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1 as exerted by the PAS domain proximal to the effector domain.
2 and Ptr-H16, fusing the P. furiosus ORF1231 effector domain.
3 -associated death domain (FADD) at the death effector domain.
4 I and HIP1 was predicted to resemble a death-effector domain.
5 ot for the growth-suppressive effects of the effector domain.
6 ts is suppressed by a second mutation in the effector domain.
7 ough Fas/CD95 and DR5 were also in the death effector domain.
8 site to the N-terminal end of the FADD death effector domain.
9 osphorylation domain inhibits the C-terminal effector domain.
10 oP-DNA interactions exclusively involved the effector domain.
11 ical for GTPase activity and in its putative effector domain.
12 decoupling of the signal pathway within the effector domain.
13 oes not interact with its NH2-terminal death effector domain.
14 eraction domains: a death domain and a death effector domain.
15 arotenoid has translocated entirely into the effector domain.
16 K-Ras in a GTP-dependent manner via the Ras effector domain.
17 main inhibits methylesterase activity of the effector domain.
18 g and transcription activation in the distal effector domain.
19 binding properties of the carboxyl-terminal effector domain.
20 and stimulation of enzymatic activity of the effector domain.
21 ted catalytically inactive dCas9 fused to an effector domain.
22 nslocation of the carotenoid deeper into the effector domain.
23 ealing allosteric control of the CNBD by the effector domain.
24 N-terminal receiver domain and a C-terminal effector domain.
25 ization of the influenza A virus NS1 protein effector domain.
26 ed both an intact NS1 RNA-binding domain and effector domain.
27 ire length of the molecule to the N-terminal effector domain.
28 encode toxins with different arrangements of effector domains.
29 odules to propagate environmental signals to effector domains.
30 specifically at leucine residues between the effector domains.
31 rocessing and intracellular release of toxin-effector domains.
32 teins, PAS domains bind ligands and modulate effector domains.
33 hyl-lysine recognition by two closely spaced effector domains.
34 l changes brought about by NTP hydrolysis to effector domains.
35 control the output activities of C-terminal effector domains.
36 to execute their as yet unknown function as effector domains.
37 mploy different mechanisms to regulate their effector domains.
38 ough the opposing activities of its terminal effector domains.
39 site recognition through their Arg-Ser-rich effector domains.
40 nated heme and regulates the activity of its effector domain, a C-terminal histidine kinase, in respo
43 Recent studies have indicated that the Fc effector domain also displays considerable heterogeneity
44 S protein and a peptide corresponding to the effector domain (an unstructured region that contains 13
45 ly, are composed of an N-terminal Nudix-like effector domain and a C-terminal DNA-binding HTH-like do
47 nse regulators stimulates DNA binding by the effector domain and how dimerization and domain orientat
48 thermore, we detected numerous new conserved effector domains and discovered new domain combinations,
49 itions C-terminal specificity and N-terminal effector domains and facilitates stable binding to adjac
50 e expression, a function requiring an intact effector domain, and via altering RpaA phosphorylation,
51 n modules that includes death domains, death effector domains, and Caspase activation and recruitment
54 nd inactivate RhoA, respectively, when other effector domains are absent, with toxin autoprocessing r
56 tions into the molecular mechanisms of these effector domains are providing insight into how the func
57 les indicates that Mgm1p's GTPase and GTPase effector domains are required for its ability to promote
58 that artificial DNA-binding proteins lacking effector domains are useful tools for studying and modul
59 t domain), DD (death domain), and DED (death effector domain), are believed to exert their effects so
60 ated that these miniproteins bind to the Ras effector domain as dimers, and high-resolution crystal s
62 previously characterised response regulator effector domains, as it is shorter than any characterise
66 irus NS1 protein, which includes part of its effector domain, blocks the covalent linkage of ISG15 to
67 important for HIPPI binding, is not a death-effector domain but is a partially opened coiled coil.
70 s (Rab8, 10, 13 and 15) and that some of the effector domains can bind two Rab proteins via separate
71 lar proteins consist of death domains, death effector domains, caspase recruitment domains, and pyrin
72 allosteric communication between sensor and effector domains, characterization of all relevant signa
73 rylation domain and a C-terminal DNA binding effector domain connected by a flexible interdomain link
75 DD), a highly conserved and ubiquitous death effector domain containing protein, exists predominantly
76 ase-3, caspase-cleaved cytokeratin-18, death-effector-domain containing DNA-binding protein and ubiqu
77 est in amino acid sequence homology to death effector domain-containing DNA-binding protein, DEDD.
