ライフサイエンスコーパス: effector

1 of a component of the T3SS apparatus and an effector.

2 se function ranges from immunosuppressive to effector.

3 ess, activating malarial proteases and other effectors.

4 llular localization, they perform poorly for effectors.

5 that impinges on specific potassium channel effectors.

6 subgroups of RNAs that respond to different effectors.

7 duce different time intervals with different effectors.

8 cells behave as protective or proatherogenic effectors.

9 g, and serves as an adaptor to recruit other effectors.

10 rm of Cas9 is fused to DNA methyltransferase effectors.

11 ped a multiplex transcription activator-like effector activation (mTALE-Act) system for simultaneous

12 enescent CD4+ T cells, and reduced naive and effector and central memory CD8+ T cells.

13 ten persistent, leading to generation of CD4 effector and effector memory T cells that contribute to

14 e chromosomal clusters each encode a pair of effector and immunity genes downstream of those encoding

15 ms are thought to be important for balancing effector and memory differentiation; however, the epigen

16 PAM acts as an allosteric effector and triggers the interdependent conformational

17 Stat1/2/3 and PML are IFNalpha downstream effectors and are pivotal regulators of angiogenesis.

18 pression and subcellular localization of Shh effectors and ciliary proteins are severely disturbed in

19 We also examined ATM effectors and found that H2AX shows a similar influence

20 ochondria are a bona fide target of Coxiella effectors and MceA is a complex-forming effector at the

21 of different T cell subsets, that is, naive, effector, and memory T cells.

22 raits, including secretion systems, putative effectors, and lipopolysaccharides (LPSs), as well as ot

23 ss is initiated by cytokines, neuroendocrine effectors, and mechanical strain that promote resident f

24 o understand the molecular targets, cellular effectors, and receptors.

25 ific signaling pathways leading to antiviral effectors are affected.

26 SS substrates, the toxic activities of these effectors are neutralized by adjacently encoded cognate

27 Little is known about how and where effectors are secreted during infection, yet such knowle

28 The auxin effector ARF5/MONOPTEROS (MP) acts both cell-autonomousl

29 be a powerful tool for the classification of effectors as well as for the functional study of effecto

30 These data demonstrate that effector-associated epigenetic programs are preserved du

31 ella effectors and MceA is a complex-forming effector at the mitochondrial outer membrane during Coxi

32 of FOXO4 is primed, in part, by the PI3K/AKT effector axis of oncogenic RAS signalling.

33 g a complex containing Cla4, a Cdc42-binding effector, Bem1, a scaffold, and Cdc24, a Cdc42 GEF.

34 ations successfully eliminated Fc-associated effector binding and functions.

35 (bHLH) transcription factors with predicted effector binding elements (EBEs) for AvrHah1.

36 h supports that some of the tested bacterial effectors can bind to membrane phospholipids and may reg

37 Unlike effector CD4(+) T cells, an MHC class II tetramer reagen

38 nsfer model to elucidate the kinetics of the effector CD8(+) T cell response in the liver following P

39 ntiation resulted in acquisition of terminal effector cell characteristics, whereas enhancement of pr

40 parts that require peripheral activation for effector cell differentiation, gammadelta T cells instea

41 phils and show the importance of an antibody/effector cell interaction in mediating humoral immunity.

42 driver of Th1 differentiation and cytotoxic effector cell maturation.

43 Propionate suppressed T effector cell migration between the intestine and the sp

44 ducted, we considered and calibrated a tumor-effector cell recruitment model under the influence of f

45 lineating the effect of complement-dependent effector-cell engagement in various therapeutic settings

46 +) T cell produces terminally differentiated effector cells and renews itself for continued defense.

47 duces targeted cell lysis in the presence of effector cells at as low as sub-picomolar concentrations

48 ty to provide long-term immunity while other effector cells develop into terminally differentiated ef

49 tic cells, CD4+ T effector cells, and CD8+ T effector cells from healthy skin samples, followed by RN

50 study, we defined the bioenergetics of Th17 effector cells generated in vivo.

