ライフサイエンスコーパス: effector function

1 by the fragmentation of the Golgi apparatus (effector function).

2 tical for cytotoxic lymphocyte signaling and effector function.

3 r activation, differentiation, survival, and effector function.

4 ry inflammation and natural killer (NK) cell effector function.

5 e result if all MBCs generated only terminal effector function.

6 ng the use of conserved regulatory cores for effector function.

7 ironmental cues influence both phenotype and effector function.

8 otential of IL-6 in regulating CD8(+) T cell effector function.

9 ours, causing profound suppression of T cell effector function.

10 molecules, cytokine secretion, and enhanced effector function.

11 ecessary and sufficient to suppress Th1 cell effector function.

12 roteins changes to appropriately guide their effector function.

13 ) cell induction, and restrain CD8(+) T cell effector function.

14 y Pbx1 as a novel regulator of CD4(+) T cell effector function.

15 ibition adversely affects early onset T-cell effector function.

16 ulted in superior intratumoral metabolic and effector function.

17 cted the natural killer (NK) cell number and effector function.

18 lly any expression system and still maintain effector function.

19 thout disrupting Ag-driven cell expansion or effector function.

20 ion via homotypic NK cell contact in NK cell effector function.

21 g pathway and increased NK cell survival and effector function.

22 s as a checkpoint for NK cell maturation and effector function.

23 ature of T cell dysfunction, activation, and effector function.

24 lso induced cytotoxicity in AML cells via Fc-effector function.

25 demonstrating that RNA is crucial for their effector function.

26 ion demonstrates a potent ability to restore effector functions.

27 , resulting in enhanced FcgammaRIII-mediated effector functions.

28 CAR T cells to the tumor site and increased effector functions.

29 ) T cells from Nlrc5(-/-) mice have impaired effector functions.

30 binding antibodies and antibody Fc-mediated effector functions.

31 tivation, T cells rapidly divide and acquire effector functions.

32 ch contributes to deficiencies in neutrophil effector functions.

33 ts of distinct subpopulations with differing effector functions.

34 deacetylase 11 (HDAC11) in regulating T-cell effector functions.

35 replication independently of adaptive immune effector functions.

36 ta1 integrins, which in turn elicit distinct effector functions.

37 the view that C5aR2 regulates C5aR1-mediated effector functions.

38 saccharides have been remodelled to optimise effector functions.

39 or Rab35 also exhibit enhanced TCR-mediated effector functions.

40 icit Abs with optimal binding properties and effector functions.

41 pressed on CD56(bright) NK cells with varied effector functions.

42 xpression determines phagocyte responses and effector functions.

43 Neonatal and adult T cells differ in their effector functions.

44 suing inflammatory reaction where they exert effector functions.

45 rmines the magnitude of Fc receptor-mediated effector functions.

46 enhancing their agonistic activities and/or effector functions.

47 vel link between ZAP-70 expression and these effector functions.

48 ism and has a role in regulating immune cell effector functions.

49 , differentiation, proliferation, death, and effector functions.

50 of antiviral IgG therapeutics with tailored effector functions.

51 CAM-1-deficient mice were defective in these effector functions.

52 allowed the inference of as yet undescribed effector functions.

53 dowed with distinct migratory capacities and effector functions.

54 ences in proliferative capacity, homing, and effector functions.

55 d T cells rescued their homing potential and effector functions.

56 cell receptor signaling with specific T cell effector functions.

57 the cytotoxicity of Fc-driven innate immune effector functions.

58 CD8(+) T cell proliferation, activation, and effector functions.

59 ereby reducing the steps necessary to revive effector functions.

60 nosurveillance and viral clearance via their effector functions.

61 romotes CD8(+) T-cell migratory behavior and effector functions.

62 st T cells and plays crucial roles in T cell effector functions.

63 n-specific CD4(+) T cells without relying on effector functions.

64 alters the Ig isotype to diversify antibody effector functions.

65 tection is antibody mediated and based on Fc effector functions.

66 ns, and tissue retention, as well as altered effector functions.