80 ssociated herpesvirus (KSHV) encodes a death effector domain-containing protein that is homologous to
83 culate that low thermostability of the MARTX effector domains correlates with that of many other memb
85 roteins required 2 conserved transcriptional effector domains (CR2 and CR3), each of which alone was
87 PEA-15 is composed of an N-terminal death effector domain (DED) and a C-terminal tail of irregular
88 solved in solution, revealing that the death effector domain (DED) and death domain (DD) are aligned
90 of apoptosis proteins (IAP); however, death effector domain (DED) caspases of the extrinsic pathway
91 ers recruitment of FADD, which via its death effector domain (DED) engages the DEDs of procaspase 8 a
92 ilaments in turn nucleate procaspase-8 death effector domain (DED) filaments in vitro and in vivo.
94 g the death domain (DD) subfamily, the death effector domain (DED) subfamily, the caspase recruitment
96 report that the expression of a small death effector domain (DED)-containing protein, NDED (NF-kappa
97 2(PYD) with the hydrophobic patches of death effector domain (DED)-containing proteins and confirm th
99 sical protein complex with Src via its death effector domains (DED) and maintains the complex in a de
101 ns (CARD); (3) Death Domains (DD); (4) Death Effector Domains (DED); (5) BIR domains of Inhibitor of
102 nsisting of only the N-terminal tandem death effector domains (DEDs) (N protein) was dramatically dec
108 bic patch 1 and alpha2 regions of both death effector domains (DEDs) within MC159 resulted in loss of
111 utoprocessing repeats-in-toxin (MARTX) toxin-effector domain DUF5(Vv) from Vibrio vulnificus to be a
112 ed that by combining zinc fingers with other effector domains, e.g., from nucleases or integrases, to
113 g NCAM antibody and a peptide comprising the effector domain (ED) of myristoylated alanine-rich C kin
114 vestigated the hypothesis that the polybasic effector domain (ED) of the abundant intracellular subst
115 domains, an RNA-binding domain (RBD) and an effector domain (ED) separated by a linker region (LR),
117 vity of their DNA-binding domains (DBDs) and effector domains (EDs) enabling the coordination of gene
118 hybrid proteins developed to direct various effector domains (EDs) of choice to predetermined DNA se
119 sion of FADD that lacks the N-terminal death effector domain (FADD(DN)) increases the sensitivity of
120 c triad is essential for function of the RID effector domain family shared by MARTX toxins produced b
122 domain is exploited in a screen of other Lrp effector domains for activation capability by constructi
123 structures of the RNA binding domain and the effector domain from non-H5N1 strains, the RNA binding d
124 port factor and can functionally replace the effector domain from the human immunodeficiency virus ty
126 selected targets, to examine the activity of effector domains from natural splicing factors and to mo
127 the RID MLD with the MLDs from two different effector domains from the Vibrio vulnificus MARTX toxin
128 ere, we report the crystal structures of the effector domains from two oomycete RXLR proteins, Phytop
130 tudies of transcription activator-like (TAL) effector domains fused to nucleases (TALENs) demonstrate
135 rizes and forms the tube surface, the GTPase effector domain (GED) mediates self-assembly, and the pa
136 ndocytosis, overexpression of dynamin GTPase effector domain (GED) mutants that are selectively defec
137 n of the GTPase domain and two in the GTPase effector domain (GED), dynamin's putative GAP, fully res
139 in cross-linking reaction performed by these effector domains has been significantly characterized, t
140 bined with the potential of fusing them with effector domains has led to the technology of engineerin
142 r, the currently available structures of NLR effector domains have not yet revealed the mechanism of
143 depends on the coupling of CO binding at an effector domain heme with the allosteric repositioning o
145 ne repression required the action of several effector domains; however, KRAB-dCas9 did not contribute
148 oduce hybrid RtxA::Bla toxins that carry one effector domain in addition to Bla were found to more ef
150 in, whereas the CARD domain functions as the effector domain in the caspase-1 activation pathway.