51 Basophils are important effector cells involved in the pathogenesis of inflammat

52 for optimal protection; however, the innate effector cells responsible for mediating this protection

53 suppression was more pronounced in terminal effector cells than in memory precursor cells and was re

54 dered neutrophils to function as nonspecific effector cells that die quickly after performing antimic

55 its differentiation intermediates and mature effector cells to expand upon demand, thereby providing

56 geting the surface-bound IgE of the allergic effector cells via low-affinity anti-human IgE Abs with

57 ferentiation is set to produce myriad immune effector cells with the ability to respond to multitudin

58 olate keratinocytes, dendritic cells, CD4+ T effector cells, and CD8+ T effector cells from healthy s

59 required destination, and differentiate into effector cells, depending on the local tissue environmen

60 thin the phagolysosome and in the cytosol of effector cells.

61 ells into inflammatory IFN-gamma-coproducing effector cells.

62 g noncoding RNAs, guide Argonaute-containing effector complexes to complementary nascent RNAs to init

63 cant upregulation in both damage-sensing and effector components of the inflammasome, including caspa

64 New single-component effector CRISPR systems are emerging from the bioinforma

65 plified tissue production of multiple T-cell effector cytokines, including IFN-gamma, IL-17, and IL-2

66 he differentiation of naive CD8 T cells into effector cytotoxic T lymphocytes upon antigen stimulatio

67 ) of the type VI secretion system (T6SS), an effector delivery pathway that mediates interbacterial c

68 e encoding the T6SS structural machinery for effector delivery.

69 a outer protein J (YopJ) family of bacterial effectors depends on a novel acetyltransferase domain to

70 cell priming or skew clonal recruitment and effector differentiation is not known.

71 osition, uniform CAR expression, and limited effector differentiation.

72 nding sites in the transmembrane helices and effector docking sites at the intracellular surface of t

73 y effector domains may depend on which other effector domain are co-delivered.

74 ated that these miniproteins bind to the Ras effector domain as dimers, and high-resolution crystal s

75 as in an unprecedented mode in which the Ras effector domain is remodeled to expose an extended pocke

76 Instead, modulation of cell function by effector domains may depend on which other effector doma

77 T follicular helper (TFH) cells, but not TH1 effectors, elicited by viral infection.

78 orylation of the canonical signaling pathway effectors Erk1/2, Akt, or STAT5 nor ErbB4 stability.

79 m of this study was to characterize the T3SS effector EspW.

80 +) ThCTL indicates they are highly activated effectors expressing high levels of binding to P-selecti

81 ector, termed Tne2 (Type VI secretion NADase effector family 2), demonstrates that it possesses poten

82 L defines a family of T3SS cysteine protease effectors found in a range of bacteria and reveals a mec

83 Transcription activator-like (TAL) effectors from Xanthomonas citri subsp. malvacearum (Xcm

84 novel insights concerning the regulation of effector function by T1-IFN in human antigen-experienced

85 e signaling could restore the acquisition of effector function in ITK-deficient CD8(+) T cells.

86 28 IFPs exhibited enhanced proliferation and effector function in response to CD200(+) leukemic cells

87 have been reported to silence or reduce the effector function of antibodies.

88 We recently demonstrated that the major effector function of neonatal CD4(+) T cells is to produ

89 ich antigen presentation controls the innate effector function of Th2 cells at the site of inflammati

90 Coordinated crosstalk of effector function suggests that MARTX toxins are not sim

91 by the fragmentation of the Golgi apparatus (effector function).

92 sequently, Lp/OVA/StII induced a more potent effector function, as shown by CTLs, in vivo assays.

93 ent kinase 5 (Cdk5) in T-cell activation and effector function, but the contribution of Cdk5 activity

94 lt in lack of glycosylation and thus loss of effector function, we demonstrate that the N297G variant

95 the IgG2 isotype is not completely devoid of effector function, whereas the IgG4 isotype can undergo

96 molecules, cytokine secretion, and enhanced effector function.

97 ibition adversely affects early onset T-cell effector function.

