ライフサイエンスコーパス: effector molecule

1 reactive oxygen species, an antileishmanial effector molecule.

2 e, in which the cytokine IL-6 is a prominent effector molecule.

3 tight junction protein and a potent anti-HCV effector molecule.

4 s either a neutralizing decoy receptor or an effector molecule.

5 erely exhausted T cells fail to produce this effector molecule.

6 ry and secondary structure and their cognate effector molecule.

7 d with high fidelity by sequestration of the effector molecule.

8 n of cytosolic tyrosines, which then recruit effector molecules.

9 ession, in response to synthetic non-natural effector molecules.

10 t restrains the expression of genes encoding effector molecules.

11 signals in the extracellular environment via effector molecules.

12 onal changes promoting binding of downstream effector molecules.

13 te the biochemistry of hosts by secretion of effector molecules.

14 rough the recruitment of other antimicrobial effector molecules.

15 acity to produce an array of proinflammatory effector molecules.

16 terized T6SSs, binds specifically to cognate effector molecules.

17 connecting upstream receptors to downstream effector molecules.

18 f the vaccine, with an increase in cytolytic effector molecules.

19 the ability to produce distinct patterns of effector molecules.

20 ant differences among the complexes with the effector molecules.

21 n-1 and transcription-independent control of effector molecules.

22 s to enable optimal interactions with murine effector molecules.

23 n, and the production of cytokines and other effector molecules.

24 ethylated at the loci of classically defined effector molecules.

25 phages as well as key cytokine and chemokine effector molecules.

26 an the lifetimes of downstream G-protein and effector molecules.

27 nic actions of leptin by blocking downstream effector molecules.

28 D8(+) T cells failed to up-regulate selected effector molecules.

29 ct binding to the promoters of these crucial effector molecules.

30 randed RNA (dsRNA) precursors into small RNA effector molecules.

31 go conformational rearrangement upon binding effector molecules.

32 egulate expression of activation markers and effector molecules.

33 th in the presence and absence of allosteric effector molecules.

34 of a broad array of receptors and downstream effector molecules.

35 TCH downstream targets and B-cell maturation/effector molecules.

36 , Rab proteins interact with proteins termed effector molecules.

37 zation and rational design of novel cereblon effector molecules.

38 Tumor Necrosis Factor Receptor to downstream effector molecules.

39 of GPCRs with heterotrimeric G proteins and effector molecules.

40 colytic activity and increased expression of effector molecules.

41 low extracellular pH, helping it to secrete effector molecules.

42 egs) and T(H)17 cells and controls important effector molecules.

43 or proper counteractions through adaptor and effector molecules.

44 es to 18 upon the addition of the allosteric effector molecule, 12-hydroxyeicosatetraenoic acid (12-H

45 teins derives from their ability to bind the effector molecules 2-oxoglutarate (2-OG) and ATP or ADP.

46 Recognition of certain effector molecules activates a strong defense, known as

47 ams that control expression of key cytolytic effector molecules, adhesion molecules, and cytokine and

48 d activation of downstream insulin signaling effector molecules AKT and Foxo1, and decreased expressi

49 e for translocation of a wide range of toxic effector molecules, allowing predatory cells to kill bot

50 Understanding how effector molecules alter the thermodynamic properties of

51 s: a receptor (aptamer) domain that binds an effector molecule and a regulatory domain (or expression

52 bility to link this regulation to downstream effector molecules and biological functions.

53 vels and resulted in increased production of effector molecules and cytotoxicity.

54 val by reducing intragraft expression of Th2 effector molecules and eosinophilic allograft infiltrati

55 ly polyfunctional, expressing high levels of effector molecules and exhibiting superior short-term co

56 modular fashion, which can be combined with effector molecules and half-life extension technologies.