67 Although both receptors mediate diverse effector functions, a quantitative comparison of the sen

68 the tissue microenvironment and adjust their effector functions according to the prevalent extracellu

69 T) cells are T lymphocytes displaying innate effector functions, acquired through a distinct thymic d

70 ADAP-deficient TRM cells exhibited impaired effector function after Ag rechallenge, correlating with

71 ole in the control of EBV, enhancing NK cell effector functions against infected B cells in the lytic

72 olic switch partially preserves CD8(+) TILs' effector functions, although co-inhibitor expression inc

73 Thus, the diminished effector function and delayed central memory differentia

74 reviously demonstrated to enhance CD8 T cell effector function and differentiation.

75 ol esterification enzyme, led to potentiated effector function and enhanced proliferation of CD8(+) b

76 can serve as a roadmap for future studies of effector function and evolution.

77 f p53 inhibitors also potentiated the T-cell effector function and improved persistence.

78 However, effector function and localization have primarily been i

79 amming of metabolism is essential for T cell effector function and memory formation.

80 T-cell exhaustion is a progressive loss of effector function and memory potential due to persistent

81 s to mixed chimeras restored their cytotoxic effector function and permitted the generation of more e

82 ion in mice, bTRM rapidly acquired cytotoxic effector function and prevented fatal brain infection, e

83 ulting in the progressive loss of both their effector function and proliferative potential, clonal de

84 he efficacy of T-cell therapy by maintaining effector function and promoting memory.

85 ng CD4(+) T cells, correlating with enhanced effector function and reduced susceptibility to apoptosi

86 onist with alpha7nAChR on ILC2s reduces ILC2 effector function and represses ILC2-dependent AHR, whil

87 nal, as they express markers consistent with effector function and show signs of suppressing viral re

88 NK cell maturation is critical for normal effector function and the innate immune response to tumo

89 s in T cells is required to maintain optimal effector function and to prevent aberrant immune respons

90 nders both MBC subsets with different immune effector function and, ultimately, LLPCs at largely sepa

91 Interferon effector functions and autophagy are evolutionarily cons

92 specific gene-expression programs that drive effector functions and cell fates that correlate with ch

93 n IgG1 (hIgG1) Abs is an approach to improve effector functions and clinical efficacy of next-generat

94 erties that determine their ability to exert effector functions and contribute to T cell memory.

95 ells are critical for performing appropriate effector functions and maintaining immune memory, they a

96 x-Foxp3 Th2 cells exhibit characteristic Th2 effector functions and provide immunity to H. polygyrus

97 t rate of proliferation but had more limited effector functions and reduced killing compared with mem

98 Intact and broad immune cell effector functions and specific individual cytokines hav

99 ogical blockade of DppIVA restored leukocyte effector functions and stemmed infection, while addition

100 Fc N-glycosylation affects antibody-mediated effector functions and varies with inflammation rooted i

101 -NMUR1 signalling reduced ILC2 frequency and effector function, and altered transcriptional programs

102 l signaling pathway links metabolic sensing, effector function, and cell differentiation with inhibit

103 mediate cellular activation, proliferation, effector function, and cell survival upon binding to its

104 ory to maintain memory CD8 T-cell longevity, effector function, and Eomes expression.

105 ic CD8 T-cell response, enhancing expansion, effector function, and memory T-cell persistence.

106 ells are vital for proper T cell activation, effector function, and memory.

107 sfer approaches to profile clonal expansion, effector function, and recruitment of HSV-specific CD8(+

108 ons as a quantitative trait locus, dampening effector function, and, regardless of compatibility, tar

109 or effective TCR signaling and normal T cell effector functions, and associates with the CD3/CD28 com

110 of the complement response, exerting direct effector functions, and helping to coordinate downstream

111 y, the fusokine enhanced NK cell activation, effector functions, and interferon gamma production, res

112 aling and transcription factors (TF), immune effector functions, and negative regulators.