98 The stable effector functionLess (SEFL) antibody was designed as an

99 Interferon effector functions and autophagy are evolutionarily cons

100 ells are critical for performing appropriate effector functions and maintaining immune memory, they a

101 Their effector functions are closely linked to their cytotoxic

102 Its effector functions are controlled through interactions b

103 mmune pathology; however, defining their key effector functions in specific autoimmune diseases remai

104 cities, locations (systemic or mucosal), and effector functions of antibodies elicited by novel HIV-1

105 o explain how matrix controls the antifungal effector functions of neutrophils under conditions that

106 GS-9620 also improved immune effector functions that specifically targeted HIV-infect

107 d mononuclear cells, and can activate immune effector functions to kill cancer cells in vitroIn vivo,

108 All cloned AHAs could restore immune effector functions to proteolytically generated F(ab')2

109 8 T cells remain poised to rapidly elaborate effector functions upon re-exposure to pathogens, but al

110 sted" CD8 T cells with impaired HIV-specific effector functions, but its role on CD4 T cells and in H

111 s for growth and survival, but also instruct effector functions, differentiation, and gene expression

112 isplayed central/effector memory and mounted effector functions, including the production of anti-M.

113 eir unique combination of CD4 and CD8 T cell effector functions, these CD4(-) CD8alphaalpha T cells a

114 nes, can trigger antibody-dependent cellular effector functions, through engagement of their Fc-gamma

115 ts of distinct subpopulations with differing effector functions.

116 ion demonstrates a potent ability to restore effector functions.

117 replication independently of adaptive immune effector functions.

118 Neonatal and adult T cells differ in their effector functions.

119 vel link between ZAP-70 expression and these effector functions.

120 , resulting in enhanced FcgammaRIII-mediated effector functions.

121 s of Gfi1 resulted in premature induction of effector genes and the transcription factors forkhead bo

122 hairpin RNA screen to identify GC-regulated "effector" genes that contribute to cell death, as well a

123 wn major binding partner [GPCRs, Gbetagamma, effectors, guanine nucleotide dissociation inhibitors (G

124 ely modular DNA binding proteins such as TAL effectors, has generally proved to be quite challenging.

125 d to anchor Arl8 (Arf-like GTPase 8) and its effector homotypic fusion/vacuole protein sorting comple

126 study we expressed the Pseudomonas syringae effector HopAI known to inactivate plant MAP kinases in

127 important role for the ubiquitin pathway in effector-host interactions and pathogen-mediated host pr

128 of dysbiosis contribute to inflammation and effector immune responses that mediate inflammatory bowe

129 y responsible for the high diversity of T6SS effector-immunity gene profiles observed for V. cholerae

130 as protegens Consistent with the established effector-immunity paradigm for antibacterial T6SS substr

131 ein kinase type IV (CaMKIV) is a key sensory/effector in excitatory synaptic scaling that senses pert

132 identified BRaf as the key missing signaling effector in the common synaptic NMDA-R-CaMKII-SynGap-Ras

133 to generate straight trajectories of the end-effector in the work space.

134 ility and biofilm formation through a single effector in this surface-motile bacterium.

135 These data unveil two novel mitochondrial effectors in H. pylori-host interaction with links on ga

136 escribes the role of endogenous RAGE ligands/effectors in normo- and pathophysiological processes, su

137 s, and physiological functions of SPI-2 T3SS effectors in the context of the selective pressures enco

138 We demonstrate translocation of a number of effectors in the U. maydis-maize system and show data th

139 in 2, Regucalcin, and Cyclin-D1 and of K-Ras effectors, including phosphorylated extracellular signal

140 Moreover, effector-induced host cell death was dependent on NbBAK1

141 etween the TA-binding site, ATPase site, and effector interaction surfaces of Get3.

142 Many pathogens deliver virulence factors or effectors into host cells in order to evade host defense

143 Pathogens deliver effectors into plant cells to suppress immunity-related

144 We found that CBI changes only for the effector involved in the movement.

145 eases in beta-catenin targets and some K-Ras effectors, leading to reduced tumor cell proliferation a

146 Here, we demonstrate that the Wnt/ss-catenin effector Lef1 is required for the differentiation of anx

147 e if host plants also contain genes encoding effector-like proteins.

148 Therefore, the candidate effectors list in this article provides both a clue for

149 We show that over 30% of the effectors localize to yeast and mammalian cell membranes

150 ht the importance of analyzing metabolism in effector lymphocytes within in vivo inflammatory context

151 However, external effectors may influence the observed co-localization ind

152 mediated phagocytosis is an important immune effector mechanism against Plasmodium falciparum-infecte

153 receptor (GPR) signaling as a prominent EVI1 effector mechanism in breast carcinoma.