57 ynapse, which mediates efficient delivery of effector molecules and intercellular signals across the

58 s as mediators of nociceptive sensitization, effector molecules and mechanisms responsible for modula

59 riptional signatures were maintained but key effector molecules and metabolic pathways were suppresse

60 ed virtually all arms, cellular players, and effector molecules and pathways involved in these crucia

61 nal properties of this subset and identified effector molecules and pathways which mediate their func

62 leptospiral proteases can deactivate immune effector molecules and represent potential targets to th

63 nti-inflammatory state; however, the biofilm effector molecules and the mechanism(s) of action respon

64 ular signaling pathways by engaging critical effector molecules and thus acts as a ligand-independent

65 These data support a role for Th1 effector molecules and transcription factors in the cont

66 T helper (Th) cell subtypes in both usage of effector molecules and transcription factors.

67 Sensor NLRs perceive pathogen-derived effector molecules and trigger robust host defense.

68 We highlight the signaling pathways, effector molecules, and cell populations that are activa

69 ntibody against the target, potent cytotoxic effector molecules, and conjugation of the monoclonal an

70 rate-limiting glycolytic enzymes, cytolytic effector molecules, and essential chemokine and adhesion

71 ecause IL-10 production, expression of other effector molecules, and general immune homeostasis are n

72 cular innate and adaptive immune cell types, effector molecules, and pathways can sometimes collectiv

73 pes based on overexpression of a single type effector molecule are not efficient in interrupting path

74 (TCIPS) or the molecular machinery by which effector molecules are released from platelets.

75 y, they are well suited for combination with effector molecules as well as half-life extension techno

76 -induced immune response is shaped by immune effector molecules at the site of vaccination.

77 Thus, PTX3, an effector molecule belonging to the humoral arm of innate

78 uPAR was physically associated with the WNT effector molecule beta-catenin on the membrane, cytoplas

79 These effector molecules bind interdependently to three anti-c

80 These effector molecules bind to IgG1 in the lower hinge-CH2 r

81 rbations in the regulatory domain induced by effector molecule binding are linked to a very specific,

82 g these structures can receive the cytolytic effector molecules, but cytotoxicity is suboptimal.

83 hese residues function to recruit downstream effector molecules, but mutagenesis and crystallization

84 ing transcription of IFN-gamma and other key effector molecules by donor CD8 cells in the epidermis,

85 By controlling the activation of effector molecules by G protein alpha and betagamma subu

86 ere is much cross-talk between the activated effector molecules by IFN-1 and other cytokines.

87 Immune-mediated effector molecules can limit cancer growth, but lack of

88 code transcription factors (including Tcf7), effector molecules, cell cycle regulators, and proteins

89 e through its ability to bind and cleave the effector molecule complement Component 4 (C4).

90 These cells could produce effector molecules constitutively, in response to phorbo

91 tion are well-defined, little is known about effector-molecules contributing to malignant expansion a

92 Tregs among CD4(+) T cells, turnover of the effector molecule CTLA-4, and their suppressive activity

93 acellular levels of the nitric oxide pathway effector molecule cyclic guanosine monophosphate (cGMP),

94 The composition of effector molecules deviates between different cell types

95 this body of work is that Arc is a critical effector molecule downstream of many molecular signaling

96 Furthermore, effector molecules downstream of BCR signaling, includin

97 pression of a wide range of genes (including effector molecules downstream of IL-17 such as cytokines

98 molecule hydrogen sulfide (H2S) as the major effector molecule driving apneas.

99 al mucosal homeostasis, as well as prominent effector molecules during chronic gut inflammatory disea

100 ent by competing nuclear receptors and their effector molecules, ecdysone and NO.

101 in-10), chemokines (IL-8), and intracellular effector molecules (exemplified by cyclooxygenase-2) was

102 The granzyme family serine proteases are key effector molecules expressed by cytotoxic lymphocytes.

103 rylation and to suppress their IL-15-induced effector molecule expression and cytolytic capacity.

104 during DC:NK cell coculture enhanced NK cell effector molecule expression as well as their cytolytic

105 T-cell and NK-cell immune effector molecule expression correlated with tumour-asso

106 ctor CD8(+) T cells showed some reduction in effector molecule expression, but primarily developed in

107 wnregulation of eomesodermin, which controls effector molecule expression.

108 on, proinflammatory cytokine production, and effector molecule expression.

109 orm in the absence of ADAP were defective in effector molecule expression.