113 ; (iii) interfering with dendritic cell (DC) effector function; and (iv) inhibiting antitumor adaptiv

114 tumoral IL-35 enhanced T cell proliferation, effector function, antigen-specific responses, and long-

115 Their effector functions are closely linked to their cytotoxic

116 These integrin-dependent effector functions are controlled temporally whereby VLA

117 Its effector functions are controlled through interactions b

118 n to adopt an exhausted state in which their effector functions are lost.

119 However, the way in which Fc-dependent effector functions are regulated by polyclonal influenza

120 iprocal regulatory interactions and multiple effector functions are well documented in these organism

121 verexpressing EGFR, but exhibited diminished effector function as the density of EGFR decreased.

122 c-REL and IkappaBNS are required for T cell effector function as well.

123 in terms of their growth, proliferation, and effector functions as they respond to immunological chal

124 sequently, Lp/OVA/StII induced a more potent effector function, as shown by CTLs, in vivo assays.

125 t mouse B10 cell development, phenotype, and effector function, as well as on mechanistic studies tha

126 heral lymphoid organs, whereas they retained effector function at the tumor site, where in synergy wi

127 e to engineer an IgG1-based scaffold lacking effector function but with stability equivalent to that

128 f LAG-3 in PD-1-deficient mice restored TCD8 effector functions but increased lung pathology, indicat

129 ecule endows educated NK cells with enhanced effector functions but is dispensable for education.

130 tigenic stimulus and tissue homing/cytotoxic-effector functions but that a vast majority of them fail

131 ent kinase 5 (Cdk5) in T-cell activation and effector function, but the contribution of Cdk5 activity

132 3 ILC and thought to be important for their effector function, but they have not been shown to be ex

133 sted" CD8 T cells with impaired HIV-specific effector functions, but its role on CD4 T cells and in H

134 CMV)-encoded protein, m12, restrains NK cell effector function by directly engaging the inhibitory NK

135 poxic and hypoglycemic conditions, regaining effector function by engaging fatty acid catabolism, whi

136 novel insights concerning the regulation of effector function by T1-IFN in human antigen-experienced

137 structures of this glycan modulate antibody effector functions by affecting the binding affinity of

138 sm regulating the activation of Fc-dependent effector functions by broadly reactive antibodies.

139 romote both the expansion and acquisition of effector functions by CD8(+) T cells, which is accomplis

140 d exploited by tumor cells to blunt antibody effector functions by transmitting an inhibitory signal

141 ed and cytotoxicity-associated) derived from effector function co-expression patterns were used to an

142 ltered morphology and polarity, with reduced effector function compared with Cav1 wild-type CD8 T cel

143 However, Fab-mediated effector functions contributed to the in vivo efficacy b

144 This increased effector function correlated to the improved control of

145 ponses from relapsers, along with T-bet, and effector function could be significantly rescued, most e

146 Effector function-deficient variants of h2G7 were assess

147 NK effector function depends on specific killer-cell immuno

148 ated CD8 T cells allows them to retain their effector functions despite chronic stimulation during a

149 produced a range of cytotoxic and secretory effector functions, despite the presence of CMV-encoded

150 s for growth and survival, but also instruct effector functions, differentiation, and gene expression

151 t which lead to effective antibody-dependent effector function directed to the nonneutralizing CD4-de

152 k donor CD8 T cell numbers and decreased CTL effector function due to impaired granzyme B/perforin an

153 hat STING signaling attenuated CD8(+) T-cell effector functions during tumorigenesis.

154 ncreased levels of TIM3, CD69, and CD25) and effector function (e.g., production of IFNgamma and kill

155 rk definitively establishes the differential effector function for exosomes in communicating the TLR

156 nnate lymphoid cells (ILC2) are important in effector functions for eliciting allergic inflammation,

157 y of these antibodies to elicit Fc-dependent effector functions has emerged as an important mechanism

158 The increased FcgammaRIII-mediated effector functions have been put to use in various afuco

159 quired to facilitate IL-23-driven pathogenic effector functions; however, the precise role of T-bet i

160 ll response by comprehensively studying five effector functions (i.e., interleukin-2, tumor necrosis

161 Parallel upregulation of several T-cell effector functions (ie, polyfunctionality) is believed t

162 ndency, subset heterogeneity, and protective effector functions important for tuberculosis immunity.