151 dent mechanism to control a diverse array of effector domains in biological and engineered proteins.
152 monstrate that even the structurally similar effector domains in rabenosyn-5 can achieve highly selec
153 to stabilize the active conformation of the effector domain increased the agonist potency in stabili
154 struct access to the functional sites of the effector domains, indicating a regulatory mechanism base
155 mino-terminus to LMP-1's function: (i) as an effector domain, interacting with cellular proteins, or
156 (iii) a NF-kappaB Essential Modifier-binding effector domain interfering with NF-kappaB activation.
158 l for virulence and that the ExoY-like MARTX effector domain is a catalytically active adenylate cycl
159 ional activation through the C-terminal Ptr2 effector domain is exploited in a screen of other Lrp ef
160 as in an unprecedented mode in which the Ras effector domain is remodeled to expose an extended pocke
164 equirement for alpha-helical transcriptional effector domains is similar to the oncogenic contributio
165 onding to a basic region in GAP43 and MARCKS effector domain-like regions in other proteins (e.g. Mac
166 in vitro study by Gay et al., suggests that effector domain MARCKS peptides could play a significant
167 he ability of a peptide corresponding to its effector domain, MARCKS(151-175), to sequester PIP2 in m
168 Instead, modulation of cell function by effector domains may depend on which other effector doma
169 that the Makes Caterpillar Floppy-like MARTX effector domain (MCFVv) is an autoproteolytic cysteine p
170 the serine/threonine kinase Raf-1 or the Ras effector domain mutant 12V/35S, which retains binding to
171 subunit of PI3-K, p110alpha-CAAX, or the Ras effector domain mutant 12V/40C, which retains binding to
178 We also generated cytosolic GTP-bound Ras effector domain mutants (EDMs), each of which reduced th
186 -dependent signaling, whereas the FADD death effector domain mutants rescued only TNF signaling.
188 Rac1, as well as activated Cdc42 containing effector domain mutations, all fail to restore antigen-s
191 minal regulatory domain (CTD), an N-terminal effector domain (NTD) and a ketocarotenoid; the chromoph
192 ctor VII (mfVII) targeting domain and the Fc effector domain of an IgG1 Ig (mfVII/Fc icon), was teste
193 f the chlorinated aromatic compound with the effector domain of CprK triggers binding of CprK to an u
194 The FADD-MBD4 interaction involved the death effector domain of FADD and a region of MBD4 adjacent to
195 ntly of the death effector domain, the death effector domain of FADD comes into direct contact with b
196 hat in contrast to current models, the death effector domain of FADD is involved in interaction with
197 previously identified mutations in the death effector domain of FADD that prevented binding to Fas/CD
199 onstrate that E6 binds directly to the death effector domain of Fas-associated death domain (FADD), w
201 entified in Drosophila Tube DD and the death effector domain of hamster PEA-15, two physiologically u
203 layer confirming the notion that PSA and the effector domain of MARCKS interact at and/or within the
205 In the presence of a peptide comprising the effector domain of MARCKS the EPR spectrum broadens, but
208 rresponding to the basic (+13), unstructured effector domain of myristoylated alanine-rich C kinase s
210 nctionally, we show that both the N-terminal effector domain of NLRC5 and its C-terminal leucine-rich
213 AF6, which directly interacts with the death effector domain of pro-caspase 8, and the N-terminal RIN
216 re effective activators: Ptr-H10, fusing the effector domain of Pyrococcus furiosus LrpA, and Ptr-H16
217 ss-linking synthetic peptide that mimics the effector domain of Rab3A and microsequence analysis, we
220 ntact effector domain since mutations in the effector domain of ScRheb are incapable of complementing
221 he Spt5 Nus-G N-terminal (NGN) domain is the effector domain of the complex that both mediates the in
222 ifically, experiments suggest that the basic effector domain of the myristoylated alanine-rich C kina
224 ptide comprising the phosphorylation site or effector domain of the protein acts as a powerful inhibi
225 udomonas syringae pv tabaci that deliver the effector domain of the Xcv AvrBs2 protein via the TTSS o
227 y transfer analysis indicates that the death-effector domains of caspase-8 and -10 both interact with
233 examined the thermodynamic stability of the effector domains of V. cholerae and A. hydrophila MARTX
235 LOV domains are associated with a variable effector domain or a separate protein signaling partner
237 yristoylated alanine-rich C kinase substrate effector domain) or elevated concentrations of Sec17p, w
