV hydrodynamic injecti

231 We also found that ectopic expression of Tbx5 is associated with foot feath

232 Ectopic expression of TET1 catalytic domain suppressed c

233 Conversely, ectopic expression of Tet3 enhanced neural differentiati

234 TGF-beta stimulation or ectopic expression of TGF-beta up-regulates S1PR3 levels

235 t of mouse and human hepatocytes, as well as ectopic expression of TGF-beta1 in mice, increases hepci

236 Consistent with a gain-of-function effect, ectopic expression of the 2 identified SAMD9L mutants de

237 Here we report that depletion of mAbp1 or ectopic expression of the ADFH domain of mAbp1 increased

238 Concurrently, ectopic expression of the auxin importer LIKE AUX1 and b

239 However, in contrast to wild-type BCAR3, ectopic expression of the Cas-binding mutant of BCAR3 fa

240 Ectopic expression of the dipeptide repeat (DPR) protein

241 Ectopic expression of the disease-associated mutant form

242 Ectopic expression of the double homeodomain transcripti

243 ortive stroma impaired HSC survival, whereas ectopic expression of the Dpt gene or protein in nonsupp

244 Ectopic expression of the EMT-activating transcription f

245 s that were reduced to 6, demonstrating that ectopic expression of the germ line-related genes PRDM1,

246 H3 lysine 9 trimethylation (H3K9me3) through ectopic expression of the H3K9me3 demethylase Kdm4d grea

247 dgehog pathway activation is associated with ectopic expression of the hedgehog ligands Sonic hedgeho

248 In a spontaneous mouse model of glioma, ectopic expression of the IE1 gene (UL123) specifically

249 hed transcripts and the genes upregulated by ectopic expression of the key notochord transcription fa

250 ey (Hordeum vulgare) Hooded mutant, in which ectopic expression of the KNOTTED1-like Homeobox (KNOX)

251 ired for normal PSM and wall biogenesis, and ectopic expression of the LEP protein Ssp1 perturbs mito

252 In embryos, ectopic Atoh1 expression drove ectopic expression of the Merkel cell marker keratin 8 (

253 Ectopic expression of the miR-183~96~182 cluster inhibit

254 dies with patient lymphoblasts and following ectopic expression of the mutant in HEK293 cells.

255 ells associated with collagen deposition and ectopic expression of the myofibroblastic markers viment

256 Removing an intronic PAS results in ectopic expression of the neuronal ankyrin isoform in no

257 Gene expression profiling revealed ectopic expression of the Notch self-renewal inhibitor B

258 We further demonstrated that ectopic expression of the oncogenes BCR-ABL, NRAS(V12),

259 be imparted to IRF8-non-expressing cells by ectopic expression of the protein.

260 In contrast, ectopic expression of the same chicken Ntn1 in the mouse

261 ectopically expressing wild-type (WT) Brg1, ectopic expression of the SE-Brg1 mutant reduced prolife

262 Ectopic expression of the SH2 domain in cells was suffic

263 poptotic effects of S1PR2 are phenocopied by ectopic expression of the small G protein Galpha13 but a

264 Ectopic expression of the splice variant of RAGE (RAGE s

265 Furthermore, ectopic expression of the transcription factor Ume6, whi

266 We show that ectopic expression of the transcription factors FOXA3, G

267 Ectopic expression of the ubiquitin E3 ligase Parkin, co

268 s of proliferation that could be restored by ectopic expression of the yeast NADH dehydrogenase Ndi1.

269 We found that ectopic expression of these H2O2-sensitive Drosophila TR

270 n to being necessary for thermotransduction, ectopic expression of these rGCs confers highly temperat

271 Ectopic expression of this transcription factor in sorgh

272 ockout cells could be restored completely by ectopic expression of TIM-1 but not TIM-3 or TIM-4.

273 tumor xenograft model, we demonstrated that ectopic expression of TIMP2 open reading frame in the hi

274 ion of autoreactive T cells by promoting the ectopic expression of tissue-specific genes in the thymi

275 Ectopic expression of TLK2 leads to enhanced aggressiven

276 Ectopic expression of TMC-1 confers alkaline sensitivity

277 We demonstrate that ectopic expression of TOR and Raptor (regulatory-associa

278 Ectopic expression of TRAF6 promoted the K63-linked ubiq

279 We find that ectopic expression of transcription factors that specify

280 microfluidic peptide array and confirmed by ectopic expression of TRP120 lysine mutants in cells.

281 channels and mouse HL-1 cardiomyocytes with ectopic expression of two pore-domain K(+) channel isofo

282 Ectopic expression of USP6 is known to drive formation o

283 on in rabbit cells, which was rescued by the ectopic expression of VACV E3 and K3.

284 Significantly, ectopic expression of vU1 genes in human skin fibroblast

285 pressed by depletion of Cyclin A activity or ectopic expression of Wee1 (a partially redundant Cdk1 i

286 Remarkably, although ectopic expression of wild-type Beclin1 promoted cardiom

287 Finally, stable ectopic expression of wild-type PDCD1LG2 and the PDCD1LG

288 Ectopic expression of wild-type Pdcd4 and Pdcd4(157-469)

289 Ectopic expression of wild-type S1PR2, but not a point m

290 rescued cellular and clinical aspects by the ectopic expression of wild-type STN1 or by thalidomide t

291 e also required for necroptosis triggered by ectopic expression of ZBP1 and caspase blockade, and ZBP

292 In contrast, ectopic expression of ZFP521 in HSCs led to a robust mai

293 Consistently, ectopic expression of ZFP871 decreases-whereas knockdown

294 Examination of the effect of ectopic expression on cultured neurons revealed that inc

295 While ectopic expression or specific knockdown of GAS5-AS1 had

296 Ectopic expression produces deleterious effects, underli

297 Of interest, Kif26b ectopic expression rescues the siDaam1 polarization defe

298 Following ectopic expression, SCL contributes to oncogenesis in T-

299 de the SA11-tsC genetic context, we employed ectopic expression systems.

300 erfering RNA/short hairpin RNA knockdown and ectopic expression, western blotting, PCR, promoter-luci