ライフサイエンスコーパス: edema factor

1 protective antigen, lethal factor (LF), and edema factor.

2 -protective antigen (PA), lethal factor, and edema factor.

3 rate proteins, called lethal factor (LF) and edema factor.

4 ive antigen (PA) with lethal factor (LF) and edema factor.

5 protective antigen (PA), lethal factor, and edema factor.

6 nated protective Ag (PA), lethal factor, and edema factor.

7 protective antigen (PA), lethal factor, and edema factor.

8 nergic effects provided by lethal factor and edema factor.

9 tance of LeTx, very recent studies show that edema factor, a potent adenyl cyclase, has the ability t

10 In addition, we found that edema factor, a potent adenylate cyclase, inhibits the h

11 o other enzyme components, lethal factor and edema factor, across the plasma membrane and into the cy

12 The edema factor also enhanced immunity to the binding PA su

13 aired in pore formation and in translocating edema factor and lethal factor across the endosomal memb

14 a purified vaccine free of bacterial toxins edema factor and lethal factor from 1 acre of land.

15 ce plasmid pXO1 at a locus distinct from the edema factor and lethal factor genes.

16 igen (PA) moiety of anthrax toxin transports edema factor and lethal factor to the cytosol of mammali

17 slocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell m

18 y binds the enzymatic moieties of the toxin, edema factor and lethal factor, and translocates them ac

19 f assembles at the cell surface from anthrax edema factor and protective antigen (PA).

20 lasmid-encoded A/B-type toxins, edema toxin (edema factor and protective antigen) and lethal toxin (l

21 ted channel, which unfolds lethal factor and edema factor and translocates them into the host cytosol

22 protective antigen (PA), lethal factor, and edema factor and virulence plasmid pXO2 that encodes cap

23 ur MAb react with three different domains of edema factor, and all were able to detect purified edema

24 ther toxin components, the lethal factor and edema factor, and domain 4, the receptor binding domain

25 Edema factor, another component of anthrax toxin, is an

26 iphtheria toxin that is conserved in anthrax edema factor, anthrax lethal factor, and botulinum neuro

27 g domain (RBD or domain 4) or the lethal and edema factor binding domain (LEF or domain 1') were engi

28 sule operon (capBCADE), lethal factor (lef), edema factor (cya), or protective antigen (pagA).

29 nts deficient in lethal factor, DeltaLF, and edema factor, DeltaEF.

30 A third component of anthrax toxin, edema factor, did not induce leakage alone or with PA.

31 i.e., protective antigen, lethal factor, and edema factor, disseminated from the lung to the spleen a

32 Edema factor (EF) and CyaA are adenylyl cyclase toxins s

33 Edema factor (EF) and CyaA are calmodulin (CaM)-activate

34 Entry of anthrax edema factor (EF) and lethal factor (LF) into the cytoso

35 surface involves competitive binding of the edema factor (EF) and lethal factor (LF) to heptameric o

36 membranes that leads to the translocation of edema factor (EF) and lethal factor (LF) to the cytosol.

37 actors and consists of the adenylate cyclase edema factor (EF) and protective antigen (PA).

38 he anthrax toxins that act by binding to the edema factor (EF) and/or lethal factor (LF) components.

39 mammalian cell surface, competitively binds edema factor (EF) and/or lethal factor (LF).

40 rough which catalytic lethal factor (LF) and edema factor (EF) are believed to translocate to the cyt

41 PA(63)), translocates lethal factor (LF) and edema factor (EF) from endosomes into the cytosol of the

42 ective antigen (PA), lethal factor (LF), and edema factor (EF) in a growth phase-dependent manner whe

43 -terminal segments of lethal factor (LF) and edema factor (EF) in anthrax toxin, we asked whether LF

44 sport the two enzymes lethal factor (LF) and edema factor (EF) into the cell.

45 Edema factor (EF) is a component of an anthrax toxin tha

46 tective Ag (PA) together with a B. anthracis edema factor (EF) mutant having reduced adenylate cyclas

47 The lethal factor (LF) and edema factor (EF) of anthrax toxin bind by means of thei

48 tein of anthrax toxin that mediates entry of edema factor (EF) or lethal factor (LF) into cells.

49 (63) oligomerizes into heptamers, which bind edema factor (EF) or lethal factor (LF) to form the toxi

50 Anthrax edema factor (EF) raises host intracellular cAMP to path

51 mediates the entry of lethal factor (LF) or edema factor (EF) through a membranal pore into target c

52 ly) form by binding of lethal factor (LF) or edema factor (EF) to the pore-forming moiety protective

53 Edema factor (EF), a key anthrax exotoxin, has an anthra

54 Edema factor (EF), a key virulence factor in anthrax pat

55 Edema factor (EF), a potent adenylyl cyclase, is one of

56 Edema factor (EF), a toxin from Bacillus anthracis (anth

57 nd Bacillus pertussis produce the AC toxins, edema factor (EF), and adenylyl cyclase toxin (ACT), res

58 e proteins, namely, protective antigen (PA), edema factor (EF), and lethal factor (LF), encoded by th

59 nent toxin consisting of lethal factor (LF), edema factor (EF), and protective antigen (PA).

60 the pXO1-encoded toxins lethal factor (LF), edema factor (EF), and protective antigen (PA).