110 Instead, chromatin loci of Th17 effector molecules failed to acquire an open conformatio

111 IGIT on Treg cells induced expression of the effector molecule fibrinogen-like protein 2 (Fgl2), whic

112 The isthmic organizer and its key effector molecule, fibroblast growth factor 8 (Fgf8), ha

113 s demonstrate that IFN-gamma is an antiviral effector molecule for MPyV infection.

114 e cytokine interleukin 13 (IL-13) is a major effector molecule for T-helper type 2 inflammation and i

115 xogenous galectin-9, in addition to being an effector molecule for Treg cells, acts synergistically w

116 uggesting that Mcl-1 might be one of the key effector molecules for BAFF-mediated survival of the Act

117 ntigen-specific T cells produce a variety of effector molecules for clearing infection but also contr

118 A search of downstream effector molecules for CPK32 led to identification of a

119 in pH that accompanies the "uncaging" of an effector molecule from o-nitrobenzaldehyde, a photoisome

120 ctions requires analysis of large numbers of effector molecules from single cells.

121 ntrinsic mechanism governed by the NF-kappaB effector molecule GADD45beta that restricts tumor-associ

122 ly induced their expression of the cytotoxic effector molecules granzyme B and perforin; their degran

123 tion, type 1 CD8 cytotoxic T cell-associated effector molecules granzyme B(+), IFN-gamma(+), TNF-alph

124 Blockade of individual effector molecules has limited efficacy in controlling G

125 Here, we investigate how the effector molecule HC-toxin (HCT), a histone deacetylase

126 f choice for studying the metabolism of this effector molecule; however, its short half-life necessit

127 ma by expressing higher levels of downstream effector molecules ido and nos2.

128 quired for the production of the key NK cell effector molecules IFN-gamma, which is important in deli

129 hile paradoxically repressing genes encoding effector molecules (IFN-gamma and granzyme B).

130 on of activation markers (CD69 and CD25) and effector molecules (IFN-gamma, granzyme B, and IL-10) di

131 The effector molecule IHP was found to lower nuFeHis selecti

132 regulatory functions and that the associated effector molecules IL-17 and IL-22 aid in restricting ti

133 rogram characterized by the induction of the effector molecules IL-7Ralpha, S1P1, and CCR7, but the u

134 These results reveal CdhR to be an effector molecule in a negative regulatory network that

135 lycogen phosphorylase (PYGM) as a novel Rac1 effector molecule in IL-2-stimulated cells.

136 These data suggest that Bim is a key effector molecule in JAK2 inhibition-induced apoptosis a

137 cer treatment, and caspase-3 is an important effector molecule in NK cell-mediated apoptosis in cance

138 genic, conditions, ICOS emerges as a pivotal effector molecule in the early decision between toleranc

139 pathways, specifically placing it as a novel effector molecule in the non-canonical Wnt/PCP pathway.

140 PDE6 (phosphodiesterase-6) is the effector molecule in the vertebrate phototransduction ca

141 Acute toxicity required two key effector molecules in CAR T cells-perforin and GM-CSF.

142 eactive and ACR patients exhibited increased effector molecules in CD8 T cells.

143 ls and induction of granzyme B and IFN-gamma effector molecules in CD8(+) T cells.

144 esting previously unknown functions of these effector molecules in endosomal trafficking.

145 f dithiolethione on NF-kappaB and downstream effector molecules in estrogen receptor-negative breast

146 one marrow (BM) and induce the expression of effector molecules in memory T cells, before their recru

147 Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease.

148 oite infection to examine the role of immune-effector molecules in resistance to the liver stage infe

149 eins (IFITMs) have been identified to be key effector molecules in the host type I interferon defense

150 icrobial proteins and peptides are essential effector molecules in this airway epithelial innate immu

151 trolled the expression of specific Treg cell effector molecules, including IL-10 and SOCS1.

152 n suppresses the upregulation of a subset of effector molecules, including ISG56 and IFITM1.

153 endently affecting a small group of powerful effector molecules; induction tolerance represented a mo

154 a identify endothelial JAM-A as an important effector molecule integrating atherogenic conditions to

155 n rates (<10%) and minimal production of the effector molecules interferon-gamma, interleukin-17, and

156 EPEC translocates effector molecules into host cells via type III secretio

157 a bacterial nanomachine for the transport of effector molecules into prokaryotic and eukaryotic cells

158 ns use type III secretion systems to deliver effector molecules into the cytoplasm of a host cell.