163 tion against pathogens by exerting early Th1 effector functions, improving function of other innate c

164 y showed that PLT-Ecto could inhibit NK cell effector function in a TGF-beta1-dependent manner, sugge

165 cial for the regulation of proliferation and effector function in CD8(+) T cells.

166 tion of memory CD8(+) T cells and a stronger effector function in comparison with IL-15.

167 tion of reduced Kv1.3 and Ca(2+) flux on TIL effector function in head and neck cancer (HNC).

168 e signaling could restore the acquisition of effector function in ITK-deficient CD8(+) T cells.

169 cytokines and other signals that drive high effector function in NK cells, are driven by abnormaliti

170 variants that are efficacious in attenuating effector function in primates retain potent complement a

171 28 IFPs exhibited enhanced proliferation and effector function in response to CD200(+) leukemic cells

172 milar to TEM, as well as increased cytotoxic effector function in TCM Collectively, this work demonst

173 Furthermore, we observed superior cytotoxic effector function in TEM compared with TCM, and we provi

174 els suggests a possible conserved Rab GTPase effector function in tomosyn vertebrate homologues.

175 induction, is critical for IL-33-driven Th2 effector function in type-2 allergic airway responses.

176 tor activation to human and mouse eosinophil effector function in vitro and in vivo.

177 Notch signaling can influence effector functions in differentiated CD4(+) T helper and

178 uce PU.1 expression or upregulate neutrophil effector functions in Hbb(th3/+) mice.

179 n concert to overcome immune recognition and effector functions in hospitalized and immunosuppressed

180 ng their role is warranted to search similar effector functions in humans.

181 14 invariant NKT (iNKT) cells with important effector functions in infections and autoimmune diseases

182 nd abrogate FcgammaRIIIa-mediated downstream effector functions in macrophages, namely TNF release an

183 beta1 integrins control distinct antifungal effector functions in response to either fungal beta-glu

184 We also show that CD4(+) T cells produce effector functions in response to HCMV-infected cells an

185 mmune pathology; however, defining their key effector functions in specific autoimmune diseases remai

186 these integrins as a target for antibody Fc effector functions in the context of cancer immunotherap

187 of this study was to characterize different effector functions in the study samples and identify ass

188 um channel Kv1.3 lowers [K(+)]i and improves effector functions in vitro and in vivo and enhances tum

189 nduced signaling and the resulting mast cell effector functions in vitro and in vivo.

190 ment iC3b-opsonized targets is essential for effector functions including phagocytosis.

191 endritic cells to vIL-10 suppresses multiple effector functions including, notably, those that link i

192 We show in this article that neutrophil effector functions, including adhesion, production of re

193 ies, direct Ag engagement elicits eosinophil effector functions, including degranulation and Ag prese

194 This leads to reduced FcgammaRI effector functions, including Fc receptor gamma-chain si

195 expansion of T helper 17 (Th17) cells, whose effector functions, including IL-17A, activate keratinoc

196 isplayed central/effector memory and mounted effector functions, including the production of anti-M.

197 verse Env epitope specificities and multiple effector functions, including tier 1 neutralization, ant

198 l memory is characterized by rapid recall of effector function, increased proliferation, and reduced

199 therapy strategy in which a toxin or immune effector function is delivered selectively to the pathog

200 Linking immune cell metabolic phenotype to effector functions is important to understand how alteri

201 E ICs and downstream inflammatory neutrophil effector functions is not known.

202 , besides neutralization, innate immune cell effector functions may play a role in the antiviral acti

203 ralizing Abs can require the contribution of effector functions mediated by Fc-Fcgamma receptor (Fc-F

204 Diverse Ab effector functions mediated by the Fc domain have been c

205 expression of proteins with broad antiviral effector functions, most of which act to prevent viral t

206 evelopment, activation, and the execution of effector functions, multiple models predict that CD4 rec

207 mportant regulator of cytotoxic T lymphocyte effector functions.NFAT nuclear translocation has been s

208 therapeutic context, however, the cytotoxic effector function of an antibody is often not desirable

209 have been reported to silence or reduce the effector function of antibodies.