61 rotective antigen (PA), the adenylyl cyclase edema factor (EF), and the metalloproteinase lethal fact

62 the proteins, called Lethal Factor (LF) and Edema Factor (EF), are enzymes that act on cytosolic sub

63 nts of anthrax toxin, lethal factor (LF) and edema factor (EF), are transported to the cytosol of mam

64 n, consisting of protective antigen (PA) and edema factor (EF), causes the edema associated with cuta

65 protective antigen and an adenylate cyclase edema factor (EF), elicits edema in host tissues, but th

66 er enzyme components, lethal factor (LF) and edema factor (EF), into the cytosol of the host cell und

67 hrax toxin is made up of three proteins: the edema factor (EF), lethal factor (LF) enzymes, and the m

68 three proteins that comprise anthrax toxin, edema factor (EF), lethal factor (LF), and protective an

69 Intact LF, edema factor (EF), or fusion proteins containing LFN fus

70 ), necessary for host cell toxin uptake, and edema factor (EF), the toxic moiety which increases host

71 ponents of the toxin, lethal factor (LF) and edema factor (EF), to form toxic complexes.

72 ective antigen (PA), lethal factor (LF), and edema factor (EF), which interact at the surface of mamm

73 oieties of the toxin--lethal factor (LF) and edema factor (EF)--across the endosomal membrane of mamm

74 ective antigen (PA), lethal factor (LF), and edema factor (EF)-that come together in binary combinati

75 ective antigen (PA), lethal factor (LF), and edema factor (EF).

76 ective antigen (PA), lethal factor (LF), and edema factor (EF).

77 er enzyme components, lethal factor (LF) and edema factor (EF).

78 nd of the adenylyl cyclase catalytic moiety, edema factor (EF).

79 (PA) and two enzymes, lethal factor (LF) and edema factor (EF).

80 of the anthrax toxin, lethal factor (LF) and edema factor (EF).

81 enzymatic components lethal factor (LF) and edema factor (EF).

82 ure and mechanism of activation with anthrax edema factor (EF).

83 enzymatic components: lethal factor (LF) and edema factor (EF).

84 PA, 83 kDa), lethal factor (LF, 90 kDa), and edema factor (EF, 89 kDa).

85 the effects of the anthrax edema toxin (ET; edema factor [EF] plus protective antigen [PA]) and leth

86 oieties of the toxin (lethal factor [LF] and edema factor [EF]).

87 ng monoclonal antibody (mAb) against anthrax edema factor, EF13D.

88 ent corresponding to the catalytic domain of edema factor (EF3) was cloned, overexpressed in Escheric

89 ino-terminal 32-kDa fragment of B. anthracis edema factor, EGFP-EF32, was used to confirm specificity

90 pose that the N terminus of PA63-bound LF or edema factor enters the PA63-channel under the influence

91 The edema factor exotoxin produced by Bacillus anthracis is

92 ected mutations based on the homology of the edema factor family revealed a conserved pair of asparta

93 Da domain (EF3-N) of EF3, the sole domain of edema factor homologous to adenylyl cyclases from Bordet

94 factor, and all were able to detect purified edema factor in Western blot analysis.

95 ax virulence factors, lethal factor (LF) and edema factor, in transgenic Drosophila.

96 Lethal factor and edema factor, individually or in combination, are incapa

97 ranes that allow for the transport of LF and edema factor into the cytosol.

98 entry of the toxin's lethal factor (LF) and edema factor into the cytosolic compartment of mammalian

99 orchestrates the delivery of the lethal and edema factors into the cytosol.

100 he delivery of the other two (the lethal and edema factors) into the cytosol.

101 its two enzyme components, lethal factor and edema factor, into the host cytosol under the proton mot

102 nts of anthrax toxin [lethal factor (LF) and edema factor] into the cytosol of mammalian cells depend

103 This suggests that edema factor may utilize a similar catalytic mechanism.

104 d to establish lethal infection, whereas its edema factor modulates progression and dissemination of

105 combination with either the lethal-factor or edema-factor moiety.

106 h the two catalytic parts (lethal factor and edema factor) or other proteins can be transported into

107 surface and docking of lethal factor and/or edema factor, PA is internalized and undergoes a conform

108 Hence, ExoY is a promiscuous cyclase and edema factor that uses cAMP and, to some extent, cGMP to

109 Edema factor, the catalytic subunit of ET, is an adenyla

110 Edema factor, the enzymatic A subunit of EdTx, is an ade

111 Protective antigen (PA), lethal factor, and edema factor, the protein toxins of Bacillus anthracis ,

112 r their cellular uptake and either lethal or edema factors, the toxigenic moieties.

113 ential for the delivery of lethal factor and edema factor to the cell cytosol.

114 lethal factor, and/or the adenylate cyclase edema factor, to generate lethal toxin (LTx) and edema t

115 y the adenylyl cyclase domain of the anthrax edema factor toxin was simulated using the empirical val

116 ective antigen (PA), lethal factor (LF), and edema factor-translocates large proteins across membrane

117 roteolytically, attaches to lethal factor or edema factor, undergoes oligomerization and internalizat

118 Abs) produced against PA, lethal factor, and edema factor, were examined in animals infected with Bac

119 xins (lethal factor, protective antigen, and edema factor) where expressed 4-6-log10-fold less than i

120 ludes protective antigen, lethal factor, and edema factor, which are the components of anthrax toxin,

121 s from the interaction of N-CaM with anthrax edema factor, which binds N-CaM via its helical domain.

122 ve antigen (PA) and traces of the lethal and edema factors, which may contribute to adverse side effe