159 thways inside of the macrophage by secreting effector molecules into the cytoplasm.

160 Some pathogens deliver anti-inflammatory effector molecules into the host cell cytoplasm via a ty

161 te infection by delivering a large number of effector molecules into the plant cell.

162 mutualistic through to pathogenic, deliver 'effector' molecules into the cytoplasm or cellular milie

163 interfering RNA class of small RNAs are the effector molecules involved in direct silencing of CER3

164 NOD2-activated enterocytes to identify novel effector molecules involved.

165 ma (STS), we show that disruption of the IFN effector molecule IRF8 decreases pSTAT1 and increases uS

166 ting TLR2-MyD88 signals in T cells increased effector-molecule levels and enhanced the clearance of L

167 from exposure and detection by innate immune effector molecules like the C-type signaling lectin Dect

168 by enabling chromatin accessibility of Th17 effector molecule loci.

169 pathology, and targeting IFN-I or downstream effector molecules may be an effective therapeutic appro

170 ediated phagocytosis (CDCP) by immunological effector molecules mediated the clearance of target cell

171 omerulonephritis by impacting both cell- and effector molecule-mediated pathways.

172 Taken together, mGBP2 is an essential immune effector molecule mediating antiparasitic resistance.

173 murine NK cells regulate the translation of effector molecule mRNAs (e.g., granzyme B, GzmB) through

174 agellin receptor TLR5 and the TLR downstream effector molecules MyD88 and TIRAP that are associated w

175 of mice genetically deficient in TLR4 or its effector molecules MYD88 or TRIF.

176 activation of the phosphodiesterase 6 (PDE6) effector molecule occurs with less gain.

177 rease in production of caspase 3, a terminal effector molecule of apoptosis.

178 Moreover, we found that a major effector molecule of ETEC, the heat-labile enterotoxin (

179 p21-activated kinase (PAK1) as a downstream effector molecule of H2.0-like homeobox (HLX), a gene fu

180 e tetraphosphate (ppGpp), which serves as an effector molecule of many processes including transcript

181 its antiproliferative effect by acting as an effector molecule of Ras, resulting in the inhibition of

182 iptional activity of GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with auto

183 cytosolic phospholipase A(2) (cPLA(2)) as an effector molecule of Src-PLD1-PKCgamma signaling in the

184 ed the temporal transcription of RNAIII, the effector molecule of the agr quorum-sensing system.

185 mor-prone Beckwith-Wiedemann syndrome, is an effector molecule of the DNA-damage response.

186 Immunoglobulin G (IgG) is a major effector molecule of the human immune response, and aber

187 novel and apparently essential bactericidal effector molecule of the innate immune system.

188 The key effector molecule of the natural protein C pathway, acti

189 ovel roles for myosin II as a key regulatory effector molecule of the pro-fibrotic phenotype, in resp

190 over, although angiotensin II is the classic effector molecule of the RAS, several RAS enzymes affect

191 l phosphorylation and activation of ERK, the effector molecule of the Ras/MAPK cascade.

192 Here, we identify a presynaptic effector molecule of the Wingless/Wnt signal, Cortactin.

193 human host requires mechanisms to resist the effector molecules of host immunity, which exert their b

194 Immunoglobulins are the effector molecules of the adaptive humoral immune system

195 h the discovery that IgE antibodies were the effector molecules of the allergic response.

196 ) binding protein 1 (4E-BP1), two downstream effector molecules of the mammalian target of rapamycin

197 e recently been identified as important host effector molecules of the type I interferon response aga

198 n has been variously interpreted as a direct effector molecule on bacterial phagosomes or on other or

199 22-producing CD4(+) T cells may express some effector molecules on the membrane, and therefore synerg

200 gulate the function of any TALE either using effector molecules or a heterodimerization reaction.

201 urs as a consequence of direct binding of an effector molecule, or through sensing of a physical para

202 irectly by allowing or preventing docking of effector molecules, or directly by changing the intrinsi

203 d reactivation of the p53 and its downstream effector molecules p21(WAF1) and Bax.