154 cellular antibodies, link this to the TRIM21 effector mechanism, and highlight how this work is expos

155 n that the hierarchy of importance of immune effector mechanisms in primary S. venezuelensis infectio

156 clearance compelling alternative neutrophil effector mechanisms to destroy these physically large mi

157 one), and gene-expression profiles in naive, effector memory (EM), and terminally differentiated EM (

158 ells for adoptive transfer displayed central/effector memory and mounted effector functions, includin

159 the HCMV proteins studied were predominantly effector memory cells and produced both cytotoxic (CD107

160 A distinct subpopulation of CD4(+) effector memory T (TEM) cells that secrete IL-17A, but n

161 , memory stem T cell, central memory T cell, effector memory T cell, and terminally differentiated ef

162 The proportions of both effector memory T cells and central memory T cells were

163 t, leading to generation of CD4 effector and effector memory T cells that contribute to protection.

164 rofiling of human resting naive, central and effector memory T cells using ChIP-Seq and found that un

165 ith cytotoxic features that is distinct from effector memory T cells.

166 and CCR6(+) Treg cells exhibit an activated effector/memory phenotype.

167 controls, while mice lacking the necroptotic effector MLKL, or both MLKL and caspase-8, were unaffect

168 Here, we identify a presynaptic effector molecule of the Wingless/Wnt signal, Cortactin.

169 Immune-mediated effector molecules can limit cancer growth, but lack of

170 h the discovery that IgE antibodies were the effector molecules of the allergic response.

171 uggestion has been to develop genes encoding effector molecules that block parasite development withi

172 owever, little is known about mechanisms and effector molecules triggering fibrosis and angiogenesis

173 protoxin-neutralizing antibodies are the key effector molecules while a shift to Th1 or Treg cells ma

174 Tumor Necrosis Factor Receptor to downstream effector molecules.

175 e receptor/JAK2 pathway and their downstream effectors, more particularly the STATs.

176 pha therefore functions as a transcriptional effector of cytokine-induced IKKbeta signaling, suggesti

177 These data identify miR-21 as an important effector of fibrosis in the peritoneal membrane, and a p

178 istic target of rapamycin signaling, a known effector of NF1 loss.

179 ulin Jkappa region (RBPJkappa), a downstream effector of Notch signaling.

180 JAK1 is a critical effector of pro-inflammatory cytokine signaling and play

181 in vivo These data validate BRD4 as a major effector of RSV-induced inflammation and disease.

182 summary, we found no evidence that ERG is an effector of SPOP mutation in human prostate cancer or mo

183 pose that ERG stabilization is the oncogenic effector of SPOP mutation.

184 A key effector of the complement response is the activation fr

185 translation control whereby, as an upstream effector of TOR, ROP2 coordinates TOR function in transl

186 dox enzymes are important post-translational effectors of actin that stereo-specifically oxidize acti

187 (encoding a cannabinoid receptor) as central effectors of B-lymphoid restriction of glucose and energ

188 Calcium Dependent Protein Kinases are key effectors of calcium signaling in malaria parasite.

189 tes ERK5 activity by regulating the upstream effectors of ERK5 and also by modulating its ubiquitinat

190 tate tissue to screen downstream targets and effectors of miR-32, we identified RAC2 as a potential,

191 Microtubules (MTs) are key cellular effectors of neuronal displacement that are assembled fr

192 ding evidence that PH domain proteins may be effectors of PI3P for protein sorting.

193 We hypothesized that downstream effectors of TGFbeta1 in fibroblasts could be attractive

194 te domain (TEAD) proteins are the downstream effectors of the Hippo signaling pathway that regulate c

195 erved Ser/Thr kinases that act as downstream effectors of the Ras/Raf/MEK/ERK signaling pathway.

196 d matrix metalloproteinase-9, the downstream effectors of TSP-2.

197 tors of transcription 5 (STAT5s) are crucial effectors of tyrosine kinase oncogenes in myeloid leukem

198 sis and oxidative stress are among the major effectors of ventilator-induced diaphragm muscle dysfunc

199 progression through inhibiting TAZ and YAP, effectors of WNT signaling.

200 late to RDN-induced reduction of sympathetic effectors on the myocardium.

201 he importance of precise neuronal control of effector pathways.