210 D-1 dominant negative receptor, restored the effector function of CD28 CAR T cells.

211 signaling provided critical support for the effector function of CD4(+) Foxp3(-) T cells during anti

212 lts link the loss of essential genes for the effector function of CD8(+) T cells with the resistance

213 enes whose loss in tumour cells impaired the effector function of CD8(+) T cells.

214 Whereas effector function of DNMT3a knockout T cells is normal,

215 CD70 reverse signaling enhanced survival and effector function of human NK cells in a B-cell acute ly

216 ical for the in vivo survival, expansion and effector function of IL-17-producing helper T (T(H)17) c

217 naling axis as an important regulator of the effector function of innate immune cells, a potential bi

218 y, none of the hypofucosylated IgGs enhanced effector function of macrophages, which, in contrast to

219 to promote T cell survival and activate the effector function of memory phenotype CD8 T cells.

220 ly shown that IL-8 production is a signatory effector function of naive T cells, at least in newborns

221 We recently demonstrated that the major effector function of neonatal CD4(+) T cells is to produ

222 ich antigen presentation controls the innate effector function of Th2 cells at the site of inflammati

223 rons, effects that entirely dependent on the effector function of the N-terminus.

224 Qualitative differences in the effector function of these anti-CD20 Abs appear specific

225 The importance of Fc-dependent effector functions of Abs induced by vaccination is incr

226 l allows for the remote control of cytotoxic effector functions of adoptively transferred T cells wit

227 CSR) increase the affinity and diversify the effector functions of antibodies during immune responses

228 cities, locations (systemic or mucosal), and effector functions of antibodies elicited by novel HIV-1

229 ransduction, transcriptional activation, and effector functions of B lymphocytes.

230 ole of tissue microenvironment in activating effector functions of committed Th17 cells, which may ha

231 ignaling pathways resulting in IL-33-induced effector functions of dendritic cells are unknown.

232 lycosylation of IgG is known to modulate the effector functions of Fcgamma receptors.

233 rasites are known to evade the antimicrobial effector functions of host immune cells.

234 roles of PKC enzymes in the development and effector functions of major hematopoietic and immune cel

235 n role of the adaptive immune system and the effector functions of mast cells and basophils at mucosa

236 o explain how matrix controls the antifungal effector functions of neutrophils under conditions that

237 pact the proliferation, differentiation, and effector functions of T cells.

238 e cytokines they produce, which parallel the effector functions of T lymphocytes.

239 a potential target to improve the cytotoxic effector functions of TCM for adoptive cell therapy appl

240 s) were found to promote the development and effector functions of Th2-type CD4(+) T cells by interac

241 These data indicate that the effector functions of TRIM5alpha can be separated from i

242 ated to remain in the tissue and exert their effector function only if they encounter their specific

243 ntibodies, and Fc fusions) requiring lack of effector function or elimination of binding to Fcgamma r

244 ations did not adversely affect the inherent effector functions or pharmacokinetic properties of the

245 f CMV pp65-specific T cells to gain multiple effector functions or polyfunctionality, which has been

246 ntiated independently but shared overlapping effector function programs that were mediated by exposur

247 T cell effector functions require sustained calcium influx.

248 T cell effector functions require the T cell antigen receptor (

249 findings suggest that the programming of NK effector function results from defined features of recep

250 ed to bind to antigens and initiate multiple effector functions such as phagocytosis, complement acti

251 f eosinophil activation and the induction of effector functions such as the expression of IL-13 to al

252 CD8(+) T-cell effector functions, such as cytokine and granzyme produc

253 n antigen-presenting cells, amplified T-cell effector functions, such as IFN-gamma and granzyme B pro