204 Importantly, ablation of the cytolytic effector molecule perforin fully protected against vascu

205 e an important role for the immune cytotoxic effector molecule perforin in regulating this process.

206 erefore, we determined whether the cytolytic effector molecules perforin (PFP) and/or FasL (CD95L) we

207 T-cells showed increased expression of the effector molecules perforin and interferon-gamma with hi

208 d to a lesser extent, CD8(+) T cells and the effector molecule, perforin.

209 is thought to regulate expression of two key effector molecules, perforin and granzyme B.

210 Multiple immune-effector molecules play a role in antimicrobial immunity

211 of Treg cells, suggesting that undetermined effector molecules produced by IFN-gamma signaling is in

212 The relative contribution of the effector molecules produced by T cells to tumour rejecti

213 shown to regulate inflammatory cytokine and effector molecule production.

214 are harnessed to maximize proliferation and effector molecule production.

215 ored these immune cells, augmented cytotoxic effector molecules, promoted systemic inflammatory respo

216 iated critical adaptor members to downstream effector molecules, promoting successful nuclear deliver

217 t in nature the pathways intersect at common effector molecules providing for a common end point effe

218 function, the process by which binding of an effector molecule provokes a functional response from a

219 signature proteins, including the cytolytic effector molecule Rab27A associated with poor prognosis,

220 duced the association of Ras with one of its effector molecules, Raf, but not with Rho and phosphatid

221 Due to its fast pharmacokinetics, the small effector molecules reach the malignant tissue quickly an

222 ied many of the intracellular signalling and effector molecules required for the response to this sig

223 We show that the Agr-driven effector molecule RNAIII promotes cap expression largely

224 Here, we investigated the effector molecule(s) involved in CXCR3-B-mediated signal

225 lence) decreased by up to 84% for two of the effector molecules, scorpine, a potent antiplasmodial pe

226 via the simultaneous measurement of a dozen effector molecules secreted from tumor antigen-specific

227 Analysis of Rab1a effector molecules showed that p115 mediated Rab1a regul

228 These included key CTL effector molecules, signaling proteins and a subset of m

229 on of the TGFbeta receptor TGFbetaR1 and its effector molecule SMAD4 was required for enrichment of C

230 to infections, neutrophils rely on preformed effector molecules stored in a variety of intracellular

231 unctions and enhance the function of several effector molecules such as FcgammaR, uPAR, and CD14.

232 L-15 also resulted in poor expression of key effector molecules such as IFN-gamma, granzyme A and C,

233 Although the NKR-P1B(+) NK cells can produce effector molecules such as IFNs and granzymes, their pro

234 sferred CD8(+) T cells in vivo, upregulating effector molecules such as perforin, granzyme B, and IFN

235 nd specificity for a tumor target that carry effector molecules such as toxins, cytokines, or radiola

236 ed cells through RLR induction of downstream effector molecules such as type I interferon (IFN) and o

237 er certain conditions, these cells and their effector molecules, such as IL-17, IL-21, IL-22, GM-CSF,

238 concomitant reduced expression of antiviral effector molecules, such as MxA/B.

239 -KO mice were deficient in the production of effector molecules, such as tumor necrosis factor-alpha,

240 expression profiles and secretion of diverse effector molecules, suggesting functional heterogeneity.

241 ests in the upregulation of a poorly studied effector molecule, TGFbeta1-induced-1, which is a TGFbet

242 Fas ligand (FasL) is a major immune effector molecule that can contribute to the clearance o

243 de strong evidence that DSPP is a downstream effector molecule that mediates the roles of DMP1 in den

244 IL-10 is considered a chief effector molecule that promotes the vitamin D-induced im

245 Thus, TDRD3 is an effector molecule that promotes transcription by binding

246 protein 3 (TDRD3) is a major methylarginine effector molecule that reads methyl-histone marks and fa

247 Furthermore, the screen identifies effector molecules that are necessary for cell-cell inte

248 uggestion has been to develop genes encoding effector molecules that block parasite development withi

249 ly modified, resulting in the recruitment of effector molecules that can influence transcription.