202 pansions have differentiated from a naive to effector phenotype associated with CD27 downregulation,

203 oding FOXO1, T cells revert to a short-lived effector phenotype, exhibit reduced viability, and manif

204 we observed that Olig1 and the BMP signaling effector, phosphorylated SMADs (Sma- and Mad-related pro

205 Nematode effectors play a crucial role in initializing and sustai

206 ces the expansion of an ICOS(+) Th1-like CD4 effector population in addition to engaging specific sub

207 most strikingly in the least abundant CD8+ T effector population.

208 several factors known to participate in the effector portion of the RdDM pathway, including RNA POLY

209 To enable prediction of effectors possessing either broad efficacy or host speci

210 that maintenance of human memory CD8 T cell effector potential during in vitro and in vivo homeostat

211 This effector potential is acquired in the human thymus, prio

212 port the crystal structures of PopP2, a YopJ effector produced by the plant pathogen Ralstonia solana

213 ausal agent of tomato wilt disease, produces effector protein Avr2.

214 structural protein sigmaNS with the major SG effector protein G3BP1 and subsequent localization of G3

215 cleavage and activation of the pore-forming effector protein gasdermin D by inflammatory caspases.

216 stigate auto-regulation of the innate immune effector protein kinase R, which phosphorylates the euka

217 le pore protein EspD, which is essential for effector protein translocation into host cells.

218 elevated response is independent of the CagA effector protein.

219 However, the neuroprotective effector proteins induced by RBM3 and the mechanisms by

220 type III secretion system (T3SS) to deliver effector proteins into eukaryotic host cells.

221 f these 3'-UTR functions are accomplished by effector proteins that are recruited by RNA-binding prot

222 s encode proteins that appear to function as effector proteins that may regulate symbiotic associatio

223 he identification and mode of action of T6SS effector proteins that mediate this protective effect re

224 hroughput, modification or overexpression of effector proteins, and low temporal resolution.

225 Many parasite effector proteins, including perforins, adhesins, and pr

226 he molecular weight and isoelectric point of effector proteins, induce their methylation or demethyla

227 nd the intracellular replication of Coxiella Effector proteins, translocated into the host cell throu

228 sed by the type III secretion system and its effector proteins.

229 ulates the immune response by modulating the effector/regulatory T ratio.

230 How effectors reprogram the cytoskeleton network remains unc

231 , we identify two previously uncharacterized effectors required for interbacterial antagonism by the

232 quired for induction and maintenance of Th17 effector responses in the inflammatory contexts of both

233 decidual microenvironment reduces CD8(+) dT effector responses to maintain tolerance to fetal antige

234 ophage inflammatory protein 1beta secretion) effector responses.

235 R7-RGS heterotrimers, indicating that these effector RhoGEFs can engage Galpha13.R7-RGS complexes.

236 s more recently been identified that protein effectors secreted by fungal pathogens can spread betwee

237 Development of the M. oryzae effector-secreting biotrophic interfacial complex (BIC)

238 the PtdIns4P-binding domain of the bacterial effector SidM.

239 projections to the vlBNST, which is also the effector site for ATII-responsive SFO neurons.

240 testinal immune homeostasis at inductive and effector sites of oral tolerance by suppressing peripher

241 tors TAZ and YAP and the TGF-beta1 (TGFbeta) effector Smad3 regulate a common set of genes, can physi

242 us fashion in vitro, and depletion of the Hh effector Smoothened (Smo) from stromal cells is associat

243 votal B-cell antigen receptor (BCR)-proximal effector spleen tyrosine kinase (SYK), which we identifi

244 nal manner between protective and pathogenic effector states.

245 tic characterization of the memory-precursor effector subset of virus-specific CD8 T cells transferre

246 hymus to generate discrete gammadelta T cell effector subsets with distinctive molecular signatures.

247 CD4 T cells can differentiate into multiple effector subsets, including ThCTL that mediate MHC class

248 may facilitate access of IRS-2 to downstream effectors such as AKT.

249 ns such as Rho and Rac, and their downstream effectors such as Rho kinase and nicotinamide adenine di

250 Downstream of gene expression, effectors such as the actomyosin contractile machinery d

251 nt, but the exact role of Ca(2+) and its key effector synaptotagmin-1 (syt1) in regulation of endocyt

252 annot be defined by the activity of a single effector system.