254 In vitro, Fab- and Fc-mediated effector functions, such as inhibition of ligand binding

255 cgammaR cross-linking that leads to cellular effector functions, such as phagocytosis, Ab-dependent c

256 Coordinated crosstalk of effector function suggests that MARTX toxins are not sim

257 omparable to those of the FcgammaR-dependent effector functions that are much better studied, while t

258 vated, Vdelta2((+)) T cells exhibit multiple effector functions that have made them attractive candid

259 okine milieu has long been known to regulate effector functions that include the choice of immunoglob

260 , they need to encode essential enzymatic or effector functions that may not be available or accessib

261 udies in a Drosophila model to define S100A4 effector functions that mediate metastatic dissemination

262 Subsequently, mAbs can use a wide range of effector functions that mostly engage the immune system.

263 ghting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammati

264 ivation and proliferation and acquisition of effector functions that require and depend on cellular m

265 GS-9620 also improved immune effector functions that specifically targeted HIV-infect

266 can activate HIV production and improve the effector functions that target latently infected cells.

267 ans on the Fc region are known to affect IgG effector functions, thereby possibly having a role in Ig

268 eir unique combination of CD4 and CD8 T cell effector functions, these CD4(-) CD8alphaalpha T cells a

269 nces clonal expansion and the acquisition of effector function through derepression of the let-7 targ

270 ents and suppressed T-cell proliferation and effector function through IL-10 production as well as ce

271 he regulation of CD8(+) T cell expansion and effector function through transcriptional repression of

272 macrophages restrain NK cell activation and effector functions through different mechanisms, leading

273 We report that GSH is essential for T cell effector functions through its regulation of metabolic a

274 nes, can trigger antibody-dependent cellular effector functions, through engagement of their Fc-gamma

275 3, CCL4, and XCL1, and modulators of NK cell effector functions (TNFRSF9, CRTAM, CD160).

276 n with a chimeric PD-1:28 receptor increases effector function to levels seen with high-avidity T cel

277 directed therapies that fine-tune macrophage effector functions to combat intracellular pathogens and

278 d mononuclear cells, and can activate immune effector functions to kill cancer cells in vitroIn vivo,

279 All cloned AHAs could restore immune effector functions to proteolytically generated F(ab')2

280 rotumor immune cells and altered immune cell effector functions to suppress antitumor immune response

281 ent with the detection of enhanced cytotoxic effector function toward autologous FL cells.

282 e as immune regulators polarizing macrophage effector functions toward more effective antiviral state

283 ncreased clonal expansion and acquisition of effector functions, Treg depletion led to the expression

284 point to a potential role for Fc-mediated Ab effector functions, tuned via differential glycosylation

285 jor theme is the need to both deliver faster effector function upon reexposure and readapt to antigen

286 detectable by Nkrp1g, which dampens NK cell effector functions upon Clr-g engagement.

287 8 T cells remain poised to rapidly elaborate effector functions upon re-exposure to pathogens, but al

288 s that respond rapidly with a broad range of effector functions upon recognition of glycolipid Ags pr

289 en to ensure that both stability and lack of effector function was achieved with a minimum number of

290 Conversely, development of effector function was attenuated at low precursor freque

291 lt in lack of glycosylation and thus loss of effector function, we demonstrate that the N297G variant

292 ee of protection from CD8(+) T cell-mediated effector functions, we evaluated whether Nef may be cont

293 -avidity TCRs that are capable of activating effector function when the concentrations of mutant pept

294 the IgG2 isotype is not completely devoid of effector function, whereas the IgG4 isotype can undergo

295 g the generation of autoantibodies and their effector functions, which include activation of innate i

296 IL-15 primes NK cells for effector functions, which were recently demonstrated to

297 that encompass transcriptional circuitry and effector functions while using nonredundant complementar

298 e feedback mechanism for constraining T cell effector function with a suitable time delay to thereby

299 that are long-lived and present rapid recall effector functions with reduced activation requirements.

300 proliferation, tissue homing, and cytotoxic effector functions, with the HLA-DR(+) CD38(+) subset be