250 en shown to carry a wide array of biological effector molecules that can play roles in cell-to-cell c

251 e developed a distinct profile of neutrophil effector molecules that closely reflected the one observ

252 high concentrations they act as microbicidal effector molecules that destroy intracellular pathogens,

253 similarities and differences in sensors and effector molecules that determine host resistance to the

254 sicular trafficking mechanisms controlled by effector molecules that include small GTPases and their

255 Tick saliva contains a number of effector molecules that inhibit host immunity and facili

256 (RANKL) is implicated as one of a number of effector molecules that mediate progesterone and prolact

257 nd proteome are mediated by pathogen-encoded effector molecules that modulate host cells through a va

258 c neutrophils may serve to inactivate select effector molecules that promote the pro-inflammatory act

259 ike growth factor 1) signal to intracellular effector molecules that regulate glucose homeostasis, be

260 lar messengers amplify signals by binding to effector molecules that trigger physiological changes.

261 h most CRP family members are coregulated by effector molecules, the activity of FixK2 is negatively

262 action profile between GR and its downstream effector molecules, the nuclear receptor coregulators, c

263 -specific memory CD8 T cells did not express effector molecules, their epigenetic landscape resembled

264 uld regulate hematopoiesis based on cytokine effector molecules they can produce.

265 nize such DAMPs and PAMPs, or the downstream effector molecules they engender, to limit inflammation.

266 Remarkably, the effector molecules through which these medications exert

267 immune regulation in which CTLA-4 acts as an effector molecule to inhibit CD28 costimulation by the c

268 d inducible nitric oxide synthase (NOS2) (an effector molecule to inhibit T. gondii growth) and the n

269 Fungal plant pathogens secrete effector molecules to establish disease on their hosts,

270 vesicles (EVs) that can transfer a range of effector molecules to host cells has made us re-think ou

271 omponents and play a role in the delivery of effector molecules to host cells.

272 because of the binding of specific signaling effector molecules to individual phosphorylated P-sites.

273 proteins Nck1/2 interact with a multitude of effector molecules to regulate diverse cellular function

274 on between receptor proteins and adaptor and effector molecules to regulate signal generation, amplif

275 Pathogens release effector molecules to suppress PTI.

276 es symbiotic bacteria to deliver antimalaria effector molecules to the midgut lumen, thus rendering h

277 ha(1D)-AR functional responses by recruiting effector molecules to the signalosome.

278 Targeting effector molecules to tumor cells is a promising mode of

279 ariable domains bind but also in the various effector molecules to which their constant regions (Fc d

280 used chemical methods for the attachment of effector-molecules to the antibody of interest.

281 ated from human peripheral blood express the effector molecule TRAIL.

282 tinct tissue markers, such as CD49a, and the effector molecules TRAIL and CD73.

283 owever, little is known about mechanisms and effector molecules triggering fibrosis and angiogenesis

284 intracellular pathogens by local delivery of effector molecules upon recognition of specific pathogen

285 (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control

286 ulating the eukaryotic host by translocating effector molecules via a type III secretion system (T3SS

287 factor 1 (CNF1), an Escherichia coli-derived effector molecule, we showed the host indirectly sensed

288 st cancer, expression of IL12A and cytotoxic effector molecules were predictive of pathological compl

289 rients and facilitating the translocation of effector molecules, whereas the exo-oligoxylanase XynA p

290 These methyl marks are interpreted by effector molecules, which harbor protein domains that bi

291 ke and NK cells expressing antimycobacterial effector molecules, which may be novel targets for tuber

292 protoxin-neutralizing antibodies are the key effector molecules while a shift to Th1 or Treg cells ma

293 repressors, these RNA elements must bind an effector molecule with high specificity against a backgr

294 The small fast-clearing radiolabelled effector molecules with a complementary functionality di

295 ural injury involves multiple cell types and effector molecules with both positive and negative effec

296 notype, which is coexpression of two or more effector molecules with cooperative action on the parasi

297 em cell memory (TSCM) CD8 T cells identified effector molecules with demethylated promoters and poise

298 Effector molecules with proven anti-sporogonic stage act

299 y identified the Formin protein Daam1 and an effector molecule XProfilin1 as links for Wnt-mediated c

300 mas, resulting in elevated expression of the effector molecule Yes-Associated Protein (YAP).