238 Second, removing basic residues from the effector domain peptide reduces the binding energy by an
242 ccompanied by a conformational change of the effector domain, presenting a block in activation subseq
244 The scaffolding protein PEA-15 is a death effector domain protein that directly interacts with ERK
246 ble cysteine protease domain to the adjacent effector domain reduces its thermodynamic stability appr
249 ing substantially different contributions to effector domain regulation in individual members of the
250 coiled-coil C-helix interface, and that this effector domain reorientation stabilizes the active posi
251 gh these proteins share the majority of core effector domain residues with Ras, recent studies sugges
255 -stranded RNA (dsRNA) binding domain and the effector domain, separated through a linker-is an antago
256 ce similarity, 2) high conservation of their effector domain sequence, 3) presence of a unique argini
257 ts modest structural changes, while the H5N1 effector domain shows significant alteration, particular
258 n of ScRheb is dependent on having an intact effector domain since mutations in the effector domain o
259 and found that biotype 3 MARTX toxin has an effector domain structure distinct from that of either b
260 , a response regulator, and in some cases an effector domain such as an adenylyl or guanylyl cyclase,
261 at the inflammasome through its tandem death effector domain (tDED), which is regulated by the tDED-c
262 oligonucleotide sensor stem-loop and an RNAi effector domain that is designed to undergo a structural
263 tudy, we have thoroughly characterized a Rab effector domain that is present in proteins of the Mical
264 arboxyl terminus of gamma(1)34.5 contains an effector domain that is required to form a functional co
265 urrent small GTPase sensors rely on specific effector domains that are available for only a small num
266 ulti-domain proteins with varying N-terminal effector domains that are responsible for regulating dow
267 ns are composite toxins comprised of arrayed effector domains that carry out distinct functions insid
268 of two F2F3 molecules wraps around two NS1A effector domains that interact with each other head-to-h
269 king the DNA-binding protein to a variety of effector domains that mediate transcriptional activation
270 ependent growth assays, we mapped the NORE1A effector domain (the minimal region of the protein respo
271 of FADD functions independently of the death effector domain, the death effector domain of FADD comes
272 ress has been made characterizing individual effector domains, the role of paired domains and how the
273 we identify a novel class of methylated H3K4 effector domains--the PHD domains of the ING (for inhibi
274 and are transmitted to the spatially distant effector domain, thereby regulating its histidine kinase
275 pite sharing <20% sequence identity in their effector domains, they display a conserved core alpha-he
276 ated K-Ras in a GTP-dependent manner via the effector domain, thus exhibiting the basic properties of
277 sed to disrupt this interaction, causing the effector domain to be released and free to bind DNA.
278 These studies specifically link the MCFVv effector domain to induction of the intrinsic apoptosis
279 g enzymes evolved by the fusion of ancillary effector domains to an ancestral catalytic module involv
280 A-binding domain was engineered and fused to effector domains to either repress (G9a, Suvdel76, SKD)
281 (CRISPR)-Cas systems can target heterologous effector domains to endogenous sites in human cells.
285 Using a unique combination of targeting and effector domains, TT30 controls cell surface CAP activat
287 complex is dependent on the variant of death effector domain (vDED) in Bap31 and is required for the
288 e requirement for 2 distinct transcriptional effector domains was also displayed by VP16, which requi
289 an forkhead family member that contains both effector domains, was also capable of transforming hemat
290 ned action of myristoylation and a polybasic effector domain, which binds phospholipids and/or F-acti
291 y unfolded protein with a conserved cationic effector domain, which mediates the cross-talk between s
297 ylation receiver (REC) domain flanked by two effector domains with putative enzymatic activities (ser
298 n flanked by putative kinase and phosphatase effector domains with similarity to partner-switching pr
299 IMCyp gene encodes a protein fusion of TRIM5 effector domains with the capsid-binding ability of a re
300 nsights into the mechanism by which distinct effector domains within a protein cooperatively modulate
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