253 cells engage distinct signaling pathways and effector systems across the entire cerebrovascular netwo

254 ogy via descending pathways to physiological effector systems, including the spinal cord and other pe

255 kin 6 (IL-6) from epithelial cells, tailored effector T cell function, promoting increases in gingiva

256 Effector T cell migration through tissues can enable con

257 memory T cell, and terminally differentiated effector T cell populations to the CD3 and CD28-activate

258 maturation and the subsequent development of effector T cell responses.

259 constitute the entire spectrum of memory and effector T cell subsets.

260 cells into functionally distinct subsets of effector T cells (T helper 1 (TH1), TH2, and TH17) defin

261 rylation (OXPHOS) for energy production, and effector T cells (Teffs) rely on glycolysis for prolifer

262 ating lymphopenia and a higher percentage of effector T cells and natural killer (NK) cells present i

263 nimmune" modality for intratumoral T reg and effector T cells in promoting tumor growth through the p

264 is was associated with an increase in BM CD8 effector T cells in RIC mice and elevated blood and BM p

265 aerobic glycolytic preference in NLRX1(-/-) effector T cells is combined with a decreased sensitivit

266 all the phenotypic characteristics of memory-effector T cells such that with acute inactivation of th

267 notype and functionality of antigen-specific effector T cells were analyzed with flow cytometry after

268 vascular inflammation, enriched for PD-1(+) effector T cells, and amplified tissue production of mul

269 sentation module, promoted the generation of effector T cells.

270 at affect the balance between regulatory and effector T cells.

271 timuli and promotes immune tolerance through effector T-cell anergy and enhanced Treg function.

272 Memory T cells sustain effector T-cell production while self-renewing in reacti

273 Although the effector T-cell response in patients with celiac disease

274 feration of Foxp3(+) Tregs, but not Foxp3(-) effector T-cells (Teff), when CD4(+) T-cells are co-cult

275 ve oxygen species source and also their main effector target; however, the pathophysiological role of

276 ficantly alters the expression levels of 71% effector targets and their downstream physical interacti

277 Here, we show that a dual role for Hippo effectors TAZ and YAP in SC proliferation and myelinatio

278 cells develop into terminally differentiated effector (TE) cells with limited survival.

279 In T cells, Blimp1 is expressed in both effector (Teff) and regulatory (Treg) cells, and mice wi

280 e in vivo conversion of alloreactive donor T effectors (Teffs; CD4(+)CD25(-)FOXP3(-)) and the direct

281 larity, biochemical characterization of this effector, termed Tne2 (Type VI secretion NADase effector

282 n was mediated by IL-5-expressing pathogenic effector Th2 cells and was independent of TCRgammadelta

283 vely, our results indicate that Cu is a host effector that is involved in protection against pathogen

284 set of previously uncharacterized Legionella effectors that appear to be able to regulate yeast vacuo

285 processed by essential ubiquitin ligases and effectors that are mutated across neurodegenerative dise

286 acellular vesicles (EVs) may represent novel effectors that might help to elucidate disease-specific

287 that rust fungi might have evolved multiple effectors that target chloroplasts or nuclei.

288 We also identified novel PI3K effectors that were commonly-regulated, including putati

289 s recruiting both innate and adaptive immune effectors to eradicate established tumors.

290 s secrete various virulence proteins, called effectors, to manipulate host cell signaling pathways an

291 Immunity, Shan et al. (2017) highlight that effector-to-memory transitioning (EMT) CD4(+) T cells ar

292 xpression; and we provide a basic driver and effector toolkit.

293 Without E1 and E2 enzymes, SidE effectors ubiquitylate serine residues in substrates via

294 s identify bile acids as important metabolic effectors under conditions of sustained BAT activation a

295 ctors as well as for the functional study of effector uptake mechanism not only in the chosen system

296 rolling postinfection CD8(+) T cell terminal effector versus memory differentiation are incompletely

297 their effects on a vast number of molecular effectors, we found that the beneficial effects on learn

298 Among these Legionella effectors, WipA has been primarily studied because of it

299 1 (Dag1) directly binds to the Hippo pathway effector Yap to inhibit cardiomyocyte proliferation in m

300 Hippo effectors YAP/TAZ act as on-off mechanosensing switches